scholarly journals Acute Intake of a Grape and Blueberry Polyphenol-Rich Extract Ameliorates Cognitive Performance in Healthy Young Adults During a Sustained Cognitive Effort

Antioxidants ◽  
2019 ◽  
Vol 8 (12) ◽  
pp. 650 ◽  
Author(s):  
Pierre Philip ◽  
Patricia Sagaspe ◽  
Jacques Taillard ◽  
Claire Mandon ◽  
Joël Constans ◽  
...  
Keyword(s):  
Working Memory ◽  
Cognitive Performance ◽  
Visual Information ◽  
Fold Increase ◽  
Cognitive Effort ◽  
Double Blind Study ◽  
Level Of Evidence ◽  
Double Blind ◽  
Safe Alternative ◽  
Memory And Attention

Despite an increasing level of evidence supporting the individual beneficial effect of polyphenols on cognitive performance, information related to the potential synergistic action of these phytonutrients on cognitive performance during a prolonged cognitive effort is currently lacking. This study investigated the acute and sustained action of a polyphenols-rich extract from grape and blueberry (PEGB), on working memory and attention in healthy students during a prolonged and intensive cognitive effort. In this randomised, cross-over, double blind study, 30 healthy students consumed 600 mg of PEGB or a placebo. Ninety minutes after product intake, cognitive functions were assessed for one hour using a cognitive demand battery including serial subtraction tasks, a rapid visual information processing (RVIP) task and a visual analogical scale. Flow-mediated dilation (FMD) and plasma flavan-3-ols metabolites quantification were also performed. A 2.5-fold increase in serial three subtraction variation net scores was observed following PEGB consumption versus placebo (p < 0.001). A trend towards significance was also observed with RVIP percentage of correct answers (p = 0.058). No treatment effect was observed on FMD. Our findings suggest that consumption of PEGB coupled with a healthy lifestyle may be a safe alternative to acutely improve working memory and attention during a sustained cognitive effort.

scholarly journals Publisher Correction to: BRAINSTORMING: A study protocol for a randomised double-blind clinical trial to assess the impact of concurrent brain stimulation (tDCS) and working memory training on cognitive performance in Acquired Brain Injury (ABI)

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Sara Assecondi ◽  
Rong Hu ◽  
Gail Eskes ◽  
Michelle Read ◽  
Chris Griffiths ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Working Memory ◽  
Brain Injury ◽  
Cognitive Performance ◽  
Acquired Brain Injury ◽  
Working Memory Training ◽  
Memory Training ◽  
Double Blind ◽  
Double Blind Clinical Trial ◽  
The Impact

Following publication of the original article [1], the authors flagged that the article had published with the Acknowledgements erroneously excluded from the declarations at the end of the article.

scholarly journals 2712. Safety and Immunogenicity of two Doses of ExPEC4V Vaccine Against Extraintestinal Pathogenic Escherichia coli Disease in Healthy Adult Participants

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S954-S954
Author(s):  
William B Smith ◽  
Darren Abbanat ◽  
Bart Spiessens ◽  
Oscar Go ◽  
Wouter Haazen ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Immune Responses ◽  
Geometric Mean ◽  
Protein A ◽  
Fold Increase ◽  
Vaccine Safety ◽  
Double Blind Study ◽  
Double Blind ◽  
Grade 3 ◽  
O Antigens

