scholarly journals Numerical and Experimental Assessment of a Novel Anchored for Intramedullary Telescopic Nails Used in Osteogenesis Imperfecta Fractures

2021 ◽  
Vol 11 (12) ◽  
pp. 5422
Author(s):  
Luis Antonio Aguilar-Pérez ◽  
José Israel Sánchez-Cruz ◽  
Juan Alejandro Flores-Campos ◽  
Christopher René Torres-SanMiguel
Keyword(s):  
Osteogenesis Imperfecta ◽  
Minimal Invasive ◽  
Long Bones ◽  
Experimental Assessment ◽  
Metal Implants ◽  
Fractures In Children ◽  
Original Length ◽  
Progressive Growth ◽  
Typical Treatment ◽  
Extension Length

Osteogenesis Imperfecta (IO) is a bone disease mainly characterized by the low bone density that produces common fractures in children around 0–7 years. The use of metal implants is a typical treatment of this disease. The intramedullary telescopic nail (ITN) was inspired by the progressive growth in the long bones such as the femur or humerus during children’s aging. This work shows an experimental assessment of the ITN’s, focusing on their fixation; the proposed improvements in the design of the intramedullary nail studied include the separation of the element into two parts for telescopic enlargement, minimal invasive fixation through the distal anchorage, and the double auto-drilled end for fixation on the distal and proximal section of the bone. The samples were manufactured in 316 L steel and mounted on specialized jaws to replicate the implants’ boundary conditions. The experimental test was repeated three times to report the intramedullary telescopic nail’s behavior at three lengths. The results show that the device supports only 79.06 N when not at extension length. However, if the device is extended 150% it will support 46.87 N which suggests that intramedullary telescopic nails can only increase by 25% of their original length before they fail.

scholarly journals Randomized Controlled Trial of the Clinical Recovery and Biodegradation of Polylactide-co-glycolide Implants Used in the Intramedullary Nailing of Children’s Forearm Shaft Fractures with at Least Four Years of Follow-Up

2021 ◽  
Vol 10 (5) ◽  
pp. 995
Author(s):  
Marja Perhomaa ◽  
Tytti Pokka ◽  
Linda Korhonen ◽  
Antti Kyrö ◽  
Jaakko Niinimäki ◽  
...  
Keyword(s):  
Intramedullary Nailing ◽  
Controlled Trial ◽  
Long Term Outcomes ◽  
Intramedullary Nails ◽  
Metal Implants ◽  
Shaft Fractures ◽  
Fractures In Children ◽  
Significant Difference

The preferred surgical fixation of forearm shaft fractures in children is Elastic Stable Intramedullary Nailing (ESIN). Due to known disadvantageous effects of metal implants, a new surgical method using biodegradable polylactide-co-glycolide (PLGA) intramedullary nails has been developed but its long-term outcomes are unclear. The aim of this study was to compare the long-term outcomes of Biodegradable Intramedullary Nailing (BIN) to ESIN and assess the biodegradation of the study implants via magnetic resonance imaging (MRI). The study population of the prospective, randomized trial consisted of paediatric patients whose forearm shaft fractures were treated with BIN (n = 19) or ESIN (n = 16). Forearm rotation at minimally four years’ follow-up was the main outcome. There was no clinically significant difference in the recovery of the patients treated with the BIN as compared to those treated with the ESIN. More than half of the implants (57.7%, n = 15/26) were completely degraded, and the rest were degraded almost completely. The PLGA intramedullary nails used in the treatment of forearm shaft fractures in this study resulted in good function and anatomy. No unexpected disadvantages were found in the degradation of the implants. However, two implant failures had occurred in three months postoperatively.

Non-union of fractures in children who have osteogenesis imperfecta.

1988 ◽  
Vol 70 (3) ◽  
pp. 439-443 ◽  
Author(s):  
J G Gamble ◽  
L A Rinsky ◽  
J Strudwick ◽  
E E Bleck
Keyword(s):  
Osteogenesis Imperfecta ◽  
Non Union ◽  
Fractures In Children

scholarly journals Bisphosphonate Treatment and the Characteristics of Femoral Fractures in Children With Osteogenesis Imperfecta

2017 ◽  
Vol 102 (4) ◽  
pp. 1333-1339 ◽  
Author(s):  
Ilkka Vuorimies ◽  
Mervi K. Mäyränpää ◽  
Helena Valta ◽  
Heikki Kröger ◽  
Sanna Toiviainen-Salo ◽  
...  
Keyword(s):  
Osteogenesis Imperfecta ◽  
Femoral Fractures ◽  
University Hospital ◽  
Type I ◽  
Fracture Type ◽  
Long Term Effects ◽  
Fracture Characteristics ◽  
Fractures In Children ◽  
Distal Shaft ◽  
Almost All

Abstract Context: The short-term benefits of bisphosphonates (BPs) are evident in the treatment of children with osteogenesis imperfecta (OI), but some concerns related to long-term effects remain. Objective: To elucidate the effect of BPs on characteristics of femoral fractures in children with OI. Design and Setting: Retrospective cohort study at a university hospital. Patients and Main Outcome Measure: The study included 93 patients with OI. We recorded fracture histories and analyzed all femoral fractures for location and fracture type using radiographs obtained at fracture diagnosis. Effects of BPs were evaluated by comparing fracture characteristics in three groups: patients (1) naive to BPs, (2) receiving ongoing BP treatment, and (3) whose treatment was discontinued. Results: In total, 127 femoral fractures occurred in 24 patients. Of the fractures, 63 (50%) occurred in patients naive to BPs, 44 (35%) during BP treatment, and 20 (16%) after treatment discontinuation. Mid or distal shaft fractures were most common (41%), followed by subtrochanteric (33%) and distal (20%) fractures. Almost all fractures were transverse (65%) or oblique (28%). The pattern of femoral fractures was similar in all three BP treatment groups (P = 0.78 for location; P = 0.35 for fracture type) and was not related to cumulative BP dose. Instead, OI type correlated with fracture characteristics, and distal location and transverse configuration were more common in the more severe types III and IV compared with type I OI. Conclusion: Characteristics of femoral fractures in children with OI are affected by OI type but not by BP exposure.

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