scholarly journals Dietary Antioxidants and Brain Health: Focus on Cognitive and Affective Disorders

Antioxidants ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 1659
Author(s):  
Justyna Godos ◽  
Giuseppe Grosso
Keyword(s):  
Risk Factors ◽  
Mental Disorders ◽  
Neurodegenerative Diseases ◽  
Affective Disorders ◽  
Brain Health ◽  
Dietary Antioxidants ◽  
Global Challenges

Today’s society faces major global challenges, including the continuously increasing prevalence of mental disorders and neurodegenerative diseases, with different risk factors contributing to the trend [...]

Unwanted pregnancy as a risk factor for offspring schizophrenia-spectrum and affective disorders in adulthood: a prospective high-risk study

2008 ◽  
Vol 39 (6) ◽  
pp. 957-965 ◽  
Author(s):  
T. F. McNeil ◽  
E. W. Schubert ◽  
E. Cantor-Graae ◽  
M. Brossner ◽  
P. Schubert ◽  
...  
Keyword(s):  
Risk Factors ◽  
High Risk ◽  
Mental Disorders ◽  
Genetic Risk ◽  
Affective Disorders ◽  
Early Life ◽  
Unwanted Pregnancy ◽  
Psychosocial Factor ◽  
Schizophrenia Spectrum Disorders ◽  
Schizophrenia Spectrum

BackgroundThis study investigated whether ‘unwanted pregnancy’ (i.e. a negative or ambivalent attitude towards the pregnancy/reproduction) is associated with schizophrenia-spectrum and affective disorders in the offspring in adulthood, and if so, whether other pregnancy, perinatal, childhood or genetic-risk factors account for this association.MethodIn a prospective study beginning during pregnancy, unwanted pregnancy (in combination with other early life risk factors) was studied in relation to adult mental disorders in 75 genetic high-risk (HR) and 91 normal-risk (NR) offspring, defined through maternal psychosis history. Early life risk factors were studied through personal interviews, observations and medical records, and offspring mental disorders were independently diagnosed through follow-up examination at about 22 years of age.ResultsUnwanted pregnancy by itself was significantly related to adult offspring schizophrenia-spectrum disorders in both the total sample and the HR subgroup, but the effect was found to be limited to the HR group and occurred in interaction with genetic risk. Other co-temporaneous pregnancy stressors and later perinatal complications, malformations and early childhood environmental stressors could not explain this relationship. Unwanted pregnancy also interacted with genetic-risk status in relating to affective disorders in the offspring.ConclusionsUnwanted pregnancy, when occurring together with genetic risk for psychosis, was found to be related to both adult schizophrenia-spectrum and affective mental disorders in the offspring. Although the effect of unwanted pregnancy could be mediated by other yet-unidentified factors, unwanted pregnancy might be a functional, discrete environmental psychosocial factor with its own deleterious impact on offspring mental development, when co-occurring with genetic risk.

Children of Parents with Bipolar Disorder: A Metaanalysis of Risk for Mental Disorders

1997 ◽  
Vol 42 (6) ◽  
pp. 623-631 ◽  
Author(s):  
Micheline Lapalme ◽  
Sheilagh Hodgins ◽  
Catherine LaRoche
Keyword(s):  
Risk Factors ◽  
Bipolar Disorder ◽  
Mental Disorders ◽  
Mental Disorder ◽  
Affective Disorder ◽  
Affective Disorders ◽  
Selection Criteria ◽  
Childhood And Adolescence ◽  
Prevalence Rates ◽  
Raw Data

Objective: To compare the prevalence rates of mental disorders among children of parents with bipolar disorder and of parents with no mental disorders. Method: Seventeen studies, meeting specific selection criteria, were included in the metaanalyses. Risks for mental disorders among children were estimated by aggregating raw data from the selected studies. Results: Results indicate that in comparison with children of parents with no mental disorders, children of parents with bipolar disorder are 2.7 times more likely to develop any mental disorder and 4.0 times more likely to develop an affective disorder. The metaanalyses indicate that during childhood and adolescence, the risks for any mental disorder and for affective disorders in children are consistently but moderately related to having a parent who suffers from bipolar disorder. Conclusions: Risk factors that could account for the psychopathology observed in children of bipolar parents are explored.

