scholarly journals Comparison of Multivariate Analysis Methods as Applied to English Speech

2020 ◽  
Vol 10 (20) ◽  
pp. 7076
Author(s):  
Yixin Zhang ◽  
Yoshitaka Nakajima ◽  
Kazuo Ueda ◽  
Takuya Kishida ◽  
Gerard B. Remijn
Keyword(s):  
Factor Analysis ◽  
Multivariate Analyses ◽  
Three Dimensional ◽  
Speech Acoustics ◽  
Spectral Changes ◽  
Acoustic Correlates ◽  
New Finding ◽  
Three Dimensional Configuration ◽  
First Time ◽  
Spectral Factor

A newly developed factor analysis, origin-shifted factor analysis, was compared with a normal factor analysis to analyze the spectral changes of English speech. Our first aim was to investigate whether these analyses would cause differences in the factor loadings and the extracted spectral-factor scores. The methods mainly differed in whether to use cepstral liftering and an origin shift. The results showed that three spectral factors were obtained in four main frequency bands, but neither the cepstral liftering nor the origin shift distorted the essential characteristics of the factors. This confirms that the origin-shifted factor analysis is more recommendable for future speech analyses, since it would reduce the generation of noise in resynthesized speech. Our second aim was to further identify acoustic correlates of English phonemes. Our data show for the first time that the distribution of obstruents in English speech constitutes an L-shape related to two spectral factors on the three-dimensional configuration. One factor had center loadings around 4100 Hz, while the other was bimodal with peaks around 300 Hz and 2300 Hz. This new finding validates the use of multivariate analyses to connect English phonology and speech acoustics.

scholarly journals Cobalt-based magnetic Weyl semimetals with high-thermodynamic stabilities

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Wei Luo ◽  
Yuma Nakamura ◽  
Jinseon Park ◽  
Mina Yoon
Keyword(s):  
Tight Binding ◽  
Three Dimensional ◽  
Interlayer Coupling ◽  
First Principles Calculation ◽  
Optimization Approach ◽  
Binding Model ◽  
Nodal Lines ◽  
Weyl Semimetal ◽  
Topological Quantum ◽  
First Time

AbstractRecent experiments identified Co3Sn2S2 as the first magnetic Weyl semimetal (MWSM). Using first-principles calculation with a global optimization approach, we explore the structural stabilities and topological electronic properties of cobalt (Co)-based shandite and alloys, Co3MM’X2 (M/M’ = Ge, Sn, Pb, X = S, Se, Te), and identify stable structures with different Weyl phases. Using a tight-binding model, for the first time, we reveal that the physical origin of the nodal lines of a Co-based shandite structure is the interlayer coupling between Co atoms in different Kagome layers, while the number of Weyl points and their types are mainly governed by the interaction between Co and the metal atoms, Sn, Ge, and Pb. The Co3SnPbS2 alloy exhibits two distinguished topological phases, depending on the relative positions of the Sn and Pb atoms: a three-dimensional quantum anomalous Hall metal, and a MWSM phase with anomalous Hall conductivity (~1290 Ω−1 cm−1) that is larger than that of Co2Sn2S2. Our work reveals the physical mechanism of the origination of Weyl fermions in Co-based shandite structures and proposes topological quantum states with high thermal stability.

scholarly journals Shell-crossing in a ΛCDM Universe

2020 ◽  
Vol 501 (1) ◽  
pp. L71-L75
Author(s):  
Cornelius Rampf ◽  
Oliver Hahn
Keyword(s):  
Dark Matter ◽  
Perturbation Theory ◽  
Large Scale ◽  
Cold Dark Matter ◽  
Three Dimensional ◽  
Random Initial Data ◽  
Recursion Relations ◽  
Indispensable Tool ◽  
First Time ◽  
Very High

ABSTRACT Perturbation theory is an indispensable tool for studying the cosmic large-scale structure, and establishing its limits is therefore of utmost importance. One crucial limitation of perturbation theory is shell-crossing, which is the instance when cold-dark-matter trajectories intersect for the first time. We investigate Lagrangian perturbation theory (LPT) at very high orders in the vicinity of the first shell-crossing for random initial data in a realistic three-dimensional Universe. For this, we have numerically implemented the all-order recursion relations for the matter trajectories, from which the convergence of the LPT series at shell-crossing is established. Convergence studies performed at large orders reveal the nature of the convergence-limiting singularities. These singularities are not the well-known density singularities at shell-crossing but occur at later times when LPT already ceased to provide physically meaningful results.

scholarly journals Imaging the Human Thyroid Using Three-Dimensional Diffuse Optical Tomography: A Preliminary Study

