scholarly journals Sequential Analysis of Trace Elements in a Micro Volume Urine Sample Using Inductively Coupled Plasma Mass Spectrometry

2021 ◽  
Vol 11 (9) ◽  
pp. 3740
Author(s):  
Nico Laur ◽  
Lars Kaiser ◽  
Hans-Peter Deigner ◽  
Ralf Kinscherf
Keyword(s):  
Mass Spectrometry ◽  
High Throughput ◽  
Inductively Coupled Plasma ◽  
Sequential Analysis ◽  
Sample Volume ◽  
Inductively Coupled ◽  
High Throughput Method ◽  
Plasma Mass Spectrometry ◽  
Polyatomic Interference ◽  
Speed Accuracy

In this work, we describe a simple, fast, cheap, accurate and high-throughput method for the determination of Al; V; Cr; Mn; Fe; Co; Cu; Zn; As; Se; Mo; Cd; Sn; Ba; TI; Pb in a micro volume of urine by using inductively coupled mass spectrometry (ICP-MS) equipped with an octupole-based collision cell. The samples were directly analyzed after a simple acidification with 3% nitric acid. Validation of this method was performed by using certified urine reference material. He and H were used as collision gas for reducing polyatomic interference for most of the measured elements. Finally, we partook in an external quality assurance conducted by ISNTAND e.V. 2. Results show that our high-throughput method is ideal for detecting elements in newborns and infants because of its simplicity, speed, accuracy and low sample volume.

High Throughput Speciation Analysis of Mercury in Water Environment by Short Column Capillary Electrophoresis On-Line Coupled with Inductively Coupled Plasma Mass Spectrometry

2011 ◽  
Vol 383-390 ◽  
pp. 790-795
Author(s):  
Bao Hui Li ◽  
Bao Juan Tian
Keyword(s):  
Mass Spectrometry ◽  
Capillary Electrophoresis ◽  
High Throughput ◽  
Inductively Coupled Plasma ◽  
Speciation Analysis ◽  
Fused Silica ◽  
Short Column ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry

A method for mercury high throughput rapid speciation analysis was built by short column capillary electrophoresis (SC-CE) coupled with inductively coupled plasma mass spectrometry (ICP-MS). A micromist nebulizer was employed to increase the nebulization efficiency and a laboratory-made removable SC-CE-ICP-MS interface on the basis of cross design was applied to alleviate buffer contamination of ICP-MS. In less than 60 s methylmercury (MeHg(I)) and inorganic mercury (Hg(II)) were separated in a 16 × 75 μm i.d. short column fused-silica capillary at 21 kV, while a mixture of 30 mmol/L boric aicd + 5% (v/v) CH3OH (pH=8.60) acted as running electrolyte. The precisions (RSD, n=5) of migration time and peak area for MeHg(I) and Hg(II) were in the range of 1.4-2.6% and 3.3-3.4%, respectively. The limits of detection (3σ) mercury species were 9.7 and 12.0 μg/L, respectively. The recoveries for Hg(II) MeHg(I) were in the range of 96-107% and 99-105%.

scholarly journals Characterisation of matrix-based polyatomic interference formation in laser ablation-inductively coupled plasma-mass spectrometry using dried micro-droplet ablation and its relevance for bioimaging

2016 ◽  
Vol 8 (41) ◽  
pp. 7552-7556 ◽  
Author(s):  
Dominic J. Hare ◽  
Fred Fryer ◽  
Bence Paul ◽  
David P. Bishop ◽  
Philip A. Doble
Keyword(s):  
Mass Spectrometry ◽  
Laser Ablation ◽  
Inductively Coupled Plasma ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry ◽  
Polyatomic Interference ◽  
Polyatomic Interferences

Dried micro-droplets were used to characterise the formation of polyatomic interferences by LA-ICP-MS.

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