scholarly journals Chemical Analysis of Astragali Complanati Semen and Its Hypocholesterolemic Effect Using Serum Metabolomics Based on Gas Chromatography-Mass Spectrometry

Antioxidants ◽  
2017 ◽  
Vol 6 (3) ◽  
pp. 57 ◽  
Author(s):  
Tung Sham ◽  
Huan Zhang ◽  
Daniel Mok ◽  
Shun Chan ◽  
Jianhong Wu ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Chemical Analysis ◽  
Gas Chromatography Mass Spectrometry ◽  
Hypocholesterolemic Effect ◽  
Chromatography Mass Spectrometry ◽  
Serum Metabolomics

Neuritogenic and Neuroprotective Activities of the Essential Oil From Rhizomes of Curcuma alismatifolia

2019 ◽  
Vol 14 (7) ◽  
pp. 1934578X1986421
Author(s):  
Sirote Kochaphum ◽  
Parinya Banyat ◽  
Sarin Tadtong ◽  
Vipaporn Sareedenchai ◽  
Sirivan Athikomkulchai
Keyword(s):  
Mass Spectrometry ◽  
Gas Chromatography ◽  
Antioxidant Activity ◽  
Chemical Analysis ◽  
Essential Oil ◽  
Cell Viability ◽  
Neuroprotective Activity ◽  
Gas Chromatography Mass Spectrometry ◽  
Chromatography Mass Spectrometry ◽  
Neuritogenic Activity

The essential oil from rhizomes of Curcuma alismatifolia Gagnep. was extracted by hydrodistillation. Chemical analysis by gas chromatography-mass spectrometry identified 12 compounds, of which the most prominent were xanthorrhizol (82.2%), ar-curcumene (6.5%), α-cedrene (1.8%), and β-bisabolol (1.1%). The essential oil at 1 ng/mL showed neuroprotective and neuritogenic activity on P19-derived neurons by significantly enhancing cell viability, length, and branching numbers of the cultured P19-derived neurons. In addition, xanthorrhizol, the major compound of the essential oil, at 10 ng/mL also exhibited the protection of P19-derived neurons. However, the mechanism of their neuroprotective activity was not correlated with their antioxidant activity.

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