scholarly journals Smart Intravenous Infusion Dosing System

2021 ◽  
Vol 11 (2) ◽  
pp. 513
Author(s):  
Dragana Oros ◽  
Marko Penčić ◽  
Jovan Šulc ◽  
Maja Čavić ◽  
Stevan Stankovski ◽  
...  
Keyword(s):  
Infusion Therapy ◽  
Blood Transfusions ◽  
Entire System ◽  
Positive Effects ◽  
Remote Location ◽  
Full Effect ◽  
Communication Layer ◽  
Patient Will ◽  
Fluid Levels ◽  
Infusion Fluid

Intravenous (IV) infusion therapy allows the infusion fluid to be inserted directly into the patient’s vein. It is used to place medications directly into the bloodstream or for blood transfusions. The probability that a hospitalized patient will receive some kind of infusion therapy, intravenously, is 60–80%. The paper presents a smart IV infusion dosing system for detection, signaling, and monitoring of liquid in an IV bottle at a remote location. It consists of (i) the sensing and computation layer—a system for detection and signaling of fluid levels in the IV bottle and a system for regulation and closing of infusion flow, (ii) the communication layer—a wireless exchange of information between the hardware part of the system and the client, and (iii) the user layer—monitoring and visualization of IV therapy reception at a remote location in real time. All layers are modular, allowing upgrades of the entire system. The proposed system alerts medical staff to continuous and timely changes of IV bottles, which can have positive effects on increasing the success of IV therapy, especially in oncology patients. The prescribed drip time of IV chemotherapy for the full effect of cytostatics should be imperative.

scholarly journals Apomorphine in the treatment of Parkinson's disease: a review

2018 ◽  
Vol 76 (12) ◽  
pp. 840-848 ◽  
Author(s):  
Renata Ramina Pessoa ◽  
Adriana Moro ◽  
Renato Puppi Munhoz ◽  
Hélio A.G. Teive ◽  
Andrew J. Lees
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Rescue Therapy ◽  
Continuous Process ◽  
Subcutaneous Administration ◽  
Historical Background ◽  
Infusion Therapy ◽  
Disease Treatment ◽  
Positive Effects

ABSTRACT Optimizing idiopathic Parkinson's disease treatment is a challenging, multifaceted and continuous process with direct impact on patients’ quality of life. The basic tenet of this task entails tailored therapy, allowing for optimal motor function with the fewest adverse effects. Apomorphine, a dopamine agonist used as rescue therapy for patients with motor fluctuations, with potential positive effects on nonmotor symptoms, is the only antiparkinsonian agent whose capacity to control motor symptoms is comparable to that of levodopa. Subcutaneous administration, either as an intermittent injection or as continuous infusion, appears to be the most effective and tolerable route. This review summarizes the historical background, structure, mechanism of action, indications, contraindications and side effects, compares apomorphine infusion therapy with other treatments, such as oral therapy, deep brain stimulation and continuous enteral infusion of levodopa/carbidopa gel, and gives practical instructions on how to initiate treatment.

scholarly journals Study of the effects of the principle of low-volume infusion therapy

2020 ◽  
pp. 9-10
Author(s):  
A. Baydamirova ◽  
I. Maharrambayli
Keyword(s):  
Heart Disease ◽  
Elderly Patients ◽  
Clinical Laboratory ◽  
Erythrocyte Aggregation ◽  
Infusion Therapy ◽  
Endothelial Layer ◽  
Positive Effects ◽  
Endogenous Intoxication ◽  
Low Volume ◽  
Positive Effect

Objective. To study the effects of low-volume infusion therapy on the pathogenetic elimination of endogenous intoxication in a patient with coronary heart disease. Materials and methods. The study included 30 patients diagnosed with COVID-19. The age of the patients was 45-65 years. All patients underwent generally accepted clinical laboratory and instrumental examinations. Rheosorbilact 200 ml intravenous was prescribed to all patients for the purpose of low-volume infusion therapy to reduce metabolic disorders, reduce the amount of free radicals and weaken inflammatory reactions, eliminate endogenous intoxication. The drug contains potassium chloride, calcium contains magnesium chloride, sodium lactate, sodium chloride and sorbitol. Results and discussion. The drug was positively received by patients during treatment and no side effects were observed. A “mild” effect on the pH of the blood was observed during the determination of Rheosorbilact. In addition, lactate has been shown to have a positive effect on cardiac function, liver and kidney detoxification function. The positive effect of Rheosorbilact on the functional state of the endothelial layer of microvascular vessels should be noted. As is known, the endothelial layer, which determines the motility of the vascular wall, has anti-inflammatory, antiplatelet, antiproliferative activity. Therefore, improvement of endothelial function under the influence of Rheosorbilact has been observed to increase the stability of hemovascular homeostasis and to maintain a stable level of adequate tissue perfusion in the examined patients. The unconditional advantage of the drug is the improvement of hemorrhagic parameters, as well as prophylactic antithrombotic effect. In elderly patients with ischemic heart disease, a 30 % decrease in platelet aggregation activity was observed during the administration of Rheosorbilact in combination with drugs for complex treatment. One of the positive effects of the drug was the improvement of rheological properties and microcirculation of the blood. In particular, a decrease in blood viscosity from 1.35±0.02 to 1.25±0.03 and a 25 % decrease in the erythrocyte aggregation index were observed in elderly patients. Conclusions. Thus, according to the results of the presented study, Rheosorbilact can be prescribed for the treatment of endogenous intoxication for small-volume infusion in patients with COVID-19 diagnosed with cardiovascular diseases. A positive effect on the size was observed.

