scholarly journals Exosomal miR-92a Concentration in the Serum of Shift Workers

2020 ◽  
Vol 10 (2) ◽  
pp. 430 ◽  
Author(s):  
Massimo Bracci ◽  
Maria Eléxpuru Zabaleta ◽  
Maria Fiorella Tartaglione ◽  
Caterina Ledda ◽  
Venerando Rapisarda ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Energy Balance ◽  
Brown Adipose Tissue ◽  
Biological Clock ◽  
Regulatory Mechanisms ◽  
Shift Workers ◽  
Metabolic Alterations ◽  
Brown Adipose ◽  
Brown Adipose Tissue Activity ◽  
Serum Exosomes

Shift work is associated with alterations in the human biological clock and metabolism. Serum exosomal miR-92a concentration was inversely correlated with brown adipose tissue activity playing a pivotal role in energy balance. In this study, miR-92a was measured in serum exosomes of 30 workers engaged in shift and daytime work. No significant metabolic alterations were shown between daytime and shift workers while a difference in serum exosomal miR-92a levels was found between the two groups. The lower levels of miR-92a in shift workers were suggestive of a higher brown adipose tissue activity compared with daytime workers. However, the possibility that other physiological and pathological processes may influence miR-92a cannot be ruled out. Our results suggest further investigations on brown adipose tissue activity and on miR-92a regulatory mechanisms, such as those related to the estrogen pathway, in shift workers.

Abstract 224: Biological Clock Strongly Regulates Brown Adipose Tissue Activity: Implications for Postprandial Triglyceride Metabolism

2016 ◽  
Vol 36 (suppl_1) ◽  
Author(s):  
Jimmy Berbée ◽  
Rosa van den Berg ◽  
Sander Kooijman ◽  
Ashna Ramkisoensing ◽  
Claudia P Coomans ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Diurnal Rhythm ◽  
Biological Clock ◽  
Day Length ◽  
Time Points ◽  
Bat Activity ◽  
Brown Adipose ◽  
Postprandial Triglyceride ◽  
Brown Adipose Tissue Activity

Background: Brown adipose tissue (BAT) is an attractive anti-dyslipidemia target as it burns high amounts of triglycerides (TG) into heat. In humans, plasma TG levels display 24 h variation independent of food intake, indicating a strong regulation by the biological clock. We recently showed that prolonged day length decreases the uptake of TG by BAT. We now aimed to assess the 24 h rhythm of BAT activity, the effect of day length thereon, and the consequences for postprandial TG metabolism. Methods and Results: Male C57Bl/6J mice were exposed to short (8 h), regular (12 h), or long (16 h) days during 5 weeks. The rhythm of BAT was determined by its capacity to take up plasma TG-derived fatty acids (FA) at 6 time points during a 24 h period. Mice exposed to regular days displayed a remarkable diurnal pattern of TG-derived FA uptake from glycerol tri[ 3 H]oleate-labeled VLDL-like particles by BAT, but not by other tissues, reaching a peak [ 3 H]FA uptake at onset of dark. Short day length increased the amplitude of [ 3 H]FA uptake by 3-fold and advanced the peak of [ 3 H]FA uptake, again to onset of dark. Conversely, long day length delayed the peak to onset of dark. We next assessed whether BAT rhythmicity affects postprandial TG clearance in dyslipidemic APOE*3-Leiden.CETP mice. Mice were fed a western-type diet that were exposed to either a short (8 h) or long 16 h (long) days and gavaged with olive oil at several time points during the day. Irrespective of day length, postprandial TG excursion was virtually absent before the onset of dark (highest BAT activity) and high before onset of light (lowest BAT activity). Conclusion: Day length dictates a diurnal rhythm in TG-derived FA uptake capacity of BAT, thereby strongly determining postprandial TG metabolism. We propose that the diurnal variations in TG levels observed in humans may be explained by a diurnal rhythm in BAT activity.

scholarly journals Contribution of brown adipose tissue activity to the control of energy balance by GLP-1 receptor signalling in mice

