scholarly journals Effect of Pulsed Electromagnetic Field Stimulation on the Growth Plate of the Tibia Bone of Rats: An In Vivo Study

2021 ◽  
Vol 11 (16) ◽  
pp. 7571
Author(s):  
Yoon-Young Sung ◽  
Jae-Woo Shin ◽  
Won-Kyung Yang ◽  
Min-Jin Kim ◽  
Ja-Ik Koo ◽  
...  
Keyword(s):  
Electromagnetic Field ◽  
Growth Plate ◽  
Bone Growth ◽  
Articular Chondrocytes ◽  
Growth Promotion ◽  
Control Group ◽  
Pulsed Electromagnetic Field ◽  
Tibia Bone ◽  
Pulsed Electromagnetic

Currently, many children undergo precocious puberty, resulting in short stature due to premature closure of the growth plate. Pulsed electromagnetic field (PEMF) stimulation induces cell proliferation of articular chondrocytes. We developed a method for growth promotion using equipment with PEMF. In this study, we aimed to evaluate the effects of PEMF on the growth rate of growth plates using an animal model. An experimental study was conducted on 16 3-week-old rats to validate the effects of the growth care device on growth and development by PEMF stimulation at 28 Hz and 20 Gauss. The tibia bones of the groups with and without PEMF administration were dissected after 10 days, and then, the length of the growth plate of the knee and levels of insulin-like growth factor (IGF)-1 hormone in serum were measured. The length of the growth plate on the tibia bone and the levels of circulating IGF-1 were significantly increased by 25.6% and 13.6%, respectively, in the experimental group to which PEMF was applied compared to those of the control group, without any side effects. These results suggest that PEMF can safely stimulate growth of the growth plate in a non-invasive manner to promote bone growth.

scholarly journals Pulsed Electromagnetic Field Affects the Development of Postmenopausal Osteoporotic Women with Vertebral Fractures

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Wei Liu ◽  
Xiao Jin ◽  
Zhiqiang Guan ◽  
Qiyun Zhou
Keyword(s):  
Electromagnetic Field ◽  
Treatment Group ◽  
Bone Loss ◽  
Vertebral Fractures ◽  
Bone Microstructure ◽  
Control Group ◽  
Pulsed Electromagnetic Field ◽  
Related Quality ◽  
Health Related ◽  
Pulsed Electromagnetic

Background. Postoperative pain, dysfunction, and significant bone loss may occur after vertebral fractures, which will lead to the occurrence of refractures and shorten the survival time, so postoperative rehabilitation is very important. Pulsed electromagnetic field therapy is noninvasive, pain-relieving, and beneficial to reduce bone loss and is an important treatment for patients to recover after surgery. Therefore, this study analyzed the effect of postmenopausal women’s vertebral fracture rehabilitation after pulsed electromagnetic field treatment. Method. This study uses a randomized controlled study, respectively, in the pulsed electromagnetic field treatment group (40 cases) and the control group (42 cases), respectively. We studied the results of health-related quality of life scores (HRQOL), back pain, body function, hip bone density, bone microstructure of tibia, and radius after 1 month and 3 months after surgery. Results. Compared with the control group, the pulsed electromagnetic field treatment group (PEMF) can improve significantly the psychological score, 6-minute walk test, and Chair Sit-and-Reach one month after the operation. And at 3 months after surgery, the pulsed electromagnetic field treatment group can improve significantly in health-related quality of life scores (HRQOL), back pain, and body function. Regarding the effect of changes in bone mass, compared with the control group, pulsed electromagnetic field treatment had no significant effect on changes in hip bone density. As a result of changes in bone microstructure, pulsed electromagnetic field treatment can significantly improve the bone microstructure of the radius and tibia three months after vertebral fractures. Conclusion. Pulsed electromagnetic field therapy has positive significance for improving pain, body functional changes, and bone loss after vertebral fracture surgery.

