scholarly journals Phytochemistry, Pharmacology, and Toxicology of Datura Species—A Review

Antioxidants ◽  
2021 ◽  
Vol 10 (8) ◽  
pp. 1291
Author(s):  
Meenakshi Sharma ◽  
Inderpreet Dhaliwal ◽  
Kusum Rana ◽  
Anil Kumar Delta ◽  
Prashant Kaushik
Keyword(s):  
Cardiac Glycosides ◽  
Tropane Alkaloids ◽  
Bioactive Constituents ◽  
Pharmacological Activities ◽  
Plant Parts ◽  
Wide Range ◽  
Potential Risks ◽  
Medicinal Properties ◽  
Pharmacology And Toxicology ◽  
Solanaceae Family

Datura, a genus of medicinal herb from the Solanaceae family, is credited with toxic as well as medicinal properties. The different plant parts of Datura sp., mainly D. stramonium L., commonly known as Datura or Jimson Weed, exhibit potent analgesic, antiviral, anti-diarrheal, and anti-inflammatory activities, owing to the wide range of bioactive constituents. With these pharmacological activities, D. stramonium is potentially used to treat numerous human diseases, including ulcers, inflammation, wounds, rheumatism, gout, bruises and swellings, sciatica, fever, toothache, asthma, and bronchitis. The primary phytochemicals investigation on plant extract of Datura showed alkaloids, carbohydrates, cardiac glycosides, tannins, flavonoids, amino acids, and phenolic compounds. It also contains toxic tropane alkaloids, including atropine, scopolamine, and hyoscamine. Although some studies on D. stramonium have reported potential pharmacological effects, information about the toxicity remains almost uncertain. Moreover, the frequent abuse of D. stramonium for recreational purposes has led to toxic syndromes. Therefore, it becomes necessary to be aware of the toxic aspects and the potential risks accompanying its use. The present review aims to summarize the phytochemical composition and pharmacological and toxicological aspects of the plant Datura.

scholarly journals Ethnobotanical, Phytochemical, Pharmacological, and Toxicological Aspects ofPersicaria hydropiper(L.) Delarbre

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
A. K. M. Moyeenul Huq ◽  
Jamia Azdina Jamal ◽  
Johnson Stanslas
Keyword(s):  
Major Group ◽  
Evidence Based ◽  
Pharmacological Activities ◽  
Herbal Products ◽  
Plant Parts ◽  
Traditional Uses ◽  
Botanical Description ◽  
Medicinal Properties ◽  
Pharmacology And Toxicology ◽  
Phytochemical Components

Persicaria hydropiper(L.) Delarbre, belonging to Polygonaceae family, is a common weed found in most of the temperate countries including Bangladesh, China, Malaysia, and Japan. The plant is also referred to as “marsh pepper” or “smart weed.” It appears to be a useful herb with evidence-based medicinal properties. The present work addresses the botanical description, traditional uses, phytochemistry, pharmacology, and toxicology ofP. hydropiper. All plant parts have been commonly used in the traditional systems of medicines. Flavonoids are the major group of phytochemical components followed by drimane-type sesquiterpenes and sesquiterpenoids, as well as phenylpropanoids. Different extracts and plant parts showed remarkable pharmacological activities including antioxidant, antibacterial, antifungal, antihelminth, antifeedant, cytotoxicity, anti-inflammatory, antinociceptive, oestrogenicity, antifertility, antiadipogenicity, and neuroprotection. Mutagenicity and acute and subchronic toxicities of the plant were also reported.P. hydropiperhas tremendous medicinal properties that could further be investigated for the development of evidence-based herbal products.

Phytochemical Constituents of Guggul and their Biological Qualities

2020 ◽  
Vol 17 (3) ◽  
pp. 277-288 ◽  
Author(s):  
Vijay Kumar ◽  
Simranjeet Singh ◽  
Ravindra Singh
Keyword(s):  
Pharmacological Activities ◽  
Commiphora Wightii ◽  
Toxicological Studies ◽  
Wide Range ◽  
Commiphora Mukul ◽  
Medicinal Properties ◽  
Phytochemical Constituents ◽  
Herbal Formulations

