scholarly journals Modeling Transient Liquid Slosh Behavior at Variable Operating Speeds Induced by Intermittent Motions in Packaging Machines

2020 ◽  
Vol 10 (5) ◽  
pp. 1859 ◽  
Author(s):  
Clemens Troll ◽  
Jens-Peter Majschak
Keyword(s):  
Experimental Data ◽  
Quality Control ◽  
Process Models ◽  
Operating Speed ◽  
Packaging Process ◽  
One Dimensional ◽  
Liquid Slosh ◽  
Predictive Efficiency ◽  
Do So

The present paper deals with the problem of modeling liquid slosh occurring in the packaging process of containers filled with liquid. Sloshing effects are induced by one-dimensional intermittent motions and are undesired due to the necessity of quality control processes, such as weighing. Therefore, motion optimizations are often applied with the intention to minimize the residual vibrations. Valid process models are required to do so. The aim of this paper is to derive models for describing the liquid slosh behavior for different motions and for common practical circumstances, e.g., different container geometries as well as machine operating speeds, and to state the model’s limits of use. Known model approaches are discussed, and their assumptions are reviewed experimentally. This leads to a set of limited ranges of operating speeds in which the applied models’ assumptions are valid. The models are derived for these sets from experimental data, and a comparison is executed that enables the determination of the models’ validity concerning their operating speed dependency. Finally, the validity of the derived models is investigated by comparing their predictive efficiency of describing the vibration for different motion profiles.

Determination of the Duration of Memory for Viscoelastic Materials

1970 ◽  
Vol 37 (2) ◽  
pp. 449-453 ◽  
Author(s):  
M. H. Gradowczyk ◽  
J. Soussou ◽  
F. Moavenzadeh
Keyword(s):  
Experimental Data ◽  
Anisotropic Material ◽  
Finite Interval ◽  
Computing Time ◽  
Three Dimensional ◽  
Viscoelastic Materials ◽  
One Dimensional

The possibility of limiting the memory of nonlinear nonaging viscoelastic materials is discussed. If the deformation histories are bounded, then the memory interval −∞ < τ ≤ t can be reduced to the finite interval t −d ≤ τ, where d ≥ 0 is the duration of memory. It is shown how the duration in relaxation and creep can be obtained for one-dimensional motions. As an application the duration of memory in relaxation and creep of solid polyurethane is computed from available experimental data. It is also shown that when the functionals are evaluated numerically, the use of the duration reduces significantly the computing time. The case of anisotropic material in three-dimensional motions is also discussed.

UV spectroscopic method for determination of phenytoin in bulk and injection forms

2019 ◽  
Author(s):  
Chem Int
Keyword(s):  
Quality Control ◽  
Spectrophotometric Method ◽  
Spectroscopic Method ◽  
Ich Guidelines ◽  
Precision And Accuracy ◽  
Routine Quality Control

Recent study was conducted to develop a simple UV spectrophotometric method to determine Phenytoin in bulk and injection form according to official requirement and validate as per ICH guidelines. λmax of Phenytoin was found 202 nm. Linearity existed perceived in the concentration assortment 2-8 μg/ml (r2 = 0.999) for the method. The method was validated pertaining to linearity, precision and accuracy studies, LOD and LOQ consistent with ICH guidelines. The existent method was establish to be simple, linear, precise, accurate as well as sensitive and can be applied for routine quality control enquiry for the analysis of Phenytoin in bulk and injection form.

Simultaneous Determination of Eight Potential Q-Markers in Zishen Tongguan Capsules Based on UHPLC-MS/MS

2020 ◽  
Vol 17 (1) ◽  
pp. 47-56
Author(s):  
Shun Liu ◽  
Xun Wang ◽  
Kaiping Zou ◽  
Wei Liu ◽  
Cunyu Li ◽  
...  
Keyword(s):  
Quality Control ◽  
Chinese Medicine ◽  
Simultaneous Determination ◽  
High Performance ◽  
Multiple Reaction Monitoring ◽  
Gradient Elution ◽  
Quality Markers ◽  
High Repeatability ◽  
Comprehensive Study

