scholarly journals Coenzyme Q10 Analogues: Benefits and Challenges for Therapeutics

Antioxidants ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 236
Author(s):  
Juan M. Suárez-Rivero ◽  
Carmen J. Pastor-Maldonado ◽  
Suleva Povea-Cabello ◽  
Mónica Álvarez-Córdoba ◽  
Irene Villalón-García ◽  
...  
Keyword(s):  
Mitochondrial Dysfunction ◽  
Coenzyme Q10 ◽  
Water Solubility ◽  
Antioxidant Properties ◽  
Mitochondrial Respiratory Chain ◽  
Medical Applications ◽  
Mobile Proton ◽  
Electron Carrier ◽  
The Past ◽  
Pathological Conditions

Coenzyme Q10 (CoQ10 or ubiquinone) is a mobile proton and electron carrier of the mitochondrial respiratory chain with antioxidant properties widely used as an antiaging health supplement and to relieve the symptoms of many pathological conditions associated with mitochondrial dysfunction. Even though the hegemony of CoQ10 in the context of antioxidant-based treatments is undeniable, the future primacy of this quinone is hindered by the promising features of its numerous analogues. Despite the unimpeachable performance of CoQ10 therapies, problems associated with their administration and intraorganismal delivery has led clinicians and scientists to search for alternative derivative molecules. Over the past few years, a wide variety of CoQ10 analogues with improved properties have been developed. These analogues conserve the antioxidant features of CoQ10 but present upgraded characteristics such as water solubility or enhanced mitochondrial accumulation. Moreover, recent studies have proven that some of these analogues might even outperform CoQ10 in the treatment of certain specific diseases. The aim of this review is to provide detailed information about these Coenzyme Q10 analogues, as well as their functionality and medical applications.

scholarly journals Vitamin K2 cannot substitute Coenzyme Q10 as electron carrier in the mitochondrial respiratory chain of mammalian cells

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Cristina Cerqua ◽  
Alberto Casarin ◽  
Fabien Pierrel ◽  
Luis Vazquez Fonseca ◽  
Giampiero Viola ◽  
...  
Keyword(s):  
Respiratory Chain ◽  
Coenzyme Q10 ◽  
Mammalian Cells ◽  
Mitochondrial Respiratory Chain ◽  
Vitamin K2 ◽  
Electron Carrier ◽  
Mitochondrial Respiratory

Oleanolic Acid Derived from Plants: Synthesis and Pharmacological Properties of A-ring Modified Derivatives

2020 ◽  
Vol 17 (9) ◽  
pp. 1084-1101
Author(s):  
Tingjuan Wu ◽  
Xu Yao ◽  
Guan Wang ◽  
Xiaohe Liu ◽  
Hongfei Chen ◽  
...  
Keyword(s):  
Drug Design ◽  
Oleanolic Acid ◽  
Water Solubility ◽  
Future Application ◽  
The Novel ◽  
Pharmacological Effects ◽  
Framework Structure ◽  
Design And Synthesis ◽  
The Past ◽  
The Relationship

Background: Oleanolic Acid (OA) is a ubiquitous product of triterpenoid compounds. Due to its inexpensive availability, unique bioactivities, pharmacological effects and non-toxic properties, OA has attracted tremendous interest in the field of drug design and synthesis. Furthermore, many OA derivatives have been developed for ameliorating the poor water solubility and bioavailability. Objective: Over the past few decades, various modifications of the OA framework structure have led to the observation of enhancement in bioactivity. Herein, we focused on the synthesis and medicinal performance of OA derivatives modified on A-ring. Moreover, we clarified the relationship between structures and activities of OA derivatives with different functional groups in A-ring. The future application of OA in the field of drug design and development also was discussed and inferred. Conclusion: This review concluded the novel achievements that could add paramount information to the further study of OA-based drugs.

scholarly journals Coenzyme Q10 and Immune Function: An Overview

Antioxidants ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 759
Author(s):  
David Mantle ◽  
Robert A. Heaton ◽  
Iain P. Hargreaves
Keyword(s):  
Immune System ◽  
Immune Function ◽  
Coenzyme Q10 ◽  
Mitochondrial Respiratory Chain ◽  
Inflammatory Gene Expression ◽  
Optimal Functioning ◽  
Human Immune ◽  
Coq10 Supplementation ◽  
Lipid Soluble Antioxidant