“Don’t praise the day before the sunset”: Paremiology in the study of depressiveness

2021 ◽  
pp. 1354067X2110257
Author(s):  
Mariusz Wołońciej ◽  
Michał Wilczewski ◽  
Shulamith Kreitler
Keyword(s):  
Mental Disorders ◽  
Affective Disorders ◽  
Personal Experience ◽  
Mental States ◽  
Important Research ◽  
Adequate Model ◽  
Narrative Structures ◽  
Collective Experience ◽  
Practical Implications ◽  
Different Levels

Psychology and psychiatry are in a constant search for an adequate model of affective disorders. Psychology has classified depression as a mood disorder, but a growing literature links mental disorders with socioculturally relevant ways in which people experience and express distress. With this study, we link depression with proverbs as omnipresent narrative structures and mini-theories that help people interpret reality and categorize personal experience. Proverbs are omnipresent narrative structures that describe, explain, and prescribe human behavior. Hence, we offer a paremiological approach to better understand the minds of the depressed. Our tenet is that proverbs may also reflect people’s mental states and attitudes by conveying different levels of optimism versus pessimism. We evidence empirically that proverbs convey optimistic and pessimistic attitudes and, thus, have the capacity to capture peoples’ mental states. Moreover, we show that this capacity is limited for people with high depressiveness. Finally, we discuss how proverbial thinking links collective experience and wisdom imprinted in proverbs with an individual’s mental states, which has important research and practical implications.

scholarly journals Molecular and cellular pathways contributing to brain aging

2021 ◽  
Vol 17 (1) ◽  
Author(s):  
Aliabbas Zia ◽  
Ali Mohammad Pourbagher-Shahri ◽  
Tahereh Farkhondeh ◽  
Saeed Samarghandian
Keyword(s):  
Neurodegenerative Diseases ◽  
Neurodegenerative Disorders ◽  
Brain Aging ◽  
Neuroprotective Effect ◽  
Ros Generation ◽  
Brain Health ◽  
Cellular Pathways ◽  
Aging Mechanisms ◽  
Oxidatively Modified ◽  
Biology Of Aging

AbstractAging is the leading risk factor for several age-associated diseases such as neurodegenerative diseases. Understanding the biology of aging mechanisms is essential to the pursuit of brain health. In this regard, brain aging is defined by a gradual decrease in neurophysiological functions, impaired adaptive neuroplasticity, dysregulation of neuronal Ca2+ homeostasis, neuroinflammation, and oxidatively modified molecules and organelles. Numerous pathways lead to brain aging, including increased oxidative stress, inflammation, disturbances in energy metabolism such as deregulated autophagy, mitochondrial dysfunction, and IGF-1, mTOR, ROS, AMPK, SIRTs, and p53 as central modulators of the metabolic control, connecting aging to the pathways, which lead to neurodegenerative disorders. Also, calorie restriction (CR), physical exercise, and mental activities can extend lifespan and increase nervous system resistance to age-associated neurodegenerative diseases. The neuroprotective effect of CR involves increased protection against ROS generation, maintenance of cellular Ca2+ homeostasis, and inhibition of apoptosis. The recent evidence about the modem molecular and cellular methods in neurobiology to brain aging is exhibiting a significant potential in brain cells for adaptation to aging and resistance to neurodegenerative disorders.

scholarly journals Low Birth Weight Prevalence in Children Diagnosed with Neurodevelopmental Disorders in Dubai

2021 ◽  
Vol 8 ◽  
pp. 2333794X2110317
Author(s):  
Faisal A. Nawaz ◽  
Meshal A. Sultan
Keyword(s):  
Risk Factors ◽  
Birth Weight ◽  
Mental Disorders ◽  
Low Birth Weight ◽  
Neurodevelopmental Disorders ◽  
Autism Spectrum ◽  
High Birth Weight ◽  
Perinatal Risk Factors ◽  
Perinatal Risk ◽  
The Impact

The aim of this study is to evaluate the prevalence of low birth weight and other perinatal risk factors in children diagnosed with neurodevelopmental disorders. This is one of the first studies in the Arabian Gulf region focused on the contribution of these factors toward the development of various disorders such as attention-deficit/hyperactivity disorder, autism spectrum disorder, and other mental disorders. This descriptive study was based on qualitative data analysis. We reviewed retrospective information from the electronic medical records of 692 patients in Dubai, United Arab Emirates. The prevalence of low birth weight in children with mental disorders was significantly higher as compared to the general population (16% vs 6% respectively). Furthermore, other risk factors, including high birth weight and preterm birth were noted to have a significant association with neurodevelopmental disorders. Future research on the impact of perinatal risk factors will contribute to advancement of early intervention guidelines.

Prevalence of Mental Disorders by Socioeconomic Status in Australia: A Cross-Sectional Epidemiological Study

2020 ◽  
pp. 089011712096865
Author(s):  
Rubayyat Hashmi ◽  
Khorshed Alam ◽  
Jeff Gow ◽  
Sonja March
Keyword(s):  
Mental Health ◽  
Risk Factors ◽  
Socioeconomic Status ◽  
Mental Disorders ◽  
National Health Survey ◽  
Cross Sectional ◽  
Lower Odds ◽  
Socioeconomic Groups ◽  
Income Groups ◽  
Weighted Prevalence

