scholarly journals MALDI-TOF Mass Spectrometry Applications for Food Fraud Detection

2021 ◽  
Vol 11 (8) ◽  
pp. 3374
Author(s):  
Carlo Zambonin
Keyword(s):  
Cost Effective ◽  
Ease Of Use ◽  
Food Control ◽  
Comprehensive Overview ◽  
Food Fraud ◽  
Complex Samples ◽  
Maldi Tof ◽  
Pre Treatment ◽  
Treatment Procedures ◽  
Milk And Dairy Products

Chemical analysis of food products relating to the detection of the most common frauds is a complex task due to the complexity of the matrices and the unknown nature of most processes. Moreover, frauds are becoming more and more sophisticated, making the development of reliable, rapid, cost-effective new analytical methods for food control even more pressing. Over the years, MALDI-TOF MS has demonstrated the potential to meet this need, also due to a series of undeniable intrinsic advantages including ease of use, fast data collection, and capability to obtain valuable information even from complex samples subjected to simple pre-treatment procedures. These features have been conveniently exploited in the field of food frauds in several matrices, including milk and dairy products, oils, fish and seafood, meat, fruit, vegetables, and a few other categories. The present review provides a comprehensive overview of the existing MALDI-based applications for food quality assessment and detection of adulterations.

Direct electrochemical analysis in complex samples using ITO electrodes modified with permselective membranes consisting of vertically ordered silica mesochannels and micelles

2015 ◽  
Vol 51 (100) ◽  
pp. 17736-17739 ◽  
Author(s):  
Fei Yan ◽  
Wenjing Zheng ◽  
Lina Yao ◽  
Bin Su
Keyword(s):  
Human Serum ◽  
Electrochemical Detection ◽  
Cost Effective ◽  
Electrochemical Analysis ◽  
Complex Media ◽  
Complex Samples ◽  
Redox Active ◽  
Cost Effective Method ◽  
Pre Treatment ◽  
Organic Analytes

Herein we report a simple and cost-effective method for direct electrochemical detection of redox-active small organic analytes in complex media, such as soil dispersions, human serum and milk, without sample pre-treatment.

scholarly journals Applications of MALDI Mass Spectrometry in Clinical Chemistry

2016 ◽  
Vol 62 (1) ◽  
pp. 134-143 ◽  
Author(s):  
Mark W Duncan ◽  
Dobrin Nedelkov ◽  
Ryan Walsh ◽  
Stephen J Hattan
Keyword(s):  
Mass Spectrometry ◽  
Clinical Chemistry ◽  
Cost Effective ◽  
Maldi Mass Spectrometry ◽  
Ease Of Use ◽  
Mass Detection ◽  
Maldi Tof Ms ◽  
Maldi Tof ◽  
Tof Ms

Abstract BACKGROUND MALDI-TOF mass spectrometry (MS) is set to make inroads into clinical chemistry because it offers advantages over other analytical platforms. These advantages include low acquisition and operating costs, ease of use, ruggedness, and high throughput. When coupled with innovative front-end strategies and applied to important clinical problems, it can deliver rapid, sensitive, and cost-effective assays. CONTENT This review describes the general principles of MALDI-TOF MS, highlights the unique features of the platform, and discusses some practical methods based upon it. There is substantial potential for MALDI-TOF MS to make further inroads into clinical chemistry because of the selectivity of mass detection and its ability to independently quantify proteoforms. SUMMARY MALDI-TOF MS has already transformed the practice of clinical microbiology and this review illustrates how and why it is now set to play an increasingly important role in in vitro diagnostics in particular, and clinical chemistry in general.

Occupational exposure to antineoplastic drugs in seven Italian hospitals: The effect of quality assurance and adherence to guidelines

2010 ◽  
Vol 17 (4) ◽  
pp. 320-332 ◽  
Author(s):  
Roberta Turci ◽  
Claudio Minoia ◽  
Cristina Sottani ◽  
Raffaella Coghi ◽  
Paolo Severi ◽  
...  
Keyword(s):  
Central Italy ◽  
Monitoring Program ◽  
Analytical Techniques ◽  
Cost Effective ◽  
Health Care Facilities ◽  
Antineoplastic Drugs ◽  
Standards Of Practice ◽  
Pre Treatment ◽  
Treatment Procedures ◽  
Needle Sticks

