scholarly journals Copenhagen Adduction Exercise to Increase Eccentric Strength: A Systematic Review and Meta-Analysis

2020 ◽  
Vol 10 (8) ◽  
pp. 2863
Author(s):  
Jorge Pérez-Gómez ◽  
Santos Villafaina ◽  
José Carmelo Adsuar ◽  
Jorge Carlos-Vivas ◽  
Miguel Ángel Garcia-Gordillo ◽  
...  
Keyword(s):  
Systematic Review ◽  
Controlled Trial ◽  
Meta Analysis ◽  
Outcome Variable ◽  
Football Players ◽  
Training Methods ◽  
Assessment Development ◽  
Before And After ◽  
Large Heterogeneity ◽  
Meta Analyses

Background: The purpose of this study was to systematically review the scientific literature about the benefits of using the Copenhagen Adductor (CA) exercise to improve eccentric hip adduction strength (EHAD), as well as to provide directions for training. Methods: A systematic search was conducted in three electronic databases following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The inclusion criteria were: (a) EHAD as outcome variable, with means and standard deviations before and after the intervention, (b) the study was a randomized controlled trial using the CA in the program intervention, (c) the article was written in English. The quality of evidence was evaluated according to the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) guidelines. A mini meta-analysis was performed to determine the overall effect. Results: Three studies were selected and included in this systematic review and mini meta-analysis. All articles reported significant enhancement in EHAD in football (soccer) players. The overall effect for the EHAD test was significant in favor to CA group (mean difference = 0.61; 95% CI from 0.20 to 1.01; p = 0.003) with large heterogeneity. Conclusions: CA exercise performed 2–3 times for 8 weeks is useful for improving EHAD in football players.

scholarly journals Effects of Ashwagandha (Withania somnifera) on VO2max: A Systematic Review and Meta-Analysis

Nutrients ◽  
2020 ◽  
Vol 12 (4) ◽  
pp. 1119 ◽  
Author(s):  
Jorge Pérez-Gómez ◽  
Santos Villafaina ◽  
José Carmelo Adsuar ◽  
Eugenio Merellano-Navarro ◽  
Daniel Collado-Mateo
Keyword(s):  
Systematic Review ◽  
Withania Somnifera ◽  
Controlled Trial ◽  
Meta Analysis ◽  
Assessment Development ◽  
Before And After ◽  
The Mean ◽  
Meta Analyses ◽  
Grade Approach

The purpose of this study was to systematically review the scientific literature about the effects of supplementation with Ashwagandha (Withania somnifera) on maximum oxygen consumption (VO2max), as well as to provide directions for clinical practice. A systematic search was conducted in three electronic databases following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Guidelines (PRISMA). The inclusion criteria were: (a) VO2max data, with means ± standard deviation before and after the supplement intervention, (b) the study was randomized controlled trial (RCT), (c) the article was written in English. The quality of evidence was evaluated according to the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach. A meta-analysis was performed to determine effect sizes. Five studies were selected in the systematic review (162 participants) and four were included in the meta-analysis (142 participants). Results showed a significant enhancement in VO2max in healthy adults and athletes (p = 0.04). The mean difference was 3.00 (95% CI from 0.18 to 5.82) with high heterogeneity. In conclusion, Ashwagandha supplementation might improve the VO2max in athlete and non-athlete people. However, further research is need to confirm this hypothesis since the number of studies is limited and the heterogeneity was high.

The therapeutic efficacy of intravenous immunoglobulin in anti-neutrophilic cytoplasmic antibody-associated vasculitis: a meta-analysis

Rheumatology ◽  
2019 ◽  
Vol 59 (5) ◽  
pp. 959-967 ◽  
Author(s):  
Takashi Shimizu ◽  
Takayoshi Morita ◽  
Atsushi Kumanogoh
Keyword(s):  
Systematic Review ◽  
Selection Criteria ◽  
Meta Analysis ◽  
Clinical Parameter ◽  
Ivig Treatment ◽  
Therapeutic Effects ◽  
Random Effects Model ◽  
Anca Associated Vasculitis ◽  
Before And After ◽  
Meta Analyses

