scholarly journals Complications of Teeth Affected by Molar-Incisor Malformation and Pathogenesis According to Microbiome Analysis

2020 ◽  
Vol 11 (1) ◽  
pp. 4
Author(s):  
Hyo-Seol Lee ◽  
Hee Jin Kim ◽  
Koeun Lee ◽  
Mi Sun Kim ◽  
Ok Hyung Nam ◽  
...  
Keyword(s):  
Poor Prognosis ◽  
Oral Microbiome ◽  
Subgingival Plaque ◽  
Pulp Chamber ◽  
Clinical Process ◽  
Microbiome Analysis ◽  
Supragingival Plaque ◽  
Localized Juvenile Periodontitis ◽  
Group 2 ◽  
Group 1

A molar-incisor malformation (MIM) is a recently reported dental anomaly that causes premature loss of the first molar with severe dentoalveolar infection. However, there has been no research on the pathogenesis yet. The aim of this study was to report the clinical process of MIMs and investigate the pathogenesis by conducting a microbiome analysis. An eight-year-old girl was diagnosed with MIM and after two years, four permanent first molars were sequentially extracted due to severe dentoalveolar infection. We recorded the patient`s clinical progress and collected oral microbiome samples from the extracted teeth with MIM and sound teeth as controls. The sites of microbiome sampling were represented by five habitats in two groups. Group (1) was the perio group: ① supragingival plaque, ② subgingival plaque, and ③ a pical abscess; and group (2) was the endo group: ④ coronal pulp chamber and ⑤ root canal. The perio group was composed predominantly of genera Streptococcus, Veilonella, and Leptotrichia. Spirochetes appeared in one sample from a severe periodontal abscess. Aggregatibacter actinomyces were not identified. In the endo groups, pulp necrosis was observed in all MIM and the genera Peptostreptococcus and Parvimonas predominated. In conclusion, MIM teeth caused localized tooth-related periodontitis with pulp necrosis rather than localized juvenile periodontitis, resulting in a poor prognosis, and timely extraction is highly recommended.

Intensified concomitant chemoradiotherapy with and without filgrastim for poor-prognosis head and neck cancer.

1994 ◽  
Vol 12 (11) ◽  
pp. 2351-2359 ◽  
Author(s):  
E E Vokes ◽  
D J Haraf ◽  
R Mick ◽  
J M McEvilly ◽  
R R Weichselbaum
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Poor Prognosis ◽  
Locoregional Control ◽  
Cumulative Toxicity ◽  
Life Threatening ◽  
Group 2 ◽  
Concomitant Radiotherapy ◽  
Group 1

PURPOSE We previously demonstrated high locoregional control rates in patients with poor-prognosis head and neck cancer using fluorouracil (5-FU), hydroxyurea (HU), and concomitant radiotherapy (FHX). In two trials reported here, we added cisplatin with and without granulocyte colony-stimulating factor (G-CSF) to 5-FU, HU, and concomitant radiotherapy. PATIENTS AND METHODS Eligible patients had failed to respond to prior local therapy (group 1); previously untreated patients with unresectable and/or metastatic disease and a projected 2-year survival rate less than 10% were also eligible (group 2). Chemoradiotherapy consisted of 1.8 to 2.0 Gy on days 1 to 5 with simultaneous infusional 5-FU at 800 mg/m2/d and HU administered every 12 hours for 11 doses at escalating doses. Cisplatin was administered at 100 mg/m2 during every other cycle. Cycles were repeated every 14 days until completion of radiotherapy. In study 2, G-CSF was added on days 6 to 13 at 5 micrograms/kg/d. RESULTS Acute and cumulative myelosuppression limited the feasibility of adding cisplatin to FHX without G-CSF. G-CSF allowed for escalation of HU to 1 g orally every 12 hours without dose-limiting acute toxicity during cycles 1 and 2. Dose-limiting cumulative toxicity consisted of severe or life-threatening myelosuppression and mucositis. To decrease total treatment duration and, thus, cumulative toxicity, a hyperfractionated radiation therapy schedule was investigated using the established chemotherapy doses with 1.5 Gy twice daily on days 1 to 5 (75 Gy over five treatment cycles). No increase in acute toxicities was seen; cumulative toxicities remained frequently severe or life-threatening. Thirty-eight of 45 assessable patients responded. The median survival duration was 12 months for both groups. Median time to treatment failure was 8 months for group 1 and has not been reached for group 2. At 1 year, local control rates were 74% and 91% for groups 1 and 2, respectively. CONCLUSION The addition of cisplatin to 5-FU, HU, and concomitant radiotherapy is feasible using G-CSF. The high locoregional control rate and failure-free interval justify further investigation of this regimen in previously untreated patients.