Abstract Background The ExPEC4V vaccine contains 4 Escherichia coli O-antigens (O1A, O2, O6A, O25B) conjugated to exotoxin protein A and is being studied for prevention of Invasive Extraintestinal pathogenic E. coli (ExPEC) Disease (IED). This phase-2 double-blind study assessed safety and immunogenicity of ExPEC4V Clinical Trial Material (CTM), manufactured via a redesigned process (optimized O1A strain). Methods Participants (≥18 years) in stable health were randomized (3:1) to receive ExPEC4V dose 4:4:4:8 μg PS/serotype or placebo on Day 1 and second vaccination on Day 181 (6 months after first vaccination). Participants will be followed for safety until end of study at Day 360. Reactogenicity and immunogenicity (by ELISA, opsonophagocytic killing [OPA] assays) were evaluated pre-vaccination, and 15 days after first and second vaccinations (Day 195). Results Of 100 participants randomized (mean age 56, 48% males) and vaccinated (ExPEC4V, n = 75; placebo, n = 25), 97 completed Day 30. Solicited local AEs were higher for ExPEC4V (38.7%) than placebo (20%); most frequent was pain/tenderness (38.7% vs 20%). Solicited systemic AEs were higher in ExPEC4V (49.3%) than placebo (20%); most frequent was fatigue (32% vs. 12%). No serious or grade 3 solicited local AEs were reported. One participant in ExPEC4V experienced a grade 3 solicited systemic fatigue considered vaccine-related by investigator. ExPEC4V demonstrated immune responses against all serotypes at Day 15. Geometric mean titer effective concentration rank by serotypes was O2 > O1A > O6 > O25B (Figures 1 and 2). At Day 15, ≥ 82% of participants in ExPEC4V and none in placebo had ≥2-fold increase from baseline of ELISA titer for all serotypes. In ExPEC4V, ≥47% had ≥2-fold increase from baseline of OPA titer for all serotypes, while 8% in placebo had ≥2-fold increase only for O6A. Good correlation was observed between ELISA and OPA across serotypes (r ≥ 0.76). Conclusion ExPEC4V elicited robust and functional immune responses across all serotypes and was well tolerated with no vaccine safety findings. This study supports the development of future multivalent ExPEC vaccine to prevent IED. Disclosures All authors: No reported disclosures.

scholarly journals Spatially Selective Alpha Oscillations Reveal Moment-by-Moment Trade-offs between Working Memory and Attention

2018 ◽  
Vol 30 (2) ◽  
pp. 256-266 ◽  
Author(s):  
Dirk van Moorselaar ◽  
Joshua J. Foster ◽  
David W. Sutterer ◽  
Jan Theeuwes ◽  
Christian N. L. Olivers ◽  
...  
Keyword(s):  
Working Memory ◽  
Visual Information ◽  
Spatial Information ◽  
Target Location ◽  
Temporal Dynamics ◽  
Covert Attention ◽  
Attention Task ◽  
Memory And Attention ◽  
Trade Offs ◽  
Oscillatory Mechanism

Current theories assume a functional role for covert attention in the maintenance of spatial information in working memory. Consistent with this view, both the locus of attention and positions stored in working memory can be decoded based on the topography of oscillatory alpha-band (8–12 Hz) activity on the scalp. Thus far, however, alpha modulation has been studied in isolation for covert attention and working memory tasks. Here, we applied an inverted spatial encoding model in combination with EEG to study the temporal dynamics of spatially specific alpha activity during a task that required observers to visually select a target location while maintaining another independently varying location in working memory. During the memory delay period, alpha-based spatial tuning functions shifted from the position stored in working memory to the covertly attended position and back again after the attention task was completed. The findings provide further evidence for a common oscillatory mechanism in both the selection and the maintenance of relevant spatial visual information and demonstrate the dynamic trade-off in prioritization between two spatial tasks.

scholarly journals The PICO Study: Impact of Phenylalanine on Cognitive, Cerebral and Neurometabolic Parameters in Adult Patients with Phenylketonuria – a Randomized, Placebo-Controlled, Crossover, Non-inferiority Trial

2019 ◽  
Author(s):  
Roman Trepp ◽  
Raphaela Muri ◽  
Lenka Bosanska ◽  
Stephanie Abgottspon ◽  
Michel Hochuli ◽  
...  
Keyword(s):  
Working Memory ◽  
Memory Task ◽  
Brain Regions ◽  
Primary Objective ◽  
Adult Patients ◽  
Target Range ◽  
Neural Activation ◽  
Level Of Evidence ◽  
Double Blind ◽  
The Brain

