scholarly journals An In Vitro Study of Antibacterial Properties of Electrospun Hypericum perforatum Oil-Loaded Poly(lactic Acid) Nonwovens for Potential Biomedical Applications

2021 ◽  
Vol 11 (17) ◽  
pp. 8219
Author(s):  
Ayben Pakolpakçıl ◽  
Zbigniew Draczyński ◽  
Justyna Szulc ◽  
Dawid Stawski ◽  
Nina Tarzyńska ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Biomedical Applications ◽  
Hypericum Perforatum ◽  
Antibacterial Properties ◽  
In Vitro Study ◽  
Nonwoven Fabric ◽  
Wound Dressings ◽  
Poly Lactic Acid ◽  
Ultrafine Fibers

The growth of population and increase in diseases that cause an enormous demand for biomedical material consumption is a pointer to the pressing need to develop new sustainable biomaterials. Electrospun materials derived from green polymers have gained popularity in recent years for biomedical applications such as tissue engineering, wound dressings, and drug delivery. Among the various bioengineering materials used in the synthesis of a biodegradable polymer, poly(lactic acid) (PLA) has received the most attention from researchers. Hypericum perforatum oil (HPO) has antimicrobial activity against a variety of bacteria. This study aimed to investigate the development of an antibacterial sustainable material based on PLA by incorporating HPO via a simple, low-cost electrospinning method. Chemical, morphological, thermal, thickness and, air permeability properties, and in vitro antibacterial activity of the electrospun nonwoven fabric were investigated. Scanning electron microscopy (SEM) was used to examine the morphology of the electrospun nonwoven fabric, which had bead-free morphology ultrafine fibers. Antibacterial tests revealed that the Hypericum perforatum oil-loaded poly(lactic acid) nonwoven fabrics obtained had high antibacterial efficiency against Escherichia coli and Staphylococcus aureus, indicating a strong potential for use in biomedical applications.

scholarly journals Chitosan-Coated Poly(lactic acid) Nanofibres Loaded with Essential Oils for Wound Healing

Polymers ◽  
2021 ◽  
Vol 13 (16) ◽  
pp. 2582
Author(s):  
Giulia Milanesi ◽  
Barbara Vigani ◽  
Silvia Rossi ◽  
Giuseppina Sandri ◽  
Elisa Mele
Keyword(s):  
Antibacterial Activity ◽  
Lactic Acid ◽  
Essential Oils ◽  
Cellular Proliferation ◽  
Healing Process ◽  
Antibacterial Properties ◽  
Wound Dressings ◽  
Poly Lactic Acid ◽  
Mechanical Resistance

Chronic skin wounds are characterised by a non-healing process that makes necessary the application of wound dressings on the damaged area to promote and facilitate the recovery of skin’s physiological integrity. The aim of the present work is to develop a bioactive dressing that, once applied on the injured tissue, would exert antibacterial activity and promote adhesion and proliferation of fibroblasts. Nanofibres consisting of poly(lactic acid) (PLA) and essential oils (EOs) were electrospun and coated with a medium molecular weight chitosan (CS). Black pepper essential oil (BP-EO) or limonene (L), well-known for their antibacterial properties, were added to the PLA/acetone solution before electrospinning; phase separation phenomena occurred due to the poor solubility of the EOs in the PLA solution and led to fibres having surface nano-pores. The porous electrospun fibres were coated with CS to produce hydrophilic membranes that were easy to handle, biocompatible, and suited to promote cellular proliferation. The fibrous scaffolds were tested in terms of mechanical resistance, wettability, antibacterial activity, in-vitro cytotoxicity, and ability to promote fibroblasts’ adhesion and proliferation. The results obtained proved that the CS coating improved the hydrophilicity of the fibrous mats, enhanced EO’s antibacterial potential, and promoted cell adhesion and proliferation.

scholarly journals Comparative Study of Physicochemical and Antibacterial Properties of ZnO Nanoparticles Prepared by Laser Ablation of Zn Target in Water and Air

2018 ◽  
Author(s):  
Ekaterina A. Gavrilenko ◽  
Daria A. Goncharova ◽  
Ivan N. Lapin ◽  
Anna L. Nemoikina ◽  
Valery A. Svetlichnyi ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Zno Nanoparticles ◽  
Biomedical Applications ◽  
Antibacterial Properties ◽  
Pulsed Laser ◽  
Wound Dressings ◽  
E Coli ◽  
Nanosecond Pulsed Laser ◽  
Bactericidal Properties ◽  
Biodegradable Poly

Here, we report on ZnO nanoparticles (NPs) generated by nanosecond pulsed laser (Nd:YAG, 1064 nm) through ablation of metallic Zn target in water and air and their comparative analysis as potential nanomaterials for biomedical applications. The prepared nanomaterials were carefully characterized in terms of their structure, composition, morphology and defects. It was found that in addition to the main wurtzite ZnO phase, which is conventionally prepared and reported by others, the sample laser-generated in air also contained some amount of monoclinic zinc hydroxynitrate. Both nanomaterials were then used to modify model wound dressings based on biodegradable poly-L-lactic acid. The as-prepared model dressings were tested as biomedical materials with bactericidal properties towards S. aureus and E. coli strains. The advantages of the NPs prepared in air over their counterparts generated in water found in this work are discussed.   

scholarly journals Comparative Study of Physicochemical and Antibacterial Properties of ZnO Nanoparticles Prepared by Laser Ablation of Zn Target in Water and Air

