scholarly journals Effects of Resistance Training and Bowdichia virgilioides Hydroethanolic Extract on Oxidative Stress Markers in Rats Submitted to Peripheral Nerve Injury

Antioxidants ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 941
Author(s):  
Luana Santos Costa ◽  
Felipe J. Aidar ◽  
Dihogo Gama de Matos ◽  
José Uilien de Oliveira ◽  
Jymmys Lopes dos Santos ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Resistance Training ◽  
Peripheral Nerve ◽  
Nerve Injury ◽  
Peripheral Nerve Injury ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Markers Of Oxidative Stress ◽  
Hydroethanolic Extract ◽  
The Brain

The objective of this study was to analyze the effects of the combination of resistance training (RT) and the hydroethanolic extract (EHE) of Bowdichia virgilioides as markers of oxidative stress (OS) in rats with peripheral nerve injury (PNI). Rats were allocated into six groups (n = 10): animals without interventions (C), animals with an exposed nerve but without injury, injured animals, trained and injured animals, injured animals that received EHE, and animals that received a combination of RT and EHE. RT comprised the climbing of stairs. EHE was orally administered (200 mg/kg) for 21 days after PNI induction. RT reduced the amount of lipoperoxidation in plasma (14.11%). EHE reduced lipoperoxidation in the plasma (20.72%) and the brain (41.36). RT associated with the extract simultaneously reduced lipoperoxidation in the plasma (34.23%), muscle (25.13%), and brain (43.98%). There was an increase in total sulhydrilyl levels (a) in the brain (33.33%) via RT; (b) in the brain (44.44%) and muscle (44.51%) using EHE; and (c) in the plasma (54.02%), brain (54.25%), and muscle using the combination of RT + EHE. These results suggest that RT associated with oral EHE results in a decrease in OS.

scholarly journals Salivary Oxidative Stress Markers’ Relation to Oral Diseases in Children and Adolescents

Antioxidants ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 1540
Author(s):  
Bahareh Nazemi Salman ◽  
Shayan Darvish ◽  
Ancuta Goriuc ◽  
Saeideh Mazloomzadeh ◽  
Maryam Hossein Poor Tehrani ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dental Caries ◽  
Pediatric Population ◽  
Current Evidence ◽  
Oxidative Stress Markers ◽  
Oral Diseases ◽  
Stress Markers ◽  
Gingival Bleeding ◽  
Whole Saliva ◽  
Markers Of Oxidative Stress

(1) Background: Current evidence suggests that salivary markers of oxidative stress are indicative of clinical disease indices such as the papillary bleeding index (PBI) and the caries index (CI). The aim of this study was to assess the relation of oxidative stress markers with oral dental caries and periodontal problems in a pediatric population. (2) Methods: In this case-control study, unstimulated whole saliva was collected from individuals aged 3–18 years (n = 177); 14 individuals were excluded. Study subjects were divided into those with caries (CI = 2, n = 78) and those who were caries-free (n = 85). These groups were then divided into another subset consisting of children (mean age 7.3 years, n = 121) and adolescents (mean age 16.1 years, n = 42). The PBI was determined in all groups. We then assessed salivary levels of oxidative stress markers. (3) Results: Total antioxidant capacity (TAC) level increased in patients with more gingival bleeding (p < 0.05) in the study group aged 3–18 years. In addition, TAC showed a significant decrease in samples with caries when compared to the caries-free group in adolescents (p = 0.008). (4) Conclusions: TAC levels may be a marker of both gingival bleeding and dental caries in young adult populations. We hope that in the near future, prophylaxis, control, follow up and even possible therapeutic use of oxidative stress markers in a chairside way will become possible as antioxidants have been shown to be effective against oral diseases.

scholarly journals Protective Effect of Hydroethanolic Extracts of Solanum scabrum and Cola verticillata Against Cyclophosphamide Induced Toxicity in Female Rats

2014 ◽  
Vol 3 (3) ◽  
pp. 18 ◽  
Author(s):  
Mbong Angie M-A ◽  
Djiokeng Paka G. ◽  
Ntentie F. R. ◽  
Dimodi H. ◽  
Ngondi J. L. ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Intraperitoneal Administration ◽  
Female Rats ◽  
Protective Effects ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Significant Toxicity ◽  
Cyclophosphamide Treatment ◽  
Hydroethanolic Extract ◽  
Antioxidant Mechanisms

