scholarly journals S-Adenosylmethionine and Superoxide Dismutase 1 Synergistically Counteract Alzheimer’s Disease Features Progression in TgCRND8 Mice

Antioxidants ◽  
2017 ◽  
Vol 6 (4) ◽  
pp. 76 ◽  
Author(s):  
Rosaria Cavallaro ◽  
Vincenzina Nicolia ◽  
Maria Fiorenza ◽  
Sigfrido Scarpa ◽  
Andrea Fuso
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Superoxide Dismutase ◽  
Superoxide Dismutase 1 ◽  
Tgcrnd8 Mice

scholarly journals Is Cerebrospinal Fluid Superoxide Dismutase 1 a Biomarker of Tau But Not Amyloid-Induced Neurodegeneration in Alzheimer's Disease?

2019 ◽  
Vol 31 (8) ◽  
pp. 572-578 ◽  
Author(s):  
Kelsey E. McLimans ◽  
Bridget E. Clark ◽  
Alexandra Plagman ◽  
Colleen Pappas ◽  
Brandon Klinedinst ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Superoxide Dismutase ◽  
Superoxide Dismutase 1

scholarly journals P3-233: ASSOCIATIONS OF CSF SUPEROXIDE DISMUTASE 1 WITH COGNITIVE, NEURAL, AND CSF BIOMARKERS ACROSS THE ALZHEIMER'S DISEASE SPECTRUM

2019 ◽  
Vol 15 ◽  
pp. P1022-P1022
Author(s):  
Kelsey E. McLimans ◽  
Bridget Clark ◽  
Colleen Pappas ◽  
Alexandra K. Plagman ◽  
Tovah Wolf ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Superoxide Dismutase ◽  
Csf Biomarkers ◽  
Superoxide Dismutase 1 ◽  
Disease Spectrum

P3-378: Misfolded superoxide dismutase 1 (SOD1) as a novel target for Alzheimer's disease

2010 ◽  
Vol 6 ◽  
pp. S563-S563
Author(s):  
Leslie I. Grad ◽  
James Donkin ◽  
Megan A. O'Neill ◽  
Jing Wang ◽  
Louise A. Scrocchi ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Superoxide Dismutase ◽  
Superoxide Dismutase 1 ◽  
Novel Target

Taurine and Camel Milk Modulate Neurobehavioral and Biochemical Changes in Aluminum Chloride-Induced Alzheimer’s Disease in Rats

2021 ◽  
pp. 1-12
Author(s):  
Teslim S. Abdulkadir ◽  
Fatima A. Dawud ◽  
Ahmed Sherif Isa ◽  
Joseph O. Ayo
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Superoxide Dismutase ◽  
Aluminum Chloride ◽  
Motor Coordination ◽  
Acetylcholinesterase Activity ◽  
Camel Milk ◽  
Aβ Peptide ◽  
Model Of Alzheimer’S Disease ◽  
Female Wistar Rats

Background: Alzheimer’s disease (AD) is a neurodegenerative disease associated with deficiency in motor coordination, cognitive impairment, and excessive reactive oxygen species production in the brain. Objective: The study evaluated effects of taurine and camel milk (CM) on neurobehavior, amyloid-beta peptide 1–42 (Aβ) expression, acetylcholinesterase, and superoxide dismutase activities in aluminum chloride (AlCl3) model of Alzheimer’s disease in rats. Methods: Thirty-five female Wistar rats were divided into seven groups (n = 5): Normal saline (0.2 mL/kg body weight); AlCl3 (100 mg/kg) (AD); CM (33 mL/kg); Taurine (50 mg/kg); AlCl3 (100 mg/kg) + CM (33 mL/kg); AlCl3 (100 mg/kg) + Taurine (50 mg/kg); and AlCl3 (100 mg/kg) + CM (33 mL/kg) + Taurine (50 mg/kg). The administration lasted for eight weeks via oral gavage. After the eighth week, neurobehavior assessments were performed. Rats were sacrificed, and brain and blood samples collected for analysis. Results: There was a significant (p <  0.0001) increase in the duration of motor endurance in AD + CM rats, compared to AD rats. Duration of forced swimming time was lowest (p <  0.0001) in AlCl3 + Taurine rats, compared to that of AD rats. Concentration of Aβ peptide decreased (p <  0.05) in AD rats, treated with CM and/or combination. In taurine-treated rats, superoxide dismutase activity was significantly (p <  0.05) higher than in AD rats. Treatment with taurine + CM increased (p <  0.05) acetylcholinesterase activity compared to controls. Conclusion: Taurine and CM enhanced cognition and sensorimotor activity by decreasing Aβ peptide concentration and increasing superoxide dismutase and acetylcholinesterase activities in AD rats.

scholarly journals Therapeutic potential of astaxanthin and superoxide dismutase in Alzheimer's disease

Open Biology ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 210013
Author(s):  
Vyshnavy Balendra ◽  
Sandeep Kumar Singh
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Superoxide Dismutase ◽  
Antioxidant System ◽  
Tau Protein ◽  
Therapeutic Potential ◽  
Plaque Burden ◽  
Memory Decline ◽  
Endogenous Antioxidants ◽  
The Brain

