scholarly journals Synthesis, In Vitro Antioxidant Properties and Distribution of a New Cyanothiophene-Based Phenolic Compound in Olive Oil-In-Water Emulsions

Antioxidants ◽  
2020 ◽  
Vol 9 (7) ◽  
pp. 623
Author(s):  
Sonia Losada-Barreiro ◽  
Matej Sova ◽  
Janez Mravljak ◽  
Luciano Saso ◽  
Carlos Bravo-Díaz
Keyword(s):  
Olive Oil ◽  
Volume Fraction ◽  
Antioxidant Properties ◽  
Tween 20 ◽  
Interfacial Region ◽  
Water Emulsion ◽  
Narrow Region ◽  
Oil In Water ◽  
Oil In Water Emulsion

We synthesized and determined the antioxidant activity and distribution of a new cyanothiophene-based compound, N-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-3,5-dihydroxybenzamide (SIM-53B), in intact stripped olive oil-in-water emulsion. The in vitro antioxidant properties of SIM-53B were evaluated and compared to those for Trolox and resveratrol. Addition of an emulsifier (Tween 20) creates a narrow region, the aqueous–oil interface, and the distribution of SIM-53B can be described by two partition constants: PWI (between aqueous/interfacial regions) and POI (between oil/interfacial regions). The effects of emulsifier concentration expressed in terms of the volume fraction, ΦI, and O/W ratio were also evaluated on its distribution. SIM-53B is predominantly distributed (>90%) in the interfacial region of 1:9 (O/W) olive oil-in-water emulsions at the lowest emulsifier volume fraction (ΦI = 0.005) and only a small fraction is located in the aqueous (<5%) and the oil (<5%) regions. Besides, the concentration of SIM-53B in the interfacial region of the emulsions is ~170–190-fold higher than the stoichiometric concentration, emphasizing the compartmentalization effects. Results suggest that the emulsifier volume fraction is a key parameter that may modulate significantly its concentration in the interface. Our study suggests that cyanothiophene-based compounds may be interesting additives for potential lipid protection in biomembranes or other lipid-based systems.

Chemical profiles and antioxidant properties of roasted rice hull extracts in bulk oil and oil-in-water emulsion

2019 ◽  
Vol 272 ◽  
pp. 242-250 ◽  
Author(s):  
JuHyuk Park ◽  
Seo Yeoung Gim ◽  
Jun-Yeong Jeon ◽  
Mi-Ja Kim ◽  
Hyung-Kyoon Choi ◽  
...  
Keyword(s):  
Antioxidant Properties ◽  
Rice Hull ◽  
Water Emulsion ◽  
Bulk Oil ◽  
Oil In Water ◽  
Chemical Profiles ◽  
Oil In Water Emulsion

scholarly journals Development and Permeability Testing of Self-Emulsifying Atorvastatin Calcium Pellets and Tablets of Compressed Pellets

Processes ◽  
2019 ◽  
Vol 7 (6) ◽  
pp. 365 ◽  
Author(s):  
Mine Diril ◽  
Yesim Karasulu ◽  
Miltiadis Toskas ◽  
Ioannis Nikolakakis
Keyword(s):  
Drug Release ◽  
Drug Transport ◽  
Tween 20 ◽  
Water Emulsion ◽  
Atorvastatin Calcium ◽  
Solubility Improvement ◽  
Pellet Surface ◽  
Oil In Water ◽  
Presystemic Metabolism ◽  
Oil In Water Emulsion

Self-emulsifying pellets (SEPs) of Atorvastatin Calcium (AtrCa) were developed and processed into tablets (SETs). Self-emulsifying drug delivery system (SEDDS) composed of oleic acid, Tween 20, Span 80 and N-Methyl-2-pyrolidone gave great solubility improvement and was used as oil in water emulsion for the preparation of SEPs. Due to the high 60% w/w SEDDS content required to achieve a therapeutic dose in the final tablet form, sonication was necessary to improve fluidity and stability. Colloidal silicon dioxide (CSD) and microcrystalline cellulose (MCC) were the solids in the pellet formulation employed at a ratio 7:3, which enabled production of pellets with high SEDDS content and acceptable friability as well. Emulsions were characterized physico-chemically, SEPs for physical properties and reconstitution, and tablets of compressed pellets for mechanical strength, disintegration into pellets and drug release. SEPs compressed with 30% MCC at 60 MPa gave tablets of adequate strength that disintegrated rapidly into pellets within 1 min. Emulsion reconstitution took longer than drug release due to adsorption of SEDDS on CSD, implying dissolution at the pellet surface in parallel to that from the dispersed droplets. Compared to the commercial tablet, drug release from the self-emulsifying forms was faster at pH 1.2 where the drug solubility is poor, but slower at pH 6.8 where the solubility is higher. Permeability and cytotoxicity were also studied using Caco-2 cells. The results showed that drug transport from the apical to basolateral compartment of the test well was 1.27 times greater for SEPs than commercial tablets, but 0.86 times lower in the opposite direction. Statistical analysis confirmed the significance of these results. Toxicity was slightly reduced. Therefore, the increased permeability in conjunction with the protection of the drug being dissolved in the SEDDS droplets, may reduce the overall effect of presystemic metabolism and enhance bioavailability.