Abstract Objectives The therapeutic effects of IVIG in patients with ANCA-associated vasculitis (AAV) have not been established so far. This study aims to estimate the effects of IVIG on AAV by conducting a systematic review and meta-analysis. Methods A comprehensive systematic review was conducted in accordance with the guidelines of PRISMA (Preferred Reporting Items for Systematic Reviews And Meta-analyses). PubMed and Google Scholar were used to search for original studies on AAV and collect clinical data before and after IVIG treatment. A meta-analysis of each clinical parameter was performed, and standardized mean difference (SMD) and 95% CI were calculated using the random effects model. Results A total of 220 studies were identified, and nine met the selection criteria for the meta-analysis. IVIG was administered to active AAV patients as an immunomodulatory therapy in the nine studies selected. Significant reductions in BVAS (SMD –1.7; 95% CI [–2.66, –0.73]; P = 0.0006), ANCA (SMD –0.72; 95% CI [–1.13, –0.31]; P = 0.0006) and CRP (SMD –0.92; 95% CI [–1.49, –0.35]; P = 0.002) were noted within 6 months after administration of IVIG. Subgroup analysis in the unmodified immunotherapy population showed reductions in BVAS (SMD –1.39; 95% CI [–2.31, –0.48]; P = 0.003) and CRP (SMD –0.56; 95% CI [–0.93, –0.19]; P = 0.002) within half a month after IVIG treatment. Conclusion IVIG was associated with rapid improvements in disease activity and the related biomarkers in patients with active AAV.

scholarly journals The Effect of Mindfulness-Based Interventions on Stress, Depression and Anxiety During the Perinatal Period in Women Without Pre-existing Stress, Depressive or Anxiety Disorders: a Systematic Review and Meta-analysis of Controlled Trials

Mindfulness ◽  
2021 ◽  
Author(s):  
Linda Corbally ◽  
Mick Wilkinson
Keyword(s):  
Mental Health ◽  
Systematic Review ◽  
Controlled Trial ◽  
Meta Analysis ◽  
Perinatal Period ◽  
Health Issues ◽  
Symptoms Of Depression ◽  
Mental Health Issues ◽  
Meta Analyses ◽  
Trial Evidence

Abstract Objectives The objective of this systematic review and meta-analysis was to examine controlled trial evidence for the effectiveness of mindfulness-based interventions on stress, anxiety and depression in the perinatal period in women without pre-existing mental health issues. Methods Six databases were searched for studies exploring the effects of mindfulness-based interventions on mental health outcomes of women during the perinatal period. Quality of both controlled trial meeting inclusion criteria were assessed using a tool specifically designed for meta-analyses of mindfulness-based interventions. Effect sizes were extracted for measures of mindfulness, depression, stress and anxiety outcomes. Effects were pooled in separate meta-analyses for all outcomes except anxiety which lacked sufficient studies. Results Twelve studies were analysed. Pooled effects suggest that mindfulness-based interventions cause small but clear increases in mindfulness and reductions in depression in women without pre-existing disorders. Effects of mindfulness-based interventions on other outcomes were unclear and confounded by heterogeneity. Conclusions Available controlled trial evidence suggests that mindfulness-based interventions improve mindfulness and decrease symptoms of depression during pregnancy in women without pre-existing mental health issues and might be a useful approach to prevent or attenuate the development of depression in the perinatal period.

A systematic review and meta-analysis of arthroscopic assisted techniques for thumb carpometacarpal joint osteoarthritis

2018 ◽  
Vol 43 (10) ◽  
pp. 1098-1105 ◽  
Author(s):  
Suzanne C. Wilkens ◽  
Claudia A. Bargon ◽  
Amin Mohamadi ◽  
Neal C. Chen ◽  
J. Henk Coert
Keyword(s):  
Systematic Review ◽  
Grip Strength ◽  
Meta Analysis ◽  
Pinch Strength ◽  
Carpometacarpal Joint ◽  
Arthroscopic Management ◽  
Thumb Carpometacarpal Joint ◽  
Before And After ◽  
Thumb Carpometacarpal ◽  
Meta Analyses

Arthroscopic management of thumb carpometacarpal (CMC) osteoarthrosis (OA) is an approach that has unclear results. We performed a systematic review encompassing three electronic databases up to May 2016 for studies describing arthroscopic-assisted techniques for thumb CMC OA. Meta-analyses of visual analogue scores (VAS) for pain, Disabilities of the Arm, Shoulder and Hand (DASH) scores, grip strength and pinch strength before and after arthroscopy were performed for ten included non-randomized cohort studies comprising 294 patients. Based on Hedges’ g measure, we found a large effect on VAS and DASH scores, a small effect on grip strength and no effect on pinch strength. On average, VAS improved by 4.1 cm, DASH by 22 points and grip strength by 2.8 kg. Complications were reported in 4% of patients. The use of arthroscopic-assisted techniques for thumb CMC OA is still limited; however, it may be a reasonable option for patients with thumb CMC OA who do not respond to non-operative treatment.

