scholarly journals Integrated Multifunctional Laryngoscope for Medical Diagnosis and Treatment

2020 ◽  
Vol 10 (21) ◽  
pp. 7491
Author(s):  
Shanshan Liang ◽  
Xinyu Li ◽  
Jiajing Kang ◽  
Jiebin Zou ◽  
Faya Liang ◽  
...  
Keyword(s):  
Laser Ablation ◽  
Early Diagnosis ◽  
White Light ◽  
Ex Vivo ◽  
Imaging Evaluation ◽  
Cross Sectional ◽  
White Light Endoscopy ◽  
Common Path ◽  
Path Design ◽  
Laryngeal Tumors

Laryngeal lesions can cause great inconvenience to patients. Early diagnosis and corresponding treatments are critical to the survival of patients. However, the diagnosis and precise removal of tumors remain a challenge under the use of a white light laryngoscope. In this work, an integrated, multifunctional laryngoscope was designed and tested for the imaging evaluation and precision laser surgery for laryngeal tissue. This integrated diagnostic and therapeutic endoscopic system included two imaging modes (i.e., optical coherence tomography and white light endoscopy) and a laser ablation treatment mode. The endoscope had a common-path design to ensure that the same position could be imaged and treated simultaneously. The ex vivo porcine larynx experimental results showed that the system imaging modes could simultaneously acquire both superficial and cross-sectional images of the sample tissue, and the ablation treatment could be performed under imaging guidance. This multifunctional laryngoscope has great potential for the early diagnosis of and accurate laser ablation surgery for laryngeal tumors.

scholarly journals Research Progress of Autofluorescence Imaging Technology in the Diagnosis of Early Gastrointestinal Tumors

2021 ◽  
Vol 28 ◽  
pp. 107327482110443
Author(s):  
Yiliang Bi ◽  
Min Min ◽  
Yinshu Cui ◽  
Yuanyuan Xu ◽  
Xiaosong Li
Keyword(s):  
Early Diagnosis ◽  
Clinical Application ◽  
White Light ◽  
Early Treatment ◽  
Gastrointestinal Tumors ◽  
New Technique ◽  
Research Progress ◽  
Autofluorescence Imaging ◽  
White Light Endoscopy ◽  
A New Technique

Early diagnosis and early treatment of gastrointestinal tumors are helpful to improve the prognosis of patients. Endoscopy is the best method for the diagnosis of early gastrointestinal tumors, but some early flat tumors may be missed under conventional white-light endoscopy. In order to improve the accuracy of endoscopic diagnosis of gastrointestinal tumors, especially early flat tumors, endoscopic autofluorescence imaging (AFI) as a new technique has been widely used in clinics in recent years. This article reviews the progress of the clinical application of AFI in the diagnosis of various gastrointestinal tumors.

GASTROINTESTINAL ABNORMALITIES IDENTIFIED BY FLUORESCENCE ENDOMICROSCOPY

2012 ◽  
Vol 05 (04) ◽  
pp. 1250026 ◽  
Author(s):  
HONGCHUN BAO ◽  
ALEX BOUSSIOUTAS ◽  
MCGEAREY ALEIXANDRIA ◽  
RITA BUSUTTIL ◽  
MIN GU
Keyword(s):  
Early Diagnosis ◽  
Real Time ◽  
White Light ◽  
Intraperitoneal Injection ◽  
Microscopic Imaging ◽  
White Light Endoscopy ◽  
Structural Differences ◽  
The Difference ◽  
Gastrointestinal Abnormalities

Real-time in vivo microscopic imaging has become a reality with the advent of confocal and nonlinear endomicroscopy. These devices are best utilized in conjunction with standard white light endoscopy. We evaluated the use of fluorescence endomicroscopy in detecting microscopic abnormalities in colonic tissues. Mice of C57bl/6 strain had intraperitoneal injection with azoxymethane once every week for five weeks and littermates, not exposed to azoxymethane served as controls. After 14 weeks, intestines were imaged by fluorescence endomicroscopy. The images show obvious cellular structural differences between those two groups of mice. The difference in endomicroscopy imaging can be used for identifying tissues suspicious for neoplasia or other changes, leading to early diagnosis of gastrointestinal track of cancer.