<p>The aim of this study was to evaluate the protective effects of hydroethanolic extracts of <em>S.</em> <em>scabrum</em> and <em>C. verticillata</em> against cyclophosphamide induced toxicity. In this light, female albino wistar rats were treated by intraperitoneal administration of 100 mg/kg BW of cyclophosphamide or distilled water every other day for 7 days associated with oral gavage using hydroethanolic extract of <em>C. verticillata</em>/<em>S. scabrum</em> at a dose of 200 or 400 mg/kg BW or not every day for the same 7 days. On the 8th day, blood and organs (liver, heart and kidney) were collected for analyses of toxicity-related and oxidative stress markers. Cyclophosphamide treatment induced significant toxicity as shown by liver enzymes, urea and creatinine levels. The administration of extracts helped reduce the levels of these markers. The antioxidant effect of these extracts also helped or not to ameliorate oxidative stress markers (MDA, NO, hydroperoxides, catalase, thiols, GPx) depending on the extract and on the dose administered. These results suggest that administration of hydroethanolic extracts of <em>S.</em> <em>scabrum</em> and <em>C. verticillata</em> can help prevent or reduce toxicity that is brought about by treatment with cyclophosphamide due to their ability to upregulate antioxidant mechanisms.</p>

scholarly journals Curcumin Reduce Sodium Fluoride-Induced Oxidative Stress in Rat Brain

2018 ◽  
Vol 15 (1) ◽  
pp. 71-77 ◽  
Author(s):  
Nagapuri Kiran Kumar ◽  
Mesram Nageshwar ◽  
Karnati Pratap Reddy
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Oxidative Damage ◽  
Oral Administration ◽  
Rat Brain ◽  
Sodium Fluoride ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
The Brain

This study reports the ameliorative role of curcumin against sodium fluoride (NaF) induced oxidative stress in the brain of rats. The rats were divided into control, NaF (20 mg/kg), NaF+Curcumin (20mg/kg) and Curcumin (20mg/kg) groups respectively and treated at everyday interval for 60 consecutive days. Oxidative stress markers in the brain were measured at 60th day. NaF treatment significantly increased LPO content, but decreased the level of GSH and activities of SOD, GPx, and CAT the brain of rats in comparison to the control rats. Oral administration of curcumin to fluoride exposed rats significantly reversed the content of lipid peroxidation, as well as enhanced the level of GSH and SOD, GPx and CAT activities to normal compared to NaF exposed rats. Thus, curcumin showed the potential to prevent sodium fluoride induced oxidative damage in the brain of rats and curcumin may be useful agents against neurodegeneration in the brain.

scholarly journals Dynamic Resistance Training Improves Cardiac Autonomic Modulation and Oxidative Stress Parameters in Chronic Stroke Survivors: A Randomized Controlled Trial

2019 ◽  
Vol 2019 ◽  
pp. 1-12 ◽  
Author(s):  
Bruno Bavaresco Gambassi ◽  
Hélio José Coelho-Junior ◽  
Camila Paixão dos Santos ◽  
Ivan de Oliveira Gonçalves ◽  
Cristiano Teixeira Mostarda ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Resistance Training ◽  
Dynamic Resistance ◽  
Stroke Survivors ◽  
Autonomic Modulation ◽  
Oxidative Stress Markers ◽  
Cardiac Autonomic Modulation ◽  
Stress Markers ◽  
Plasma Nitrite ◽  
And Oxidative Stress

Stroke survivors are at substantial risk of recurrent cerebrovascular event or cardiovascular disease. Exercise training offers nonpharmacological treatment for these subjects; however, the execution of the traditional exercise protocols and adherence is constantly pointed out as obstacles. Based on these premises, the present study investigated the impact of an 8-week dynamic resistance training protocol with elastic bands on functional, hemodynamic, and cardiac autonomic modulation, oxidative stress markers, and plasma nitrite concentration in stroke survivors. Twenty-two patients with stroke were randomized into control group (CG, n=11) or training group (TG, n=11). Cardiac autonomic modulation, oxidative stress markers, plasma nitrite concentration, physical function and hemodynamic parameters were evaluated before and after 8 weeks. Results indicated that functional parameters (standing up from the sitting position (P=0.011) and timed up and go (P=0.042)) were significantly improved in TG. Although not statistically different, both systolic blood pressure (Δ=−10.41 mmHg) and diastolic blood pressure (Δ=−8.16 mmHg) were reduced in TG when compared to CG. Additionally, cardiac autonomic modulation (sympathovagal balance–LF/HF ratio) and superoxide dismutase were improved, while thiobarbituric acid reactive substances and carbonyl levels were reduced in TG when compared to the CG subjects. In conclusion, our findings support the hypothesis that dynamic resistance training with elastic bands may improve physical function, hemodynamic parameters, autonomic modulation, and oxidative stress markers in stroke survivors. These positive changes would be associated with a reduced risk of a recurrent stroke or cardiac event in these subjects.

scholarly journals Correlation between the Activity of Aldehyde Dehydrogenase and Oxidative Stress Markers in the Saliva of Diabetic Patients