scholarly journals Sex Differences in Presentation of Stroke: A Systematic Review and Meta-Analysis

Stroke ◽  
2021 ◽  
Author(s):  
Mariam Ali ◽  
Hendrikus J.A. van Os ◽  
Nelleke van der Weerd ◽  
Jan W. Schoones ◽  
Martijn W. Heymans ◽  
...  
Keyword(s):  
Systematic Review ◽  
Sex Differences ◽  
Acute Stroke ◽  
Transient Ischemic Attack ◽  
Controlled Trial ◽  
Meta Analysis ◽  
Neurological Symptoms ◽  
Cross Sectional ◽  
Ischemic Attack ◽  
Meta Analyses

Background and Purpose: Women have worse outcomes than men after stroke. Differences in presentation may lead to misdiagnosis and, in part, explain these disparities. We investigated whether there are sex differences in clinical presentation of acute stroke or transient ischemic attack. Methods: We conducted a systematic review and meta-analysis according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Inclusion criteria were (1) cohort, cross-sectional, case-control, or randomized controlled trial design; (2) admission for (suspicion of) ischemic or hemorrhagic stroke or transient ischemic attack; and (3) comparisons possible between sexes in ≥1 nonfocal or focal acute stroke symptom(s). A random-effects model was used for our analyses. We performed sensitivity and subanalyses to help explain heterogeneity and used the Newcastle-Ottawa Scale to assess bias. Results: We included 60 studies (n=582 844; 50% women). In women, headache (pooled odds ratio [OR], 1.24 [95% CI, 1.11–1.39]; I 2 =75.2%; 30 studies) occurred more frequently than in men with any type of stroke, as well as changes in consciousness/mental status (OR, 1.38 [95% CI, 1.19–1.61]; I 2 =95.0%; 17 studies) and coma/stupor (OR, 1.39 [95% CI, 1.25–1.55]; I 2 =27.0%; 13 studies). Aspecific or other neurological symptoms (nonrotatory dizziness and non-neurological symptoms) occurred less frequently in women (OR, 0.96 [95% CI, 0.94–0.97]; I 2 =0.1%; 5 studies). Overall, the presence of focal symptoms was not associated with sex (pooled OR, 1.03) although dysarthria (OR, 1.14 [95% CI, 1.04–1.24]; I 2 =48.6%; 11 studies) and vertigo (OR, 1.23 [95% CI, 1.13–1.34]; I 2 =44.0%; 8 studies) occurred more frequently, whereas symptoms of paresis/hemiparesis (OR, 0.73 [95% CI, 0.54–0.97]; I 2 =72.6%; 7 studies) and focal visual disturbances (OR, 0.83 [95% CI, 0.70–0.99]; I 2 =62.8%; 16 studies) occurred less frequently in women compared with men with any type of stroke. Most studies contained possible sources of bias. Conclusions: There may be substantive differences in nonfocal and focal stroke symptoms between men and women presenting with acute stroke or transient ischemic attack, but sufficiently high-quality studies are lacking. More studies are needed to address this because sex differences in presentation may lead to misdiagnosis and undertreatment.

scholarly journals Prognosis of Regenerative Endodontic Procedures in Mature Teeth: A Systematic Review and Meta-Analysis of Clinical and Radiographic Parameters

Materials ◽  
2021 ◽  
Vol 14 (16) ◽  
pp. 4418
Author(s):  
Pantaleo Scelza ◽  
Fabiano Gonçalves ◽  
Isleine Caldas ◽  
Fernanda Nunes ◽  
Emanuelle Stellet Lourenço ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Periapical Lesion ◽  
Immature Teeth ◽  
Radiographic Parameters ◽  
Sensitivity Tests ◽  
High Incidence ◽  
Before And After ◽  
Meta Analyses