scholarly journals Estimation of radiographic angles and distances in coronal part of mandibular molars: A study of panoramic radiographs using EMAGO software

2014 ◽  
Vol 08 (01) ◽  
pp. 090-094 ◽  
Author(s):  
Ioannis N. Tsatsoulis ◽  
Christos G. Filippatos ◽  
Spyros G. Floratos ◽  
Evangelos G. Kontakiotis
Keyword(s):  
Age Groups ◽  
Pulp Chamber ◽  
Panoramic Radiographs ◽  
Dimensional Changes ◽  
Mandibular Molars ◽  
Group 5 ◽  
Group 2 ◽  
Dentin Formation ◽  
Chamber Floor ◽  
Group 1

ABSTRACT Objective: This study was designed to investigate radiographically the effects of age and external irritating stimuli on the morphology and thickness of the pulp chamber ceiling and floor in mandibular molars. Materials and Methods: A total of 234 panoramic radiographs were recruited and 494 mandibular molars were examined in this study. The sample was divided into six age groups: Group 1, <20 years; Group 2, 20-29 years; Group 3, 30-39 years; Group 4, 40-49 years; Group 5, 50-59 years and Group 6, >60 years. Each group was subdivided into two subgroups with regard to the tooth condition (intact or non-intact teeth). Four distances, two angles and two ratios were measured, in order to estimate the dimensions of the pulp chamber and the thickness of the pulp chamber ceiling and floor. Results: The thickness of the pulp chamber ceiling and floor increased significantly from Group 1 to 6. The pulp chamber floor angle presented progressive sharpness from Group 1 to 6 whereas the pulp chamber ceiling angle presented progressive bluntness from Group 1 to 5 and sharpness from Group 5 to 6. Significant differences were identified in the thickness of the pulp chamber ceiling, the thickness of the pulp chamber floor and the ceiling-floor distance between intact and non-intact teeth. Conclusion: Based on those results, there are differences in the location of secondary dentin formation between the two pulp chamber walls. Age is related to diminished pulp chamber size. The increase rate of the pulp chamber ceiling thickness is similar to that of the pulp chamber floor thickness. Furthermore, external irritating stimuli have an effect on the pulp chamber dimensional changes.

scholarly journals Resin Bonding of Self-Etch Adhesives to Bovine Dentin Bleached from Pulp Chamber

2016 ◽  
Vol 2016 ◽  
pp. 1-7
Author(s):  
Akiko Haruyama ◽  
Atsushi Kameyama ◽  
Junji Kato ◽  
Shinji Takemoto ◽  
Yutaka Oda ◽  
...  
Keyword(s):  
Bond Strength ◽  
Resin Composite ◽  
Adhesive System ◽  
Unit Group ◽  
Tooth Bleaching ◽  
Pulp Chamber ◽  
Halogen Light ◽  
Group 2 ◽  
Self Etch ◽  
Group 1

