scholarly journals Multi-modal Anterior Eye Imager Combining Ultra-High Resolution OCT and Microvascular Imaging for Structural and Functional Evaluation of the Human Eye

2020 ◽  
Vol 10 (7) ◽  
pp. 2545
Author(s):  
Peng Xiao ◽  
Zhengyu Duan ◽  
Gengyuan Wang ◽  
Yuqing Deng ◽  
Qian Wang ◽  
...  
Keyword(s):  
Blood Flow ◽  
High Resolution ◽  
Imaging System ◽  
Corneal Tissue ◽  
Functional Evaluation ◽  
Movement Trajectory ◽  
Slit Lamp ◽  
Healthy Human ◽  
Vessel Network ◽  
Microvascular Imaging

To establish complementary information for the diagnosis and evaluation of ocular surface diseases, we developed a multi-modal, non-invasive optical imaging platform by combining ultra-high resolution optical coherence tomography (UHR-OCT) with a microvascular imaging system based on slit-lamp biomicroscopy. Our customized UHR-OCT module achieves an axial resolution of ≈2.9 μm in corneal tissue with a broadband light source and an A-line acquisition rate of 24 kHz with a line array CCD camera. The microvascular imaging module has a lateral resolution of 3.5 μm under maximum magnification of ≈187.5× with an imaging rate of 60 frames/s, which is sufficient to image the conjunctival vessel network and record the movement trajectory of clusters of red blood cells. By combining the imaging optical paths of different modules, our customized multi-modal anterior eye imaging platform is capable of performing real-time cross-sectional UHR-OCT imaging of the anterior eye, conjunctival vessel network imaging, high-resolution conjunctival blood flow videography, fluorescein staining and traditional slit-lamp imaging on a single device. With self-developed software, a conjunctival vessel network image and blood flow videography were further analyzed to acquire quantitative morphological and hemodynamics parameters, including vessel fractal dimensions, blood flow velocity and vessel diameters. The ability of our multi-modal anterior eye imager to provide both structural and functional information for ophthalmic clinical applications was demonstrated on a healthy human subject and a keratitis patient.

scholarly journals Associations between haemodynamics and wall enhancement of intracranial aneurysm

2021 ◽  
pp. svn-2020-000636
Author(s):  
Miaoqi Zhang ◽  
Fei Peng ◽  
Xin Tong ◽  
Xin Feng ◽  
Yunduo Li ◽  
...  
Keyword(s):  
Blood Flow ◽  
High Resolution ◽  
Ordinal Regression ◽  
Parent Artery ◽  
Black Blood ◽  
4D Flow Mri ◽  
4D Flow ◽  
Unruptured Intracranial Aneurysms ◽  
Black Blood Mri ◽  
Flow Mri

Background and purposePrevious studies have reported about inflammation processes (IPs) that play important roles in aneurysm formation and rupture, which could be driven by blood flow. IPs can be identified using aneurysmal wall enhancement (AWE) on high-resolution black-blood MRI (BB-MRI) and blood flow haemodynamics can be demonstrated by four-dimensional-flow MRI (4D-flow MRI). Thus, this study investigated the associations between AWE and haemodynamics in unruptured intracranial aneurysms (IA) by combining 4D-flow MRI and high-resolution BB-MRI.Materials and methodsBetween April 2014 and October 2017, 48 patients with 49 unruptured IA who underwent both 4D-flow MRI and high-resolution BB-MRI were retrospectively included in this study. The haemodynamic parameters demonstrated using 4D-flow MRI were compared between different AWE patterns using the Kruskal-Wallis test and ordinal regression.ResultsThe results of Kruskal-Wallis test showed that the average wall shear stress in the IA (WSSavg-IA), maximum through-plane velocity in the adjacent parent artery, inflow jet patterns and the average vorticity in IA (vorticityavg-IA) were significantly associated with the AWE patterns. Ordinal regression analysis identified WSSavg-IA (p=0.002) and vorticityavg-IA (p=0.033) as independent predictors of AWE patterns.ConclusionA low WSS and low average vorticity were independently associated with a high AWE grade for IAs larger than 4 mm. Therefore, WSS and average vorticity could predict AWE and circumferential AWE.

scholarly journals Rapid Single Image-Based DTM Estimation from ExoMars TGO CaSSIS Images Using Generative Adversarial U-Nets

2021 ◽  
Vol 13 (15) ◽  
pp. 2877
Author(s):  
Yu Tao ◽  
Siting Xiong ◽  
Susan J. Conway ◽  
Jan-Peter Muller ◽  
Anthony Guimpier ◽  
...  
Keyword(s):  
High Resolution ◽  
Large Scale ◽  
Imaging System ◽  
Landing Site ◽  
Parameter Tuning ◽  
Processing Parameters ◽  
Input Image ◽  
Large Area ◽  
Laser Altimeter ◽  
Imaging Science