scholarly journals In vivo effect of two different pulsed electromagnetic field frequencies on osteoarthritis

2014 ◽  
Vol 32 (5) ◽  
pp. 677-685 ◽  
Author(s):  
F. Veronesi ◽  
P. Torricelli ◽  
G. Giavaresi ◽  
M. Sartori ◽  
F. Cavani ◽  
...  
Keyword(s):  
Electromagnetic Field ◽  
Pulsed Electromagnetic Field ◽  
Pulsed Electromagnetic

scholarly journals Electrotransfer of siRNA to Silence Enhanced Green Fluorescent Protein in Tumor Mediated by a High Intensity Pulsed Electromagnetic Field

Vaccines ◽  
2020 ◽  
Vol 8 (1) ◽  
pp. 49 ◽  
Author(s):  
Simona Kranjc Brezar ◽  
Matej Kranjc ◽  
Maja Čemažar ◽  
Simon Buček ◽  
Gregor Serša ◽  
...  
Keyword(s):  
Electromagnetic Field ◽  
Green Fluorescent Protein ◽  
High Intensity ◽  
Enhanced Green Fluorescent Protein ◽  
Fluorescent Protein ◽  
Gene Electrotransfer ◽  
Pulsed Electromagnetic Field ◽  
Pulsed Electromagnetic ◽  
Green Fluorescent

The contactless high intensity pulsed electromagnetic field (HI-PEMF)-induced increase of cell membrane permeability is similar to conventional electroporation, with the important difference of inducing an electric field non-invasively by exposing a treated tissue to a time-varying magnetic field. Due to the limited number of studies in the field of electroporation induced by HI-PEMF, we designed experiments to explore the feasibility of such a contactless delivery technique for the gene electrotransfer of nucleic acids in tissues in vivo. By using HI-PEMF for gene electrotransfer, we silenced enhanced green fluorescent protein (EGFP) with siRNA molecules against EGFP in B16F10-EGFP tumors. Six days after the transfer, the fluorescent tumor area decreased by up to 39% as determined by fluorescence imaging in vivo. In addition, the silencing of EGFP to the same extent was confirmed at the mRNA and protein level. The results obtained in the in vivo mouse model demonstrate the potential use of HI-PEMF-induced cell permeabilization for gene therapy and DNA vaccination. Further studies are thus warranted to improve the equipment, optimize the protocols for gene transfer and the HI-PEMF parameters, and demonstrate the effects of HI-PEMF on a broader range of different normal and tumor tissues.

scholarly journals Beneficial Effects of Pulsed Electromagnetic Field during Cast Immobilization in Patients with Distal Radius Fracture

2020 ◽  
Vol 2020 ◽  
pp. 1-8
Author(s):  
Lucyna Krzyżańska ◽  
Anna Straburzyńska-Lupa ◽  
Patrycja Rąglewska ◽  
Leszek Romanowski
Keyword(s):  
Electromagnetic Field ◽  
Distal Radius ◽  
Upper Limb ◽  
Distal Radius Fractures ◽  
Control Group ◽  
Pulsed Electromagnetic Field ◽  
Radius Fractures ◽  
Cast Immobilization ◽  
Beneficial Effects ◽  
Pulsed Electromagnetic

To assess whether pulsed electromagnetic field therapy during cast immobilization of distal radius fractures has beneficial effects on pain and limb function, the study included 52 patients (mean age 60.8 ± 15.0 years) with distal radius fractures treated with cast immobilization. Patients were allocated to a pulsed electromagnetic field group (n = 27) or a control group (n = 25). Pain; forearm and arm circumference; range of motion; disabilities of the arm, shoulder, and hand score; and touch sensation were evaluated on the day of the plaster cast dressing and 3 and 6 weeks after. In comparison to the control group, the pulsed electromagnetic field group reported significant changes after 3 and 6 weeks of treatment: lower pain levels (p=0.0052; p<0.0001, respectively), greater mobility of upper-limb joints, improvement in exteroceptive sensation, and reduction in disability of the upper limb (disabilities of the arm, shoulder, and hand) (p=0.0003; p<0.0001, respectively). Our results suggest that early addition of pulsed electromagnetic field treatment, during cast immobilization of distal radius fractures, has beneficial effects on the pain, exteroceptive sensation, range of motion, and daily functioning of patients.