This work aimed to investigate the use of Regenerative Endodontic Procedures (REP) on the treatment of pulp necrosis in mature teeth through systematic review and meta-analysis of evidence on clinical and radiographic parameters before and after REP. A search was performed in different databases on 9 September 2020, including seven clinical studies and randomized controlled trials (RCT). The methodological quality was assessed using Revised Cochrane risk-of-bias (RoB 2) and Before-and-After tools. Meta-analyses were performed to evaluate the success incidences regarding the reduction of periapical lesion and recovery of sensitivity. The certainty of the evidence was assessed using GRADE. Meta-analysis showed a high overall success of 0.95 (0.92, 0.98) I2 = 6%, with high periapical lesion reduction at 12 months (0.93 (0.86, 0.96) I2 = 37%) and by the end of follow-up (0.91 (0.83, 0.96) I2 = 13%). Lower incidences of positive sensitivity response were identified for the electrical (0.58 (0.46, 0.70) I2 = 51%) and cold tests (0.70 (0.54, 0.84) I2 = 68%). The calculated levels of REP success were similar to those reported for immature teeth. With a very low certainty of evidence, the meta-analysis showed a high incidence of REP’s success for mature teeth with necrotic pulp evidenced by periapical lesion reduction and moderate positive responses to sensitivity tests.

scholarly journals Elimination and Reduction of Harmful Substances in Cigarette Smoke, Using Nanomaterials: Study Protocol for a Systematic Review

2021 ◽  
Author(s):  
Mohammad Hossein Chalak ◽  
Soqrat Omari Shekaftik ◽  
Hossein Jafari ◽  
Hamid Reza Ghaffari ◽  
Sakineh Dadipoor ◽  
...  
Keyword(s):  
Systematic Review ◽  
Cigarette Smoke ◽  
Systematic Reviews ◽  
Meta Analysis ◽  
Evaluation Methodology ◽  
Toxic Substances ◽  
Assessment Development ◽  
Effective Interventions ◽  
Harmful Substances ◽  
Meta Analyses

Abstract Background Cigarette smoke is an aerosol containing more than thousands of chemical compounds, several of which are carcinogens and toxic. Many efforts have been made to use nanomaterials (NMs) to remove and filter toxic substances in cigarette smoke. Due to the characteristics of MLs and their selectivity to different compounds, NMs have a high potential for practical application in reducing harmful compounds in cigarette smoke. The objective of this systematic review is to collect, combine, and analyze the basic intervention research on NMs for removal and reduction of harmful substances in cigarette smoke. This systematic review will determine the most important factors and expected characterizations for the development or commercialization of a new filters. Finally, we will review the challenges of using NMs-based interventions. Methods This protocol is based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA)-P protocol and Cochrane methodology. The inclusion/exclusion criteria are determined based on PICOTS (Population, Intervention, Comparator, Outcome, Time, Study Design) Framework. The Comprehensive literature searches will be conducted in international databases such as PubMed, Scopus, Science Direct and 3Iranian database, including SID, Iranmedex and Magiran. The quality of the papers and the risk of bias will be assessed using GRADE (Grading of Recommendations, Assessment, Development, and Evaluation) methodology. The results will be presented in the text as well as in a table and figure based on the SWiM guidelines (Synthesis Without Meta-analysis). the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist and guidelines will be tracked to certify a robustness and reproducibility of the process. Discussion A comprehensive analysis of the studies conducted in this field can identify research needs, examine the current and expected situation, provide the necessary parameters for research and development of new filters and ultimately determine the effective priorities for further effective interventions.

Parent–Infant Interventions to Promote Parental Sensitivity During NICU Hospitalization: Systematic Review and Meta-Analysis

2021 ◽  
pp. 105381512199192
Author(s):  
Andréane Lavallée ◽  
Gwenaëlle De Clifford-Faugère ◽  
Ariane Ballard ◽  
Marilyn Aita
Keyword(s):  
Systematic Review ◽  
Systematic Reviews ◽  
Standard Care ◽  
Assessment Tool ◽  
Meta Analysis ◽  
Risk Of Bias ◽  
Parental Sensitivity ◽  
Assessment Development ◽  
Implementation Failure ◽  
Meta Analyses