Materials ◽  
2019 ◽  
Vol 12 (1) ◽  
pp. 186 ◽  
Author(s):  
Ekaterina A. Gavrilenko ◽  
Daria A. Goncharova ◽  
Ivan N. Lapin ◽  
Anna L. Nemoykina ◽  
Valery A. Svetlichnyi ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Zno Nanoparticles ◽  
Biomedical Applications ◽  
Antibacterial Properties ◽  
Pulsed Laser ◽  
Wound Dressings ◽  
E Coli ◽  
Nanosecond Pulsed Laser ◽  
Bactericidal Properties ◽  
Biodegradable Poly

Here, we report on ZnO nanoparticles (NPs) generated by nanosecond pulsed laser (Nd:YAG, 1064 nm) through ablation of metallic Zn target in water and air and their comparative analysis as potential nanomaterials for biomedical applications. The prepared nanomaterials were carefully characterized in terms of their structure, composition, morphology and defects. It was found that in addition to the main wurtzite ZnO phase, which is conventionally prepared and reported by others, the sample laser generated in air also contained some amount of monoclinic zinc hydroxynitrate. Both nanomaterials were then used to modify model wound dressings based on biodegradable poly l-lactic acid. The as-prepared model dressings were tested as biomedical materials with bactericidal properties towards S. aureus and E. coli strains. The advantages of the NPs prepared in air over their counterparts generated in water found in this work are discussed.

In vitro study of poly(lactic acid) pin degradation

Polymer ◽  
1999 ◽  
Vol 40 (23) ◽  
pp. 6465-6473 ◽  
Author(s):  
E.A.R Duek ◽  
C.A.C Zavaglia ◽  
W.D Belangero
Keyword(s):  
Lactic Acid ◽  
In Vitro Study ◽  
Vitro Study ◽  
Poly Lactic Acid

In Vitro Study on Cytocompatibility of Mg Wire/Poly(Lactic Acid) Composite Rods

2021 ◽  
Author(s):  
Hong Cai ◽  
Xuan Li ◽  
Feng Xue ◽  
Chenglin Chu ◽  
Chao Guo ◽  
...  
Keyword(s):  
Lactic Acid ◽  
In Vitro Study ◽  
Vitro Study ◽  
Poly Lactic Acid

scholarly journals Smart hydrogels based on itaconic acid for biomedical application

2009 ◽  
Vol 63 (6) ◽  
pp. 603-610
Author(s):  
Simonida Tomic ◽  
Maja Micic ◽  
Bojana Krezovic ◽  
Sava Dobic ◽  
Edin Suljovrujic ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Itaconic Acid ◽  
Biomedical Applications ◽  
Biomedical Application ◽  
In Vitro Study ◽  
Mechanical Analysis ◽  
Wound Dressings ◽  
Temperature Sensitive ◽  
Stimuli Responsive

pH and temperature sensitive hydrogels, based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) copolymers, were prepared by gamma irradiation and characterized in order to examine their potential use in biomedical applications. The influence of comonomer ratio in these smart copolymers on their morphology, mechanical properties, biocompatibility and microbe penetration capability was investigated. The mechanical properties of copolymers were investigated using the dynamic mechanical analysis (DMA), while their morphology was examined by scanning electron microscopy (SEM). The morphology and mechanical properties of these hydrogels were found to be suitable for most requirements of biomedical applications. The in vitro study of P(HEMA/IA) biocompatibility showed no evidence of cell toxicity nor any considerable hemolytic activity. Furthermore, the microbe penetration test showed that neither Staphylococcus aureus nor Escherichia coli passed through the hydogel dressing; thus the P(HEMA/IA) dressing could be considered a good barrier against microbes. All results indicate that stimuli-responsive P(HEMA/IA) hydrogels have great potential for biomedical applications, especially for skin treatment and wound dressings.

scholarly journals In Vitro and In Vivo Biosafety Analysis of Resorbable Polyglycolic Acid-Polylactic Acid Block Copolymer Composites for Spinal Fixation

Polymers ◽  
2020 ◽  
Vol 13 (1) ◽  
pp. 29
Author(s):  
Seung Kyun Yoon ◽  
Jin Ho Yang ◽  
Hyun Tae Lim ◽  
Young-Wook Chang ◽  
Muhammad Ayyoob ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Animal Experiments ◽  
Polymeric Materials ◽  
Polyglycolic Acid ◽  
Poly Lactic Acid ◽  
Skin Sensitization ◽  
Spinal Fixation ◽  
In Vivo Degradation

Herein, spinal fixation implants were constructed using degradable polymeric materials such as PGA–PLA block copolymers (poly(glycolic acid-b-lactic acid)). These materials were reinforced by blending with HA-g-PLA (hydroxyapatite-graft-poly lactic acid) and PGA fiber before being tested to confirm its biocompatibility via in vitro (MTT assay) and in vivo animal experiments (i.e., skin sensitization, intradermal intracutaneous reaction, and in vivo degradation tests). Every specimen exhibited suitable biocompatibility and biodegradability for use as resorbable spinal fixation materials.

scholarly journals Long-term antibacterial properties of a nanostructured titanium alloy surface: An in vitro study

2022 ◽  
Vol 13 ◽  
pp. 100176
Author(s):  
Richard Bright ◽  
Daniel Fernandes ◽  
Jonathan Wood ◽  
Dennis Palms ◽  
Anouck Burzava ◽  
...  
Keyword(s):  
Titanium Alloy ◽  
Antibacterial Properties ◽  
In Vitro Study ◽  
Vitro Study ◽  
Alloy Surface ◽  
Nanostructured Titanium
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