scholarly journals Alterations of Hematologic and Hematopoietic Parameters in Mice Exposed to Pulsed Electromagnetic Field

2019 ◽  
Vol 2019 ◽  
pp. 1-6
Author(s):  
Kangchu Li ◽  
Zenghui Teng ◽  
Zhaohui Liu ◽  
Yuxing Zhang ◽  
Kaiping Long ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Electromagnetic Field ◽  
Blood Cells ◽  
Bone Marrow Cells ◽  
Exposed Group ◽  
Control Group ◽  
Pulsed Electromagnetic Field ◽  
Gm Csf ◽  
Pulsed Electromagnetic ◽  
Marrow Cells

Effects of pulsed electromagnetic field (PEMF) on hematology and hematopoiesis might vary with different PEMF parameters. The purpose of this study was to evaluate the possible effects of PEMF exposure at different pulses on hematologic and hematopoietic parameters in mice. Groups of male BALB/c mice were whole body exposed or were sham exposed (control) to PEMF at 100, 1000, and 10000 pulses. After PEMF exposure, blood samples and bone marrow cells of mice were collected for hematologic examinations, bone marrow nucleated cell counting, colony-forming units of granulocyte-macrophage (CFU-GM) colony assay, and serum granulocyte-macrophage colony-stimulating factor (GM-CSF) assay. Compared with the control group, white blood cells (WBC) and lymphocytes (LYM) in the 100 and 1000 pulses exposed groups were significantly increased but not changed in the 10000 pulses exposed group. Red blood cells (RBC), hemoglobin (HGB), and platelets (PLT) were not changed in all exposed groups. There was no significant difference in mouse bone marrow nucleated cell number between the control group and each exposed group 7 days after PEMF exposure. The CFU-GM clone number of bone marrow cells and serum GM-CSF level were significantly increased in the 100 and 1000 pulses exposed group but not changed in the 10000 pulses exposed group. Our results indicated that the PEMF exposure at fewer pulses may induce statistically significant alterations in some hematologic and hematopoietic parameters of mice but no changes can be found in the more pulses PEMF-exposed groups.

scholarly journals Electrochemotherapy by pulsed electromagnetic field treatment (PEMF) in mouse melanoma B16F10 in vivo

2016 ◽  
Vol 50 (1) ◽  
pp. 39-48 ◽  
Author(s):  
Simona Kranjc ◽  
Matej Kranjc ◽  
Janez Scancar ◽  
Jure Jelenc ◽  
Gregor Sersa ◽  
...  
Keyword(s):  
Electromagnetic Field ◽  
Tumor Growth ◽  
Combined Treatment ◽  
Drug Uptake ◽  
Growth Delay ◽  
Pulsed Electromagnetic Field ◽  
Tumor Growth Delay ◽  
Mouse Melanoma ◽  
Pulsed Electromagnetic