: In the herbal drug pharmaceutical industry, guggul is enjoying emergent consumer acceptance around the world. In the Indian market, more than fifty formulations of guggul have been introduced by well-known brands including Himalaya, Patanjali and Baidyanath Pharmaceuticals. Basically, guggul is the gum resin from Commiphora wightii (syn. Commiphora Mukul). It has been used to treat various ailments including obesity, osteoarthritis, arthritis, constipation, liver disorders, inflammation, anemia, diabetes, etc. Including medicinal properties, it is used as a good binding agent and mixed in various herbal formulations. To review the major phytochemical, medicinal properties and analytical methods involved in the detection of guggul by using the exhaustive bibliographic research by means of various scientific engines and databases. Guggul contained approximately 66 phytochemical including gallic acid, quercetin, and guggulsterones E and Z. These phytochemicals have a wide range of pharmacological activities such as antioxidant, antibacterial, antimutagenic, antivenom and antitumor. It has been noticed that the mode of action of guggulsterone has not been fully explored. Pharmacology and toxicological studies are very few. These works have shown huge literature gap, which is to be fulfilled through the detailed in-vivo and in-vitro studies.

scholarly journals From Traditional Usage to Pharmacological Evidence: Systematic Review ofGunnera perpensaL.

2016 ◽  
Vol 2016 ◽  
pp. 1-14 ◽  
Author(s):  
Alfred Maroyi
Keyword(s):  
Biological Activities ◽  
Pharmaceutical Products ◽  
Future Research ◽  
Pharmacological Activities ◽  
Sexually Transmitted ◽  
Animal Diseases ◽  
Wide Range ◽  
Medicinal Properties ◽  
Human And Animal Diseases

Gunnera perpensais the only species of the genusGunnerathat has been recorded in Africa. Its leaves, rhizomes, roots, and stems are reported to possess diverse medicinal properties and used to treat or manage various human and animal diseases and ailments.Gunnera perpensais an ingredient in many herbal concoctions and prescriptions which have been used to induce or augment labour, postnatal medication, to treat parasitic diseases, urinary complaints, kidney problems, general body pains, sexually transmitted infections, and many other diseases. Several classes of phytochemicals including alkaloids, benzoquinones, ellagic acids, flavonoids, phenols, proanthocyanidins, tannins, and minerals have been isolated fromG. perpensa. Scientific studies onG. perpensaindicate that it has a wide range of pharmacological activities including acetylcholinesterase, anthelmintic, antibacterial, antifungal, antinociceptive, anti-inflammatory, antioxidant, antitumour, lactogenic, and uterotonic.Gunnera perpensahas a lot of potential as a possible source of pharmaceutical products for the treatment of a wide range of both human and animal diseases and ailments. Some of the chemical compounds isolated fromG. perpensahave demonstrated various biological activities when investigated inin vitroassays. Future research should focus on the mechanisms of action of the isolated compounds, their efficacy, toxicity, and clinical relevance.

scholarly journals REVIEW ON NYCTANTHES ARBOR-TRISTIS (HARSINGHAR) - A HERBAL MEDICAMENT WITH SPECIAL REFERENCE TO UNANI MEDICINE

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Azma Azma ◽  
Waseem Ahmad ◽  
Asim Ali Khan ◽  
Mohammad Fazil
Keyword(s):  
Cardiac Glycosides ◽  
Therapeutic Potential ◽  
Herbal Drugs ◽  
Pharmacological Activities ◽  
Unani Medicine ◽  
Pharmacological Studies ◽  
Different Types ◽  
Medicinal Properties ◽  
Coloring Matter ◽  
Different Parts

Nyctanthes arbor-tristis Linn is one of the important herbal drugs used for therapeutic purpose in India. It is described with the name 'Harsinghar' in Unani Medicine. Various parts of the plant are used medicinally to cure various diseases since centuries ago. These medicinal properties of the plant are due to the active phytochemicals present in the plant. Various chemicals have been isolated from this miracle plant having therapeutic potential possessing ethnomedical and pharmacological activities. It is a rich source of important phytochemicals like nycanthine, astringent principle, beta cortisol, coloring matter, tannins, flavonoids, cardiac glycosides, saponins and alkaloids etc. Pharmacological actions of Harsinghar include cholagogue, anthelmintic, laxative, antipyretic, diaphoretic, diuretic; for which the the plant is employed in the treatment of skin disorders, dandruff, malaria, different types of fever, hemorrhoids, palpitation, cough, excessive menstrual bleeding menstrual etc. Diverse pharmacological studies of the plant have been reported such as antimicrobial, anti-inflammatory, antidepressant, antipyretic, antioxidant activity proving the traditional claims scientifically. In this paper, an attempt has been made to summarize the information described in classical Unani texts and updated scientific research conducted on different parts of the N. arbor-tristis plant.

scholarly journals Chemical constituents and pharmacological activities of Mirabilis jalapa- A review