Abstract Background The population of adult patients with early-treated phenylketonuria (PKU) following newborn screening is growing substantially. The ideal target range of blood Phe levels in adults outside pregnancy is discussed controversially. Therefore, prospective intervention studies are needed to evaluate the effects of an elevated Phe concentration on cognition and structural, functional and neurometabolic parameters of the brain. Methods The PICO (Phenylalanine and Its Impact on Cognition) Study evaluates the effect of a 4-week phenylalanine (Phe) load on cognition and cerebral parameters in 30 adults with early-treated PKU in a double-blind, randomized, placebo-controlled, crossover, non-inferiority trial. The primary objective of the PICO Study is to prospectively assess whether a temporarily elevated Phe level influences cognitive performance in adults with early-treated PKU. As secondary objective, the PICO Study will elucidate cerebral and neurometabolic mechanisms, which accompany changes in Phe concentration using advanced neuroimaging methods. In addition to the intervention study, cognition, structural and functional parameters of the brain of adult patients with early-treated PKU will be cross-sectionally compared to healthy controls, who will be comparable with regard to age, gender and education level. Advanced MR-techniques will be used to investigate intensity of neural activation during the working memory task (fMRI), strength of functional connectivity between brain regions related to performance in working memory (rsfMRI), white matter integrity (DTI), cerebral blood flow (ASL) and brain Phe concentrations (MRS). Discussion Using a combination of neuropsychological and neuroimaging data, the PICO study will considerably contribute to improve the currently insufficient level of evidence on how adult patients with early-treated PKU should be managed.

scholarly journals Evidence for Cognitive Placebo and Nocebo Effects in Healthy Individuals

2018 ◽  
Author(s):  
Zsolt Turi ◽  
Espen Bjørkedal ◽  
Luisa Gunkel ◽  
Andrea Antal ◽  
Walter Paulus ◽  
...  
Keyword(s):  
Cognitive Performance ◽  
Learning Performance ◽  
Double Blind Study ◽  
Double Blind ◽  
Non Invasive ◽  
Learning Rates ◽  
Adult Participants ◽  
Nocebo Effects ◽  
Study Designs ◽  
Model Based Analysis

Inactive interventions can have significant effects on cognitive performance. Understanding the generation of these cognitive placebo/nocebo effects is crucial for evaluating the cognitive impacts of interventional methods, such as non-invasive brain stimulation (NIBS). We report both cognitive placebo and nocebo effects on reward-based learning performance induced using an active sham NIBS protocol, verbal suggestions and conditioning in 80 healthy participants. Whereas our placebo manipulation increased both expected and perceived cognitive performance, nocebo had a detrimental effect on both. Model- based analysis suggests manipulation-specific strategic adjustments in learning-rates: Participants in the placebo group showed stronger learning from losses and reduced behavioral noise, whereas in the nocebo group stronger learning from gains and increased behavioral noise. We conclude that experimentally induced expectancy can impact cognitive functions of healthy adult participants. This has important implications for the use of double-blind study designs that can effectively maintain blinding in NIBS studies.

Memory Improvements and Pharmacological Treatment: A Method to Distinguish Direct Effects on Memory from Secondary Effects Due to Attention Improvement

1992 ◽  
Vol 4 (1) ◽  
pp. 119-126 ◽  
Author(s):  
Mario Fioravanti ◽  
Franco Di Cesare
Keyword(s):  
Pharmacological Treatment ◽  
Structural Model ◽  
Double Blind Study ◽  
Factor Scores ◽  
Double Blind ◽  
Direct Benefit ◽  
Cognitive Efficiency ◽  
Memory And Attention ◽  
Memory Functioning ◽  
Memory Efficiency