Cost of Current Iron Chelation Infusion Therapy and Cost-Effectiveness of Once-Daily Oral Deferasirox in Transfusion-Dependent Thalassemia Patients in Canada.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 3349-3349
Author(s):  
T.E. Delea ◽  
K. El Ouagari ◽  
O. Sofrygin
Keyword(s):  
Cost Effectiveness ◽  
Iron Overload ◽  
Chelation Therapy ◽  
Thalassemia Major ◽  
Infusion Therapy ◽  
Published Data ◽  
Blood Transfusions ◽  
Once Daily ◽  
Life Years ◽  
The Cost

Abstract Background: Deferasirox (Exjade®) is a recently approved once-daily oral chelator that has been shown to produce reductions in liver iron concentrations and serum ferritin similar to those with infusional deferoxamine (Desferal®), in patients with β-thalassemia major or sickle cell disease (SCD) and chronic iron overload from blood transfusions. The objective of this study was to estimate the cost of deferoxamine administration in Canada and evaluate the cost-effectiveness of deferasirox versus deferoxamine for chronic iron overload from blood transfusions from the Ontario provincial healthcare system. Methods: Cost of chelation therapy with deferoxamine was estimated from five major treatment centers in Canada. Costs comprised the material used and the time spent by hospital pharmacists in preparing deferoxamine infusions. Cost-effectiveness of the new oral iron chelator, deferasirox, which could replace deferoxamine, was estimated using a Markov model. The model estimates and compares the total lifetime costs and quality-adjusted life years (QALYs) related to the use of deferasirox or deferoxamine in patients with β-thalassemia major at risk of chronic iron overload from blood transfusions. Dosages of deferasirox and deferoxamine used in the model were those that have been shown to be similarly effective in such patients. Compliance with deferoxamine was based on analyses of health-insurance claims data from transfusion-dependent thalassemia patients. Probabilities of complications of iron overload and death by compliance with chelation were estimated from published studies. Because data on compliance with deferasirox in typical clinical practice are unavailable, we used published data on compliance with the oral chelator deferiprone versus deferoxamine. Costs of deferasirox, deferoxamine, and drugs used in the treatment of complications of iron overload were based on publicly available data sources. Utilities were based on a study of patient preferences for oral versus infusional chelation therapy, as well as published literature and assumption. Future costs and QALYs were discounted at 5% annually. Costs were adjusted to 2004 Canadian dollars. Results: Cost of yearly infusion therapy in Canada was estimated at $6,000 per patient, excluding deferoxamine drug cost. Cost-effectiveness of deferasirox compared to deferoxamine was estimated at $45,054 per QALY gained resulting mainly from a gain in 2.9 QALYs obtained at an expected lifetime cost of $130,058 per patient. Cost-effectiveness is sensitive to the estimated costs of deferoxamine and infusional therapy, as well as the quality of life benefit associated with oral versus infusional therapy, and is more favorable in younger patients. Conclusion: In patients with transfusion-dependent β-thalassemia, the cost-effectiveness of deferasirox versus deferoxamine is within the range generally considered acceptable in Canada.

scholarly journals Incidence of Phlebitis Following the Use of Peripheral IV Line at X Hospital

2021 ◽  
pp. 79-86
Author(s):  
Margareta Sijabat ◽  
Sisilia Desiana Nduru ◽  
Ayu Monaretha B ◽  
Yenni Ferawati Sitanggang ◽  
Elissa Oktoviani Hutasoit
Keyword(s):  
Medication Administration ◽  
Infusion Therapy ◽  
Inclusion Criteria ◽  
Intrinsic Factors ◽  
Line Therapy ◽  
Modifiable Factors ◽  
Chemical Factors ◽  
Mechanical Factors ◽  
Infusion Fluid ◽  
Catheter Location

