scholarly journals Rapid Sonochemically-Assisted Synthesis of Highly Stable Gold Nanoparticles as Computed Tomography Contrast Agents

2020 ◽  
Vol 10 (20) ◽  
pp. 7020
Author(s):  
Mohammed Ali Dheyab ◽  
Azlan Abdul Aziz ◽  
Mahmood S. Jameel ◽  
Pegah Moradi Khaniabadi ◽  
Ammar A. Oglat
Keyword(s):  
Computed Tomography ◽  
Gold Nanoparticles ◽  
Contrast Agents ◽  
Spherical Shape ◽  
Metal Nanostructures ◽  
Fast Method ◽  
Sonochemical Method ◽  
X Rays ◽  
Attenuation Rate ◽  
Ct Contrast Agent

One of the most widely used modalities of clinical imaging is computed tomography (CT). Recent reports of new contrast agents toward CT imaging have been numerous. The production of gold nanoparticles (AuNPs) as contrast agents for CT is primarily a topic of intense interest. AuNPs have beneficial features for this application, including excellent X-ray attenuation, flexible sizes and shapes, tailorable surface chemistry, excellent biocompatibility and high levels of contrast generating matter. AuNPs with a size of about 18.5 nm and semi-spherical shape were synthesized using a sonochemical method. The attenuation rate of X-rays as measured in Hounsfield units per unit concentration (HU/mg) was measured. Ultrasound treatment for a duration of five min has been shown to produce highly stable AuNPs in different media (AuNPs in water and phosphate-buffered saline (PBS) was −42.1 mV and −39.5 mV, respectively). The CT value (HU = 395) of the AuNPs increased linearly with an increase in the AuNP dosage. The results confirm the use of ultrasonic treatment for the production of metal nanostructures, particularly highly stable non-toxic AuNPs, with good morphology and high-quality crystal structure using an easy and fast method. Synthesized AuNPs have the potential to be used as a CT contrast agent in medical imaging applications.

scholarly journals Tunable, biodegradable gold nanoparticles as contrast agents for computed tomography and photoacoustic imaging

Biomaterials ◽  
2016 ◽  
Vol 102 ◽  
pp. 87-97 ◽  
Author(s):  
Rabee Cheheltani ◽  
Rami M. Ezzibdeh ◽  
Peter Chhour ◽  
Kumidini Pulaparthi ◽  
Johoon Kim ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Gold Nanoparticles ◽  
Contrast Agents ◽  
Photoacoustic Imaging

X-ray computed tomography contrast agents prepared by seeded growth of gold nanoparticles in PEGylated dendrimer

2010 ◽  
Vol 21 (24) ◽  
pp. 245104 ◽  
Author(s):  
Chie Kojima ◽  
Yasuhito Umeda ◽  
Mikako Ogawa ◽  
Atsushi Harada ◽  
Yasuhiro Magata ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Gold Nanoparticles ◽  
Contrast Agents ◽  
Seeded Growth ◽  
X Ray ◽  
X Ray Computed

Gold Nanoparticle-Optimized Computed Tomography Imaging Combined with Transcranial Magnetic Stimulation on Rehabilitation Training of Children with Cerebral Palsy

2021 ◽  
Vol 13 (9) ◽  
pp. 1674-1684
Author(s):  
Yangfan Zhang ◽  
Yuanyuan Luo ◽  
Xinglei Wu ◽  
Liuqiong Yang ◽  
Dandan Cui ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Gold Nanoparticles ◽  
Transcranial Magnetic Stimulation ◽  
Contrast Agents ◽  
Magnetic Stimulation ◽  
Ct Imaging ◽  
Nude Mouse Model ◽  
Children With Cerebral Palsy ◽  
Movement Function ◽  
Ct Contrast

Traditional computed tomography (CT) contrast agents, such as iodine-containing small molecules (omnipaque), have limitations in some applications. The development of nanotechnology has made it possible to develop CT contrast agents based on this technology. In this study, a large number of surface functional groups of the fifth-generation polyamide-amine dendrimer (P5-NH2) were applied to functionally modify polyethylene glycol (PEG), targeting molecules, or drugs, which were used as the carrier of CT contrast agents. With the help of sodium borohydride (NaBH4), there was a rapid reduction. The fluorescein thiocyanate (FT) and PEG modified with lactobionic acid (PEG-LA) weres connected before gold coating to obtain gold nanoparticles coated with targeted dendrimer (Au(P5-LA)DENPs). In the experiment, the gold nanoparticles were characterized, and the liver cancer nude mouse model was established, so as to analyze the CT imaging performance of the material. Besides, the above was applied in the motor function of children with cerebral palsy, and the improvement effect of CT imaging combined with transcranial magnetic stimulation based on the preparation of nanomaterials on the movement function of children was analyzed and demonstrated with the help of graph theory. The results showed that the average particle size of gold nanoparticles was 1.88 nm. Within the range of 5 °C–50 °C and pH = 4–7, the physical properties of the aqueous solution of this material were stable. What’s more, the cell activity still exceeded 80% when the material concentration reached 2000 nm. The nude mouse model of liver cancer indicated that the CT imaging based on this material enhanced the image contrast effect of the tumor part, and the material had no obvious toxic and side effects. CT imaging based on the preparation of nanomaterials can promote transcranial magnetic stimulation to accelerate the efficiency of brain movement, accelerate the global and local information exchange and integration speed of brain network, thereby improving the movement function of children.