Oxidative stress, the imbalance of the antioxidant system, results in an accumulation of neurotoxic proteins in Alzheimer's disease (AD). The antioxidant system is composed of exogenous and endogenous antioxidants to maintain homeostasis. Superoxide dismutase (SOD) is an endogenous enzymatic antioxidant that converts superoxide ions to hydrogen peroxide in cells. SOD supplementation in mice prevented cognitive decline in stress-induced cells by reducing lipid peroxidation and maintaining neurogenesis in the hippocampus. Furthermore, SOD decreased expression of BACE1 while reducing plaque burden in the brain. Additionally, Astaxanthin (AST), a potent exogenous carotenoid, scavenges superoxide anion radicals. Mice treated with AST showed slower memory decline and decreased depositions of amyloid-beta (A β ) and tau protein. Currently, the neuroprotective potential of these supplements has only been examined separately in studies. However, a single antioxidant cannot sufficiently resist oxidative damage to the brain, therefore, a combinatory approach is proposed as a relevant therapy for ameliorating pathological changes in AD.

scholarly journals Magnolol Ameliorates Behavioral Impairments and Neuropathology in a Transgenic Mouse Model of Alzheimer’s Disease

2020 ◽  
Vol 2020 ◽  
pp. 1-17 ◽  
Author(s):  
Yan-Fang Xian ◽  
Chang Qu ◽  
Yue Liu ◽  
Siu-Po Ip ◽  
Qiu-Ju Yuan ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Deficits ◽  
Molecular Mechanisms ◽  
Interleukin 10 ◽  
Spatial Learning And Memory ◽  
Necrosis Factor Alpha ◽  
App Processing ◽  
Model Of Alzheimer’S Disease ◽  
Tgcrnd8 Mice

Alzheimer’s disease (AD) is a common neurodegenerative disease characterized by progressive memory loss. Magnolol (MN), the main active ingredient of Magnolia officinalis, possesses anti-AD effects in several experimental models of AD. In this study, we aimed to explore whether MN could ameliorate the cognitive deficits in TgCRND8 transgenic mice and to elucidate its molecular mechanisms. Male TgCRND8 mice were orally administered with MN (20 and 40 mg/kg) daily for 4 consecutive months, followed by assessing the spatial learning and memory functions using the open-field, radial arm maze, and novel object recognition tests. The results demonstrated that MN (20 and 40 mg/kg) could markedly ameliorate the cognitive deficits in TgCRND8 mice. In addition, MN significantly increased the expression of postsynaptic density protein 93 (PSD93), PSD-95, synapsin-1, synaptotagmin-1, synaptophysin (SYN), and interleukin-10 (IL-10), while markedly reduced the protein levels of tumor necrosis factor alpha (TNF-α), IL-6, IL-1β, Aβ40, and Aβ42, and modulated the amyloid precursor protein (APP) processing and phosphorylation. Immunofluorescence showed that MN significantly suppressed the activation of microglia (Iba-1) and astrocytes (GFAP) in the hippocampus and cerebral cortex of TgCRND8 mice. Mechanistic studies revealed that MN could significantly increase the ratios of p-GSK-3β (Ser9)/GSK-3β, p-Akt (Ser473)/Akt, and p-NF-κB p65/NF-κB p65. These findings indicate that MN exerted cognitive deficits improving effects via suppressing neuroinflammation, amyloid pathology, and synaptic dysfunction through regulating the PI3K/Akt/GSK-3β and NF-κB pathways, suggesting that MN is a promising naturally occurring polyphenol worthy of further developing into a therapeutic agent for AD treatment.

scholarly journals Neuroprotective Effect of Ethanol Extract of Leaves of Malva parviflora against Amyloid-β- (Aβ-) Mediated Alzheimer’s Disease

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Muhammad Aslam ◽  
Ali Akbar Sial
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Superoxide Dismutase ◽  
Water Maze ◽  
Neuroprotective Effect ◽  
Amyloid Β ◽  
Ethanol Extract ◽  
Neuroprotective Activity ◽  
Malva Parviflora ◽  
Lipid Peroxidase

Malva parviflora L. possesses significant antioxidant potential. This study was conducted to evaluate the neuroprotective effect of ethanol extract of the leaves of Malva parviflora against amyloid-β- (Aβ-) mediated Alzheimer’s disease. In Morris water maze model, the extract significantly restored the defected memory of amyloid-β injected mice (P<0.01). The reduced levels of brain antioxidant enzymes such as glutathione peroxidase, glutathione reductase, catalase, and superoxide dismutase were also restored significantly to similar levels as seen in normal control mice (P<0.01). The levels of lipid peroxidase were decreased significantly in treatment group mice when compared to Alzheimer group mice (P<0.01). So, this study showed that ethanol extract of the leaves of Malva parviflora possesses neuroprotective activity in mice.

scholarly journals Motor deficits are independent of axonopathy in an Alzheimer's disease mouse model of TgCRND8 mice

Oncotarget ◽  
2017 ◽  
Vol 8 (58) ◽  
pp. 97900-97912 ◽  
Author(s):  
Qiuju Yuan ◽  
Jian Yang ◽  
Wutian Wu ◽  
Zhi-Xiu Lin
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Motor Deficits ◽  
Tgcrnd8 Mice
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