In health care facilities, dermal contact and inhalation are considered to be the main routes of exposure to cytotoxic antineoplastic drugs (ADs). Hand-to-mouth contamination or accidental needle sticks as well as events due to inadequate disposal may also contribute to exposure. In order to measure the extent of contamination, biological and environmental monitoring are essential tools for routine testing. Moreover, reliable sampling and analytical procedures are required. During the last decade, several methods have been developed and validated. The appropriate analytical techniques were used to quantify even very low levels of some of the more commonly used ADs, such as cyclophosphamide, 5-fluoruracil, taxol, anthracyclines, and platinum-compounds. The main objective of this study is to assess the adherence to existing standards of practice through an effective monitoring program, including environmental and biological measurements. In seven hospitals located in Northern-Central Italy, periodic surveys were scheduled to verify continuing compliance with guidelines over a 5-year period. All biological samples were found to be below detection limits and a progressive, significant decrease in workplace contamination was observed. Our results confirm that a cost-effective monitoring regime, including fast and simple sample pre-treatment procedures, simultaneous determination of the analytes and their metabolites, validated procedures including uncertainty evaluation, and periodic surveys, is the adequate approach for the collection of reliable exposure data and hence for effective intervention.

scholarly journals Recent Advances in Conventional Methods and Electrochemical Aptasensors for Mycotoxin Detection

Foods ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1437
Author(s):  
Jing Yi Ong ◽  
Andrew Pike ◽  
Ling Ling Tan
Keyword(s):  
Quantitative Analysis ◽  
Animal Feed ◽  
Cost Effective ◽  
Preventive Action ◽  
High Affinity ◽  
Recent Advances ◽  
Recognition Elements ◽  
Key Features ◽  
Pre Treatment ◽  
And Performance

The presence of mycotoxins in foodstuffs and feedstuffs is a serious concern for human health. The detection of mycotoxins is therefore necessary as a preventive action to avoid the harmful contamination of foodstuffs and animal feed. In comparison with the considerable expense of treating contaminated foodstuffs, early detection is a cost-effective way to ensure food safety. The high affinity of bio-recognition molecules to mycotoxins has led to the development of affinity columns for sample pre-treatment and the development of biosensors for the quantitative analysis of mycotoxins. Aptamers are a very attractive class of biological receptors that are currently in great demand for the development of new biosensors. In this review, the improvement in the materials and methodology, and the working principles and performance of both conventional and recently developed methods are discussed. The key features and applications of the fundamental recognition elements, such as antibodies and aptamers are addressed. Recent advances in aptasensors that are based on different electrochemical (EC) transducers are reviewed in detail, especially from the perspective of the diagnostic mechanism; in addition, a brief introduction of some commercially available mycotoxin detection kits is provided.

scholarly journals Utilising Commercially Fabricated Printed Circuit Boards as an Electrochemical Biosensing Platform

Micromachines ◽  
2021 ◽  
Vol 12 (7) ◽  
pp. 793
Author(s):  
Uroš Zupančič ◽  
Joshua Rainbow ◽  
Pedro Estrela ◽  
Despina Moschou
Keyword(s):  
Printed Circuit Boards ◽  
Electrochemical Sensors ◽  
Cost Effective ◽  
Electrochemical Sensing ◽  
Label Free ◽  
Circuit Boards ◽  
Printed Circuit ◽  
Sensing Applications ◽  
Electrochemical Biosensing ◽  
Pre Treatment

Printed circuit boards (PCBs) offer a promising platform for the development of electronics-assisted biomedical diagnostic sensors and microsystems. The long-standing industrial basis offers distinctive advantages for cost-effective, reproducible, and easily integrated sample-in-answer-out diagnostic microsystems. Nonetheless, the commercial techniques used in the fabrication of PCBs produce various contaminants potentially degrading severely their stability and repeatability in electrochemical sensing applications. Herein, we analyse for the first time such critical technological considerations, allowing the exploitation of commercial PCB platforms as reliable electrochemical sensing platforms. The presented electrochemical and physical characterisation data reveal clear evidence of both organic and inorganic sensing electrode surface contaminants, which can be removed using various pre-cleaning techniques. We demonstrate that, following such pre-treatment rules, PCB-based electrodes can be reliably fabricated for sensitive electrochemical biosensors. Herein, we demonstrate the applicability of the methodology both for labelled protein (procalcitonin) and label-free nucleic acid (E. coli-specific DNA) biomarker quantification, with observed limits of detection (LoD) of 2 pM and 110 pM, respectively. The proposed optimisation of surface pre-treatment is critical in the development of robust and sensitive PCB-based electrochemical sensors for both clinical and environmental diagnostics and monitoring applications.

