scholarly journals Radiochromic Films for the Two-Dimensional Dose Distribution Assessment

2021 ◽  
Vol 11 (5) ◽  
pp. 2132
Author(s):  
Pierluigi Casolaro

Radiochromic films are mainly used for two-dimensional dose verification in photon, electron, and proton therapy treatments. Moreover, the radiochromic film types available today allow their use in a wide dose range, corresponding to applications from low-medical diagnostics to high-dose beam profile measurements in charged particle medical accelerators. An in-depth knowledge of the characteristics of radiochromic films, of their operating principles, and of the dose reading techniques is of paramount importance to exploit all the features of this interesting and versatile radiation detection system. This short review focuses on these main aspects by considering the most recent works on the subject.

Radiochromic film dosimetry has been commonly used for determination of dose measurement in radiotherapy for many years because of their high spatial resolution, low energy dependence and its approximate tissue equivalent. Additionally, it has other practical advantages, e.g.it is suitable for therapy range beam qualities, a water resistance material, a relatively insensitive to visible light, and does not need to make bathing process to obtain dose information. They are also independent to dose rate. Hence they are very useful and practical for clinical applications such as brachytherapy, electron therapy, skin dose measurements and stereotactic radiotherapy. Among them, the dynamic dose range of EBT3 radiochromic films are generally recommended for the dose range of 0.1 to 20 Gy. However, in this study, it is aimed to observe the behavior of EBT3 films in high dose range of up to 90 Gy under the irradiations. For this aim, the net optical densities were obtained with increasing dose values under photon and electron beams by employing three color scanning channel (red-green-blue). Thus, for making calibration curves, it was decided which color channel for EBT3 radiochromic film would be the most suitable one in different dose ranges. In experimental setup, the reference circumstances were first established and dose calibration procedure were carried out in RW3 phantom. Then the irradiated films were cut carefully into 2x2.5 cm2 pieces, and they were grouped into 2 as irradiation and control groups. The control group was waited for background, i.e. they are not irradiated. Before the irradiation, two groups of films have been scanned in flatbed scanner for three channels. After that, the irradiation group films was placed to align the exact place of effective point of ionization chamber under the reference condition. Later, they were irradiated one by one to up to 90 Gy with using 6 MV and 6 MeV beam qualities, respectively. Subsequently, both of film groups were again scanned in flatbed scanner for three –color channels. Optical densities and their standard deviations corresponding to the chosen dose values were obtained from the scanned films. Thus, calibration curves were plotted for all three colors channel according to two different beam conditions. The results obtained for 6 MV beam quality showed that if red color channel is selected for 0.9 Gy-7.3 Gy dose range, and green color channel is selected for 7.3 Gy-42.8 Gy dose range, and blue color channel is selected for 42.8 Gy-90.0 Gy dose range, the percentage uncertainty values in the obtained results are minimal. For the 6 MeV beam quality, if red color channel is selected for 0.9 Gy-7.7 Gy dose range, and green color channel is selected for 7.7 Gy-45.3 Gy dose range, and blue color channel is selected for 45.3 Gy-90.0 Gy dose range, the percentage uncertainty values in the obtained results are minimal. In conclusion, the percentage uncertainty values for the obtained results were evaluated for 6 MV photon and 6 MeV electron energies by using different scanning channels of EBT3 radiochromic film. It has been found that measurements having low percentage uncertainty values can be achieved by changing the scanning channel by deciding proper combinations with increasing doses for both energies (6MV photon and 6 MeV electron). The study also shows that EBT3 radiochromic films can be used at lower percentage uncertainty values ​​at doses higher than the recommended dose range values.


2020 ◽  
Vol ahead-of-print (ahead-of-print) ◽  
Author(s):  
Awad AL Zahrany ◽  
Khalid Rabaeh ◽  
Molham Eyadeh ◽  
Ahmed Basfar