The lack of adequate stereo coverage and where available, lengthy processing time, various artefacts, and unsatisfactory quality and complexity of automating the selection of the best set of processing parameters, have long been big barriers for large-area planetary 3D mapping. In this paper, we propose a deep learning-based solution, called MADNet (Multi-scale generative Adversarial u-net with Dense convolutional and up-projection blocks), that avoids or resolves all of the above issues. We demonstrate the wide applicability of this technique with the ExoMars Trace Gas Orbiter Colour and Stereo Surface Imaging System (CaSSIS) 4.6 m/pixel images on Mars. Only a single input image and a coarse global 3D reference are required, without knowing any camera models or imaging parameters, to produce high-quality and high-resolution full-strip Digital Terrain Models (DTMs) in a few seconds. In this paper, we discuss technical details of the MADNet system and provide detailed comparisons and assessments of the results. The resultant MADNet 8 m/pixel CaSSIS DTMs are qualitatively very similar to the 1 m/pixel HiRISE DTMs. The resultant MADNet CaSSIS DTMs display excellent agreement with nested Mars Reconnaissance Orbiter Context Camera (CTX), Mars Express’s High-Resolution Stereo Camera (HRSC), and Mars Orbiter Laser Altimeter (MOLA) DTMs at large-scale, and meanwhile, show fairly good correlation with the High-Resolution Imaging Science Experiment (HiRISE) DTMs for fine-scale details. In addition, we show how MADNet outperforms traditional photogrammetric methods, both on speed and quality, for other datasets like HRSC, CTX, and HiRISE, without any parameter tuning or re-training of the model. We demonstrate the results for Oxia Planum (the landing site of the European Space Agency’s Rosalind Franklin ExoMars rover 2023) and a couple of sites of high scientific interest.

scholarly journals Ultra-High-Resolution 1 m/pixel CaSSIS DTM Using Super-Resolution Restoration and Shape-from-Shading: Demonstration over Oxia Planum on Mars

2021 ◽  
Vol 13 (11) ◽  
pp. 2185
Author(s):  
Yu Tao ◽  
Sylvain Douté ◽  
Jan-Peter Muller ◽  
Susan J. Conway ◽  
Nicolas Thomas ◽  
...  
Keyword(s):  
High Resolution ◽  
3D Reconstruction ◽  
Imaging System ◽  
Processing System ◽  
Digital Terrain Model ◽  
Super Resolution ◽  
Landing Site ◽  
Shape From Shading ◽  
Stereo Pair ◽  
Terrain Model

We introduce a novel ultra-high-resolution Digital Terrain Model (DTM) processing system using a combination of photogrammetric 3D reconstruction, image co-registration, image super-resolution restoration, shape-from-shading DTM refinement, and 3D co-alignment methods. Technical details of the method are described, and results are demonstrated using a 4 m/pixel Trace Gas Orbiter Colour and Stereo Surface Imaging System (CaSSIS) panchromatic image and an overlapping 6 m/pixel Mars Reconnaissance Orbiter Context Camera (CTX) stereo pair to produce a 1 m/pixel CaSSIS Super-Resolution Restoration (SRR) DTM for different areas over Oxia Planum on Mars—the future ESA ExoMars 2022 Rosalind Franklin rover’s landing site. Quantitative assessments are made using profile measurements and the counting of resolvable craters, in comparison with the publicly available 1 m/pixel High-Resolution Imaging Experiment (HiRISE) DTM. These assessments demonstrate that the final resultant 1 m/pixel CaSSIS DTM from the proposed processing system has achieved comparable and sometimes more detailed 3D reconstruction compared to the overlapping HiRISE DTM.

Pontine ataxic hemiparesis studied by a high-resolution magnetic resonance imaging system

1987 ◽  
Vol 21 (2) ◽  
pp. 204-207 ◽  
Author(s):  
Hidehiko Nabatame ◽  
Hidenao Fukuyama ◽  
Ichiro Akiguchi ◽  
Masakuni Kameyama ◽  
Kazumasa Nishimura ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
High Resolution ◽  
Imaging System ◽  
Magnetic Resonance Imaging System ◽  
Resonance Imaging ◽  
Ataxic Hemiparesis

scholarly journals Quantification of Hepatic Blood Flow Using a High-Resolution Phase-Contrast MRI Sequence With Compressed Sensing Acceleration

2015 ◽  
Vol 204 (3) ◽  
pp. 510-518 ◽  
Author(s):  
Hadrien A. Dyvorne ◽  
Ashley Knight-Greenfield ◽  
Cecilia Besa ◽  
Nancy Cooper ◽  
Julio Garcia-Flores ◽  
...  
Keyword(s):  
Blood Flow ◽  
High Resolution ◽  
Compressed Sensing ◽  
Hepatic Blood Flow ◽  
Phase Contrast ◽  
Phase Contrast Mri
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