scholarly journals Correlation between Myocardial Function and Electric Current Pulsatility of the Sputnik Left Ventricular Assist Device: In-Vitro Study

2021 ◽  
Vol 11 (8) ◽  
pp. 3359
Author(s):  
Dmitry V. Telyshev ◽  
Alexander A. Pugovkin ◽  
Ivan A. Ephimov ◽  
Aleksandr Markov ◽  
Steffen Leonhardt ◽  
...  
Keyword(s):  
Cardiac Output ◽  
Electric Current ◽  
Left Ventricular Assist Device ◽  
Pulsatility Index ◽  
Myocardial Function ◽  
Left Ventricular ◽  
Assist Device ◽  
Ventricular Assist ◽  
Cardiac Power ◽  
Left Ventricular Assist

This study assesses the electric current parameters and reports on the analysis of the associated degree of myocardial function during left ventricular assist device (LVAD) support. An assumption is made that there is a correlation between cardiac output and the pulsatility index of the pump electric current. The experimental study is carried out using the ViVitro Pulse Duplicator System with Sputnik LVAD connected. Cardiac output and cardiac power output are used as a measure of myocardial function. Different heart rates (59, 73, 86 bpm) and pump speeds (7600–8400 rpm in 200 rpm steps) are investigated. In our methodology, ventricular stroke volumes in the range of 30–80 mL for each heart rate at a certain pump speed were used to simulate different levels of contractility. The correlation of the two measures of myocardial function and proposed pulsatility index was confirmed using different correlation coefficients (values ≥ 0.91). Linear and quadratic models for cardiac output and cardiac power output versus pulsatility index were obtained using regression analysis of measured data. Coefficients of determination for CO and CPO models were in the ranges of 0.914–0.982 and 0.817–0.993, respectively. Study findings suggest that appropriate interpretation of parameters could potentially serve as a valuable clinical tool to assess myocardial therapy using LVAD infrastructure.

Left ventricle assist device pulsatility index at the time of implantation is associated with follow-up pulmonary hemodynamics

2020 ◽  
Vol 43 (7) ◽  
pp. 452-460
Author(s):  
Jacob J Schaefer ◽  
Pavol Sajgalik ◽  
Sudhir S Kushwaha ◽  
Lyle J Olson ◽  
John M Stulak ◽  
...  
Keyword(s):  
Pulmonary Artery ◽  
Left Ventricular Assist Device ◽  
Ventricular Assist Device ◽  
Pulsatility Index ◽  
Left Ventricular ◽  
Assist Device ◽  
Heartmate Ii ◽  
Ventricular Assist ◽  
Post Surgery ◽  
Left Ventricular Assist

HeartMate II left ventricular assist device controllers provide data including pulsatility index, reflecting the relationship between pump function and hemodynamics. We propose that a higher pulsatility index at hospital discharge following implant may be associated with less vascular congestion and improved clinical outcomes. A retrospective analysis of 40 patients (age 59.2 ± 10.3 years) supported with the HeartMate II devices was conducted. Data revealed moderate Pearson correlations between pulsatility index at discharge and right atrial pressure, pulmonary artery systolic pressure, pulmonary artery diastolic pressure, mean pulmonary arterial pressure, and pulmonary capillary wedge pressure, respectively, post-surgery (median of 377 days), demonstrating a stronger relationship when analyzed for the EPC controller (n = 28) only (r = −.57, p < .01; r = −.38, p < .05; r = −.59, p < .01; r = −.47, p = .01 and r = −.53, p < .01, respectively). The pulsatility index derived from the EPC controller was associated with the significant risk of re-hospitalization within 1 and 2 years after the implantation of left ventricular assist device; hazard ratio = 0.557 with 95% confidence interval (0.315–0.983), p = .04 and hazard ratio = .579 (0.341–0.984), p = .04. A higher pulsatility index at discharge was associated with greater volume unloading, lower pulmonary pressures, and lower risk of all-cause re-hospitalizations within 1 and 2 years post-surgery. As such, pump-derived data may provide additional value in predicting left ventricular assist device hemodynamics.

scholarly journals Cardiac Output Assessment in Patients Supported with Left Ventricular Assist Device

ASAIO Journal ◽  
2017 ◽  
Vol 63 (4) ◽  
pp. 433-437 ◽  
Author(s):  
David M. Tehrani ◽  
Jonathan Grinstein ◽  
Sara Kalantari ◽  
Gene Kim ◽  
Nitasha Sarswat ◽  
...  
Keyword(s):  
Cardiac Output ◽  
Left Ventricular Assist Device ◽  
Ventricular Assist Device ◽  
Left Ventricular ◽  
Assist Device ◽  
Ventricular Assist ◽  
Left Ventricular Assist

scholarly journals Evaluation of Left Ventricular Assist Device Electrical Current as a Predictor of Left Ventricular Recovery

2020 ◽  
Author(s):  
Dmitry Telyshev ◽  
Alexander Pugovkin ◽  
Ivan Ephimov ◽  
Aleksandr Markov ◽  
Steffen Leonhardt ◽  
...  
Keyword(s):  
Electric Current ◽  
Left Ventricular Assist Device ◽  
Ventricular Assist Device ◽  
Left Ventricular ◽  
Clinical Tool ◽  
Assist Device ◽  
Ventricular Assist ◽  
Pump Speed ◽  
Hemodynamic Assessment ◽  
Left Ventricular Assist

In this paper, we aim to assess the electric current parameters and report the analysis of the associated degree of ventricular recovery during left ventricular assist device (LVAD) support. An assumption was made there is a linear relationship between ventricular recovery degree and the pump electric current pulsatility index (PI). The experimental study was carried out using the ViVitro Pulse Duplicator System with Sputnik 1 LVAD connected. Cardiac output (CO) and cardiac power output (CPO) were used as a measure of ventricular recovery degree. Different heart rates (HR) (59, 73, 86 bpm) and pump speeds (7600–8400 rpm in 200 rpm steps) were investigated. Ventricular stroke volumes in the range of 30–80 ml for each heart rate at certain pump speed were used. The obtained relationships of CO and CPO vs. PI was linear as the coefficients of determination for each regression curve were more than 0.8. CO vs. PI: R2=0.9218; 0.9271; 0.9172 and CPO vs. PI: R2=0.8517; 0.841; 0.8244 for HR=59 bpm; 73 bpm; 86 bpm, respectively. Study findings suggest that adequate interpretation of parameters could potentially serve as a valuable clinical tool to assess ventricular recovery based on LVAD infrastructure without requiring any special hemodynamic assessment.

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