Background: Zishen Tongguan (ZSTG) capsules were prepared at the Affiliated Hospital of Nanjing University of Chinese Medicine and have been proven to be clinically effective for treating pyelonephritis and benign prostatic hyperplasia. However, the quality standards are not ideal; a comprehensive study of the “quality markers” (Q-markers), the chemicals inherent in traditional Chinese medicine and its preparations, has not been carried out. Experimental Methods: In this paper, a sensitive and specific ultra-high-performance liquid chromatographictandem mass spectrometry (UHPLC-MS/MS) method was developed for the simultaneous determination of eight potential Q-markers of ZSTG, including timosaponin A3, berberine, jatrorrhizine, phellodendrine, palmatine, mangiferin, neomangiferin, and timosaponin BII. A Kromasil 100-3.5 C18 column was used with a mobile phase of 0.2% formic acid with acetonitrile, and gradient elution at a flow rate of 0.2 mL/min was achieved in 13 minutes and used for separation. Detection was performed in positive/negative mode with multiple reaction monitoring (MRM). Results: The analytical method was validated in terms of the sensitivity, linearity, accuracy, precision, repeatability, stability and recovery. The method established here was successfully applied to study the potential Q-markers in 8 batches of commercial samples, which demonstrated its use in improving the quality control of ZSTG. Conclusion: The developed method had high repeatability and accuracy and was suitable for the simultaneous analysis of multiple Q-markers, which may provide a new basis for the comprehensive assessment and overall quality control of ZSTG.

Quality Control Optimization Solutions for Determination of Rutin in Supplements Containing Ginkgo Biloba Extract

2016 ◽  
Vol 12 (4) ◽  
pp. 386-390 ◽  
Author(s):  
Ivanka P. Pencheva ◽  
Vania N. Maslarska ◽  
Assena C. Stoimenova ◽  
Manoela M. Manova ◽  
Lily A. Andonova ◽  
...  
Keyword(s):  
Quality Control ◽  
Ginkgo Biloba ◽  
Ginkgo Biloba Extract ◽  
Control Optimization

A Versatile Stability-indicating Liquid Chromatographic Method for the Simultaneous Determination of Atenolol, Hydrochlorothiazide and Chlorthalidone

2020 ◽  
Vol 16 (8) ◽  
pp. 1037-1051
Author(s):  
Ehab Farouk Elkady ◽  
Marwa Ahmed Fouad ◽  
Abdulgabar A. Ezzy Faquih
Keyword(s):  
Quality Control ◽  
Chromatographic Method ◽  
Degradation Products ◽  
Pharmaceutical Dosage Forms ◽  
Potassium Dihydrogen ◽  
Ich Guidelines ◽  
Liquid Chromatographic Method ◽  
Liquid Chromatographic ◽  
Potassium Dihydrogen Orthophosphate

Background: Atenolol is a selective beta 1 blocker that can be used alone or in combination with hydrochlorothiazide or with chlorthalidone for the treatment of hypertension and prevention from a heart attack. Objective: The main target of this work was to improve modern, easy, accurate and selective liquid chromatographic method (RP-HPLC) for the determination of these drugs in the presence of their degradation products. These methods can be used as analytical gadgets in quality control laboratories for a routine examination. Methods: In this method, the separation was accomplished through an Inertsil® ODS-3V C18 column (250 mm x 4.6 mm, 5 μm), the mobile phase used was 25 mM aqueous potassium dihydrogen orthophosphate solution adjusted to pH 6.8 by using 0.1M sodium hydroxide and acetonitrile (77 : 23, v/v), the flow rate used was 1 ml/min and detection was achieved at 235 nm using UV. Results: All peaks were sharp and well separated, the retention times were atenolol degradation (ATN Deg.) 2.311 min, atenolol (ATN) 2.580 min, hydrochlorothiazide degradation (HCT Deg.) 5.890 min, hydrochlorothiazide (HCT) 7.016 min, chlorthalidone degradation CTD Deg 8.018 min and chlorthalidone (CTD) 14.972 min. Linearity was obtained and the range of concentrations was 20- 160 μg/ml for atenolol, 10-80 μg/ml for hydrochlorothiazide and 10-80 μg/ml for chlorthalidone. According to ICH guidelines, method validation was accomplished, these methods include linearity, accuracy, selectivity, precision and robustness. Conclusion: The optimized method demonstrated to be specific, robust and accurate for the quality control of the cited drugs in pharmaceutical dosage forms.

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