scholarly journals Multiple Brain Abscesses of Odontogenic Origin. May Oral Microbiota Affect Their Development? A Review of the Current Literature

2021 ◽  
Vol 11 (8) ◽  
pp. 3316
Author(s):  
Nicola Montemurro ◽  
Paolo Perrini ◽  
Walter Marani ◽  
Bipin Chaurasia ◽  
Massimo Corsalini ◽  
...  
Keyword(s):  
Oral Microbiota ◽  
High Morbidity ◽  
Oral Diseases ◽  
Oral Infections ◽  
Odontogenic Infections ◽  
Odontogenic Origin ◽  
Brain Abscesses ◽  
Systemic Infections ◽  
Systemic Condition

In the last few years, the role of oral microbiota in the setting of oral diseases such as caries, periodontal disease, oral cancer and systemic infections, including rheumatoid arthritis, cardiovascular disease and brain abscess (BA), has attracted the attention of physicians and researchers. Approximately 5–7% of all BAs have an odontogenic origin, representing an important pathological systemic condition with a high morbidity and mortality. A systematic search of two databases (Pubmed and Ovid EMBASE) was performed for studies published up to 5 January 2021, reporting multiple BAs attributed to an odontogenic origin. According to PRISMA guidelines, we included a total of 16 papers reporting multiple BAs due to odontogenic infections. The aim of this review is to investigate the treatment modality and the clinical outcome of patients with multiple BAs due to odontogenic infections, as well as to identify the most common pathogens involved in this pathological status and their role, in the oral microbiota, in the onset of oral infections. A multidisciplinary approach is essential in the management of multiple BAs. Further studies are required to understand better the role of microbiota in the development of multiple BAs.

scholarly journals Protein Tyrosine and Serine/Threonine Phosphorylation in Oral Bacterial Dysbiosis and Bacteria-Host Interaction

2022 ◽  
Vol 11 ◽  
Author(s):  
Liang Ren ◽  
Daonan Shen ◽  
Chengcheng Liu ◽  
Yi Ding
Keyword(s):  
Community Development ◽  
Oral Bacteria ◽  
Bacterial Metabolism ◽  
Oral Microbiota ◽  
Bacterial Protein ◽  
Oral Diseases ◽  
Host Interactions ◽  
Host Interaction ◽  
Systemic Health

The human oral cavity harbors approximately 1,000 microbial species, and dysbiosis of the microflora and imbalanced microbiota-host interactions drive many oral diseases, such as dental caries and periodontal disease. Oral microbiota homeostasis is critical for systemic health. Over the last two decades, bacterial protein phosphorylation systems have been extensively studied, providing mounting evidence of the pivotal role of tyrosine and serine/threonine phosphorylation in oral bacterial dysbiosis and bacteria-host interactions. Ongoing investigations aim to discover novel kinases and phosphatases and to understand the mechanism by which these phosphorylation events regulate the pathogenicity of oral bacteria. Here, we summarize the structures of bacterial tyrosine and serine/threonine kinases and phosphatases and discuss the roles of tyrosine and serine/threonine phosphorylation systems in Porphyromonas gingivalis and Streptococcus mutans, emphasizing their involvement in bacterial metabolism and virulence, community development, and bacteria-host interactions.

scholarly journals Dysbiosis From a Microbial and Host Perspective Relative to Oral Health and Disease

2021 ◽  
Vol 12 ◽  
Author(s):  
Carla Cugini ◽  
Narayanan Ramasubbu ◽  
Vincent K. Tsiagbe ◽  
Daniel H. Fine
Keyword(s):  
Oral Disease ◽  
Oral Diseases ◽  
Oral Infections ◽  
The Future ◽  
Technical Advances ◽  
Health And Disease ◽  
Oral Microbiology ◽  
Immunological Research