This study evaluated the microtensile bond strength (μTBS) of 1-step self-etch adhesives (1-SEAs) and 2-step self-etch adhesives (2-SEAs) to pulp chamber dentin immediately after bleaching with 2 types of common bleaching techniques. Pulp chamber dentin of bovine teeth was bleached using 30% hydrogen peroxide (H2O2) solution with quartz-tungsten-halogen light-curing unit (Group 1) and 3.5% H2O2-containing titanium dioxide (TiO2) (Pyrenees®) activated with 405-nm violet diode laser for 15 min (Group 2). Unbleached specimens were placed in distilled water for 15 min and used as controls. After treatment, dentin was bonded with resin composite using 1-SEA or 2-SEA and stored in water at 37°C for 24 h. Each specimen was sectioned and trimmed to an hourglass-shape andμTBS was measured. Fractured specimens were examined under a scanning electron microscope to determine fracture modes. All specimens in Group 1 failed before proper bonding tests. In Group 2, theμTBS of 2-SEA was significantly greater (with no failed specimens) than 1-SEA (where 21 out of 36 failed). These results indicate that 2-SEA is a better adhesive system than 1-SEA on bleached dentin. Our results also demonstrated that application of H2O2significantly decreases bond strength of resin to dentin; however, in the case of nonvital tooth bleaching, Pyrenees® is a better alternative to the conventional 30% H2O2bleaching.

scholarly journals Evaluation of the permeability of the furcation area of deciduous molars conditioned with Er:YAG laser and cyanoacrylate

2003 ◽  
Vol 17 (3) ◽  
pp. 212-216 ◽  
Author(s):  
Adriene Mara Souza Lopes-Silva ◽  
José Luiz Lage-Marques
Keyword(s):  
Treatment Group ◽  
Er:Yag Laser ◽  
Pulp Chamber ◽  
Analysis Group ◽  
Group 4 ◽  
Group 3 ◽  
Group 2 ◽  
Deciduous Molars ◽  
Group 1

The purpose of this study was to evaluate in vitro the dentin permeability of the deciduous pulp chamber floor after employing 2-octyl cyanoacrylate and Er:YAG laser. Twenty four deciduous molars were used, divided into four groups. After chemical-surgical preparation each group received a different treatment: Group 1 - control, without treatment; Group 2 - the floor of the pulp chamber was covered with a fine layer of 2-octyl cyanoacrylate; Group 3 - the floor of the pulp chamber was irradiated with Er:YAG laser (250 mJ, 10 Hz for 30 seconds, 80 J of energy and 320 pulses), and covered with a fine layer of 2-octyl cyanoacrylate; and Group 4 - the floor of the pulp chamber was irradiated with Er:YAG laser set at the parameters already described. After that the specimens received application of 0.5% methylene blue, for 15 minutes. The teeth were cut, photographed, and the digitalized images were analyzed using the ImageLab program. The results obtained were submitted to statistical analysis. Group 4 (Er:YAG) presented the largest averages in percentage of dye penetration area (19.5%), followed by Group 1 (11.1%), Group 3 (1.4%) and Group 2 (0.2%). The experimental model allowed to conclude that the specimens conditioned with 2-octyl cyanoacrylate (Group 2) and Er:YAG laser associated to 2-octyl cyanoacrylate (Group 3) presented a decrease in permeability, and the specimens treated with Er:YAG laser (Group 4) presented an increase in permeability of the analyzed area.

scholarly journals Influence of different methods of cervical flaring on establishment of working length

2006 ◽  
Vol 14 (5) ◽  
pp. 351-354 ◽  
Author(s):  
Dieison Nardi Lazzaretti ◽  
Bernardo Alievi Camargo ◽  
Alvaro Della Bona ◽  
Volmir João Fornari ◽  
José Roberto Vanni ◽  
...  
Keyword(s):  
Analysis Of Variance ◽  
Sodium Hypochlorite ◽  
Statistical Difference ◽  
Length Measurement ◽  
Pulp Chamber ◽  
Tukey Test ◽  
Working Length ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

OBJECTIVE: to investigate the influence of three different rotary systems for cervical flaring on establishment of the real working length. MATERIAL AND METHODS: Thirty mandibular first molars were submitted to conventional endodontic access and initial working length measurement, followed by irrigation/suction of the pulp chamber with 5% sodium hypochlorite. Teeth were randomly divided into 3 groups (n=10) and cervical flaring of the mesiobuccal canals were performed using one of the following instrument systems: Group 1 - Gates-Glidden burs; Group 2 - Orifice Openers; Group 3 - La Axxess system. Two subsequent numbers of instruments of each rotary system were used and the final working length was recorded. A digital calyper was used to record the working length, in millimeters, to investigate a possible discrepancy between initial and final measurements. RESULTS: Analysis of variance (Anova) na Tukey test revealed statistical difference between Group 1 and Groups 2 and 3 (p£ 0.05). CONCLUSIONS: all groups presented shorter working length after cervical flaring; groups prepared with instruments La Axxes and Orifice Opener presented the best results among the systems studied.