The Efficacy of Virtual Chromoendoscopy in the Diagnosis of Portal Hypertensive Gastropathy

2016 ◽  
Vol 25 (3) ◽  
pp. 289-293
Author(s):  
Anda Carmen Achim ◽  
Stefan Cristian Vesa ◽  
Eugen Dumitru
Keyword(s):  
Diagnostic Criteria ◽  
White Light ◽  
Narrow Band Imaging ◽  
Endoscopic Examination ◽  
Kappa Statistics ◽  
Portal Hypertensive Gastropathy ◽  
Mosaic Pattern ◽  
White Light Endoscopy ◽  
A New Technique ◽  
Virtual Chromoendoscopy

Background: Diagnosis of portal hypertensive gastropathy (PHG) is based on endoscopic criteria. I-scan technology, a new technique of virtual chromoendoscopy, increases the diagnostic accuracy for lesions in the gastrointestinal tract. Aim: To establish the role of i-scan endoscopy in the diagnosis of PHG. Method: In this prospective study, endoscopic examination was conducted first by using white light and after that i-scan 1 and i-scan 2 technology in a group of 50 consecutive cirrhotic patients. The endoscopic diagnostic criteria for PHG followed the Baveno criteria. The interobserver agreement between white light endoscopy and i-scan endoscopy was determined using Cohen’s kappa statistics. Results: Forty-five of the 50 patients met the diagnostic criteria for PHG when examined by i-scan endoscopy and 39 patients were diagnosed with PHG by white light endoscopy. The strength of agreement between the two methods for the diagnosis of PHG was moderate (k=0.565; 95%CI 0.271-0.859; p<0.001). I-scan 1 classified the mosaic pattern better than classic endoscopy; i-scan 2 described better the red spots. Conclusion: I-scan examination increased the diagnostic sensitivity of PHG. The diagnostic criteria (mosaic pattern and red spots) were easier to observe endoscopically using i-scan than in white light.Abbreviations: FICE: Fuji Intelligent chromoendoscopy; GAVE: gastric antral vascular ectasia; NBI: narrow band imaging; PHG: portal hypertensive gastropathy; PHT: portal hypertension; UGIB: upper gastrointestinal bleeding.

UPDATE ON THE DIAGNOSIS AND MANAGEMENT OF EARLY GASTRIC CANCER

2015 ◽  
pp. 5-14
Author(s):  
Van Huy Tran ◽  
Quang Trung Tran
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Early Diagnosis ◽  
Cancer Diagnosis ◽  
Good Prognosis ◽  
Accurate Diagnosis ◽  
White Light Endoscopy ◽  
Key Factor ◽  
Magnified Endoscopy ◽  
Endoscopic Characteristics

The prognosis of gastric cancer depends principally upon an early diagnosis. An early and accurate diagnosis of gastric cancer needs some basic knowledges about the endoscopic characteristics of white light endoscopy, chromoendoscopy, magnified endoscopy, FICE and NBI…A strategy of screening is also a key factor for early diagnosis. The treatment of early gastric cancer by endoscopy techniques have showed more and more advantages. Beside of EMR, the technique of ESD is now applied more widely and lead to a very good prognosis and nearly a curative treatment for the patients with early gastric cancer. Key words: gastric cancer, early gastric cancer, diagnosis, endoscopy

The Influence of Force Direction on the Fracture Pattern and Fracture Resistance of Canine Teeth in Dogs

2017 ◽  
Vol 34 (1) ◽  
pp. 8-17 ◽  
Author(s):  
Stephanie Goldschmidt ◽  
Catherine Zimmerman ◽  
Caitlyn Collins ◽  
Scott Hetzel ◽  
Heidi-Lynn Ploeg ◽  
...  
Keyword(s):  
Fracture Resistance ◽  
Ex Vivo ◽  
Testing Machine ◽  
Fracture Pattern ◽  
Hard Tissue ◽  
Canine Tooth ◽  
Cross Sectional ◽  
Significant Difference ◽  
Force Direction ◽  
Testing Group