Diabetologia ◽  
2015 ◽  
Vol 58 (9) ◽  
pp. 2124-2132 ◽  
Author(s):  
Kristy M. Heppner ◽  
Sarah Marks ◽  
Jenna Holland ◽  
Nickki Ottaway ◽  
David Smiley ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Energy Balance ◽  
Brown Adipose Tissue ◽  
Receptor Signalling ◽  
Brown Adipose ◽  
Brown Adipose Tissue Activity

Short Dietary Intervention with Olive Oil Increases Brown Adipose Tissue Activity in Lean But Not Overweight/Obese Subjects

2020 ◽  
Author(s):  
Milena Monfort-Pires ◽  
Muuez U-Din ◽  
Guilherme A. Nogueira ◽  
Juliana de Almeida-Faria ◽  
Davi Sidarta-Oliveira ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Olive Oil ◽  
Dietary Intervention ◽  
Brown Adipose ◽  
Obese Subjects ◽  
Brown Adipose Tissue Activity

Reduced brown adipose tissue activity during cold exposure is a metabolic feature of the human thrifty phenotype

Metabolism ◽  
2021 ◽  
Vol 117 ◽  
pp. 154709 ◽  
Author(s):  
Tim Hollstein ◽  
Karyne Vinales ◽  
Kong Y. Chen ◽  
Aaron M. Cypess ◽  
Alessio Basolo ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Cold Exposure ◽  
Thrifty Phenotype ◽  
Brown Adipose ◽  
Metabolic Feature ◽  
Brown Adipose Tissue Activity

scholarly journals Modulation of musculoskeletal hyperalgesia by brown adipose tissue activity in mice

Pain ◽  
2016 ◽  
Vol 157 (11) ◽  
pp. 2561-2570 ◽  
Author(s):  
Elizabeth M. Goudie-DeAngelis ◽  
Ramy E. Abdelhamid ◽  
Myra G. Nunez ◽  
Casey L. Kissel ◽  
Katalin J. Kovács ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Brown Adipose ◽  
Brown Adipose Tissue Activity

Role of thermogenesis in the regulation of energy balance in relation to obesity

1989 ◽  
Vol 67 (4) ◽  
pp. 394-401 ◽  
Author(s):  
Jean Himms-Hagen
Keyword(s):  
Adipose Tissue ◽  
Energy Balance ◽  
Energy Expenditure ◽  
Brown Adipose Tissue ◽  
Thermal Balance ◽  
Prominent Feature ◽  
Thermic Effect Of Food ◽  
Brown Adipose ◽  
Effect Of Food ◽  
Thermic Effect

Obligatory thermogenesis is a necessary accompaniment of all metabolic processes involved in maintenance of the body in the living state, and occurs in ail organs. It includes energy expenditure involved in ingesting, digesting, and processing food (thermic effect of food (TEF)). At certain life stages extra energy expenditure for growth, pregnancy, or lactation would also be obligatory. Facultative thermogenesis is superimposed on obligatory thermogenesis and can be rapidly switched on and rapidly suppressed by the nervous system. Facultative thermogenesis is important in both thermal balance, in which control of thermoregulatory thermogenesis (shivering in muscle, nonshivering in brown adipose tissue (BAT)) balances neural control of heat loss mechanisms, and in energy balance, in which control of facultative thermogenesis (exercise-induced in muscle, diet-induced thermogenesis (DIT) in BAT) balances control of energy intake. Thermal balance (i.e., body temperature) is much more stringently controlled than energy balance (i.e., body energy stores). Reduced energy expenditure for thermogenesis is important in two types of obesity in laboratory animals. In the first type, deficient DIT in BAT is a prominent feature of altered energy balance. It may or may not be associated with hyperphagia. In a second type, reduced cold-induced thermogenesis in BAT as well as in other organs is a prominent feature of altered thermal balance. This in turn results in altered energy balance and obesity, exacerbated in some examples by hyperphagia. In some of the hyperphagic obese animals it is likely that the exaggerated obligatory thermic effect of food so alters thermal balance that BAT thermogenesis is suppressed. In all obese animals, deficient hypothalamic control of facultative thermogenesis and (or) food intake is implicated.Key words: thermogenesis, brown adipose tissue, energy balance, obesity, cold, thermoregulation, diet.

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