scholarly journals The Relationship between Mitochondria and Neurodegeration in the Eye: A Review

2021 ◽  
Vol 11 (16) ◽  
pp. 7385
Author(s):  
Hongtao Liu ◽  
Hanhan Liu ◽  
Verena Prokosch

Mitochondria are the energy factories of cells. Mitochondrial dysfunction directly affects the function and morphology of cells. In recent years, growing evidence has shown that mitochondrial dysfunction plays an important role in neurodegenerative diseases. In the eye, some age-related diseases are considered to be neurodegenerative diseases, such as primary open-angle glaucoma (POAG) and age-related macular degeneration (AMD). Here, we review the mechanisms of mitochondrial damage, post-injury repair, and the roles of mitochondria in various tissues of the eye. In the following sections, the potential for treating glaucoma by reducing mitochondrial damage and promoting post-injury repair is also discussed.

2019 ◽  
Vol 3 (4) ◽  
Author(s):  
Karla Tratsk

PURPOSE: In ophthalmology many diseases lead to irreversible blindness, something that implies millions of dollars in care because people with these difficulties loose their autonomy, becoming dependent in all their everyday activities. This presentation will focus on clinical cases of the following pathologies treated with Ozone Therapy because all these were already being treated in a conventional way without signs of improvement. They are primary open-angle glaucoma, age-related macular degeneration, diabetic retinopathy, occlusion of the central retinal artery, facial paralysis and herpetic polyneuropathy associated with orbital apex syndrome. CASE PRESENTATION: As an example, a patient, 73 , female, insulin-dependent diabetes for 10 years, with primary open angle glaucoma, diabetic retinopathy with various laser photocoagulations, vitrectomies and intravitreal injections in both eyes (BE). Visual acuity (VA) of 20/200 in right eye (RE) and 20/100 in left eye (LE). Subjected to the facectomy in RE and with cataract in LE. The fundoscopy was stable in BE. The VA went to 20/200 on 1st day of postoperative period and remained stable until 21st day. After integrative treatment with Ozone Therapy the patient got a VA of 20/60-2 in RE and 20/40-2 in LE, restoring vision and improving her quality of life. Furthermore, she stopped to be insulin dependent, only having to take oral medication. CONCLUSION: The result shows that Ozone therapy should be a therapeutic tool to be associated with Ophthalmology because in many cases, including difficult treatment and evolution, it recovers visual acuity and re-establishes ocular physiology, promoting the maintenance of eye health and vision, contributing to the preservation of autonomy in the lives of patients.


2014 ◽  
Vol 7 (1) ◽  
pp. 19-27 ◽  
Author(s):  
R. V. Avdeyev ◽  
A. S. Aleksandrov ◽  
A. S. Basinskiy ◽  
Ye. A. Blyum ◽  
A. Yu. Brezhnev ◽  
...  

A study of cross-impact degree and morpho-functional correlation characteristics of primary open angle glaucoma and age-related macular degeneration was performed at 25 clinical sites in Russia and some CIS countries from January through May 2013. The study final protocol included 87 patients (108 eyes) divided into two groups, mean age of patients was 66.6 ± 5.65 years (min 55; max 81). Intragroup and intergroup variance analysis did not establish any significant difference in the macular area between the «glaucoma» group and the «glaucoma + AMD» group depending on the disease stage. The findings suggest that macular degeneration develops subsequent to a preexisting glaucomatous state.


2021 ◽  
Vol 2 (3) ◽  
pp. 5-10
Author(s):  
Saida Egamberdiyeva ◽  
◽  
Sarvarkhon Yuldashov ◽  
Azamjon Korabaev ◽  
Namunahon Askarova

Age-related macular degeneration (AMD) is a progressive eye disease in which the physiological function of the choriocapillaries, Bruch’s membrane, and retinal pigment epithelium (RPE) areimpaired, a defect in the photoreceptor layer occurs, and central vision is irreversible. Primary open-angle glaucoma (POAG)is a pathological process characterized by impaired hydrodynamicsof intraocular fluid and damage to the optic nerve, althoughthe anterior chamber angle is open. In this disease, intraocular pressure (IOP) often increases and peripheral vision decreases depending on the retinallayer's level of compression. According to WHO statistics, POAG is then complicated by the “dry” form of AMD in 41% of cases, i.e. an effectivecombination of the above two pathologies can be observed in clinical practice. Consumption of foods rich in antioxidant micronutrients and drugslikes“Ophthalmocomplex” in the prevention and treatment of chronic degenerative eye diseases such as primary open-angle glaucoma (POAG) and age-related macular degeneration (AMD) can shorten the rehabilitation period. Themechanisms of development of pathologicalprocesses (especially inflammation, degeneration) are different. Still,the main pathogenetic point is the disruption of the antioxidant defense system as a result of detoxification.Keywords: age-related macular degeneration (AMD), primary open-angle glaucoma (POAG), vitamins, antioxidants, partially oxidized free radicals, Ophthalmocomplex drug, healthy eating


Sign in / Sign up

Export Citation Format

Share Document