scholarly journals Clinical and biologic features predict a poor prognosis in acute lymphoid leukemias in infants: a Pediatric Oncology Group Study

Blood ◽  
1986 ◽  
Vol 67 (1) ◽  
pp. 135-140 ◽  
Author(s):  
W Crist ◽  
J Pullen ◽  
J Boyett ◽  
J Falletta ◽  
J van Eys ◽  
...  
Keyword(s):  
Poor Prognosis ◽  
Poor Response ◽  
Response To Treatment ◽  
Remission Induction ◽  
Age Group ◽  
Older Children ◽  
Lymphoid Leukemia ◽  
Bulky Disease ◽  
Group 2 ◽  
Group 1

Abstract Analysis of remission induction rates for 1,117 children 18 months to 10 years of age (group 1) and 90 infants less than 18 months of age (group 2) with acute lymphoid leukemia (ALL) and of duration of continuous complete remission (CCR) for 454 in group 1 and 33 in group 2 revealed that infants fared significantly worse in both measures of outcome (P = .03 and P less than .0001). To examine potential reasons for the poor prognosis of affected infants, clinical and biologic features of their ALL were compared. Infants had higher WBC counts (P less than .001), a higher incidence of massive splenomegaly (P less than .001), massive hepatomegaly (P less than .001), more central nervous system (CNS) disease at diagnosis (P less than .01), and lower platelet counts (P less than .001). Also, their blasts were less often PAS+ (P = .02). The incidence of non(T, B, pre-B), T and pre-B immunophenotypes of ALL did not differ significantly between the two groups. However, in patients with non(T, B, pre-B) ALL, the majority (51%) of infants had common ALL antigen (CALLA)-negative blasts, as compared with only 7% in group 1 (P less than .001). Furthermore, infants with non(T, B, pre-B) cell ALL who were less than 12 months of age were almost always CALLA- (18 of 21). The blasts of children from both groups usually expressed Ia-like antigens. These data illustrate that infants with ALL have extensive and bulky disease more often than do older children and are more often affected with a prognostically unfavorable phenotype of acute leukemia (AL) which expresses Ia-like antigens but is more often PAS- and CALLA-. We believe that these clinical and biological differences predict and explain in part the observed poor response to treatment of infants with ALL.

scholarly journals Comparison of the effectiveness of Trioxident and Сanal Mineral Trioxide agregate for capping perforations in the pulp cavity

2021 ◽  
Vol 25 (1) ◽  
pp. 35-41
Author(s):  
Ekaterina A. Lipetskaya ◽  
Taras V. Furtsev
Keyword(s):  
Therapeutic Potential ◽  
Cold Test ◽  
Modern Trend ◽  
Biological Method ◽  
Pulp Chamber ◽  
Minimal Invasiveness ◽  
Icd 10 ◽  
Group 2 ◽  
Group 1 ◽  
Clinical Cases