2021 ◽  
Vol 11 (4) ◽  
pp. 1670
Author(s):  
Tetsuya Mimura ◽  
Shinpei Okawa ◽  
Hiroshi Kawaguchi ◽  
Yukari Tanikawa ◽  
Yoko Hoshi
Keyword(s):  
Optical Tomography ◽  
Tumor Hypoxia ◽  
Three Dimensional ◽  
Diffuse Optical Tomography ◽  
Element Model ◽  
Needle Aspiration ◽  
Human Thyroid ◽  
Tissue Oxygen Saturation ◽  
Preliminary Study ◽  
First Time

Thyroid cancer is usually diagnosed by ultrasound imaging and fine-needle aspiration biopsy. However, diagnosis of follicular thyroid carcinomas (FTC) is difficult because FTC lacks nuclear atypia and a consensus on histological interpretation. Diffuse optical tomography (DOT) offers the potential to diagnose FTC because it can measure tumor hypoxia, while image reconstruction of the thyroid is still challenging mainly due to the complex anatomical features of the neck. In this study, we attempted to solve this issue by creating a finite element model of the human neck excluding the trachea (a void region). By reconstruction of the absorption coefficients at three wavelengths, 3D tissue oxygen saturation maps of the human thyroid are obtained for the first time by DOT.

scholarly journals The on-axis magnetic well and Mercier's criterion for arbitrary stellarator geometries

2021 ◽  
Vol 87 (2) ◽  
Author(s):  
P. Kim ◽  
R. Jorge ◽  
W. Dorland
Keyword(s):  
Magnetic Field ◽  
Original Work ◽  
Three Dimensional ◽  
Radial Distance ◽  
Analytical Form ◽  
One Dimensional ◽  
Modern Notation ◽  
Magnetic Well ◽  
First Time ◽  
Dimensional Integral

A simplified analytical form of the on-axis magnetic well and Mercier's criterion for interchange instabilities for arbitrary three-dimensional magnetic field geometries is derived. For this purpose, a near-axis expansion based on a direct coordinate approach is used by expressing the toroidal magnetic flux in terms of powers of the radial distance to the magnetic axis. For the first time, the magnetic well and Mercier's criterion are then written as a one-dimensional integral with respect to the axis arclength. When compared with the original work of Mercier, the derivation here is presented using modern notation and in a more streamlined manner that highlights essential steps. Finally, these expressions are verified numerically using several quasisymmetric and non-quasisymmetric stellarator configurations including Wendelstein 7-X.

scholarly journals Towards an Improved Model of the Galaxy

1998 ◽  
Vol 11 (1) ◽  
pp. 570-570
Author(s):  
Johan Holmberg ◽  
Lennart Lindegren ◽  
Chris Flynn
Keyword(s):  
Three Dimensional ◽  
Direct Determination ◽  
Galactic Structure ◽  
Open Clusters ◽  
Selection Effects ◽  
Observational Errors ◽  
Red Giant ◽  
Improved Model ◽  
First Time ◽  
Hr Diagram

We use the Hipparcos survey to derive an improved model of the local galactic structure. The availability of parallaxes for all the stars permits direct determination of stellar distributions, eliminating the basic indeterminacy of classical methods based on star counts. Hipparcos gives for the first time a truly three-dimensional view of the solar vicinity, and a complete, homogeneous and highly accurate set of magnitudes and colours. This means that new techniques can be applied in the treatment of the data which place strong constraints on a model that tries to describe the local Galactic structure. Here we investigate how well a static model of low complexitycan describe the Hipparcos observations. The interpretation of the Hipparcos data is complicated by various observational errors and selection effects that are hard to treat correctly. We do not try to correct the data, but instead use a model and subject this model to the same observational errors and selection effects. A model catalogue is created that can be compared with the observed catalogue directly in the observational domain, thereby eliminating the effects from various biases. Many features in the HR diagram are for the first time seen in field stars thanks to Hipparcos, such as the slanted red giant clump, previously seen in rich old open clusters such as Berkeley 18. This and other features ofthe observed HR diagram are well reproduced by the model thanks to the rather detailed modelling of the joint Mv/B — V distribution. Actually, separate distributions were derived for the three different components, disk, thick disk and halo, using the kinematic characteristics of the components to discriminate between them.

scholarly journals Ethusa sp. (Decapoda, Brachyura, Ethusidae) from the Pliocene of Valduggia (Vercelli, Piedmont, NW Italy)

2016 ◽  
Vol 3 (1) ◽  
pp. 53
Author(s):  
Giovanni Pasini ◽  
Alessandro Garassino
Keyword(s):  
Mediterranean Basin ◽  
New Finding ◽  
Nw Italy ◽  
First Time ◽  
Stratigraphic Range

<em>Ethusa</em> sp. (Decapoda, Brachyura, Ethusidae) from Valduggia (Vercelli, Piedmont, NW Italy) is here reported for the first time from the Pliocene of Italy. This new finding enlarges our knowledge on the distribution and stratigraphic range of this genus in the paleo- Mediterranean basin.

