scholarly journals The Incidence and Intensity of Postendodontic Pain and Flareup in Single and Multiple Visit Root Canal Treatments: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 11 (8) ◽  
pp. 3358
Author(s):  
Satish Vishwanathaiah ◽  
Prabhadevi C Maganur ◽  
Sanjeev B Khanagar ◽  
Hitesh Chohan ◽  
Luca Testarelli ◽  
...  
Keyword(s):  
Root Canal ◽  
Meta Analysis ◽  
Grey Literature ◽  
Root Canal Treatment ◽  
Rotary Instruments ◽  
Multiple Visit ◽  
Significant Difference ◽  
The Difference ◽  
Randomised Controlled ◽  
Independent Determinant

To assess the incidence and intensity of postendodontic pain and flareup in single and multiple visit root canal treatment (RCT) and determine if the difference between the two is significant, a search of PubMed, Medline, Embase, Cochrane, Scopus and Web of science was conducted. The grey literature was searched using Google Scholar and Saudi digital library. Randomised controlled trials evaluating the incidence and intensity of postendodontic pain and flareup published in English from 1 January 2000 to 15 April 2020 were searched. The PRISMA protocol was followed to select the articles. A random effects model was used for the meta-analysis of the data in the included studies. Twenty-one articles were included in the review. Three compared both the incidence and the intensity, while the rest compared either one of the parameters. Most studies used both hand-driven and rotary instruments and irrigated with sodium hypochlorite. Twelve studies used an intracanal medicament. Although individual studies showed discordant treatment outcomes, the meta-analysis did not reveal any significant difference in the incidence or the intensity of the postendodontic flareup between the single and multiple visit RCT groups. Single or a multiple visit root canal treatment is not an independent determinant for the risk of postendodontic pain or a flareup.

scholarly journals Micro-push-out bond strength of Mineral—based root canal sealer in canals with different tapers.

2021 ◽  
Vol 10 (1) ◽  
pp. 1-7
Author(s):  
Nunna Vasavi ◽  
◽  
Kantheti Sirisha ◽  
Keyword(s):  
Bond Strength ◽  
Root Canal ◽  
Testing Machine ◽  
Root Canal Sealer ◽  
Rotary Instruments ◽  
Significant Difference ◽  
Ah Plus ◽  
Bond Strengths ◽  
The Difference ◽  
Push Out

Objective: The aim of this study was to assess the micro-push-out bond strength of a mineral-based root canal sealer, BioRoot RCS in canals prepared by K3XF rotary systems of two different tapers. Material and Methods: Eighty caries free maxillary central incisors were used in this study. The samples were allocated into 4 groups (n=20) according to the root canal sealer and taper of the rotary instruments. The samples were obturated using single cone obturation technique. From each root 1mm thick slices at coronal, middle and apical thirds were collected using hard tissue microtome under continuous water coolant. Push-out tests were done for these sections using a Universal testing machine (INSTRON 8801) at a crosshead speed of 1mm/min. One-way analysis of variance (ANOVA) was used to compare the bond strengths within groups and Tukey’s multiple post hoc analysis was used for pair-wise comparison of bond strengths. Results: AH Plus exhibited higher micro-push-out bond strength than BioRootRCS though they did not differ significantly (p>0.05). Preparation of root canals with 6% taper rotary instruments showed higher bond strength than 4% though they did not differ significantly (p>0.05). Conclusion: There was no significant difference between micro-push-out bond strength values of BioRoot RCS and AH Plus. The bond strength values were high in 6% taper canals than 4% canals though the difference was not significant statistically.

scholarly journals Postoperative Pain Following Multi-Visit Root Canal Treatment of Teeth with Vital and Non-Vital Pulps

1970 ◽  
Vol 6 (2) ◽  
pp. 28-31 ◽  
Author(s):  
F Farzana ◽  
SMI Hossain ◽  
SMN Islam ◽  
MA Rahman
Keyword(s):  
Postoperative Pain ◽  
Root Canal ◽  
Root Canal Treatment ◽  
Military Hospital ◽  
Chi Square ◽  
College Hospital ◽  
Multiple Visit ◽  
Significant Difference ◽  
Postoperative Dental Pain ◽  
Group 2