BACKGROUND: The modern trend of dentistry is the principle of minimal invasiveness. Preservation of the vitality of the tooth is an actual principle of operation. In the treatment of deep caries or pulpitis by a biological method, the pulp chamber is often opened. Even with bleeding, there is a chance to leave the tooth vital. After hemostasis, antibacterial treatment of the carious cavity and padding were performed. Domestic manufacturers offer two analogues for these purposes "Trioxident" and "Kanal MTA. AIM: The purpose of the study is to compare the effectiveness of domestic materials "Trioxident" and "Kanal MTA" when used as a therapeutic and insulating coating of pulp. MATERIALS AND METHODS: 27 clinical cases were analyzed in patients aged 2335 with a diagnosis of "deep dentine caries" K02.2 (according to ICD-10) of molars and premolars of the upper and lower jaws. All clinical cases combined patients' complaints of intermittent aching pains, the depth of carious cavities and the opened tooth cavity at one point. The patients were divided into two groups, in each of which the following stages of diagnosis and treatment were carried out. Diagnostics was carried out before the start of work and during examination after 7 days, 6, 12, 18 months. The stages of caries treatment were the same, only the materials for closing the perforations differed: in group 1 "Trioxidant", in group 2 "Kanal MTA". RESULTS: It is noted that the use of materials "Trioxident" and "Kanal MTA" is an effective choice for closing perforations of the pulp chamber in the treatment of deep caries and chronic pulpitis. Pain was absent in 30.8% and 42.1% of patients in groups 1 and 2, respectively. After 6, 12, 18 months, patients did not complain about the treated teeth, the cold test was positive for a short time in 26 cases, the average current at electroodontodiagnostic (minimum value 4, maximum value 8) was 5.6 A, 25 restorations had an Alpha rating according to Ryge criteria, in one case in group 1, the tooth crown darkened pointwise from the vestibular surface. CONCLUSION: The materials "Trioxident" and "Kanal MTA" are recommended for use in the biological method of pulpitis treatment. They have therapeutic potential to cover the pulp and are competitive in relation to the foreign equivalent of "MTA Prorut", which gives them an economic advantage in providing dental care within the framework of compulsory medical insurance.

scholarly journals Temperature rise caused in the pulp chamber under simulated intrapulpal microcirculation with different light-curing modes

2015 ◽  
Vol 85 (3) ◽  
pp. 381-385 ◽  
Author(s):  
Sabri Ilhan Ramoglu ◽  
Hilal Karamehmetoglu ◽  
Tugrul Sari ◽  
Serdar Usumez
Keyword(s):  
Temperature Rise ◽  
Critical Value ◽  
Pulp Chamber ◽  
Group 4 ◽  
Blood Microcirculation ◽  
Light Curing ◽  
Group 3 ◽  
Group 2 ◽  
Labial Surface ◽  
Group 1

ABSTRACT Objective:  To evaluate and compare intrapulpal temperature rise with three different light-curing units by using a study model simulating pulpal blood microcirculation. Materials and Methods:  The roots of 10 extracted intact maxillary central incisors were separated approximately 2 mm below the cement-enamel junction. The crowns of these teeth were fixed on an apparatus for the simulation of blood microcirculation in pulp. A J-type thermocouple wire was inserted into the pulp chamber through a drilled access on the palatal surfaces of the teeth. Four measurements were made using each tooth for four different modes: group 1, 1000 mW/cm2 for 15 seconds; group 2, 1200 mW/cm2 for 10 seconds; group 3, 1400 mW/cm2 for 8 seconds; and group 4, 3200 mW/cm2 for 3 seconds. The tip of the light source was positioned at 2 mm to the incisor's labial surface. Results:  The highest temperature rise was recorded in group 1 (2.6°C ± 0.54°C), followed by group 2 (2.57°C ± 0.62°C) and group 3 (2.35°C ± 0.61°C). The lowest temperature rise value was found in group 4 (1.74°C ± 0.52°C); this value represented significantly lower ΔT values when compared to group 1 and group 2 (P  =  .01 and P  =  .013, respectively). Conclusions:  The lowest intrapulpal temperature rise was induced by 3200 mW/cm2 for 3 seconds of irradiation. Despite the significant differences among the groups, the temperature increases recorded for all groups were below the critical value of 5.6°C.