Introduction: Intravenous (IV) line infusion therapy is a therapy given to patients who are admitted or having a specific therapy. The IV-line therapy may include fluid therapy, medication administration and blood therapy. Based on the data found in Hospital X, there were 30 incidence of phlebitis in 2017. This study aimed to describe the factors of phlebitis incidence in X hospital. Method: This study was a retrospective study using 50 clinical record of the inpatient patients. The inclusion criteria were all documents of those who are hospitalized at least three days. Result: The result describes three factors following the incidence of phlebitis, such as intrinsic factors, chemical factors, and mechanical factors. The Intrinsic factors included age, gender and medical diagnosis. While Mechanical factors consist of the size of catheter, location and length of infusion. The Chemical factors were of infusion fluid type and infusion rate. Conclusion: The conclusion of this study was the three factors are modifiable factors. Thus, nurses need to assess and evaluate patients’ infusion in order to prevent a higher case of phlebitis. As a recommendation for further study is to analyze the correlation between those factors to the incidence of phlebitis. 

Optimal Frequency of Changing Intravenous Administration Sets: Is It Safe to Prolong Use Beyond 72 Hours?

2001 ◽  
Vol 22 (03) ◽  
pp. 136-139 ◽  
Author(s):  
Issam Raad ◽  
Hend A. Hanna ◽  
Abeer Awad ◽  
Amin Alrahwan ◽  
Carol Bivins ◽  
...  
Keyword(s):  
Parenteral Nutrition ◽  
Total Parenteral Nutrition ◽  
Randomized Study ◽  
Interleukin 2 ◽  
Group Versus ◽  
Cost Effective ◽  
Cancer Center ◽  
Infusion Therapy ◽  
Blood Transfusions ◽  
Comparable Rate

AbstractObjective:To determine the safety and cost-effectiveness of replacing the intravenous (TV) tubing sets in hospitalized patients at 4- to 7-day intervals instead of every 72 hours.Design:Prospective, randomized study of infusion-related contamination associated with changing IV tubing sets within 3 days versus within 4 to 7 days of placement.Setting:A tertiary university cancer center.Patients and Methods:Cancer patients requiring IV infusion therapy were randomized to have the IV tubing sets replaced within 3 days (280 patients) or within 4 to 7 days of placement (232 patients). Demographic, microbiological, and infusion-related data were collected for all participants. The main outcome measures were infusion- or catheter-related contamination or colonization of IV tubing, determined by quantitative cultures of the infusate, and infusion- or catheter-related bloodstream infection (BSI), determined by quantitative culture of the infusate in association with blood cultures in febrile patients.Results:The two groups were comparable in terms of patient and catheter characteristics and the agents given through the IV tubing. Intent-to-treat analysis demonstrated a higher level of tubing colonization in the 4- to 7-day group versus the 3-day group (median, 145 vs 50 colony-forming units;P=.02). In addition, there were three episodes of possible infusion-related BSIs, all of which occurred in the 4- to 7-day group (P=.09). However, when the 84 patients who received total parenteral nutrition, blood transfusions, or interleukin-2 through the IV tubing were excluded, the two groups had a comparable rate of colonization (0.4% vs 0.5%), with no catheter- or infusion-related BSIs in either group.Conclusion:In patients at low risk for infection from infusion- or catheter-related infection who are not receiving total parenteral nutrition, blood transfusions, or interleukin-2, delaying the replacement of IV tubing up to 7 days may be safe, as well as cost-effective.

scholarly journals Intravenous lidocaine and magnesium on responses of A-δ and A-β nerve fibers at non-affected and affected areas in three cases of neuralgias

2021 ◽  
Vol 9 (5) ◽  
Author(s):  
Young-Chang Arai ◽  
Makoto Nishihara ◽  
Tatsunori Ikemoto ◽  
Hironori Saisu ◽  
Keiko Owari
Keyword(s):  
Intravenous Infusion ◽  
Tactile Stimulation ◽  
Nerve Fibers ◽  
Infusion Therapy ◽  
Intractable Pain ◽  
Evoked Responses ◽  
Present Case Report ◽  
Positive Effects ◽  
Intravenous Magnesium ◽  
Intercostal Neuralgia

Intravenous magnesium and lidocaine have been used for the management of intractable pain individually or in combination. A study reported on the positive effects when used in combination on neuralgia when antiepileptic drugs failed, but nobody has clarified how the combination works. The aim of the present case report is to see how a combination of intravenous magnesium and lidocaine influenced electrically-evoked responses of peripheral A-δ and A-β nerve fibers at non-affected and affected areas in three patients with neuralgia. For nociceptive stimulation, a method of intraepidermal electrical stimulation (IES) was used for the selective activation of cutaneous A-δ fibers, using a stainless steel concentric bipolar needle electrode. For tactile stimulation, similar cutaneous sites were stimulated for cutaneous A-β fibers using the same electrode. Three patients with intractable trigeminal neuralgia or intercostal neuralgia were treated using an intravenous infusion of a combination of 1.2g of magnesium and 100mg of lidocaine for one hour. Although all patients experienced sound pain relief after the combined intravenous infusion therapy, the combination had a different effect on electrically-evoked responses of peripheral A-δ and A-β nerve fibers at non-affected and affected areas in each patient.