2021 ◽  
Vol 1 (2) ◽  
pp. 034-045
Author(s):  
Ali Esmail Al-Snafi ◽  
Tayseer Ali Talab ◽  
Wajdi M. Jabbar ◽  
Ali M. Alqahtani
Keyword(s):  
Cardiac Glycosides ◽  
Chemical Constituents ◽  
Therapeutic Effects ◽  
Pharmacological Effects ◽  
Phytochemical Screening ◽  
Pharmacological Activities ◽  
Current Review ◽  
Wide Range ◽  
Pharmacological Studies ◽  
Mirabilis Jalapa

Mirabilis jalapa was used traditionally in the treatment of kidney infections, as diuretic, tonic, cathartic, purgative and emetic. The phytochemical screening of the extracts of the leaves and stems of the Mirabilis jalaparevealed the presence of tannins, alkaloids, flavonoids, phenolic compounds, carbohydrates, terpenes, glycosides, saponins, protein, cardiac glycosides, steroids and emodin. The previous pharmacological studies revealed that Mirabilis jalapa possessed wide range of pharmacological and therapeutic effects included antimicrobial, antiparasitic, dermatological, anticancer, anti-inflammatory, analgesic, antidiabetic, antihistaminic, immune-modulatory, antispasmodic and many other pharmacological effects. The chemical constituents, nutritional, pharmacological and therapeutic effects ofMirabilis jalapawere discussed in the current review.

scholarly journals ASSESSMENT OF ANTIMICROBIAL ACTIVITY OF AZADIRACHTA INDICA FROM MAHALAPURAM, JAIPUR

2019 ◽  
Vol 8 (3) ◽  
Author(s):  
Sweta Mishra ◽  
Vishnu Sharma ◽  
Rincy Yesudas ◽  
Ritu Singh Rajput
Keyword(s):  
Antimicrobial Activity ◽  
Azadirachta Indica ◽  
Cardiac Glycosides ◽  
Bioactive Constituents ◽  
Phytochemical Study ◽  
Antimicrobial Studies ◽  
The World ◽  
Aqueous Leaf Extract ◽  
Medicinal Properties ◽  
Positive Results

The medicinal plants have been used for years in daily life to treat infections all over the world. Azadirachta indica is a very valuable traditional therapeutic plant in the sub-continent regions. Each part of the tree has remarkable medicinal properties. In the present study, Phytochemical study yielded positive results for tannins, cardiac glycosides, anthraquinones, and saponins. The terpenoids was found to be missing. In antimicrobial studies, the organic and aqueous Leaf extract of Azadirachta indica found to show inhibitory action against the growth of Staphylococcus aureus and Escherichia coli that reveal the presence of pharmacologically bioactive constituents in Azadirachta indica. Key words: Nature; Azadirachta indica; Ayurveda; antimicrobial activity

scholarly journals Solanum tuberosum L: Botanical, Phytochemical, Pharmacological and Nutritional Significance

2018 ◽  
Vol 10 (3) ◽  
pp. 115
Author(s):  
Anjum Sahair R ◽  
Sneha S ◽  
Raghu N ◽  
Gopenath TS ◽  
Murugesan Karthikeyan ◽  
...  
Keyword(s):  
Solanum Tuberosum ◽  
Nutritional Value ◽  
Geographic Origin ◽  
Pantothenic Acid ◽  
Vitamin B3 ◽  
Pharmacological Activities ◽  
Collective Data ◽  
Medicinal Properties ◽  
Phytochemical Constituents ◽  
Solanaceae Family

<p>Solanum tuberosum commonly known as potato belongs to solanaceae family. The whole part of potato plant including leaves; tuber, peel and juice are used in traditional medicine. A number of pharmacological activities of potato have been reported viz. Antioxidant, anticancer, antiallergy, antibacterial, anti-inflammatory, antiobesity, anti-ulcer activity. Potato contains Phenolic acids, anthocyanin, flavonoids, vitamin B6, vitamin B3, pantothenic acid, potassium, manganese, phosphorous; copper and fibres. The medicinal properties, traditional uses, nutritional value, phytochemical constituents, taxonomy, geographic origin and distribution have been mentioned in this present review to provide collective data for multipurpose benefits.</p><p> </p>

scholarly journals MESUA FERREA LINN. (NAGKESAR): A POTENT ANTIMICROBIAL PLANT SPECIES

2021 ◽  
pp. 6-13
Author(s):  
SHIFALI THAKUR ◽  
HEMLATA KAURAV ◽  
GITIKA CHAUDHARY
Keyword(s):  
Chemical Constituents ◽  
Vital Role ◽  
New Drugs ◽  
Renal Diseases ◽  
General Description ◽  
Bioactive Constituents ◽  
Pharmacological Activities ◽  
Herbal Plants ◽  
Medicinal Properties ◽  
Therapeutic Activities