Introduction: Post-obturation pain is one of the primary problems following root canal treatment. Although in most cases pain does not last long, but could be a source of embarrassment to the dentist and annoying for the patient.Objectives: This prospective study was conducted to assess the incidence of postoperative pain after multivisit root canal treatment of teeth with vital and nonvital pulps.Methods: Total, 52 patients with teeth requiring endodontic treatment were identified and included in this study. The patients were randomly assigned and treated in a military hospital and in government dental college hospital into two groups. The teeth of patients in group 1 were with vital inflamed pulp; group 2 were with non-vital pulp with or without periapical radiolucency (0-5mm). Patients were treated in multiple visit procedure. They were asked whether they experienced any postoperative pain to rate the level of discomfort as no, mild, moderate, or severe pain. Data were analyzed statistically using the chi-square test.Results: No significant difference in postoperative pain was found between vital and non-vital pulps (p=0.2). Mild and moderate pain occurred in 4.34% and 4.34% respectively in teeth with vital pulp and 17.3% and 3.44% in teeth with non-vital pulp respectively. There was no significant difference in postoperative pain between the two groups (p>0.05).Conclusions: The incidence of postoperative pain did not differ between vital and non-vital teeth.Key words: Postoperative dental pain; root canal treatment; vital and non-vital pulp DOI: 10.3329/jafmc.v6i2.7271JAFMC Bangladesh. Vol 6, No 2 (December) 2010 pp.28-31

scholarly journals Single-visit versus multiple-visits endodontic treatment of apical periodontitis: A meta-analysis of outcome assessed by intra oral radiographs

2019 ◽  
Author(s):  
Bahar Dehghan Manshadi ◽  
Asgeir Bårdsen
Keyword(s):  
Root Canal ◽  
Null Hypothesis ◽  
Meta Analysis ◽  
Primary Root ◽  
Apical Periodontitis ◽  
Root Canal Treatment ◽  
Treatment Modalities ◽  
National Library ◽  
Single Visit ◽  
Multiple Visit

Abstract The established multiple-visit treatment for necrotic teeth with apical periodontitis has been challenged by single-visit treatment. However, there is no clear support for the one or the other treatment in the literature. The aim of this meta-analysis was to investigate if non-surgical primary root canal treatment carried out in single-visit or multiple-visit makes any difference in terms of radiographic healing in necrotic teeth with apical periodontitis. The null hypothesis was: there is no difference in the rate of apical healing for the two treatment modalities The literature search was organized through the National Centre for Biotechnology Information (NCBI) at the U.S. National Library of Medicine (NLM the National Library of Medicine (NLM)) using PubMed database and EMBASE Ovid to select articles with single-visit or multiple-visit included teeth with pulp necrosis and apical periodontitis. Of the 60 identified studies, only eight studies were included in current meta-analysis. The main reasons for exclusions were teeth with other diagnosis except necrotic pulp and apical periodontitis, studies with no comparison between single- and multiple-visit endodontics within the same study and studies without healing rate appearance. Results from each of the included studies were entered into the statistical program Stata, Version 15 (Texas, USA). The odds ratio (OR) and the 95% confidence interval for each study were calculated (dependent variable: single-visit/multiple-visit, independent variables: healed/not healed based on intra oral radiographs) with the random effect model. There was no significant difference in radiographic evidence of periapical healing between single-visit endodontics and multiple-visit treatment modalities, of the primary root canal treatment in necrotic teeth with apical periodontitis (OR = 1.10, 95% CI: 0.67-1.83) as evaluated on intra oral radiographs. Thus, the null hypothesis could not be rejected.

scholarly journals Assessment of post-operative pain with use of rotary and conventional root canal instruments in single and multiple visit root canal treatment

2021 ◽  
Vol 2 (2) ◽  
pp. 216-224
Author(s):  
Sheenam Markan ◽  
Gurvanit Kaur Lehl
Keyword(s):  
Root Canal ◽  
Root Canal Treatment ◽  
Single Visit ◽  
Post Operative Pain ◽  
Subgroup Ii ◽  
Multiple Visit ◽  
Significant Difference ◽  
Group A ◽  
Group B ◽  
Post Hoc