Prognostic Role Of The Microenvironment In Follicular lymphoma

Blood ◽  
2013 ◽  
Vol 122 (21) ◽  
pp. 5052-5052
Author(s):  
Ekaterina S. Nesterova ◽  
Sergey K. Kravchenko ◽  
Eduard G. Gemdjian ◽  
Valeri G. Savchenko ◽  
Alla M. Kovrigina
Keyword(s):  
Lymph Node ◽  
Light Microscopy ◽  
Microvessel Density ◽  
Poor Prognosis ◽  
Tumor Tissue ◽  
Vessel Density ◽  
Random Numbers ◽  
Cytotoxic Lymphocytes ◽  
Group 2 ◽  
Group 1

Abstract Background Follicular lymphoma (FL) is characterized by clinical heterogeneity. There is a need for easily quantifiable prognostic biomarkers. No consensus has been achieved regarding the prognostic significance of the microvessel density, number of macrophages and cytotoxic lymphocytes within the tumor. Objectives To characterize the microvessel density, number of macrophages and cytotoxic lymphocytes within tumor tissue using immunohistochemical (IHC) analysis of sections from paraffin blocks of lymph node biopsies in two groups of patients with different clinical courses of FL. Patients and methods The study included 59 patients with FL: 39 women (67%) and 20 men (33%). The median age was 53 years (range: 27–83 years). Forty nine patients were observed in the National Research Center for Hematology (Moscow), and 10 patients in Cancer Research Center (Moscow), from April 2001 until May 2011. Group 1, “good outcome”, included 28 patients who were followed for 2 or more years after the therapy, had remission, or developed relapse in five or more years from the start of treatment (late relapse). Group 2, “poor outcome”, included 31 patients who died due to tumor progression in the first 1–2 years from the time of diagnosis, had primary tumor resistance, or developed FL relapse in the first year from the start of treatment (early relapse). Patients in both groups received the same initial treatment with rituximab. Five year OS rate in group 1 was significantly higher than in group 2 (83±7% vs 28±13%; ð=0.03). In all 59 cases the samples for IHC analysis were selected by using a table of random numbers, without knowing to which study group they belonged. Each study parameter (microvessel density, number of cytotoxic lymphocytes and macrophages within a tumor) was evaluated and then assigned to prognostic group 1 or 2. The vascularization of tumor tissue was assessed by IHC on sections from paraffin blocks of tumor lymph node biopsies. CD34 and D2-40 (podoplanin) antibodies were used for the visualization of blood and lymphatic vessels, respectively. CD68 antibody was used to detect activated macrophages. Granzyme B antibody was used to visualize cytotoxic lymphocytes. Morphometric analysis was performed using light microscopy and a Leica digital camera (400x). The pictures were processed by the computer program “VideoTesT-Morphology 5.2” in order to estimate the percentage of vessels in the tumor tissue. IHC specimen evaluation was carried out using a table of random numbers. Number of macrophages and cytotoxic lymphocytes in nodular and nodular-diffuse types of tumor growth was evaluated by light microscopy (400x): the cells were counted in 1 mm2 of tumor tissue, and the number of positive cells was determined in the intrafollicular and interfollicular space. Results Blood vessel density and lymph vessel density in group 2 were significantly higher than in group 1 (p=0.03). The cut-off point for blood and lymphatic vessel density in 1 mm2, which differentiates group 1 from group 2, was 0.04. The number of cytotoxic lymphocytes in intrafollicular space, interfollicular space and diffuse area of tumor nodules in group 1 was significantly higher than in group 2 (ð=0.05). The cut-off point for tumor-associated cytotoxic lymphocytes in 1 mm2, which differentiates group 1 from group 2, was 100 (Figure 1). The number of macrophages within tumors with nodular and diffuse growth in group 2 was significantly higher than in group 1 (ð=0.01) (Figure 2). The cut-off point for macrophages in 1 mm2, which differentiates group 1 from group 2, was 250. Statistical analysis were done using JMP ver. 10.0 (SAS, Cary, NC). Conclusion Our results demonstrate an association between higher angiogenic activity in the tumor and poor prognosis. A low number of cytotoxic lymphocytes and a high number of macrophages within the tumor were also associated with a poor prognosis. We suggest that these results will help to predict clinical response in FL using rituximab. Disclosures: No relevant conflicts of interest to declare.

scholarly journals Acute Myeloid Leukemia with Myelodisplasia-Related Changes (AML-MRC) Defined Only By Morphological Findings May Not Represent a Poor Prognosis AML