Introduction Pulsed electromagnetic field (PEMF) induces pulsed electric field, which presumably increases membrane permeabilization of the exposed cells, similar to the conventional electroporation. Thus, contactless PEMF could represent a promising approach for drug delivery. Materials and methods Noninvasive electroporation was performed by magnetic field pulse generator connected to an applicator consisting of round coil. Subcutaneous mouse B16F10 melanoma tumors were treated with intravenously injection of cisplatin (CDDP) (4 mg/kg), PEMF (480 bipolar pulses, at frequency of 80 Hz, pulse duration of 340 μs) or with the combination of both therapies (electrochemotherapy − PEMF + CDDP). Antitumor effectiveness of treatments was evaluated by tumor growth delay assay. In addition, the platinum (Pt) uptake in tumors and serum, as well as Pt bound to the DNA in the cells and Pt in the extracellular fraction were measured by inductively coupled plasma mass spectrometry. Results The antitumor effectiveness of electrochemotherapy with CDDP mediated by PEMF was comparable to the conventional electrochemotherapy with CDDP, with the induction of 2.3 days and 3.0 days tumor growth delay, respectively. The exposure of tumors to PEMF only, had no effect on tumor growth, as well as the injection of CDDP only. The antitumor effect in combined treatment was related to increased drug uptake into the electroporated tumor cells, demonstrated by increased amount of Pt bound to the DNA. Approximately 2-fold increase in cellular uptake of Pt was measured. Conclusions The obtained results in mouse melanoma model in vivo demonstrate the possible use of PEMF induced electroporation for biomedical applications, such as electrochemotherapy. The main advantages of electroporation mediated by PEMF are contactless and painless application, as well as effective electroporation compared to conventional electroporation.

Evaluation of pulsed electromagnetic field protocols in implant osseointegration: in vivo and in vitro study

2020 ◽  
Author(s):  
Camilla Magnoni Moretto Nunes ◽  
Camila Lopes Ferreira ◽  
Daniella Vicensotto Bernardo ◽  
Cássia Carolina Rabelo Lopes ◽  
Luma Collino ◽  
...  
Keyword(s):  
Electromagnetic Field ◽  
In Vitro Study ◽  
Vitro Study ◽  
Pulsed Electromagnetic Field ◽  
Pulsed Electromagnetic

scholarly journals Effect of the Pulsed Electromagnetic Field (PEMF) on Dental Implants Stability: A Randomized Controlled Clinical Trial

Materials ◽  
2020 ◽  
Vol 13 (7) ◽  
pp. 1667 ◽  
Author(s):  
Bhukya P. Nayak ◽  
Oleg Dolkart ◽  
Parth Satwalekar ◽  
Yeramala P. Kumar ◽  
Anam Chandrasekar ◽  
...  
Keyword(s):  
Electromagnetic Field ◽  
Primary Stability ◽  
Treated Group ◽  
Control Group ◽  
Controlled Clinical Trial ◽  
Pulsed Electromagnetic Field ◽  
Mean Values ◽  
Overall Stability ◽  
Pulsed Electromagnetic ◽  
The Stability

A pulsed electromagnetic field (PEMF) has been shown to contribute to heightening bone regeneration in a range of clinical areas, including dentistry. Due to the scarcity of studies using PEMF in oral implantology, the present experiment scrutinized the effect of PEMF can lead to improving the stability of the implant. A total of 19 subjects (40 implants in total) were selected to participate in the current study and were randomly allocated to either the PEMF group or control group. Subjects in the PEMF group received an activated miniaturized electromagnetic device (MED) while the control group received a sham healing cup. Implants stability was assessed by resonance frequency analyses (RFA) via implant stability quotient (ISQ) calculations. RFA were recorded as following: immediately after procedure, and then 2, 4, 6, 8 and 12 weeks later. Radiographic analysis was performed at baseline, 6 and 12 weeks after implant placement. Proinflammatory cytokines were evaluated in peri-implant crevicular fluid (PICF). The PEMF group presented higher ISQ mean values when compared to the control group. The primary stability time frame (the first 2 weeks) MED group depicted an increase in stability of 6.8%, compared to a decrease of 7.6% in the control group related to the baseline. An overall stability increase of 13% was found in MED treated group (p = 0.02), in contrast, the overall stability in the control group decreased by 2% (p = 0.008). TNF-α concentration during first 4 weeks was lower in the MED treated group. The data strongly suggests that MED generated continuing a PEMF may be considered as a new way to stimulate the stability of the implants at the early healing period.

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