Chronic cerevrovascular disturbances of the aged are characterized by a decline of attention. When these patients undergo pharmacological treatment, it is very difficult to distinguish between a direct benefit and/or a secondary effect on memory resulting from attention improvement. In our study we have proposed and evaluated a new method for identifying the different components of therapeutic efficacy on memory and attention in chronic cerebrovascular patients. This method is based on the use of the Randt Memory Test, traditional scores of memory efficiency (Acquisition, Recall, and a combined index), and the RMT three-factor scores derived from a structural model of memory functioning. The three scores have been called Encoding and Organization, Cognitive Efficiency, and Attention Efficiency. Participants were 96 selected chronic cerebrovascular patients treated in a double-blind study for 12 weeks with dihydroergocristine versus placebo. While changes in both acquisition and recall scores were related to the treatment, only changes of the Encoding and Organization factor scores were systematically related to therapy. Changes in Attention Efficiency were positively related to therapy only in proportion to the degree of cerebrovascular impairment.

scholarly journals Modafinil modulates anterior cingulate function in chronic schizophrenia

2005 ◽  
Vol 187 (1) ◽  
pp. 55-61 ◽  
Author(s):  
Sean A. Spence ◽  
Russell D. Green ◽  
Iain D. Wilkinson ◽  
Mike D. Hunter
Keyword(s):  
Working Memory ◽  
Anterior Cingulate Cortex ◽  
Cognitive Performance ◽  
Cognitive Deficits ◽  
Brain Activity ◽  
Memory Task ◽  
Cingulate Cortex ◽  
Chronic Schizophrenia ◽  
Anterior Cingulate ◽  
Double Blind

BackgroundSchizophrenia is associated with widespread cognitive deficits that have an impact on social function. Modafinil promotes wakefulness and is reported to enhance cognition.AimsTo study the acute effects of modafinil administration upon brain activity and cognitive performance in people with chronic schizophrenia.MethodIn a randomised double-blind placebo-controlled crossover design, 19 patients received either modafinil (100 mg) or placebo prior to undertaking a working memory task with functional magnetic resonance imaging.ResultsSeventeen patients completed the study and another underwent acute relapse 4 days post-drug. Modafinil administration was associated with significantly greater activation in the anterior cingulate cortex during the working memory task. The anterior cingulate cortex signal correlated with cognitive performance, although only a subset of patients exhibited ‘enhancement’.ConclusionsModafinil modulates anterior cingulate cortex function in chronic schizophrenia but its beneficial cognitive effects may be restricted to a subset of patients requiring further characterisation.

Effect of a two-week rTMS treatment on brain activity in healthy subjects during a working memory task: A randomized double blind study

L Encéphale ◽  
2012 ◽  
Vol 38 (4) ◽  
pp. S21
Author(s):  
C. Gaudeau-Bosma ◽  
V. Moulier ◽  
A.-C. Allard ◽  
D. Sidhoumi ◽  
N. Bouaziz ◽  
...  
Keyword(s):  
Working Memory ◽  
Healthy Subjects ◽  
Brain Activity ◽  
Memory Task ◽  
Blind Study ◽  
Double Blind Study ◽  
Double Blind

scholarly journals THE INFLUENCE OF ISCHEMIC PRECONDITIONING ON NEUROMUSCULAR PERFORMANCE

2021 ◽  
Vol 27 (2) ◽  
pp. 207-211
Author(s):  
Vinícius José de Santana ◽  
Carlos Eduardo de Oliveira Deângelo ◽  
Vera Maria Cury Salemi ◽  
Douglas Pinheiro Miranda
Keyword(s):  
Ischemic Preconditioning ◽  
Lower Limbs ◽  
Wilcoxon Test ◽  
Double Blind Study ◽  
Level Of Evidence ◽  
Double Blind ◽  
Significance Level ◽  
Neuromuscular Performance ◽  
Results Of Treatment ◽  
The Right

