scholarly journals Glycemic Control Potential of Chemically Characterized Extract from Withania frutescens L. Roots in Severe Diabetes-Induced Mice

2021 ◽  
Vol 11 (9) ◽  
pp. 3998
Author(s):  
Abdelfattah El Moussaoui ◽  
Hamza Mechchate ◽  
Mohammed Bourhia ◽  
Imane Es-safi ◽  
Ahmad Mohammad Salamatullah ◽  
...  
Keyword(s):  
Chemical Analysis ◽  
Plant Extract ◽  
Biochemical Parameters ◽  
Pharmaceutical Drugs ◽  
Glucose Lowering ◽  
Natural Agents ◽  
Severe Diabetes ◽  
Treatment Of Diabetes ◽  
Different Doses

Diabetes mellitus is a metabolic syndrome that causes impairment, mortality, and many other complications. Insulin and several synthetic medications are currently used in the treatment of diabetes. However, these pharmaceutical drugs are costly, and therefore medicines place priority on alternatives to fight this lethal disease. This modest study aims to investigate the chemical composition, antidiabetic and antihyperglycemic potentials along with subacute toxicity (bodyweight change and biochemical parameters) of hydroethanol extract from Withania frutescens L. roots (WFRE). The chemical analysis was carried out using GC–MS after extract silylation. The chemical analysis identified many potentially active compounds that may determine the antidiabetic results of WFRE. The antidiabetic effect of WFRE was evaluated in mice with severe diabetes using oral administration of doses up to 400 mg/kg for 28 days. The results of the antidiabetic and antihyperglycemic tests indicate that WFRE possesses promising glucose-lowering effects and, as a result, it may serve as an antidiabetic alternative for long-term use. The 4-week treatments with different doses of plant extract did not alter the bodyweight appearance of the diabetic mice nor their biochemical parameters (AST and ALT). The findings obtained indicate that the studied plant extract controlled severe diabetes in mice. Therefore, Withania frutescens L. can serve society as it provides natural agents to control diabetes.

Удобрение огурца в Западной Сибири

2018 ◽  
Author(s):  
Т.А. Кuznetsova ◽  
N.А. Коlpakov
Keyword(s):  
Organic Fertilizers ◽  
Control Variant ◽  
Positive Effect ◽  
Different Doses

Показано, что длительное применение как минеральных, так и органических удобрений в различных дозах и сочетаниях положительно влияет на урожайность огурца. Установлено, что в условиях 14-й ротации урожайность на всех вариантах опыта была выше, чем на контрольном варианте и составила 16,4–22,3 т/га, против 16,0 т/га в контроле.The authors show that the long-term use of both mineral and organic fertilizers in different doses and combinations has a positive effect on the yield of cucumber. It was found that under 14 rotation conditions the yield on all variants of the experiment was higher than on the control variant and amounted to 16.4–22.3 t/ha, against 16.0 t/ha on the control.

scholarly journals Nutritional Status in Spanish Adults with Celiac Disease Following a Long-Term Gluten-Free Diet Is Similar to Non-Celiac

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1626
Author(s):  
Catalina Ballestero-Fernández ◽  
Gregorio Varela-Moreiras ◽  
Natalia Úbeda ◽  
Elena Alonso-Aperte
Keyword(s):  
Bone Mineral Density ◽  
Vitamin D ◽  
Celiac Disease ◽  
Vitamin E ◽  
Nutritional Status ◽  
Bone Mineral ◽  
Biochemical Parameters ◽  
Gluten Free ◽  
Mineral Density

The only available treatment for celiac disease is life-long gluten exclusion. We conducted a cross-sectional age- and gender-matched study in 64 celiac adults on a long-term (>1 year) gluten-free diet and 74 non-celiac volunteers from Spain, using dietary, anthropometric, and biochemical parameters, as well as assessing bone mineral density and physical activity. Celiac adults had deficient intake (below 2/3 of the recommended intake) for folates, vitamin E, and iodine and low intake of calcium (below 80% of the recommended intake). Iron intake was also below 2/3 of the recommended intake in celiac women. Vitamin D intake was extremely low, and 34% of celiac patients had moderately deficient plasma levels. According to bone mineral density, celiac women may be more prone to osteopenia and osteoporosis. However, we found a perfectly analogous nutritional status scenario in celiac as compared to healthy volunteers, with the dietary deviations found being similar to those of the Spanish population, i.e., both groups followed a high-lipid, high-protein, and low-carbohydrate diet. Values for biochemical parameters were found within the reference ranges. Celiac disease had no influence on body weight, but body fat in celiac patients tended to be higher. According to our results, vitamin D, calcium, folates, vitamin E, iodine, and iron nutritional status should be specifically assessed and monitored in the celiac population.

scholarly journals The Effects of N-Acetylcysteine on the Rat Mesocorticolimbic Pathway: Role of mGluR5 Receptors and Interaction with Ethanol

2021 ◽  
Vol 14 (6) ◽  
pp. 593
Author(s):  
Sandra Fernández-Rodríguez ◽  
Claudia Esposito-Zapero ◽  
Teodoro Zornoza ◽  
Ana Polache ◽  
Luis Granero ◽  
...  
Keyword(s):  
Behavioral Activation ◽  
Ethanol Administration ◽  
Metabotropic Receptors ◽  
Negative Allosteric Modulator ◽  
High Doses ◽  
Cell Expression ◽  
Mucolytic Agent ◽  
Different Doses