scholarly journals Sea Buckthorn Oil as a Valuable Source of Bioaccessible Xanthophylls

Nutrients ◽  
2019 ◽  
Vol 12 (1) ◽  
pp. 76 ◽  
Author(s):  
Cristina Tudor ◽  
Torsten Bohn ◽  
Mohammed Iddir ◽  
Francisc Vasile Dulf ◽  
Monica Focşan ◽  
...  
Keyword(s):  
In Vitro Digestion ◽  
Sea Buckthorn ◽  
Cholesterol Esterase ◽  
Water Emulsion ◽  
Oil In Water ◽  
Sea Buckthorn Oil ◽  
Oil In Water Emulsion ◽  
Zeaxanthin Dipalmitate ◽  
Β Carotene

Sea buckthorn oil, derived from the fruits of the shrub, also termed seaberry or sandthorn, is without doubt a strikingly rich source of carotenoids, in particular zeaxanthin and β-carotene. In the present study, sea buckthorn oil and an oil-in-water emulsion were subjected to a simulated gastro-intestinal in vitro digestion, with the main focus on xanthophyll bioaccessibility. Zeaxanthin mono- and di-esters were the predominant carotenoids in sea buckthorn oil, with zeaxanthin dipalmitate as the major compound (38.0%). A typical fatty acid profile was found, with palmitic (49.4%), palmitoleic (28.0%), and oleic (11.7%) acids as the dominant fatty acids. Taking into account the high amount of carotenoid esters present in sea buckthorn oil, the use of cholesterol esterase was included in the in vitro digestion protocol. Total carotenoid bioaccessibility was higher for the oil-in-water emulsion (22.5%) compared to sea buckthorn oil (18.0%) and even higher upon the addition of cholesterol esterase (28.0% and 21.2%, respectively). In the case of sea buckthorn oil, of all the free carotenoids, zeaxanthin had the highest bioaccessibility (61.5%), followed by lutein (48.9%), making sea buckthorn oil a potential attractive source of bioaccessible xanthophylls.

A Model for Lubrication by Oil-in-Water Emulsions

2009 ◽  
Vol 132 (1) ◽  
Author(s):  
Sy-Wei Lo ◽  
Tzu-Chun Yang ◽  
Yong-An Cian ◽  
Kuo-Cheng Huang
Keyword(s):  
Film Thickness ◽  
Volume Fraction ◽  
Ph Value ◽  
Oil Viscosity ◽  
Water Emulsion ◽  
Oil In Water ◽  
Critical Volume Fraction ◽  
Oil Concentration ◽  
Dynamics Simulations ◽  
Oil In Water Emulsion

A model for oil-in-water emulsion has been developed in this paper. A group of viscosity coefficients transiting smoothly and incessantly from the thick film region to the thin film region is defined. The contributions from disperse and continuous phases to the total lubricant pressure and pressure gradient are functions of the oil concentration and the film thickness. The parameters used in these functions are determined by a series of computational fluid dynamics simulations. The onset of inversion and the viscosity after inversion are also investigated. It is found that the critical volume fraction of oil in the inception of inversion is dependent on the oil viscosity and a factor regarding the combined effects from the emulsifier, pH value, droplet size, and the shear rate. A series of simulations using the proposed model has been carried out and compared with the experimental results, such as the film thickness and the extension of oil pool for various rolling speeds and supply oil concentrations. The numerical outputs are basically in agreement with the experiments.

Isolation of Fucoxanthin from Brown Algae and Its Antioxidant Activity: In Vitro and 5% Fish Oil-In-Water Emulsion

2018 ◽  
Vol 95 (7) ◽  
pp. 835-843 ◽  
Author(s):  
Sabeena Farvin Koduvayur Habeebullah ◽  
Alagarsamy Surendraraj ◽  
Charlotte Jacobsen
Keyword(s):  
Antioxidant Activity ◽  
Fish Oil ◽  
Brown Algae ◽  
Water Emulsion ◽  
Oil In Water ◽  
Oil In Water Emulsion
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