The significance of microbiology and immunology with regard to caries and periodontal disease gained substantial clinical or research consideration in the mid 1960's. This enhanced emphasis related to several simple but elegant experiments illustrating the relevance of bacteria to oral infections. Since that point, the understanding of oral diseases has become increasingly sophisticated and many of the original hypotheses related to disease causality have either been abandoned or amplified. The COVID pandemic has reminded us of the importance of history relative to infectious diseases and in the words of Churchill “those who fail to learn from history are condemned to repeat it.” This review is designed to present an overview of broad general directions of research over the last 60 years in oral microbiology and immunology, reviewing significant contributions, indicating emerging foci of interest, and proposing future directions based on technical advances and new understandings. Our goal is to review this rich history (standard microbiology and immunology) and point to potential directions in the future (omics) that can lead to a better understanding of disease. Over the years, research scientists have moved from a position of downplaying the role of bacteria in oral disease to one implicating bacteria as true pathogens that cause disease. More recently it has been proposed that bacteria form the ecological first line of defense against “foreign” invaders and also serve to train the immune system as an acquired host defensive stimulus. While early immunological research was focused on immunological exposure as a modulator of disease, the “hygiene hypothesis,” and now the “old friends hypothesis” suggest that the immune response could be trained by bacteria for long-term health. Advanced “omics” technologies are currently being used to address changes that occur in the host and the microbiome in oral disease. The “omics” methodologies have shaped the detection of quantifiable biomarkers to define human physiology and pathologies. In summary, this review will emphasize the role that commensals and pathobionts play in their interaction with the immune status of the host, with a prediction that current “omic” technologies will allow researchers to better understand disease in the future.

scholarly journals Personalized Dentistry: Approaching a New Way for Diagnosis and Treatment of Oral Diseases

2020 ◽  
Vol 10 (2) ◽  
pp. 35
Author(s):  
Romeo Patini
Keyword(s):  
In Vivo Studies ◽  
Oral Microbiota ◽  
Oral Diseases ◽  
Therapeutic Approaches ◽  
Bacterial Populations ◽  
Treatment Techniques ◽  
Wide Range ◽  
Analysis Of Results

For years, it has been thought that the field of dentistry was referring exclusively to some diseases that strictly affect the oral cavity. Dental caries, periodontal disease, and pathologies associated with their worsening were considered almost the only interest in scientific research in dentistry. Recent studies have begun to shed light on the effect of the oral microbiota on general health and on the crucial role of dentistry in its maintenance. In this way, we came to understand that the bacterial populations that make up the oral microbiota can vary profoundly between individuals and that contribute in a fundamental way to outlining the so-called “oral signature”. This characteristic is called into question to evaluate the susceptibility, or lack thereof, of the subject to the contraction of a wide range of pathologies, apparently not connected with oral health. From this evidence, it will also be possible to study therapeutic approaches aimed at the eradication of species considered at risk or colonization with species considered protective; thus, giving life to so-called “personalized dentistry”. Therefore, this Special Issue is aimed at spreading the scientific knowledge over the current limits in terms of new molecular and culturomic approaches towards the diagnosis of oral microbiota and the treatment techniques of eventually associated systemic diseases. In vivo studies and systematic literature reviews with quantitative analysis of results, when possible, will be given a high priority.

scholarly journals The role of health insurance in the coverage of oral health care in Senegal

2018 ◽  
Vol 9 (3) ◽  
Author(s):  
Mbathio Diop ◽  
Aida Kanouté ◽  
Massamba Diouf ◽  
Amadou Diaw Ndiaye ◽  
Cheikh Mouhamadou Mbacké Lo ◽  
...  
Keyword(s):  
Health Care ◽  
Health Insurance ◽  
Oral Health ◽  
Health Spending ◽  
Oral Health Care ◽  
Oral Diseases ◽  
Self Medication ◽  
Oral Infections ◽  
Insurance Agents

Oral diseases costs are among the most expensive health care benefits. In Senegal, households contribute up to 37.6% of the national health spending through direct payments. The aim of this work was to study the role of health insurance in the coverage of oral health care in Senegal. The study was based on health insurance agents and policyholders. The study reveals that oral health care coverage through health insurance still does not meet requirements for treatment of oral infections. In financial terms, oral health care costs health insurance too much. As a result, carriers cover them partially. On top of that, the majority of the population’s lack of knowledge about mutual, because they have a little background on oral health care, the latter weighs heavily on health insurance leading to the use of self-medication, traditional medicine and handicraft prosthetists. The analysis reveals an unequal access to oral health care through the health insurance system. To bring under control the expenditure for oral health care, carriers and dental surgeons must work together to raise the populations’ awareness on community solidarity.