N-acetylcysteine (NAC) is a prodrug that is marketed as a mucolytic agent and used for the treatment of acetaminophen overdose. Over the last few decades, evidence has been gathered that suggests the potential use of NAC as a new pharmacotherapy for alcohol use disorder (AUD), although its mechanism of action is already being debated. In this paper, we set out to assess both the potential involvement of the glutamate metabotropic receptors (mGluR) in the possible dual effect of NAC administered at two different doses and NAC’s effect on ethanol-induced activation. To this aim, 30 or 120 mg/kg of NAC was intraperitoneally administered to rats with the presence or absence of the negative allosteric modulator of mGluR5 (MTEP 0.1 mg/kg). Thereafter, the cFOS IR-cell expression was analyzed. Secondly, we explored the effect of 120 mg/kg of NAC on the neurochemical and behavioral activation induced by intra-VTA ethanol administration (150 nmol). Our results showed that the high NAC dose stimulated cFOS expression in the NAcc, and that this effect was suppressed in the presence of MTEP, thus suggesting the implication of mGluR5. Additionally, high doses could attenuate the ethanol-induced increase in cFOS-expression in the NAcc, probably due to a phenomenon based on the long-term depression of the MSNs. Additional experiments are required to corroborate our hypothesis.

scholarly journals Role of Glucose-Lowering Medications in Erectile Dysfunction

2021 ◽  
Vol 10 (11) ◽  
pp. 2501
Author(s):  
Angelo Cignarelli ◽  
Valentina Annamaria Genchi ◽  
Rossella D’Oria ◽  
Fiorella Giordano ◽  
Irene Caruso ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Current Knowledge ◽  
Smooth Muscle Contractility ◽  
Glucose Lowering ◽  
Glycation End Products ◽  
Altered Metabolism

Erectile dysfunction (ED) is a long-term complication of type 2 diabetes (T2D) widely known to affect the quality of life. Several aspects of altered metabolism in individuals with T2D may help to compromise the penile vasculature structure and functions, thus exacerbating the imbalance between smooth muscle contractility and relaxation. Among these, advanced glycation end-products and reactive oxygen species derived from a hyperglycaemic state are known to accelerate endothelial dysfunction by lowering nitric oxide bioavailability, the essential stimulus of relaxation. Although several studies have explained the pathogenetic mechanisms involved in the generation of erectile failure, few studies to date have described the efficacy of glucose-lowering medications in the restoration of normal sexual activity. Herein, we will present current knowledge about the main starters of the pathophysiology of diabetic ED and explore the role of different anti-diabetes therapies in the potential remission of ED, highlighting specific pathways whose activation or inhibition could be fundamental for sexual care in a diabetes setting.

scholarly journals Effect of Pericampylus glaucus on plasma glucose concentration and lipid profile in streptozotocin-induced diabetic rats

2016 ◽  
Vol 11 (1) ◽  
pp. 200 ◽  
Author(s):  
Muhammad Kifayatullah ◽  
Pinaki Sengupta
Keyword(s):  
Lipid Profile ◽  
Plasma Glucose ◽  
Glucose Concentration ◽  
Ethanolic Extract ◽  
Diabetic Rats ◽  
Plasma Glucose Concentration ◽  
Short And Long Term ◽  
Different Doses ◽  
Long Term Studies

<p class="Abstract">The purpose of this study was to evaluate the effects of <em>Pericampylus glaucus</em> extract on plasma glucose concentration and lipid profile in normal and streptozotocin-induced diabetic rats. The ethanolic extract were administered orally at three different doses (400, 600 and 800 mg/kg) and glibenclamide (20 mg/kg p.o.) for 21 days after 72 hours of streptozotocin injection. During the short- and long-term studies, the extract was found to possess significant (p&lt;0.01, p&lt;0.001) anti-diabetic activity in normal and diabetic rats compared with untreated normal and untreated diabetic group. It also caused reduction in the level of total cholesterol, triglyceride, and LDL etc. and improvement in the HDL level compared with untreated diabetic rats. Reduction in the fasting blood sugar, cholesterol, triglyceride, urea, LDL, creatinine levels and improvement in the HDL by<em> P. glaucus</em> indicates that plant has anti-diabetic activity along with anti hyperlipidemic efficacy and provides a scientific rationale for the use.</p><p> </p>

scholarly journals CHEMICAL ANALYSIS OF CEMENT HYDRATES IN CONCRETE AFTER LONG-TERM EXPOSURE AND IT’S CARBONATION MECHANISM

2015 ◽  
Vol 69 (1) ◽  
pp. 257-263
Author(s):  
Daisuke TAKAICHI ◽  
Toshiyuki SUDO ◽  
Tsuyoshi SAITO ◽  
Tatsuhiko SAEKI
Keyword(s):  
Chemical Analysis

scholarly journals Safe and effective use of the oral bihormonal drug for the long-term regulation of reproductive function in home cats

2020 ◽  
Vol 2020 (1) ◽  
pp. 14-20
Author(s):  
Orhan Zeynalov ◽  
Elena Belova ◽  
Sergey Mukaseev ◽  
Denis Beloglazov
Keyword(s):  
Biochemical Parameters ◽  
Clinical Status ◽  
Reproductive Function ◽  
Genital Area ◽  
Hormonal Preparation ◽  
Effective Use

The article presents the results of monitoring the safety of prolonged use of the oral bihormonal contraceptive drug SEX BARRIER® for delaying and interrupting estrus in home cats by their owners. The use of the bihormonal contraceptive preparation SEX BARRIER® in the home cats by the owners does not lead to disturbances in the genital area, clinical status, morphological and biochemical parameters of animals blood. All owners have confirmed the 100 % effectiveness of the bi-hormonal preparation SEX BARRIER® for both interruption and delay of estrus.

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