Blood ◽  
2019 ◽  
Vol 134 (Supplement_1) ◽  
pp. 2612-2612
Author(s):  
Ana Pérez ◽  
Olga Salamero ◽  
Helena Pomares ◽  
Maria Julia Montoro ◽  
Montserrat Arnan Sangerman ◽  
...  
Keyword(s):  
Overall Survival ◽  
Board Of Directors ◽  
Myeloid Leukemia ◽  
Research Funding ◽  
Poor Prognosis ◽  
Advisory Committees ◽  
Group 3 ◽  
Group 2 ◽  
Acute Myeloid ◽  
Group 1

According to the 2016 WHO classification, AML-MRC encompasses an heterogeneous group of acute myeloid leukemias (AML) comprising: AML emerged from a previous myelodysplastic syndrome (MDS) or myeloproliferative /myelodysplastic disease (group 1), AML with MDS-defining cytogenetic abnormalities (group 2), or acute myeloid leukemia (AML) with dysplasia in at least 2 cell lineages without the above mentioned (group 3). In spite that AML-MRC has been considered a high-risk entity with poor prognosis, little is known on the relationship of clinical and biological characteristics with outcomes in these three groups. The aim of this study was to describe the clinical and biological characteristics of patients with AML-MRC and analyze their prognostic variables and outcomes. We retrospectively analyzed AML-MRC cases diagnosed between January-2009 and December- 2018 in two institutions. Descriptive variables were studied to compare the three AML-MRC groups. AML cytogenetic risk and response were defined according to the European Leukemia Net recommendations. Overall survival (OS) was considered as the time from the diagnosis to the last visit. Survival analysis were performed with Kaplan Meier method and comparisons with the log-rank test. Among 575 cases of AML identified, 186 (32.3%) met AML-MRC criteria and were included in the study. The main patient characteristics are shown in Table1. Median age was 72 (range, 22-88) years and 32% were female. Adverse karyotype was present in 29% of patients, being more prevalent in the AML-MRC group 2. Sixty one patients (33%) received an intensive chemotherapy approach and 36 (19%) an allogeneic stem cell transplantation. Patients in group 3 exhibit a higher probability of achieving a complete response than groups 1 and 2 (Table 2). After a median follow-up for survivors of 28.5 months (range, 5-130), 149 (80%) died in this period. Three years Overall Survival (OS) for patients in groups 1, 2 and 3 was 3 (0-117), 5 (0-93) and 10 (0-130) months, respectively (p=0.012) (Figure 1). Type of treatment (intensive, non intensive or best supportive care) and cytogenetic risk also showed impact on OS. Multivariant analysis adjusting these factors showed that patients in group 3 also presented better OS than patients in group 1 (HR=0,42 [IC95% 0,18-0,84], p=0,02), both with around a 30% of patients with adverse cytogenetics. To conclude the present study suggests that group 3 of AML-MRC, for which the diagnosis is based solely on morphologic findings, showed better prognosis than the other groups. A more detailed molecular characterization might contribute to improve prognostic stratification of this heterogeneous AML entity, particularly in patients with non-high risk cytogenetics. Disclosures Salamero: Pfizer: Honoraria; Daichii Sankyo: Honoraria; Celgene: Honoraria; Novartis: Honoraria. Valcárcel:Jazz Pharmaceuticals: Honoraria; Novartis: Consultancy, Honoraria, Speakers Bureau; Amgen: Consultancy, Honoraria; Celgene: Consultancy, Honoraria, Other: spouse is an employee in the company, Speakers Bureau; Pfizer: Honoraria. Bosch:AstraZeneca: Honoraria, Research Funding; Acerta: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding, Speakers Bureau; AbbVie: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding, Speakers Bureau; Janssen: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding, Speakers Bureau; Celgene: Honoraria, Research Funding; F. Hoffmann-La Roche Ltd/Genentech, Inc.: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding, Speakers Bureau; Takeda: Honoraria, Research Funding; Kyte: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding, Speakers Bureau; Novartis: Consultancy, Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding, Speakers Bureau.

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