This systematic review and meta-analysis examined the effectiveness of parent–infant interventions for parents of preterm infants on parental sensitivity compared to standard care or active comparators. This review follows the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines and was prospectively registered in the International Prospective Register of Systematic Reviews (PROSPERO; registration ID: CRD42016047083). Database searches were performed from inception to 2020 to identify eligible randomized controlled trials. Two review authors independently selected studies, extracted data, and assessed the risk of bias using the Cochrane risk of bias assessment tool and quality of evidence using the Grades of Recommendation, Assessment, Development and Evaluation (GRADE) guidelines. A total of 19 studies ( n = 2,111 participants) were included and 14 were suitable to be pooled in our primary outcome meta-analysis. Results show no significant effect of parent–infant interventions over standard care or basic educational programs, on parental sensitivity. Results may not necessarily be due to the ineffectiveness of the interventions but rather due to implementation failure or high risk of bias of included studies.

scholarly journals Association between vision impairment and mortality: protocol for a systematic review and meta-analysis

BMJ Open ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. e037556
Author(s):  
Joshua R Ehrlich ◽  
Jacqueline Ramke ◽  
David Macleod ◽  
Bonnielin K Swenor ◽  
Helen Burn ◽  
...  
Keyword(s):  
Systematic Review ◽  
Global Health ◽  
Data Extraction ◽  
Meta Analysis ◽  
Risk Of Bias ◽  
Vision Impairment ◽  
Published Data ◽  
Assessment Development ◽  
Evaluation Approach ◽  
Meta Analyses

IntroductionDue to growth and ageing of the world’s population, the number of individuals worldwide with vision impairment (VI) and blindness is projected to increase rapidly over the coming decades. VI and blindness are an important cause of years lived with disability. However, the association of VI and blindness with mortality, including the risk of bias in published studies and certainty of the evidence, has not been adequately studied in an up-to-date systematic review and meta-analysis.Methods and analysisThe planned systematic review and meta-analysis will adhere to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Databases, including MEDLINE Ovid, Embase Ovid and Global Health, will be searched for relevant studies. Two reviewers will then screen studies and review full texts to identify studies for inclusion. Data extraction will be performed, and for included studies, the risk of bias and certainty of the evidence will be assessed using the Grades of Recommendation, Assessment, Development and Evaluation approach. The prognostic factor in this study is visual function, which must have been measured using a standard objective ophthalmic clinical or research instrument. We will use standard criteria from WHO to categorise VI and blindness. All-cause mortality may be assessed by any method one or more years after baseline assessment of vision. Results from included studies will be meta-analysed according to relevant sections of the Meta-analysis Of Observational Studies in Epidemiology checklist.Ethics and disseminationThis review will only include published data; therefore, ethics approval will not be sought. The findings of this review and meta-analysis will be published in an open-access, peer-reviewed journal and will be included in the ongoing Lancet Global Health Commission on Global Eye Health.

scholarly journals Does pain influence force steadiness? A protocol for a systematic review

BMJ Open ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. e042525
Author(s):  
Michail Arvanitidis ◽  
Deborah Falla ◽  
Andy Sanderson ◽  
Eduardo Martinez-Valdes
Keyword(s):  
Systematic Review ◽  
Systematic Reviews ◽  
Meta Analysis ◽  
Grey Literature ◽  
Force Steadiness ◽  
Assessment Development ◽  
Ethical Approval ◽  
Registration Number ◽  
Meta Analyses

IntroductionPerforming contractions with minimum force fluctuations is essential for everyday life as reduced force steadiness impacts on the precision of voluntary movements and functional ability. Several studies have investigated the effect of experimental or clinical musculoskeletal pain on force steadiness but with conflicting findings. The aim of this systematic review is to summarise the current literature to determine whether pain, whether it be clinical or experimental, influences force steadiness.Methods and analysisThis protocol for a systematic review was informed and reported in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols and the Cochrane Handbook for Systematic Reviews of Interventions. Key databases will be searched from inception to 31 August 2020, including MEDLINE, EMBASE, PubMed, CINAHL Plus, ZETOC and Web of Science. Grey literature and key journals will be also reviewed. Risk of bias will be assessed with the Newcastle-Ottawa tool, and the quality of the cumulative evidence assessed with the Grading of Recommendations, Assessment, Development and Evaluation guidelines. If homogeneity exists between groups of studies, meta-analysis will be conducted. Otherwise, a narrative synthesis approach and a vote-counting method will be used, while the results will be presented as net increases or decreases of force steadiness.Ethics and disseminationThe findings will be presented at conferences and the review will be also submitted for publication in a refereed journal. No ethical approval was required.PROSPERO registration numberCRD42020196479

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