Quantum Dots as Components of Electrochemical Sensing Platforms for the Detection of Environmental and Food Pollutants: a Review

2017 ◽  
Vol 100 (4) ◽  
pp. 950-961 ◽  
Author(s):  
María Pedrero ◽  
Susana Campuzano ◽  
José M Pingarrón
Keyword(s):  
Quantum Dots ◽  
Signal Amplification ◽  
Cost Effective ◽  
Ease Of Use ◽  
Electrochemical Sensing ◽  
Multiplexed Detection ◽  
Sensing Platforms ◽  
Target Analytes

Abstract The determination of organic and inorganic environmental and food pollutants is a key matter of concern in analytical chemistry due to their effects as a serious threat to human health. Focusing on this issue, several methodologies involving the use of nanostructured electrochemical platforms have been recently reported in the literature. Among these methods, those employing the use of quantum dots (QDs) stand out because of features such as signal amplification, good reproducibility and selectivity, and the possibility for multiplexed detection, and because they preserve the outstanding characteristics of electrochemical methodologies with respect to simplicity, ease-of-use, and cost-effective instrumentation. This review describes recent electrochemical strategies, in which design QDs play a key role, for the determination of pollutants in food and environmental samples. The particular role of QDs in the reported methodologies, their preparation, and the electrochemical platform design, as well as the advantages that QDs provide in the analysis of target analytes, are critically discussed.

Anaerobic digestion for sustainable development: a natural approach

2002 ◽  
Vol 45 (10) ◽  
pp. 321-328 ◽  
Author(s):  
H.J. Gijzen
Keyword(s):  
Industrial Wastewater ◽  
Systems Approach ◽  
Cost Effective ◽  
Anaerobic Treatment ◽  
High Rate ◽  
Natural Ecosystems ◽  
Natural Systems ◽  
Anaerobic Reactors ◽  
Rural And Urban ◽  
Pre Treatment

After the discovery of methane gas by Alessandro Volta in 1776, it took about 100 years before anaerobic processes for the treatment of wastewater and sludges were introduced. The development of high rate anaerobic digesters for the treatment of sewage and industrial wastewater took until the nineteen-seventies and for solid waste even till the nineteen-eighties. All digesters have in common that they apply natural anaerobic consortia of microorganisms for degradation and transformation processes. In view of this, it could be rewarding to evaluate the efficiency of natural ecosystems for their possible application. Examples of high rate anaerobic natural systems include the forestomach of ruminants and the hindgut of certain insects, such as termites and cockroaches. These “natural reactors” exhibit volumetric methane production rates as high as 35 l/l.d. The development of anaerobic reactors based on such natural anaerobic systems could produce eco-technologies for the effective management of a wide variety of solid wastes and industrial wastewater. Important limitations of anaerobic treatment of domestic sewage relate to the absence of nutrient and pathogen removal. A combination of anaerobic pre-treatment followed by photosynthetic post-treatment is proposed for the effective recovery of energy and nutrients from sewage. This eco-technology approach is based on the recognition that the main nutrient assimilating capacity is housed in photosynthetic plants. The proposed anaerobic-photosynthetic process is energy efficient, cost effective and applicable under a wide variety of rural and urban conditions. In conclusion: a natural systems approach towards waste management could generate affordable eco-technologies for effective treatment and resource recovery.

Synchronous Luminescence Spectroscopy: Methodology and Applicability

1982 ◽  
Vol 36 (5) ◽  
pp. 576-581 ◽  
Author(s):  
Tuan Vo-Dinh
Keyword(s):  
Direct Determination ◽  
Cost Effective ◽  
Luminescence Spectroscopy ◽  
Second Derivative ◽  
Experimental Conditions ◽  
Complex Samples ◽  
Figures Of Merit ◽  
Synchronous Luminescence Spectroscopy ◽  
Complex Organic

This paper discusses the figures of merit associated with the synchronous luminescence (SL) technique in multicomponent analysis of complex samples. Spectral interferences and experimental factors that influence the choice of experimental conditions are investigated. The efficacy of SL is demonstrated in the direct determination of anthracene and 2-methylanthracene in a raw coal liquid. The application of the second-derivative technique to the SL measurement of organic samples is shown. Special emphasis is directed toward the applicability of the SL technique as a practical and cost-effective screening procedure in the routine analysis of complex organic samples.

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