CMR 2007: 8.03: Gold nanoparticles as contrast agents for MRI and X-ray computed tomography imaging

2007 ◽  
Vol 2 (6) ◽  
pp. 292-293
Author(s):  
S. Roux ◽  
C. Alric ◽  
J. Taleb ◽  
C. Mandon ◽  
C. Billotey ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Gold Nanoparticles ◽  
Contrast Agents ◽  
Computed Tomography Imaging ◽  
X Ray ◽  
Tomography Imaging ◽  
X Ray Computed

scholarly journals Investigation of imaging properties of novel contrast agents based on gold, silver and bismuth nanoparticles in spectral computed tomography using Monte Carlo simulation

2020 ◽  
Vol 26 (1) ◽  
pp. 21-29
Author(s):  
Maryam Sadeghian ◽  
Parisa Akhlaghi ◽  
Asghar Mesbahi
Keyword(s):  
Computed Tomography ◽  
Gold Nanoparticles ◽  
Monte Carlo ◽  
Contrast Agents ◽  
Ct Number ◽  
Bismuth Nanoparticles ◽  
Iodinated Contrast ◽  
Spectral Computed Tomography ◽  
Iodinated Contrast Agent ◽  
Imaging Properties

AbstractIn the present paper, some imaging properties of nanoparticles-based contrast agents including gold, bismuth, and silver were assessed and compared with conventional (iodinated) contrast agent in spectral computed tomography (CT). A spectral CT scanner with photon-counting detectors (PCD) and 6 energy bins was simulated using the Monte Carlo (MC) simulation method. The nanoparticles were designed with a diameter of 50 nm at concentrations of 2, 4, and 8 mg/ml. Water-filled cylindrical phantom was modeled with a diameter of 10 cm containing a hole with a diameter of 5 cm in its center, where was filled with contrast agents. The MC results were used to reconstruct images. Image reconstruction was accomplished with the filtered back-projection (FBP) method with hamming filter and linear interpolation method. CT number and contrast-to-noise ratio (CNR) of all studied contrast materials were calculated in spectral images. The simulations indicated that nanoparticle-based contrast agents have a higher CT number and CNR than the iodinated contrast agent at the same concentration and for all energy bins. In general, gold nanoparticles produced the highest CT number and CNR compared to silver and bismuth nanoparticles at the same concentration. However, at low energies (below 80 keV), silver nanoparticles performed similarly to gold nanoparticles and at high energies (120 keV), bismuth nanoparticles can be a good substitute for gold nanoparticles.

AuNP-DG: Deoxyglucose-Labeled Gold Nanoparticles as X-ray Computed Tomography Contrast Agents for Cancer Imaging

2010 ◽  
Vol 12 (5) ◽  
pp. 463-467 ◽  
Author(s):  
Bulent Aydogan ◽  
Ji Li ◽  
Tijana Rajh ◽  
Ahmed Chaudhary ◽  
Steven J. Chmura ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Gold Nanoparticles ◽  
Contrast Agents ◽  
Cancer Imaging ◽  
X Ray ◽  
X Ray Computed

Gold nanoparticles as contrast agents in x-ray imaging and computed tomography

Nanomedicine ◽  
2015 ◽  
Vol 10 (2) ◽  
pp. 321-341 ◽  
Author(s):  
Lisa E Cole ◽  
Ryan D Ross ◽  
Jennifer MR Tilley ◽  
Tracy Vargo-Gogola ◽  
Ryan K Roeder
Keyword(s):  
Computed Tomography ◽  
Gold Nanoparticles ◽  
Contrast Agents ◽  
X Ray ◽  
X Ray Imaging

scholarly journals Wulff in a cage gold nanoparticles as contrast agents for computed tomography and photoacoustic imaging

Nanoscale ◽  
2018 ◽  
Vol 10 (39) ◽  
pp. 18749-18757 ◽  
Author(s):  
Maryam Hajfathalian ◽  
Ahmad Amirshaghaghi ◽  
Pratap C. Naha ◽  
Peter Chhour ◽  
Jessica C. Hsu ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Gold Nanoparticles ◽  
Contrast Agents ◽  
Photoacoustic Imaging ◽  
Core Shell

A core–shell nanostructure yields balanced contrast production for both CT and photoacoustics.

Gadolinium Chelate Coated Gold Nanoparticles As Contrast Agents for Both X-ray Computed Tomography and Magnetic Resonance Imaging

2008 ◽  
Vol 130 (18) ◽  
pp. 5908-5915 ◽  
Author(s):  
Christophe Alric ◽  
Jacqueline Taleb ◽  
Géraldine Le Duc ◽  
Céline Mandon ◽  
Claire Billotey ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Computed Tomography ◽  
Gold Nanoparticles ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Resonance Imaging ◽  
X Ray ◽  
Gadolinium Chelate ◽  
X Ray Computed
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