Aim: To compare the post-operative pain after the use of rotary and conventional root canal instruments in single and multiple visit root canal treatment Materials and Method: 168 patients requiring Root Canal Treatment [RCT] in maxillary and mandibular 1st molar were involved in the study. On the basis of vitality and radiographic features two groups were made, multiple visit (Group A n=72), single visit (Group B n=96). Then the patients were randomly divided into 4 subgroups. Subgroup I n=36 (multiple visit conventional RCT), Subgroup II n=36 (multiple visit rotary RCT), Subgroup III n=48 (single visit Conventional RCT) and Subgroup IV n=48 (single visit rotary RCT). In subgroup I & Subgroup III Canal preparation was done with stainless steel K files in step back manner. In subgroup II & Subgroup IV, rotary Protaper Next was used. Irrigation was done with 3 % NaOCl and Ethylenediamine tetraacetic acid (EDTA) alternatively followed by obturation. The postobturation pain was recorded at 6hr, 12hr, 24hr, 1 week using visual analogue scale. Statistical Analysis was done using Tukey HSD Post Hoc Test and ANOVA Test. Results: Within 24 hours there was statistically significant difference between the groups (p< 0.05) but after 7 days no statistically significant difference was there (p>0.05). Conclusion: Patients in the groups either in single and multiple visit experience less postobturation pain if the canal preparation was done with the rotary files at all the time intervals (6hrs, 12hrs, 24hrs ) but after 7 days no statistical difference was found.

scholarly journals Effects of Herbal Mouthwashes on Plaque and Inflammation Control for Patients with Gingivitis: A Systematic Review and Meta-Analysis of Randomised Controlled Trials

2020 ◽  
Vol 2020 ◽  
pp. 1-16 ◽  
Author(s):  
He Cai ◽  
Junyu Chen ◽  
Nirmala K. Panagodage Perera ◽  
Xing Liang
Keyword(s):  
Oral Hygiene ◽  
Randomised Controlled Trials ◽  
Meta Analysis ◽  
Grey Literature ◽  
Controlled Trials ◽  
Cochrane Central Register ◽  
Gingival Index ◽  
Eligibility Criteria ◽  
Significant Difference ◽  
Randomised Controlled

Objective. The aim of this study was to evaluate the overall effects of herbal mouthwashes as supplements to daily oral hygiene on plaque and inflammation control compared with placebos and chlorhexidine (CHX) mouthwashes in the treatment of gingivitis. Methods. PubMed, EMBASE, Cochrane Database of Systematic Reviews, Cochrane Central Register of Controlled Trials, and grey literature databases were searched. Only randomised controlled trials (RCTs) comparing herbal mouthwashes with placebos or CHX in the daily oral hygiene of patient with gingivitis were included to compare the effect of different mouthwashes on plaque and inflammation control. Results. A total of 13 studies satisfied the eligibility criteria, and 11 studies were included in meta-analyses. Significant differences were observed in favour of herbal mouthwashes compared with placebos in both plaque- and inflammation-related indices (Quigley-Hein Plaque Index, QHPI: WMD = −0.61, 95% CI (−0.80, −0.42), P<0.001; Gingival Index, GI: −0.28 (−0.51, −0.06), P=0.01; Modified Gingival Index, MGI: −0.59 (−1.08, −0.11), P=0.02; Gingival Bleeding Index, GBI: −0.06 (−0.09, −0.04), P<0.001). No significant difference was found between herbal and CHX mouthwashes. Conclusions. Herbal mouthwashes have potential benefits in plaque and inflammation control as supplements to the daily oral hygiene of patients with gingivitis. Although no difference was observed between herbal and CHX mouthwashes in the selected studies, further high-quality RCTs are needed for more firm support before advising patients with gingivitis about whether they can use herbal mouthwashes to substitute for CHX mouthwashes or not (PROSPERO registration number: CRD42019122841).

scholarly journals Calcium Silicate-Based Sealers Do Not Reduce the Risk and Intensity of Postoperative Pain after Root Canal Treatment when Compared with Epoxy Resin-Based Sealers: A Systematic Review and Meta-Analysis

2021 ◽  
Author(s):  
Emílio Carlos Sponchiado Junior ◽  
Walbert de Andrade Vieira ◽  
Ana Gabriela Costa Normando ◽  
Juliana Vianna Pereira ◽  
Caio Cezar Randi Ferraz ◽  
...  
Keyword(s):  
Postoperative Pain ◽  
Pain Intensity ◽  
Epoxy Resin ◽  
Root Canal ◽  
Calcium Silicate ◽  
Meta Analysis ◽  
Risk Of Bias ◽  
Root Canal Treatment ◽  
Cochrane Library ◽  
Significant Difference