Oral probiotic and its delivery carriers to improve oral health: A review

Microbiology ◽  
2021 ◽  
Vol 167 (8) ◽  
Author(s):  
Yu-Hsuan How ◽  
Siok-Koon Yeo
Keyword(s):  
Oral Health ◽  
Oral Cavity ◽  
Health Effects ◽  
Oral Microbiota ◽  
Oral Diseases ◽  
Probiotic Product ◽  
Adherence Ability ◽  
Probiotic Delivery

In recent years, oral probiotics have been researched on their effectiveness in reducing and preventing oral diseases. Oral probiotics could be introduced into the oral cavity to keep the equilibrium of the microbiome. Hence, the delivery carrier for oral probiotics plays an important factor to ensure a high number of oral probiotics were delivered and released into the oral cavity. This review presents a brief overview of oral microbiota and the role of oral probiotics in reducing oral diseases. Moreover, important aspects of the oral probiotic product such as viability, adherence ability, health effects, safety, and delivery site were discussed. Besides that, the importance of utilizing indigenous oral probiotics was also emphasized. Oral probiotics are commonly found in the market in the form of chewing tablets, lozenges, and capsules. Hence, the oral probiotic carriers currently used in the market and research were reviewed. Furthermore, this review introduces new potential oral probiotic delivery carriers such as oral strip, bucco-adhesive gel, and mouthwash. Their effectiveness in delivering oral probiotics for oral health was also explored.

scholarly journals Microbiota populations in supragingival plaque, subgingival plaque, and saliva habitats of adult dogs

2021 ◽  
Vol 3 (1) ◽  
Author(s):  
Patrícia M. Oba ◽  
Meredith Q. Carroll ◽  
Celeste Alexander ◽  
Helen Valentine ◽  
Amy J. Somrak ◽  
...  
Keyword(s):  
Oral Health ◽  
Oral Cavity ◽  
Periodontal Disease ◽  
Bacterial Species ◽  
Oral Disease ◽  
Oral Microbiota ◽  
Subgingival Plaque ◽  
Oral Diseases ◽  
Supragingival Plaque

Abstract Background Oral diseases are common in dogs, with microbiota playing a prominent role in the disease process. Oral cavity habitats harbor unique microbiota populations that have relevance to health and disease. Despite their importance, the canine oral cavity microbial habitats have been poorly studied. The objectives of this study were to (1) characterize the oral microbiota of different habitats of dogs and (2) correlate oral health scores with bacterial taxa and identify what sites may be good options for understanding the role of microbiota in oral diseases. We used next-generation sequencing to characterize the salivary (SAL), subgingival (SUB), and supragingival (SUP) microbial habitats of 26 healthy adult female Beagle dogs (4.0 ± 1.2 year old) and identify taxa associated with periodontal disease indices. Results Bacterial species richness was highest for SAL, moderate for SUB, and lowest for SUP samples (p < 0.001). Unweighted and weighted principal coordinates plots showed clustering by habitat, with SAL and SUP samples being the most different from one another. Bacteroidetes, Proteobacteria, Firmicutes, Fusobacteria, Actinobacteria, and Spirochaetes were the predominant phyla in all habitats. Paludibacter, Filifactor, Peptostreptococcus, Fusibacter, Anaerovorax, Fusobacterium, Leptotrichia, Desulfomicrobium, and TG5 were enriched in SUB samples, while Actinomyces, Corynebacterium, Leucobacter, Euzebya, Capnocytophaga, Bergeyella, Lautropia, Lampropedia, Desulfobulbus, Enhydrobacter, and Moraxella were enriched in SUP samples. Prevotella, SHD-231, Helcococcus, Treponema, and Acholeplasma were enriched in SAL samples. p-75-a5, Arcobacter, and Pasteurella were diminished in SUB samples. Porphyromonas, Peptococcus, Parvimonas, and Campylobacter were diminished in SUP samples, while Tannerella, Proteocalla, Schwartzia, and Neisseria were diminished in SAL samples. Actinomyces, Corynebacterium, Capnocytophaga, Leptotrichia, and Neisseria were associated with higher oral health scores (worsened health) in plaque samples. Conclusions Our results demonstrate the differences that exist among canine salivary, subgingival plaque and supragingival plaque habitats. Salivary samples do not require sedation and are easy to collect, but do not accurately represent the plaque populations that are most important to oral disease. Plaque Actinomyces, Corynebacterium, Capnocytophaga, Leptotrichia, and Neisseria were associated with higher (worse) oral health scores. Future studies analyzing samples from progressive disease stages are needed to validate these results and understand the role of bacteria in periodontal disease development.