Biomechanical studies of the elongated canine tooth of animals are few, and thus our understanding of mechanical and physical properties of animal teeth is limited. The objective of the present study was to evaluate the influence of force direction on fracture resistance and fracture pattern of canine teeth in an ex vivo dog cadaver model. Forty-five extracted canine teeth from laboratory beagle dogs were standardized by hard tissue volume and randomly distributed among 3 force direction groups. The teeth were secured within a universal testing machine and a load was applied at different directions based on testing group. The maximum force to fracture and the fracture pattern classification were recorded for each tooth. After correcting for hard tissue cross-sectional area in a multivariate analysis, no significant difference in the amount of force required for fracture was apparent between the different force direction groups. However, the influence of force direction on fracture pattern was significant. The results of this study may allow the clinician to educate clients on possible causal force directions in clinically fractured teeth and, thus, help prevent any contributing behavior in the future.

scholarly journals The Impact of Narrow-band Imaging on the Pre- and Intra- operative Assessments of Neoplastic and Preneoplastic Laryngeal Lesions. A Systematic Review

2020 ◽  
Author(s):  
Carmelo Saraniti ◽  
Enzo Chianetta ◽  
Giuseppe Greco ◽  
Norhafiza Mat Lazim ◽  
Barbara Verro
Keyword(s):  
White Light ◽  
Diagnostic Tool ◽  
Narrow Band ◽  
Narrow Band Imaging ◽  
Resection Margins ◽  
Predictive Values ◽  
White Light Endoscopy ◽  
Laryngeal Lesions ◽  
Sensitivity Specificity ◽  
The Impact

Introduction Narrow-band imaging is an endoscopic diagnostic tool that, focusing on superficial vascular changes, is useful to detect suspicious laryngeal lesions, enabling their complete excision with safe and tailored resection margins. Objectives To analyze the applications and benefits of narrow-band imaging in detecting premalignant and malignant laryngeal lesions through a comparison with white-light endoscopy. Data Synthesis A literature search was performed in the PubMed, Scopus and Web of Science databases using strict keywords. Then, two authors independently analyzed the articles, read the titles and abstracts, and read completely only the relevant studies according to certain eligibility criteria. In total, 14 articles have been included in the present review; the sensitivity, specificity, positive and negative predictive values, and accuracy of pre- and/or intraoperative narrow-band imaging were analyzed. The analysis showed that narrow-band imaging is better than white-light endoscopy in terms of sensitivity, specificity, positive and negative predictive values, and accuracy regarding the ability to identify cancer and/or precancerous laryngeal lesions. Moreover, the intraoperative performance of narrow-band imaging resulted more effective than the in-office performance. Conclusion Narrow-band imaging is an effective diagnostic tool to detect premalignant and malignant laryngeal lesions and to define proper resection margins. Moreover, narrow-band imaging is useful in cases of leukoplakia that may cover a possible malignant lesion and that cannot be easily assessed with white-light endoscopy. Finally, a shared, simple and practical classification of laryngeal lesions, such as that of the European Laryngological Society, is required to identify a shared lesion management strategy. Key Points

Sa1727 - Chromoendoscopy Versus High Definition White Light Endoscopy for Dysplasia Detection in Patients with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis

2018 ◽  
Vol 154 (6) ◽  
pp. S-371
Author(s):  
Ramprasad Jegadeesan ◽  
Madhav Desai ◽  
Tharani Sundararajan ◽  
Venkata Subhash Gorrepati ◽  
Viveksandeep Thogulva Chandrasekar ◽  
...  
Keyword(s):  
Systematic Review ◽  
Inflammatory Bowel Disease ◽  
White Light ◽  
Bowel Disease ◽  
Meta Analysis ◽  
High Definition ◽  
White Light Endoscopy ◽  
Inflammatory Bowel

Ex Vivo assessment of competent strut coverage after coronary stenting by optical coherence tomography