Purpose The purpose of this paper is to present a radiochromic film dosimeter containing polyvinyl alcohol (PVA) matrix and various concentrations of methyl red (MR) dye for high dose measurements. Design/methodology/approach The MR-PVA films were exposed to irradiation up to 60 kGy using 60Co source of gamma ray. The ultraviolet and visible regions (UV/VIS) spectrophotometry were used to examine the optical density of pre-and post-irradiated dosimeters at 424 nm. Findings The dose sensitivity of MR-PVA films increases significantly with increasing MR dye concentrations in the dose range of 5 to 60 kGy. The impact of relative humidity, irradiation temperature, dose rate and the stability of the films has been analyzed. The overall uncertainty of the MR-PVA film dosimeter is 6.12% (Double Standard-deviation, 95% confidence level). Practical implications It was found that the MR-PVA films may be used as high dose dosimeter with an acceptable overall uncertainty in routine industrial radiation processing. Originality/value The color bleaching of irradiated MR-PVA films in terms of specific absorbance curves increases significantly with increasing absorbed dose up to 60 kGy.


2018 ◽  
Vol 106 (8) ◽  
pp. 695-702 ◽  
Author(s):  
Eftekhar Sadat Noorin ◽  
Shahzad Feizi ◽  
Shahram Moradi Dehaghi

Abstract Two novel radiochromic films with 20 μm thickness were made from casting of solutions of polycarbonate (PC) containing 0.5 wt.% tetra phenyl porphyrin (TPPH2) and 5,10,15,20-tetraphenyl-21H,23H-porphine iron(III) chloride (Fe-TPP). Dosimetric characterization of the films as routine dosimeters were studied by spectrophotometric method. On subjecting TPPH2/PC and Fe-TPP/PC film dosimeters to gamma radiation, radiolytic bleaching of films was observed. The effects of metal-complexation on the radiation response of the film dosimeters were studied under 60Co γ-rays exposure in dose range of 0–100 kGy. The results were also compared with the PC/TPPF20 (PC/tetrakis (pentafluorophenyl) porphyrin) dosimeter to evaluate the substituent effect (role of fluorine groups). Experimental parameters including humidity, temperature and pre-irradiation (shelf-life) and post-irradiation storage in dark and in indirect sunlight were examined. The maximum absorbance of Soret band of dyes had meaningful shifts and reduction which arose from complexation and substituents. The dyed films characteristics were found to be stable enough in media with high degrees of temperature and humidity. The results indicate that the radiation-induced decoloration of TPPH2/PC and Fe-TPP/PC films can be reliably tuned and used in high dose dosimetry.


2019 ◽  
Vol 107 (3) ◽  
pp. 271-278
Author(s):  
Eftekhar Sadat Noorin ◽  
Shahzad Feizi ◽  
Shahram Moradi Dehaghi

Abstract As the utilizing of porphyrins and metalloporphyrins in high dose dosimetry becomes more prevalent, research on structural effects of these molecules on dosimetric characteristics and physicochemical properties of their film dosimeters becomes more and more essential. The present study emphasizes dosimetry (measuring radiolytic bleaching of two novel film dosimeters with spectrophotometric methods against 60Co γ-rays exposure in dose range of 0–100 kGy) and evaluating substituent effects on the radiation response of the film dosimeters (role of organic groups and changing the metal core of porphyrins). With casting of solutions of polycarbonate (PC) containing 0.5 wt.% 5,10,15,20-Tetrakis(2,4,6-trimethoxyphenyl) porphyrin (TTMPP) and 5,10,15,20-Tetraphenyl-21H,23H-porphine manganese (III) chloride (Mn-TPP), two novel radiochromic films with the thickness of 20 μm were fabricated. The presence of porphyrin fragments has been observed in the UV–Vis spectra after γ radiation. Due to the changes of the metal core and substituents of the dye ring, meaningful shifts of maximum absorbance of Soret bands of porphyrins and different radiation response of film-dosimeters were observed. The results were compared with the other polycarbonate/porphyrin film dosimeters. The results indicate that the radiation-induced decoloration of PC/Porphyrin films can be reliably tuned and used in high dose dosimetry.


Materials ◽  
2021 ◽  
Vol 14 (18) ◽  
pp. 5203
Author(s):  
Sara Pettinato ◽  
Marco Girolami ◽  
Riccardo Olivieri ◽  
Antonella Stravato ◽  
Cristina Caruso ◽  
...  