A New Category of Three-Dimensional Chaotic Flows with Identical Eigenvalues

2020 ◽  
Vol 30 (02) ◽  
pp. 2050026 ◽  
Author(s):  
Zahra Faghani ◽  
Fahimeh Nazarimehr ◽  
Sajad Jafari ◽  
Julien C. Sprott
Keyword(s):  
Chaotic Systems ◽  
Autonomous Systems ◽  
Three Dimensional ◽  
Special Property ◽  
Computer Search ◽  
Chaotic Flows ◽  
Stable Equilibria ◽  
Dynamical Properties ◽  
Simple Systems ◽  
First Time

In this paper, some new three-dimensional chaotic systems are proposed. The special property of these autonomous systems is their identical eigenvalues. The systems are designed based on the general form of quadratic jerk systems with 10 terms, and some systems with stable equilibria. Using a systematic computer search, 12 simple chaotic systems with identical eigenvalues were found. We believe that systems with identical eigenvalues are described here for the first time. These simple systems are listed in this paper, and their dynamical properties are investigated.

scholarly journals Improvement on Permeability of Cyclic Peptide/Peptidomimetic: Backbone N-Methylation as A Useful Tool

Marine Drugs ◽  
2021 ◽  
Vol 19 (6) ◽  
pp. 311
Author(s):  
Yang Li ◽  
Wang Li ◽  
Zhengshuang Xu
Keyword(s):  
Cyclic Peptides ◽  
Cyclic Peptide ◽  
Three Dimensional ◽  
Conformational Space ◽  
Cell Permeability ◽  
Relative Importance ◽  
Intrinsic Properties ◽  
Surface Areas ◽  
Synthetic Methodologies ◽  
Three Dimensional Configuration

Peptides have a three-dimensional configuration that can adopt particular conformations for binding to proteins, which are well suited to interact with larger contact surface areas on target proteins. However, low cell permeability is a major challenge in the development of peptide-related drugs. In recent years, backbone N-methylation has been a useful tool for manipulating the permeability of cyclic peptides/peptidomimetics. Backbone N-methylation permits the adjustment of molecule’s conformational space. Several pathways are involved in the drug absorption pathway; the relative importance of each N-methylation to total permeation is likely to differ with intrinsic properties of cyclic peptide/peptidomimetic. Recent studies on the permeability of cyclic peptides/peptidomimetics using the backbone N-methylation strategy and synthetic methodologies will be presented in this review.

scholarly journals Structure of the Lectin Mannose 6-Phosphate Receptor Homology (MRH) Domain of Glucosidase II, an Enzyme That Regulates Glycoprotein Folding Quality Control in the Endoplasmic Reticulum

2013 ◽  
Vol 288 (23) ◽  
pp. 16460-16475 ◽  
Author(s):  
Linda J. Olson ◽  
Ramiro Orsi ◽  
Solana G. Alculumbre ◽  
Francis C. Peterson ◽  
Ivan D. Stigliano ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Three Dimensional ◽  
Binding Pocket ◽  
Dimensional Structure ◽  
Mannose Residue ◽  
Glucosidase Ii ◽  
Mannose 6 Phosphate ◽  
First Time ◽  
Conserved Residue

Here we report for the first time the three-dimensional structure of a mannose 6-phosphate receptor homology (MRH) domain present in a protein with enzymatic activity, glucosidase II (GII). GII is involved in glycoprotein folding in the endoplasmic reticulum. GII removes the two innermost glucose residues from the Glc3Man9GlcNAc2 transferred to nascent proteins and the glucose added by UDP-Glc:glycoprotein glucosyltransferase. GII is composed of a catalytic GIIα subunit and a regulatory GIIβ subunit. GIIβ participates in the endoplasmic reticulum localization of GIIα and mediates in vivo enhancement of N-glycan trimming by GII through its C-terminal MRH domain. We determined the structure of a functional GIIβ MRH domain by NMR spectroscopy. It adopts a β-barrel fold similar to that of other MRH domains, but its binding pocket is the most shallow known to date as it accommodates a single mannose residue. In addition, we identified a conserved residue outside the binding pocket (Trp-409) present in GIIβ but not in other MRHs that influences GII glucose trimming activity.

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