scholarly journals Does Platelet-Rich Fibrin Decrease Dimensional Changes and Improve Postoperative Comfort in Post-Extraction Sockets? An Overview of Systematic Reviews

2020 ◽  
Vol 10 (17) ◽  
pp. 5750 ◽  
Author(s):  
Vittorio Moraschini ◽  
Carlos Fernando de Almeida Barros Mourão ◽  
Rafael Coutinho de Mello Machado ◽  
Jhonathan Raphaell Barros Nascimento ◽  
Kayvon Javid ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Bone Regeneration ◽  
Systematic Reviews ◽  
Selection Process ◽  
Soft Tissue Healing ◽  
Socket Preservation ◽  
Platelet Rich Fibrin ◽  
Dimensional Changes ◽  
Tissue Healing ◽  
The Impact

This overview aimed to evaluate the methods, quality, and outcomes of systematic reviews (SRs) conducted to investigate the effects of platelet-rich fibrin (PRF) in dental sockets on promoting bone regeneration and soft tissue healing and diminishing the incidence of pain, swelling, trismus, and alveolar osteitis after tooth extraction. An electronic search without date or language restriction was done in PubMed/MEDLINE, Cochrane, and Web of Science until March 2020. Eligibility criteria included SRs that assessed the effect of PRF for human alveolar socket preservation. The quality assessment of the included studies was performed using AMSTAR 2 guidelines. The protocol of this overview was recorded in PROSPERO under the number CRD42018089617. The search and selection process yielded 13 studies published between 2011 and 2018. The analysis of the studies showed inconclusive data for the effect of the PRF and the dimensional changes. There is no definitive evidence for the impact of using PRF alone on bone regeneration in post-extraction sockets. The use of PRF improves soft tissue healing and reduces pain, bleeding, and osteitis in post-extraction sockets.

COMPARISON OF POST EXTRACTION SOCKET HEALING WITH AND WITHOUT USING PLATELET RICH FIBRIN (PRF) – A CLINICAL AND RADIOGRAPHIC STUDY

2021 ◽  
pp. 62-65
Author(s):  
S.P. Indra Kumar ◽  
Kavin T ◽  
Narendar R ◽  
E. Gayathri Priyadharshini ◽  
Akshaya murugan ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Maxillofacial Surgery ◽  
Test Group ◽  
Control Group ◽  
Oral And Maxillofacial Surgery ◽  
Soft Tissue Healing ◽  
Extraction Socket ◽  
Platelet Rich Fibrin ◽  
Tissue Healing ◽  
Socket Healing

AIM: The aim of this study is to comparatively evaluate the post extraction socket healing clinically and radiographically with and without using Platelet Rich Fibrin (PRF). MATERIALS AND METHODS: Fifty, otherwise healthy individuals undergoing dental treatment in the department of Oral and Maxillofacial surgery, Vivekananda Dental College for women, Thiruchengode, were randomly selected and the participants were divided into two groups – test group(PRF, n=25) and control group (Blood clot, n=25). Blood was freshly obtained from the participants of the test group and PRF was prepared. PRF was placed in the sockets of the test group and followed by the pressure application and suturing. Control group were allowed to heal naturally. Clinically, soft tissue healing and socket closure were assessed. Radiographic analysis of socket healing done by comparison of pre- and post-operative radiographs. The clinical follow-up assessments were done at an interval of 3 days, 1 week and 4 weeks and the data obtained were assessed. The patients were aged above 18 years, i RESULT: ncluding 33 females and 17 males. The soft tissue and socket healing were higher in the test group when compared with the control group clinically and the mean proportion of radiographic bone ll was signicantly higher in the test group in all the time intervals of 3 days, 1 week and 4 weeks, respectively. Outcome of the study CONCLUSION: demonstrate that the PRF placement in the extraction socket accelerates soft tissue healing and socket healing and increases the bone ll and reduces the bone resorption using clinical and radiographic methods.

scholarly journals Microbial adherence affinity and clinical characteristics of polypropylene versus silk sutures in oral surgery

2018 ◽  
Vol 146 (5-6) ◽  
pp. 258-263 ◽  
Author(s):  
Miroslav Dragovic ◽  
Marko Pejovic ◽  
Jelena Stepic ◽  
Svetlana Dragovic ◽  
Nadja Nikolic ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Clinical Features ◽  
Oral Surgery ◽  
Statistical Significance ◽  
Bacterial Adherence ◽  
Silk Suture ◽  
Soft Tissue Healing ◽  
Tissue Healing ◽  
The Impact ◽  
Polypropylene Sutures