[Intra-arterial infusion therapy of maxillary cancer]

1969 ◽  
Vol 33 (4) ◽  
pp. 581-584
Author(s):  
H Sasaki ◽  
T Wakutani ◽  
S Oda ◽  
Y Yamazaki
Keyword(s):  
Infusion Therapy ◽  
Arterial Infusion ◽  
Maxillary Cancer ◽  
Arterial Infusion Therapy

A Family With Autosomal-Dominant Progressive Sensorineural Hearing Loss

1996 ◽  
Vol 5 (1) ◽  
pp. 23-32 ◽  
Author(s):  
Chris Halpin ◽  
Barbara Herrmann ◽  
Margaret Whearty
Keyword(s):  
Speech Production ◽  
Hearing Aids ◽  
Role Models ◽  
Speech Intelligibility ◽  
Large Scale ◽  
Speech Language Pathology ◽  
The Family ◽  
Patient Will ◽  
Language Pathology

The family described in this article provides an unusual opportunity to relate findings from genetic, histological, electrophysiological, psychophysical, and rehabilitative investigation. Although the total number evaluated is large (49), the known, living affected population is smaller (14), and these are spread from age 20 to age 59. As a result, the findings described above are those of a large-scale case study. Clearly, more data will be available through longitudinal study of the individuals documented in the course of this investigation but, given the slow nature of the progression in this disease, such studies will be undertaken after an interval of several years. The general picture presented to the audiologist who must rehabilitate these cases is that of a progressive cochlear degeneration that affects only thresholds at first, and then rapidly diminishes speech intelligibility. The expected result is that, after normal language development, the patient may accept hearing aids well, encouraged by the support of the family. Performance and satisfaction with the hearing aids is good, until the onset of the speech intelligibility loss, at which time the patient will encounter serious difficulties and may reject hearing aids as unhelpful. As the histological and electrophysiological results indicate, however, the eighth nerve remains viable, especially in the younger affected members, and success with cochlear implantation may be expected. Audiologic counseling efforts are aided by the presence of role models and support from the other affected members of the family. Speech-language pathology services were not considered important by the members of this family since their speech production developed normally and has remained very good. Self-correction of speech was supported by hearing aids and cochlear implants (Case 5’s speech production was documented in Perkell, Lane, Svirsky, & Webster, 1992). These patients received genetic counseling and, due to the high penetrance of the disease, exhibited serious concerns regarding future generations and the hope of a cure.

Effects of a 6-Week Straw Phonation in Water Exercise Program on the Aging Voice

2020 ◽  
Vol 63 (4) ◽  
pp. 1018-1032
Author(s):  
Chia-Hsin Wu ◽  
Roger W. Chan
Keyword(s):  
Acoustic Analysis ◽  
Vocal Tract ◽  
Exercise Program ◽  
Analysis Of Covariance ◽  
Elderly Subjects ◽  
Control Group ◽  
Perceptual Evaluation ◽  
Positive Effects ◽  
Aging Voice ◽  
Before And After

Purpose Semi-occluded vocal tract (SOVT) exercises with tubes or straws have been widely used for a variety of voice disorders. Yet, the effects of longer periods of SOVT exercises (lasting for weeks) on the aging voice are not well understood. This study investigated the effects of a 6-week straw phonation in water (SPW) exercise program. Method Thirty-seven elderly subjects with self-perceived voice problems were assigned into two groups: (a) SPW exercises with six weekly sessions and home practice (experimental group) and (b) vocal hygiene education (control group). Before and after intervention (2 weeks after the completion of the exercise program), acoustic analysis, auditory–perceptual evaluation, and self-assessment of vocal impairment were conducted. Results Analysis of covariance revealed significant differences between the two groups in smoothed cepstral peak prominence measures, harmonics-to-noise ratio, the auditory–perceptual parameter of breathiness, and Voice Handicap Index-10 scores postintervention. No significant differences between the two groups were found for other measures. Conclusions Our results supported the positive effects of SOVT exercises for the aging voice, with a 6-week SPW exercise program being a clinical option. Future studies should involve long-term follow-up and additional outcome measures to better understand the efficacy of SOVT exercises, particularly SPW exercises, for the aging voice.

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