AbstractThis review aims to evaluate whether root canal obturation with calcium silicate-based (CSB) sealers reduces the risk and intensity of endodontic postoperative pain when compared to epoxy resin-based (ERB) sealers. The review was registered at PROSPERO (CRD42020169255). Two independent reviewers conducted an electronic search in PubMed, Scopus, EMBASE, Web of Science, Cochrane Library and LILACS until November 2020 and included only randomized clinical trials with adult health participants undergoing root canal treatment. After selection, the JBI Critical Appraisal tool was used to assess the risk of bias. A fixed-effect meta-analysis was performed to summarize the results of pain risk and pain intensity at time intervals of 24 and 48 hours. Finally, the certainty of evidence was assessed using the GRADE approach. The search resulted in 1,206 records, of which five studies (n = 421 patients) met the eligibility criteria and presented moderate to low risk of bias. There was no significant difference between groups in the risk of pain in the first 24 hours (relative risk or RR = 0.83, 95% confidence interval or CI: 0.60, 1.16, I 2 =) or 48 hours (RR = 0.56, 95% CI: 0.26, 1.21, I 2 =). Silicate-based sealers led to lower pain intensity only at 48 hours (mean and standard deviation = 0.37, 95% CI: 0.69, 0.05). All analyses revealed low heterogeneity (I 2 < 25%). The evidence presented moderate level of certainty. Currently available evidence has shown that there is no difference between CSB and ERB sealers in the risk or intensity of postoperative pain.

Is there Sex-related Outcome Difference According to oral P2Y12 Inhibitors in Patients with Acute Coronary Syndromes? A Systematic Review and Meta-Analysis of 107,126 Patients

2019 ◽  
Vol 17 (2) ◽  
pp. 191-203
Author(s):  
Oliver Brown ◽  
Jennifer Rossington ◽  
Gill Louise Buchanan ◽  
Giuseppe Patti ◽  
Angela Hoye
Keyword(s):  
Systematic Review ◽  
Acute Coronary Syndromes ◽  
Meta Analysis ◽  
Indirect Comparison ◽  
Bleeding Risk ◽  
Cardiovascular Death ◽  
P2y12 Inhibitors ◽  
Significant Difference ◽  
Coronary Syndromes ◽  
Randomised Controlled

Background and Objectives: The majority of patients included in trials of anti-platelet therapy are male. This systematic review and meta-analysis aimed to determine whether, in addition to aspirin, P2Y12 blockade is beneficial in both women and men with acute coronary syndromes. </P><P> Methods: Electronic databases were searched and nine eligible randomised controlled studies were identified that had sex-specific clinical outcomes (n=107,126 patients). Risk Ratios (RR) and 95% Confidence Intervals (CI) were calculated for a composite of cardiovascular death, myocardial infarction or stroke (MACE), and a safety endpoint of major bleeding for each sex. Indirect comparison analysis was performed to statistically compare ticagrelor against prasugrel. </P><P> Results: Compared to aspirin alone, clopidogrel reduced MACE in men (RR, 0.79; 95% CI, 0.68 to 0.92; p=0.003), but was not statistically significant in women (RR, 0.88; 95% CI, 0.75 to 1.02, p=0.08). Clopidogrel therapy significantly increased bleeding in women but not men. Compared to clopidogrel, prasugrel was beneficial in men (RR, 0.84; 95% CI, 0.73 to 0.97; p=0.02) but not statistically significant in women (RR, 0.94; 95% CI, 0.83 to 1.06; p=0.30); ticagrelor reduced MACE in both men (RR, 0.85; 95% CI, 0.77 to 0.94; p=0.001) and women (RR, 0.84; 95% CI, 0.73 to 0.97; p=0.02). Indirect comparison demonstrated no significant difference between ticagrelor and prasugrel in either sex. Compared to clopidogrel, ticagrelor and prasugrel increased bleeding risk in both women and men. </P><P> Conclusion: In summary, in comparison to monotherapy with aspirin, P2Y12 inhibitors reduce MACE in women and men. Ticagrelor was shown to be superior to clopidogrel in both sexes. Prasugrel showed a statistically significant benefit only in men; however indirect comparison did not demonstrate superiority of ticagrelor over prasugrel in women.

scholarly journals Comparison of the Effects of a Bioceramic and Conventional Resin-Based Sealers on Postoperative Pain after Nonsurgical Root Canal Treatment: A Randomized Controlled Clinical Study