Introduction/Objective. The purpose of this study was to compare polypropylene and silk suture materials in terms of bacterial adherence and clinical features including the impact on soft tissue healing. Methods. Ten healthy patients were included in this study. Unilateral upper and lower wisdom teeth were extracted at the same time and wounds were sutured with different threads (one monofilament ? polypropylene ? and one multifilament ? silk suture). Stitches were removed seven days postoperatively. Real-time polymerase chain reaction was used to analyze bacterial adherence. Intraoperative handling and ease of removal were assessed with the help of Visual Analogue Scale. Landry healing index was used for evaluation of soft tissue healing. Results. Significantly more pronounced bacterial adherence was found on silk compared to polypropylene sutures (p = 0.005). Superior intraoperative handling properties were registered suturing with polypropylene compared to silk (p = 0.005). Soft tissue healing was significantly better around polypropylene sutures, both on the third and the seventh postoperative day (p = 0.016). Patient discomfort was slightly higher for polypropylene sutures, but without statistical significance. Conclusion. Polypropylene suture material showed significantly lower bacterial adherence and superior clinical features compared to silk, including better soft tissue healing.

Soft Tissue Healing in Alveolar Socket Preservation Technique: Histologic Evaluations

2014 ◽  
Vol 34 (4) ◽  
pp. 531-539 ◽  
Author(s):  
Gaia Pellegrini ◽  
Giulio Rasperini ◽  
Gregory Obot ◽  
Davide Farronato ◽  
Claudia Dellavia
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Healing ◽  
Socket Preservation ◽  
Tissue Healing ◽  
Preservation Technique

scholarly journals The Effectiveness of Advanced Platelet-Rich Fibrin in comparison with Leukocyte-Platelet-Rich Fibrin on Outcome after Dentoalveolar Surgery

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Alaa Z. Makki ◽  
Anoud M. Alsulami ◽  
Arwa S. Almatrafi ◽  
Moroj Z. Sindi ◽  
Shahinaz N. Sembawa
Keyword(s):  
Soft Tissue ◽  
Tooth Extraction ◽  
Control Group ◽  
Soft Tissue Healing ◽  
Control Groups ◽  
Platelet Rich Fibrin ◽  
Healing Index ◽  
Tissue Healing ◽  
Surgical Extraction ◽  
And Control

Background and Purpose. Some physiological changes may occur following tooth extraction, and symptoms during the postextraction period may affect the patient’s quality of life. Many techniques have been developed to improve postextraction pain and soft tissue healing. Accordingly, this study will compare the postextraction pain and early soft tissue healing characteristics of extraction sites treated with leukocyte-platelet-rich fibrin (L-PRF) and advanced platelet-rich fibrin (A-PRF). The aim is to evaluate the effect of advanced PRF in comparison with L-PRF on soft tissue healing and pain after teeth extraction and to advice dental practitioner to use the advanced PRF in clinic to enhance soft tissue healing and decrease pain. Methods. The study included 60 patients according to sample size calculation, recruited from patients seeking tooth extraction at oral and maxillofacial surgery clinic at Umm Al-Qura University, Faculty of Dentistry. Patients were divided into three groups. Group Ӏ included 20 patients managed by advanced platelet-rich fibrin after extraction. Group ӀӀ included 20 patients managed by leukocyte-platelet-rich fibrin after tooth extraction. Group ӀII included 20 patients left without any addition. Each group was further subdivided into surgical and nonsurgical extraction. Afterwards, patients in each group were assessed for postextraction pain by VAS, number of analgesics, and early soft tissue healing by LWHI. Results. The study outcomes demonstrate that the use of A-PRF significantly reduces postoperative pain in the 1st and 2nd day. VAS pain scores on the first day were significantly higher in the control surgical extraction group and L-PRF nonsurgical extraction group. In early soft tissue healing. The Landry Wound Healing Index (LWHI) was used after 1 and 2 weeks of extraction to evaluate the extraction site. In first week, the A-PRF group and L-PRF group (nonsurgical extraction) had a better healing index when compared to control group, and A-PRF group (surgical extraction) had a best healing index when compared to L-PRF and control groups. In the second week, individuals in the A-PRF group (surgical and nonsurgical extraction) had a better healing index when compared to L-PRF and control groups.