Coenzyme Q10 (CoQ10) has a number of important roles in the cell that are required for optimal functioning of the immune system. These include its essential role as an electron carrier in the mitochondrial respiratory chain, enabling the process of oxidative phosphorylation to occur with the concomitant production of ATP, together with its role as a potential lipid-soluble antioxidant, protecting the cell against free radical-induced oxidation. Furthermore, CoQ10 has also been reported to have an anti-inflammatory role via its ability to repress inflammatory gene expression. Recently, CoQ10 has also been reported to play an important function within the lysosome, an organelle central to the immune response. In view of the differing roles CoQ10 plays in the immune system, together with the reported ability of CoQ10 supplementation to improve the functioning of this system, the aim of this article is to review the current literature available on both the role of CoQ10 in human immune function and the effect of CoQ10 supplementation on this system.

CORDIAL CYBORG

2021 ◽  
pp. 29-31
Author(s):  
Saumya Jaiswal ◽  
Shivangi Tiwari ◽  
Vivek Kumar Tripathi ◽  
Ajay Sharma
Keyword(s):  
Direct Contact ◽  
Medical Robotics ◽  
Medical Applications ◽  
Collaborative Robotics ◽  
Medical Robots ◽  
The Past ◽  
Medicine Prescription ◽  
Hospital Stays ◽  
Return Home ◽  
Spread Of Infection

1. What are robots used in healthcare? Areas within healthcare which are starting to use robots include: telepresence, rehabilitation, medical transportation, sanitization and prescription dispensing. But we are most interested in collaborative robotics. We will be discussing the COBOT(Cordial Robot) applications. Most modern healthcare robots are especially designed for their target applications. 2. Is it possible to use robotics in medicine? Robotics in medicine can happen in many ways, here are some. Healthcare has been predicted as “a promising industry for robotics” for the past 45 years or more. Since as far back as 1974, researchers have been looking for ways to incorporate robotics into medical applications. 3. Is there a need for more surgery/telepresence/rehabilitation/medical transportation/sanitation and disinfection/medicine prescription dispensing robots? There is denitely a need for many more surgery robots, laparoscopic, endoscopic and nanorobots, as the technology allows more functionalities with miniature propulsion mechanisms. M.A. Zenati, M. Mahvash, from the science of medical robotics, 2012. 4. How are medical robots used to treat patients, reduce contact, and cure pain? Using the medical robots reduces the direct contact between the doctor and the patient, helps in reducing pain, by minimizing the need for more medication and longer hospital stays, allowing the person to return home by the therapy sooner without any spread of infection.

Ubiquinone (coenzyme Q10) prevents renal mitochondrial dysfunction in an experimental model of type 2 diabetes

2012 ◽  
Vol 52 (3) ◽  
pp. 716-723 ◽  
Author(s):  
Karly C. Sourris ◽  
Brooke E. Harcourt ◽  
Peter H. Tang ◽  
Amy L. Morley ◽  
Karina Huynh ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Mitochondrial Dysfunction ◽  
Experimental Model ◽  
Coenzyme Q10

scholarly journals Coenzyme Q10 and its effects in the treatment of neurodegenerative diseases

2009 ◽  
Vol 45 (4) ◽  
pp. 607-618 ◽  
Author(s):  
Graciela Cristina dos Santos ◽  
Lusânia Maria Greggi Antunes ◽  
Antonio Cardozo dos Santos ◽  
Maria de Lourdes Pires Bianchi
Keyword(s):  
Neurodegenerative Diseases ◽  
Health Risks ◽  
Coenzyme Q10 ◽  
Cellular Respiration ◽  
Irreversible Loss ◽  
Beneficial Effects ◽  
Pathological Conditions ◽  
Electron Transportation ◽  
The Brain ◽  
Lateral Sclerosis