Many plants have not been investigated thoroughly, which are used traditionally as a medicine to cure various diseases. Herbal plants play a vital role in the development of new drugs which can be used for various therapeutic indications. Mesua ferrea linn., commonly known as 'Nagchampa' or 'Nagkesar', is one such herbal plant having many potential therapeutic activities. It is used in diseases like rheumatism, asthma, inflammation, fever, dyspepsia, renal diseases, dysentery, bleeding piles, a bacterial and fungal infection. This plant possesses many bioactive chemical constituents like coumarins, xanthones, pyranoxanthones, flavonoids, terpenoids and steroids which can be easily isolated. It can act as precursors on many ailments. These bioactive constituents have many pharmacological activities such as anticancer, antimicrobial, antifungal, anti-inflammatory, anti-arthritis, analgesic, diuretic, anti-hemorrhoid, antiulcer and many more. Almost every part of the plant is reported to have beneficial medicinal properties. But further studies are still needed to explore the pharmacological activities of Mesua ferrea linn. plant so as to gain benefit for the treatment of various diseases. This review highlights the general description, phytochemical profiling, traditional uses and proven pharmacological attributes of Mesua ferrea linn. plant.

Ethnomedicinal uses, Phytochemistry and Pharmacological Aspects of the Genus Berberis Linn: A Comprehensive Review

2020 ◽  
Vol 23 ◽  
Author(s):  
Roohi Mohi-ud-din ◽  
Reyaz Hassan Mir ◽  
Prince Ahad Mir ◽  
Saeema Farooq ◽  
Syed Naiem Raza ◽  
...  
Keyword(s):  
Chemical Constituents ◽  
Pharmacological Activities ◽  
Traditional Use ◽  
Comprehensive Review ◽  
Wide Range ◽  
Anti Cancer ◽  
Comprehensive Survey ◽  
Ethnomedicinal Uses

Background: Genus Berberis (family Berberidaceae), which contains about 650 species and 17 genera worldwide, has been used in folklore and various traditional medicine systems. Berberis Linn. is the most established group among genera with around 450-500 species across the world. This comprehensive review will not only help researchers for further evaluation but also provide substantial information for future exploitation of species to develop novel herbal formulations. Objective: The present review is focussed to summarize and collect the updated review of information of Genus Berberis species reported to date regarding their ethnomedicinal information, chemical constituents, traditional/folklore use, and reported pharmacological activities on more than 40 species of Berberis. Conclusion: A comprehensive survey of the literature reveals that various species of the genus possess various phytoconstituents mainly alkaloids, flavonoid based compounds isolated from different parts of a plant with a wide range of pharmacological activities. So far, many pharmacological activities like anti-cancer, anti-hyperlipidemic, hepatoprotective, immunomodulatory, anti-inflammatory both in vitro & in vivo and clinical study of different extracts/isolated compounds of different species of Berberis have been reported, proving their importance as a medicinal plant and claiming their traditional use.

Nanoparticles Functionalized with Venom-Derived Peptides and Toxins for Pharmaceutical Applications

2020 ◽  
Vol 21 (2) ◽  
pp. 97-109 ◽  
Author(s):  
Ana P. dos Santos ◽  
Tamara G. de Araújo ◽  
Gandhi Rádis-Baptista
Keyword(s):  
Oral Absorption ◽  
Current Data ◽  
Pharmacological Activities ◽  
Venom Peptides ◽  
Essential Components ◽  
Wide Range ◽  
Different Types ◽  
Direct Use ◽  
Animal Venoms ◽  
Pharmaceutical Biotechnology

Venom-derived peptides display diverse biological and pharmacological activities, making them useful in drug discovery platforms and for a wide range of applications in medicine and pharmaceutical biotechnology. Due to their target specificities, venom peptides have the potential to be developed into biopharmaceuticals to treat various health conditions such as diabetes mellitus, hypertension, and chronic pain. Despite the high potential for drug development, several limitations preclude the direct use of peptides as therapeutics and hamper the process of converting venom peptides into pharmaceuticals. These limitations include, for instance, chemical instability, poor oral absorption, short halflife, and off-target cytotoxicity. One strategy to overcome these disadvantages relies on the formulation of bioactive peptides with nanocarriers. A range of biocompatible materials are now available that can serve as nanocarriers and can improve the bioavailability of therapeutic and venom-derived peptides for clinical and diagnostic application. Examples of isolated venom peptides and crude animal venoms that have been encapsulated and formulated with different types of nanomaterials with promising results are increasingly reported. Based on the current data, a wealth of information can be collected regarding the utilization of nanocarriers to encapsulate venom peptides and render them bioavailable for pharmaceutical use. Overall, nanomaterials arise as essential components in the preparation of biopharmaceuticals that are based on biological and pharmacological active venom-derived peptides.

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