ABSTRACT Introduction: Ischemic preconditioning (IPC) has been described in the literature as a resource capable of improving physical performance. Objective: The purpose of this randomized double-blind study was to evaluate the influence of IPC on the neuromuscular performance of trained individuals. Methods: Twenty-four (24) resistance training participants (6 of them women) with a mean age of 25.8 ± 4.6 years were selected and divided into two groups: the upper limb group (ULG) composed of 12 individuals (4 women) and the lower limb group (LLG) composed of 12 individuals (2 women). The maximum repetitions test was applied in the bench press for the ULG and in the 45° leg press for the LLG, with 50% of the one-repetition maximum under control, placebo and IPC conditions, at a random interval of 72 hours between tests. The IPC was applied four hours before the tests by means of an analog sphygmomanometer cuff inflated to 220 mmHg on the arm for the ULG and on the thigh for LLG, with three cycles of five minutes each of ischemia and reperfusion, alternating between the right and left sides. For the placebo, the cuff was inflated to 40 mmHg without causing ischemia. The significance level for the Wilcoxon test was p <0.017, due to the Bonferroni correction. The effect size (ES) was also analyzed. Results: With IPC, the ULG performed 34.8 ± 4.8 repetitions, representing an improvement of 11.29% (IPC vs. control, ES = 0.68 and p = 0.002) and the LLG performed 40.5 ± 15.7 repetitions, representing an improvement of 37.47% (IPC vs. control, ES = 0.84 and p = 0.002). No significant improvements were observed for the placebo in either group. Conclusion: Our data showed that IPC positively influenced neuromuscular performance of both the upper and lower limbs. Level of evidence II; Therapeutic studies investigating the results of treatment (Prospectived comparative studye).

scholarly journals Working memory training efficacy in COPD: the randomised double-blind placebo-controlled Cogtrain trial

2021 ◽  
pp. 00475-2021
Author(s):  
Martijn van Beers ◽  
Sarah W. Mount ◽  
Katrijn Houben ◽  
Harry R. Gosker ◽  
Lisanne Schuurman ◽  
...  
Keyword(s):  
Working Memory ◽  
Cognitive Performance ◽  
Healthy Lifestyle ◽  
Working Memory Training ◽  
Psychological Wellbeing ◽  
Memory Training ◽  
Second Phase ◽  
Double Blind ◽  
Cognitive Stress ◽  
Stress Susceptibility

BackgroundCognitive impairment (CI) is highly prevalent in chronic obstructive pulmonary disease (COPD) and is associated with a sedentary lifestyle, unhealthy diet and increased cognitive stress susceptibility. Enhancement of cognitive performance by working memory training (WMT) may reverse these effects. Therefore, this study aimed to investigate the efficacy of WMT in COPD on cognitive performance, healthy lifestyle behaviours and cognitive stress susceptibility.MethodsThe double-blind randomised, placebo-controlled Cogtrain trial consisted of a 12-week training phase comprising 30 active or sham WMT sessions, followed by a second 12-week maintenance phase with 12 sessions. Measurements took place at baseline and after the first and second phases. The primary outcome was cognitive performance. Secondary outcomes were the recall of prespecified healthy lifestyle goals, physical capacity and activity, dietary quality, and cognitive stress susceptibility. Motivation towards exercising and healthy eating and psychological wellbeing were exploratory outcomes.ResultsSixty-four patients with moderate COPD (45% male, aged 66.2±7.2 years, median FEV1 60.6% predicted) were randomised. WMT significantly increased patients’ performance on the trained tasks in the first phase, which remained stable in the second phase. Of the 17 cognitive outcome measures only one measure of memory improved after the first phase and one measure of reaction time after the second phase. This intervention did not influence physical capacity and activity, recall of prespecified healthy lifestyle goals, psychological wellbeing, or cognitive stress susceptibility.ConclusionWMT improved performance on the trained tasks but not overall cognitive performance, healthy lifestyle behaviours or cognitive stress susceptibility in patients with COPD.

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