Purpose: To present the prevalence of 3 broad categories of mental disorder (anxiety-related, affective and other disorders) by socioeconomic status and examine the associated socioeconomic risk factors of mental disorders in Australia. Design: A population-based, cross-sectional national health survey on mental health and its risk factors across Australia. Setting: National Health Survey (NHS), 2017-2018 conducted by the Australian Bureau of Statistics (ABS) Participants: Under aged: 4,945 persons, Adult: 16,370 persons and total: 21,315 persons Measures: Patient-reported mental disorder outcomes Analysis: Weighted prevalence rates by socioeconomic status (equivalised household income, education qualifications, Socio-Economic Index for Areas (SEIFA) scores, labor force status and industry sector where the adult respondent had their main job) were estimated using cross-tabulation. Logistic regression utilizing subsamples of underage and adult age groups were analyzed to test the association between socioeconomic status and mental disorders. Results: Anxiety-related disorders were the most common type of disorders with a weighted prevalence rate of 20.04% (95% CI: 18.49-21.69) for the poorest, 13.85% (95% CI: 12.48-15.35) for the richest and 16.34% (95% CI: 15.7-17) overall. The weighted prevalence rate for mood/affective disorders were 20.19% (95% CI: 18.63-21.84) for the poorest, 9.96% (95% CI: 8.79-11.27) for the richest, and 13.57% (95% CI: 12.99-14.17) overall. Other mental disorders prevalence were for the poorest: 9.07% (95% CI: 7.91-10.39), the richest: 3.83% (95% CI: 3.14-4.66), and overall: 5.93% (95% CI: 5.53-6.36). These patterns are also reflected if all mental disorders were aggregated with the poorest: 30.97% (95% CI: 29.15-32.86), the richest: 19.59% (95% CI: 18.02-21.26), and overall: 23.93% (95% CI: 23.19-24.69). The underage logistic regression model showed significant lower odds for the middle (AOR: 0.75, 95% CI: 0.53 -1.04, p < 0.1), rich (AOR: 0.71, 95% CI: 0.5-0.99, p < 0.05) and richest (AOR: 0.6, 95% CI: 0.41-0.89, p < 0.01) income groups. Similarly, in the adult logistic model, there were significant lower odds for middle (AOR: 0.84, 95% CI: 0.72-0.98, p < 0.05), rich (AOR: 0.73, 95% CI: 0.62-0.86, p < 0.01) and richest (AOR: 0.76, 95% CI: 0.63-0.91, p < 0.01) income groups. Conclusion: The prevalence of mental disorders in Australia varied significantly across socioeconomic groups. Knowledge of different mental health needs in different socioeconomic groups can assist in framing evidence-based health promotion and improve the targeting of health resource allocation strategies.

Mental disorders as risk factors for suicidal behavior in young people: A meta-analysis and systematic review of longitudinal studies

2019 ◽  
Vol 245 ◽  
pp. 152-162 ◽  
Author(s):  
Margalida Gili ◽  
Pere Castellví ◽  
Margalida Vives ◽  
Alejandro de la Torre-Luque ◽  
José Almenara ◽  
...  
Keyword(s):  
Risk Factors ◽  
Systematic Review ◽  
Young People ◽  
Mental Disorders ◽  
Longitudinal Studies ◽  
Suicidal Behavior ◽  
Meta Analysis

scholarly journals Implementing the Proclamation of Stroke and Potentially Preventable Dementias

2018 ◽  
Vol 13 (8) ◽  
pp. 780-786 ◽  
Author(s):  
Vladimir Hachinski ◽  
Detlev Ganten ◽  
Daniel Lackland ◽  
Reinhold Kreutz ◽  
Konstantinos Tsioufis ◽  
...  
Keyword(s):  
Risk Factors ◽  
Alzheimer Disease ◽  
Large Population ◽  
Therapeutic Approaches ◽  
Brain Health ◽  
Vascular Dysregulation ◽  
New Therapeutic Approaches ◽  
The World ◽  
National Organizations ◽  
Recent Developments

Brain health plays a central role in wellbeing and in the management of chronic diseases. Stroke and dementia pose the two greatest threats to brain health, but recent developments suggest the possibility that preventing stroke may also prevent some dementias: 1. A large population study showed a 32% decrease in the incidence of stroke and a concomitant 7% reduction in the incidence of dementia; 2. Treatment of atrial fibrillation resulted not only in stroke reduction, but a 48% decrease in dementia; 3. A hypothesis free analyses has shown that the first phase of Alzheimer disease involves vascular dysregulation, opening the door to new therapeutic approaches; 4. Cognitive impairment, often treatable and reversible, accompanies heart and kidney failure. These developments, combined with the knowledge that stroke, dementia and heart disease share the same major treatable risk factors, particularly hypertension, offers an opportunity for their joint prevention. This aspiration is expressed by a Proclamation of the World Stroke Organization on Stroke and Potentially Preventable Dementias and endorsed by the World Heart Federation, the World Hypertension League, Alzheimer Disease International and 18 other international, regional and national organizations as a call for action.

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