One of the goals of modern dynamic radiotherapy treatments is to deliver high-dose values in the shortest irradiation time possible. In such a context, fast X-ray detectors and reliable front-end readout electronics for beam diagnostics are crucial to meet the necessary quality assurance requirements of care plans. This work describes a diamond-based detection system able to acquire and process the dose delivered by every single pulse sourced by a linear accelerator (LINAC) generating 6-MV X-ray beams. The proposed system is able to measure the intensity of X-ray pulses in a limited integration period around each pulse, thus reducing the inaccuracy induced by unnecessarily long acquisition times. Detector sensitivity under 6-MV X-photons in the 0.1–10 Gy dose range was measured to be 302.2 nC/Gy at a bias voltage of 10 V. Pulse-by-pulse measurements returned a charge-per-pulse value of 84.68 pC, in excellent agreement with the value estimated (but not directly measured) with a commercial electrometer operating in a continuous integration mode. Significantly, by intrinsically holding the acquired signal, the proposed system enables signal processing even in the millisecond period between two consecutive pulses, thus allowing for effective real-time dose-per-pulse monitoring.


2021 ◽  
Vol 18 (6) ◽  
pp. 691-699
Author(s):  
D. M. Borowicz ◽  
M. Kruszyna-Mochalska ◽  
K. Shipulin ◽  
A. Molokanov ◽  
G. Mytsin ◽  
...  

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Gertraud Eylert ◽  
Reinhard Dolp ◽  
Alexandra Parousis ◽  
Richard Cheng ◽  
Christopher Auger ◽  
...  

Abstract Background Multipotent mesenchymal stromal/stem cell (MSC) therapy is under investigation in promising (pre-)clinical trials for wound healing, which is crucial for survival; however, the optimal cell dosage remains unknown. The aim was to investigate the efficacy of different low-to-high MSC dosages incorporated in a biodegradable collagen-based dermal regeneration template (DRT) Integra®. Methods We conducted a porcine study (N = 8 Yorkshire pigs) and seeded between 200 and 2,000,000 cells/cm2 of umbilical cord mesenchymal stromal/stem cells on the DRT and grafted it onto full-thickness burn excised wounds. On day 28, comparisons were made between the different low-to-high cell dose groups, the acellular control, a burn wound, and healthy skin. Result We found that the low dose range between 200 and 40,000 cells/cm2 regenerates the full-thickness burn excised wounds most efficaciously, followed by the middle dose range of 200,000–400,000 cells/cm2 and a high dose of 2,000,000 cells/cm2. The low dose of 40,000 cells/cm2 accelerated reepithelialization, reduced scarring, regenerated epidermal thickness superiorly, enhanced neovascularization, reduced fibrosis, and reduced type 1 and type 2 macrophages compared to other cell dosages and the acellular control. Conclusion This regenerative cell therapy study using MSCs shows efficacy toward a low dose, which changes the paradigm that more cells lead to better wound healing outcome.


2021 ◽  
pp. 1-10
Author(s):  
Chien-Cheng Leea ◽  
Zhongjian Gao ◽  
Xiu-Chi Huanga

This paper proposes a Wi-Fi-based indoor human detection system using a deep convolutional neural network. The system detects different human states in various situations, including different environments and propagation paths. The main improvements proposed by the system is that there is no cameras overhead and no sensors are mounted. This system captures useful amplitude information from the channel state information and converts this information into an image-like two-dimensional matrix. Next, the two-dimensional matrix is used as an input to a deep convolutional neural network (CNN) to distinguish human states. In this work, a deep residual network (ResNet) architecture is used to perform human state classification with hierarchical topological feature extraction. Several combinations of datasets for different environments and propagation paths are used in this study. ResNet’s powerful inference simplifies feature extraction and improves the accuracy of human state classification. The experimental results show that the fine-tuned ResNet-18 model has good performance in indoor human detection, including people not present, people still, and people moving. Compared with traditional machine learning using handcrafted features, this method is simple and effective.


Author(s):  
L F Campanile ◽  
R Jähne ◽  
A Hasse

Classical beam models do not account for partial restraint of anticlastic bending and are therefore inherently inaccurate. This article proposes a modification of the exact Bernoulli–Euler equation which allows for an exact prediction of the beam's deflection without the need of two-dimensional finite element calculations. This approach offers a substantial reduction in the computational effort, especially when coupled with a fast-solving schema like the circle-arc method. Besides the description of the new method and its validation, this article offers an insight into the somewhat disregarded topic of anticlastic bending by a short review of the published theories and a selection of representative numerical results.


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