scholarly journals Beneficial Role of Antioxidant Secondary Metabolites from Medicinal Plants in Maintaining Oral Health

Antioxidants ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1061
Author(s):  
Manoj Kumar ◽  
Suraj Prakash ◽  
Radha ◽  
Neeraj Kumari ◽  
Ashok Pundir ◽  
...  
Keyword(s):  
Oral Health ◽  
Medicinal Plants ◽  
Secondary Metabolites ◽  
Essential Oils ◽  
Periodontal Diseases ◽  
Oral Microbiota ◽  
Oral Diseases

Plant-derived phytochemicals have been touted as viable substitutes in a variety of diseases. All over the world, dentists have turned to natural remedies for dental cure due to the negative possessions of certain antibacterial mediators used in dentistry. Antimicrobial and other drugs are currently in use, but they show some side effects. Since ancient times, antioxidant EOs have been used for different ailments and have grown in popularity over time. Several in vitro, in vivo, and clinical trials have shown the safety and effectiveness of antioxidant essential oils (EOs) in oral health obtained from medicinal plants. The current review of literature provides a summary of secondary metabolites, more specifically EOs from 20 most commonly used medicinal plants and their applications in maintaining oral health. Dental caries and periodontal diseases are the most common and preventable global infectious diseases, with diseases of the oral cavity being considered major diseases affecting a person’s health. Several clinical studies have shown a connection between oral diseases and oral microbiota. This review discusses the role of antioxidant secondary metabolites in inhibiting the growth of oral pathogens and reducing the formation of dental plaque, and as well as reducing the symptoms of oral diseases. This review article contributes a basic outline of essential oils and their healing actions.

scholarly journals Brain abscess of odontogenic origin in patients with malignant tumors: A report of two cases

2021 ◽  
Vol 12 ◽  
pp. 417
Author(s):  
Teishiki Shibata ◽  
Nobukazu Hashimoto ◽  
Atsuhiko Okura ◽  
Mitsuhito Mase
Keyword(s):  
Cancer Treatment ◽  
Brain Abscess ◽  
Malignant Tumors ◽  
Bacterial Flora ◽  
Oral Infection ◽  
Oral Infections ◽  
Causative Microorganism ◽  
Odontogenic Origin ◽  
Brain Abscesses ◽  
Normal Bacterial Flora

Background: Oral infection and dental manipulations can lead to the development of brain abscesses, a rare but potentially life-threatening condition. Herein, we report patients undergoing cancer treatment who developed brain abscesses of odontogenic origin at our hospital. Case Description: Two patients developed brain abscesses during cancer treatment. Both underwent neurosurgical aspiration, and the causative microorganism was identified as Streptococcus intermedius of the Streptococcus anginosus group, which is a part of the normal bacterial flora in the oral cavity. There was clinical and radiographic evidence of dental infection in one of the patients diagnosed with a brain abscess of odontogenic origin. No infectious foci were found in the other patient during hospitalization for the abscess. However, the patient had undergone extraction of an infected tooth approximately 3 months before admission for the abscess, suggesting origination from an oral infection or dental manipulation. The patients’ cancers rapidly worsened because cancer treatment in both patients was interrupted for several months to treat the brain abscess. Conclusion: Oral infections can cause severe infections, such as brain abscesses, particularly during the treatment of malignant tumors. Improving the oral environment or treating oral infections before initiating treatment for malignant tumors is highly recommended. In addition, the possibility of odontogenic origin should always be considered as a potential etiology of brain abscesses.

scholarly journals Relationships Between Oral Microecosystem and Respiratory Diseases