The use of leukocyte- and platelet-rich fibrin in the management of soft tissue healing and pain in post-extraction sockets: A randomized clinical trial

2020 ◽  
Vol 48 (4) ◽  
pp. 452-457 ◽  
Author(s):  
Carlos Fernando de Almeida Barros Mourão ◽  
Rafael Coutinho de Mello-Machado ◽  
Kayvon Javid ◽  
Vittorio Moraschini
Keyword(s):  
Clinical Trial ◽  
Soft Tissue ◽  
Randomized Clinical Trial ◽  
Soft Tissue Healing ◽  
Platelet Rich Fibrin ◽  
Tissue Healing

scholarly journals Effects of Leukocyte-Platelet-Rich Fibrin (L–PRF) on Pain, Soft Tissue Healing, Growth Factors, and Cytokines after Third Molar Extraction: A Randomized, Split-Mouth, Double-Blinded Clinical Trial

2021 ◽  
Vol 11 (4) ◽  
pp. 1666
Author(s):  
Madelaine Torres da Silva ◽  
Carlos Fernando de Almeida Barros Mourão ◽  
Rafael Coutinho Mello-Machado ◽  
Pietro Montemezzi ◽  
Renata de Lima Barbosa ◽  
...  
Keyword(s):  
Growth Factors ◽  
Postoperative Pain ◽  
Soft Tissue ◽  
Third Molar ◽  
Local Concentration ◽  
Third Molars ◽  
Soft Tissue Healing ◽  
Platelet Rich Fibrin ◽  
Tissue Healing ◽  
Double Blinded

This study assessed the effects of leukocyte-platelet-rich fibrin (L–PRF) on soft tissue healing and the correlation with the local concentration of growth factors (GF) and cytokines in the dental socket of lower third molars. Forty lower-third molars (20 participants) were included in this randomized, double-blinded, split-mouth study. After extractions, randomized sides received alveolar filling with L–PRF on one side and a natural blood clot on the other side. The pain was assessed for up to seven days and soft tissue healing (Landry index) for 14 days post-extraction. Swabs were collected from the surgical sites for GF and cytokine assessment by flow luminometry. Participants reported lower postoperative pain on the sides grafted with L–PRF, which also presented increased tissue healing scores (p < 0.05). There were increased levels of all GFs and several cytokines at the L–PRF site at day one, while vascular endothelial growth factor (VEGF), IL–10, and IL1–RA remained higher throughout for seven days (p < 0.05). VEGF concentration at L–PRF sites correlated positively with the participants’ blood platelet content (ρ = 0.769). PDGF correlated negatively with pain experience on days 2 and 3, and positively with soft tissue healing scores, while FGFb presented a weak correlation with a reduction of pain on day 3. The use of L–PRF improves the soft tissue healing process and decreases postoperative pain after the third molar extractions, which correlates with an increase in the local concentration of growth factors such as PDGF and FGFb.

scholarly journals Postoperative Administration of the Acetylcholinesterase Inhibitor, Donepezil, Interferes with Bone Healing and Implant Osseointegration in a Rat Model

Biomolecules ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 1318
Author(s):  
Faez Saleh Al-Hamed ◽  
Ola M. Maria ◽  
Jeff Phan ◽  
Ahmed Al Subaie ◽  
Qiman Gao ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Bone Healing ◽  
Immune Cell ◽  
Acetylcholinesterase Inhibitor ◽  
Titanium Implant ◽  
Soft Tissue Healing ◽  
Tissue Healing ◽  
Custom Made ◽  
The Impact ◽  
Postoperative Administration

Donepezil is an acetylcholinesterase inhibitor commonly used to treat mild to moderate Alzheimer’s disease. Its use has been associated with increased bone mass in humans and animals. However, the effect of postoperative administration of donepezil on bone healing remains unknown. Therefore, this study aimed to assess the impact of postoperative injection of donepezil on bone healing, titanium-implant osseointegration, and soft tissue healing. Twenty-two Sprague-Dawley rats were randomly assigned to receive a daily dose of either donepezil (0.6 mg/kg) or saline as a control. In each rat, a uni-cortical defect was created in the right tibia metaphysis and a custom-made titanium implant was placed in the left tibiae. After two weeks, rats were euthanized, and their bones were analysed by Micro-CT and histology. The healing of bone defect and implant osseointegration in the rats treated with donepezil were significantly reduced compared to the saline-treated rats. Histomorphometric analysis showed lower immune cell infiltration in bone defects treated with donepezil compared to the saline-treated defects. On the other hand, the healing time of soft tissue wounds was significantly shorter in donepezil-treated rats compared to the controls. In conclusion, short-term administration of donepezil hinders bone healing whereas enhancing soft tissue healing.

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