Materials ◽  
2021 ◽  
Vol 14 (10) ◽  
pp. 2661
Author(s):  
Kiche Shim ◽  
Young-Eun Jang ◽  
Yemi Kim
Keyword(s):  
Postoperative Pain ◽  
Postoperative Period ◽  
Root Canal ◽  
Continuous Wave ◽  
Root Canal Treatment ◽  
Root Canals ◽  
Anterior Teeth ◽  
Significant Difference ◽  
Ah Plus ◽  
Group 2

Background: This clinical trial aimed to compare the effects of bioceramic sealer and resin-based sealer on the incidence and intensity of postoperative pain. Methods: Patients with anterior teeth or premolars requiring root canal treatment were assigned to group 1 (n = 51). Those with molars requiring treatment were assigned to group 2 (n = 57). In groups 1En and 2En, root canals were obturated with Endoseal MTA using the single-cone technique. In groups 1AH and 2AH, the sealer used was AH Plus with the continuous wave technique. On the day of canal filling, each patient was instructed to indicate their pain intensity over the 7 day postoperative period, at rest and, while biting, using a visual analog scale. Results: There was no significant difference in the incidence or intensity of postoperative pain between the Endoseal MTA and AH Plus groups during the 7 day postoperative period (p > 0.05). Less time was needed to seal the root canals with Endoseal MTA, especially in group 2 (p < 0.05). Conclusions: Endoseal MTA and AH Plus had similar effects on the incidence and intensity of postoperative pain. The obturation time was shorter when using Endoseal MTA compared to AH Plus.

scholarly journals Comparative efficacy and safety of interventions for treating head lice: a protocol for systematic review and network meta-analysis

2021 ◽  
Vol 5 (1) ◽  
pp. e001129
Author(s):  
Bill Stevenson ◽  
Wubshet Tesfaye ◽  
Julia Christenson ◽  
Cynthia Mathew ◽  
Solomon Abrha ◽  
...  
Keyword(s):  
Systematic Review ◽  
Randomised Controlled Trials ◽  
Meta Analysis ◽  
Grey Literature ◽  
Risk Of Bias ◽  
Controlled Trials ◽  
Head Lice ◽  
Efficacy And Safety ◽  
Randomised Controlled ◽  
Meta Analyses

BackgroundHead lice infestation is a major public health problem around the globe. Its treatment is challenging due to product failures resulting from rapidly emerging resistance to existing treatments, incorrect treatment applications and misdiagnosis. Various head lice treatments with different mechanism of action have been developed and explored over the years, with limited report on systematic assessments of their efficacy and safety. This work aims to present a robust evidence summarising the interventions used in head lice.MethodThis is a systematic review and network meta-analysis which will be reported in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses statement for network meta-analyses. Selected databases, including PubMed, Embase, MEDLINE, Web of Science, CINAHL and Cochrane Central Register of Controlled Trials will be systematically searched for randomised controlled trials exploring head lice treatments. Searches will be limited to trials published in English from database inception till 2021. Grey literature will be identified through Open Grey, AHRQ, Grey Literature Report, Grey Matters, ClinicalTrials.gov, WHO International Clinical Trials Registry and International Standard Randomised Controlled Trials Number registry. Additional studies will be sought from reference lists of included studies. Study screening, selection, data extraction and assessment of methodological quality will be undertaken by two independent reviewers, with disagreements resolved via a third reviewer. The primary outcome measure is the relative risk of cure at 7 and 14 days postinitial treatment. Secondary outcome measures may include adverse drug events, ovicidal activity, treatment compliance and acceptability, and reinfestation. Information from direct and indirect evidence will be used to generate the effect sizes (relative risk) to compare the efficacy and safety of individual head lice treatments against a common comparator (placebo and/or permethrin). Risk of bias assessment will be undertaken by two independent reviewers using the Cochrane Risk of Bias tool and the certainty of evidence assessed using the Grading of Recommendations, Assessment, Development and Evaluations guideline for network meta-analysis. All quantitative analyses will be conducted using STATA V.16.DiscussionThe evidence generated from this systematic review and meta-analysis is intended for use in evidence-driven treatment of head lice infestations and will be instrumental in informing health professionals, public health practitioners and policy-makers.PROSPERO registration numberCRD42017073375.

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