2019 ◽  
Vol 27 (1) ◽  
pp. 67-73
Author(s):  
Hina Younus ◽  
Sumbul Ahmad ◽  
Md. Fazle Alam
Keyword(s):  
Oxidative Stress ◽  
Aldehyde Dehydrogenase ◽  
Early Stage ◽  
Control Group ◽  
Diabetic Patients ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Patients With Diabetes ◽  
Markers Of Oxidative Stress ◽  
And Oxidative Stress

Background: Reactive aldehydes are involved in diseases associated with oxidative stress, including diabetes. Human salivary aldehyde dehydrogenase (hsALDH) presumably protects us from many toxic ingredient/contaminant aldehydes present in food. Objective: This study aimed to probe the activity of hsALDH in patients with diabetes and than to correlate it with various oxidative stress markers in the saliva. Methods: The saliva samples were collected from total 161 diabetic patients from Rajiv Gandhi Centre for Diabetes, Jawaharlal Nehru Medical College (JNMC), AMU, Aligarh, (India). HsALDH activity and markers of oxidative stress [8-hydroxydeoxyguanosine (8-OHDG), malondialdehyde (MDA) and advanced glycation end products (AGEs)] were measured in the saliva samples. Results: Patients with early stage of diabetes had higher activity of hsALDH when compared with the control group. As the history of diabetes increases, the activity of the enzyme decreases and also higher oxidative stress markers (8-OHDG, MDA and AGEs) are detected in the saliva samples. Negative significant correlation between hsALDH activity and oxidative stress markers were observed (p <0.0001). Conclusion: The activity of hsALDH increases in early stages of diabetes most probably to counter the increased oxidative stress associated with diabetes. However, in later stages of diabetes, the activity of the enzyme decreases, possibly due to its inactivation resulting from glycation.

Multi-organ Toxicity Attenuation by Cerium Oxide and Yttrium Oxide Nanoparticles: Comparing the Beneficial Effects on Tissues Oxidative Damage Induced by Sub-acute Exposure to Diazinon

2020 ◽  
Vol 8 (3) ◽  
pp. 225-238
Author(s):  
Mona Navaei-Nigjeh ◽  
Marzieh Daniali ◽  
Mahban Rahimifard ◽  
Mohammad R. Khaksar
Keyword(s):  
Oxidative Stress ◽  
Cerium Oxide ◽  
Metal Oxide Nanoparticles ◽  
Radical Scavenging ◽  
Oxide Nanoparticles ◽  
Oxidative Stress Markers ◽  
Beneficial Effects ◽  
Stress Markers ◽  
Kidney Liver ◽  
The Brain

Background: Excessive use of diazinon, as an organophosphate pesticide (OP), contributes to cytotoxic and pathologic cellular damage and, in particular, oxidative stress. However, metal-oxide nanoparticles (NPs), such as cerium oxide (CeO2) and yttrium oxide (Y2O3), with the property of free radical scavenging demonstrated beneficial effects in the alleviation of oxidative stress biomarkers. Objective: The aims of this study include evaluating beneficial effects of CeO2 NPs, Y2O3 NPs, and their combination against diazinon-induced oxidative stress in different tissues of brain, heart, lung, kidney, liver, and spleen. Methods: Eight randomized groups of 6 adult male Wistar rats were formed. Each group of rats administered a different combination of diazinon, CeO2 and Y2O3 NPs daily and levels of oxidative stress markers, such as reactive oxygen species (ROS), lipid peroxidation (LPO), total thiol molecules (TTM) and total anti-oxidant power (TAP) and catalase enzyme, were measured after 2 weeks of the treatment. Results: Measurements of the mentioned markers in the brain, heart, lung, kidney, liver, and spleen showed that the administration of NPs could significantly alleviate the oxidative stress induced by diazinon. However, the findings of this study illustrated that the combination of both CeO2 and Y2O3 NPs led to a better reduction in oxidative stress markers. Conclusion: Sub-acute exposure of diazinon in rats led to increased levels of oxidative stress markers in pivotal tissues such as the brain, heart, lung, kidney, liver, and spleen. CeO2 and Y2O3 NPs neutralize the oxidative stress to compensate diazinon-induced tissue damages. Lay Summary: Organophosphate pesticides (OPs), which are mainly used for pest control, are responsible for the entry of pesticides into the human food cycle. Organophosphate such as diazinon increases the molecular biomarkers of oxidative stress inside the cells of vital tissues such as the heart, liver, lungs, etc. Metal oxide nanoparticles (NPs) such as cerium oxide (CeO2) and yitrium oxide (Y2O3) can have free radical scavenging potential under oxidative stress and through various mechanisms. Although these nanoparticles reduce oxidative stress, it should be borne in the design of the study that additional doses of these substances reverse the beneficial effects.

Sign in / Sign up

Export Citation Format

Share Document