According to clinical and pre-clinical studies, oxidative stress and its consequences may be the cause or, at least, a contributing factor, to a large number of neurodegenerative diseases. These diseases include common and debilitating disorders, characterized by progressive and irreversible loss of neurons in specific regions of the brain. The most common neurodegenerative diseases are Parkinson's disease, Huntington's disease, Alzheimer's disease and amyotrophic lateral sclerosis. Coenzyme Q10 (CoQ10) has been extensively studied since its discovery in 1957. It is a component of the electron transportation chain and participates in aerobic cellular respiration, generating energy in the form of adenosine triphosphate (ATP). The property of CoQ10 to act as an antioxidant or a pro-oxidant, suggests that it also plays an important role in the modulation of redox cellular status under physiological and pathological conditions, also performing a role in the ageing process. In several animal models of neurodegenerative diseases, CoQ10 has shown beneficial effects in reducing disease progression. However, further studies are needed to assess the outcome and effectiveness of CoQ10 before exposing patients to unnecessary health risks at significant costs.

scholarly journals Targeting Mitochondria as Therapeutic Strategy for Metabolic Disorders

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Daniela Sorriento ◽  
Antonietta Valeria Pascale ◽  
Rosa Finelli ◽  
Anna Lisa Carillo ◽  
Roberto Annunziata ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Mitochondrial Dysfunction ◽  
Small Molecules ◽  
Metabolic Disorders ◽  
Therapeutic Strategy ◽  
Cell Metabolism ◽  
Therapeutic Interventions ◽  
Mtdna Mutations ◽  
Pathological Conditions ◽  
Mitochondria Targeting

Mitochondria are critical regulator of cell metabolism; thus, mitochondrial dysfunction is associated with many metabolic disorders. Defects in oxidative phosphorylation, ROS production, or mtDNA mutations are the main causes of mitochondrial dysfunction in many pathological conditions such as IR/diabetes, metabolic syndrome, cardiovascular diseases, and cancer. Thus, targeting mitochondria has been proposed as therapeutic approach for these conditions, leading to the development of small molecules to be tested in the clinical scenario. Here we discuss therapeutic interventions to treat mitochondrial dysfunction associated with two major metabolic disorders, metabolic syndrome, and cancer. Finally, novel mechanisms of regulation of mitochondrial function are discussed, which open new scenarios for mitochondria targeting.

scholarly journals Development and evaluation of coenzyme Q10 loaded solid lipid nanoparticle hydrogel for enhanced dermal delivery

2013 ◽  
Vol 63 (4) ◽  
pp. 517-529 ◽  
Author(s):  
Emrah Korkm ◽  
Evren H. Gokce ◽  
Ozgen Ozer
Keyword(s):  
Coenzyme Q10 ◽  
High Speed ◽  
Antioxidant Properties ◽  
Spherical Shape ◽  
Entrapment Efficiency ◽  
Tween 80 ◽  
Trolox Equivalent Antioxidant Capacity ◽  
Scanning Calorimetry ◽  
Transmission Electron Microscopy Analysis ◽  
Solid Lipid

Abstract Coenzyme Q10 (Q10) loaded solid lipid nanoparticles (SLN) were prepared by the high speed homogenization method and incorporated into Carbopol 974P hydrogels. Compritol 888 ATO (C888) was employed as the lipid base; Poloxamer 188 (P188) and Tween 80 (Tw80) were used as surfactant and co-surfactant. Optimum particle size with narrow distribution was obtained as 152.2 nm for blank and 142.4 nm for Q10 loaded SLNs. The overall charge of loaded SLNs was -13.7 ± 1.3 mV. Q10 entrapment efficiency was 89 % and the production yield was 94 %. Transmission electron microscopy analysis provided evidence of colloidal size, spherical shape while differential scanning calorimetry analysis confirmed recrystallization of the lipid after the preparation of SLNs. Trolox equivalent antioxidant capacity (TEAC) analysis has shown that antioxidant potential of Q10 can be protected in SLNs. Rheological characteristics demonstrated that the SLN incorporating gels were shear thinning and the mechanical strength of the gels was suitable for topical application. Diffusion studies from rat abdominal skin revealed that the delivery of Q10 was doubled in SLN incorporating gels, approximately 40 μg cm-2, in comparison with gels prepared with only Q10 (not incorporated in SLNs). As a result, it can be stated that Q10-SLN loaded gels can be successful delivery systems for carrying Q10 efficiently into the skin without losing its antioxidant properties.

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