2022 ◽  
Vol 8 ◽  
Author(s):  
Jiajia Dong ◽  
Wei Li ◽  
Qi Wang ◽  
Jiahao Chen ◽  
Yue Zu ◽  
...  
Keyword(s):  
Oral Health ◽  
Respiratory Infection ◽  
Respiratory Diseases ◽  
Oral Microbiome ◽  
Chronic Obstructive ◽  
Oral Microbiota ◽  
Respiratory Pathogens ◽  
Oral Diseases ◽  
Oral Microbes

Oral microecosystem is a very complicated ecosystem that is located in the mouth and comprises oral microbiome, diverse anatomic structures of oral cavity, saliva and interactions between oral microbiota and between oral microbiota and the host. More and more evidence from studies of epidemiology, microbiology and molecular biology is establishing a significant link between oral microecosystem and respiratory diseases. Microbiota settling down in oral microecosystem is known as the main source of lung microbiome and has been associated with the occurrence and development of respiratory diseases like pneumonia, chronic obstructive pulmonary disease, lung cancer, cystic fibrosis lung disease and asthma. In fact, it is not only indigenous oral microbes promote or directly cause respiratory infection and inflammation when inhaled into the lower respiratory tract, but also internal environment of oral microecosystem serves as a reservoir for opportunistic respiratory pathogens. Moreover, poor oral health and oral diseases caused by oral microecological dysbiosis (especially periodontal disease) are related with risk of multiple respiratory diseases. Here, we review the research status on the respiratory diseases related with oral microecosystem. Potential mechanisms on how respiratory pathogens colonize oral microecosystem and the role of indigenous oral microbes in pathogenesis of respiratory diseases are also summarized and analyzed. Given the importance of oral plaque control and oral health interventions in controlling or preventing respiratory infection and diseases, we also summarize the oral health management measures and attentions, not only for populations susceptible to respiratory infection like the elderly and hospitalized patients, but also for dentist or oral hygienists who undertake oral health care. In conclusion, the relationship between respiratory diseases and oral microecosystem has been established and supported by growing body of literature. However, etiological evidence on the role of oral microecosystem in the development of respiratory diseases is still insufficient. Further detailed studies focusing on specific mechanisms on how oral microecosystem participate in the pathogenesis of respiratory diseases could be helpful to prevent and treat respiratory diseases.

A Study on Revealing Agents in the Context of Photodynamic Therapy in Dental Medicine - A Literature Review

2017 ◽  
Vol 376 ◽  
pp. 54-65 ◽  
Author(s):  
Monica Laura Dascalu (Rusu) ◽  
Codruta Sarosi ◽  
Marioara Moldovan ◽  
Mândra Eugenia Badea
Keyword(s):  
Photodynamic Therapy ◽  
Bacterial Resistance ◽  
Gram Negative Bacteria ◽  
Antimicrobial Photodynamic Therapy ◽  
Oral Diseases ◽  
Resistance Development ◽  
Oral Infections ◽  
Gram Positive Bacteria ◽  
Normal Microflora ◽  
Systemic Infections

Photodynamic therapy (PDT) also known as Phototherapy or Photo chemotherapy involves the use of a photoactive dye (photosensitive) which is activated by exposure to light of a certain wavelength in the presence of oxygen. Dentists have to deal regularly with oral infections which untreated may cause systemic infections. Oral infections such as caries, periodontal infections and infections of the oral mucosa are available lighting so photodynamic therapy is particularly suitable for oral diseases [1,2]. Antimicrobial chemical treatment is nowadays widely used in the prophylaxis and treatment of inflammation-induced plaque with the risk of resistance development. The use of photodynamic therapy as a therapeutic approach can eliminate this risk, however. Studies in the literature show that both Gram-positive bacteria and Gram-negative bacteria are susceptible to the treatment. Among the advantages of using this method is counted rapid elimination of bacteria, minimal chances of developing bacterial resistance and safety in terms of host tissue and existing normal microflora in the oral cavity [3]. Antimicrobial photodynamic therapy (aPDT) by photochemical reaction uses light at a specific wavelength to activate a nontoxic photosensitizer (PS) in the presence of oxygen to produce cytotoxic products. There are different PSs used in dentistry including methylene blue (MB), toluidine blue O (TBO), indocyanine green (ICG) and curcumin [4].

Sign in / Sign up

Export Citation Format

Share Document