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
R Bhoite ◽  
H Jinnouchi ◽  
F Otsuka ◽  
Y Sato ◽  
A Sakamoto ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Predictive Value ◽  
Ex Vivo ◽  
High Sensitivity ◽  
Optical Coherence ◽  
Cross Sectional ◽  
Neointimal Thickness ◽  
Stent Strut ◽  
Oct Imaging ◽  
Definition Of

Abstract Background In many studies, struts coverage is defined as &gt;0 mm of tissue overlying the stent struts by optical coherence tomography (OCT). However, this definition has never been validated using histology as the “gold standard”. The present study sought to assess the appropriate cut-off value of neointimal thickness of stent strut coverage by OCT using histology. Methods OCT imaging was performed on 39 human coronary arteries with stents from 25 patients at autopsy. A total of 165 cross-sectional images from 46 stents were co-registered with histology. The optimal cut-off value of strut coverage by OCT was determined. Strut coverage by histology was defined as endothelial cells with at least underlying two layers of smooth muscle cells. Considering the resolution of OCT is 10–20 μm, 3 different cut-off values (i.e. at ≥20, ≥40, and ≥60 μm) were assessed. Results A total of 2235 struts were evaluated by histology. Eventually, 1216 struts which were well-matched struts were analyzed in this study. By histology, uncovered struts were observed in 160 struts and covered struts were observed in 1056 struts. The broadly used definition of OCT-coverage which does not consider neointimal thickness yielded a poor specificity of 37.5% and high sensitivity 100%. Of 3 cut-off values, the cut-off value of &gt;40 μm was more accurate as compared to &gt;20 and &gt;60 mm [sensitivity (99.3%), specificity (91.0%), positive predictive value (98.6%), and negative predictive value (95.6%)] Conclusion The most accurate cut-off value was ≥40 μm neointimal thickness by OCT in order to identify stent strut coverage validated by histology. Funding Acknowledgement Type of funding source: None

scholarly journals Endoscopic Ex Vivo Evaluation of Bile Concentrations by Narrow Band Imaging: A Pilot Study

2015 ◽  
Vol 2015 ◽  
pp. 1-3
Author(s):  
Roberta Maselli ◽  
Haruhiro Inoue ◽  
Haruo Ikeda ◽  
Manabu Onimaru ◽  
Akira Yoshida ◽  
...  
Keyword(s):  
Pilot Study ◽  
White Light ◽  
Potential Role ◽  
Narrow Band ◽  
Ex Vivo ◽  
Narrow Band Imaging ◽  
Initial Study ◽  
Bile Concentration ◽  
Duodenogastroesophageal Reflux

Background. Bile juice plays a major role in duodenogastroesophageal reflux (DGERD). Several devices to directly measure the bile concentration have been proposed. We aimed to ex-vivo evaluate the bile concentration by narrow band imaging (NBI).Method. From six surgical cholecystectomies, the content of the gallbladders was aspirated and the total biliary acid (TBA) concentration was evaluated. 2 mL was employed for serial twofold dilutions. Each dilution was scoped. Images on white light (WL) and NBI were captured and grouped accordingly to NBI-appearance and TBA-concentration.Results. Nondiluted bile had a TBA-concentration of 61965 ± 32989 μmol/L. Final dilution (1 : 4096) had 1.16 μmol/L. NBI and correspondent WL images were grouped into seven groups, and an NBI/Bile scale was created.Conclusion. The scale showed that not only NBI scale but also white light scale could be useful to predict the bile concentration. This initial study shows that NBI has a potential role in the detection of DGERD and further investigation is warranted to distinguish the presence and the concentration of bile, especially at very low TBA concentrations.

Creating a cumulative equivalent thermal isoeffect dosimetry model in several ex vivo tissue models mimicking focal laser ablation treatment of the prostate

2021 ◽  
Vol 79 ◽  
pp. S604
Author(s):  
L.A.M.J.G. Van Riel ◽  
R.A.A. Van Kollenburg ◽  
T.M. De Reijke ◽  
C.D. Savci - Heijink ◽  
R. Zweije ◽  
...  
Keyword(s):  
Laser Ablation ◽  
Ex Vivo ◽  
Ex Vivo Tissue ◽  
Tissue Models
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