scholarly journals Dietary Energy Levels Affect Growth Performance through Growth Hormone and Insulin-Like Growth Factor 1 in Yak (Bos grunniens)

Animals ◽  
2019 ◽  
Vol 9 (2) ◽  
pp. 39 ◽  
Author(s):  
Chao Yang ◽  
Jianbo Zhang ◽  
Anum Ahmad ◽  
Pengjia Bao ◽  
Xian Guo ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Energy Level ◽  
Growth Performance ◽  
Growth Hormone Receptor ◽  
Energy Levels ◽  
High Energy ◽  
Dietary Energy ◽  
Insulin Like Growth Factor ◽  
Feed Conversion

The objective of this study was to investigate the effects of different dietary energy levels on serum concentrations of growth hormone (GH) and insulin-like growth factor 1 (IGF-1), as well as gene expression of their associated binding proteins and receptors in yak. Fifteen adult male yaks with BW of 276.1 ± 3.5 kg were allotted in three dietary groups and were fed with low (LE), medium (ME), and high energy (HE) level diet having different NEg of 5.5 MJ/kg, 6.2 MJ/kg, 6.9 MJ/kg, respectively. The effects of these treatments on ADG, BW, ADFI, and feed conversion ratio were significant (p < 0.05) throughout the experimental period. Serum GH concentration decreased (p < 0.05) with an increase in dietary energy level on d 30 and d 60. While IGF-1 concentration was higher (p < 0.05) in ME group, as compared to LE and HE groups on d 60. The expression level of growth hormone receptor (GHR) was decreased (p < 0.001) and IGF-1 was increased with the increase in the dietary energy level. The relative expression of insulin-like growth factor binding protein 3 (IGFBP-3) was higher (p < 0.001) in ME and HE groups, except the LE group. In conclusion, our findings provide a first insight into the combined effect of GH and IGF-1 in controlling the metabolism and productivity of yak. It also showed that medium energy level diet contributed to promote growth performance of yak during the cold season.

The effects of dietary energy and crude protein concentration on growth and serum insulin-like growth factor-I levels of cattle that differ in mature body size

1993 ◽  
Vol 73 (2) ◽  
pp. 303-313 ◽  
Author(s):  
J. J. McKinnon ◽  
R. D. H. Cohen ◽  
B. Laarveld ◽  
D. A. Christensen ◽  
S. D. M. Jones
Keyword(s):  
Growth Factor ◽  
Energy Level ◽  
Crude Protein ◽  
High Energy ◽  
Carcass Composition ◽  
Dietary Energy ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Igf I ◽  
Growth Factor I

An experiment was conducted to examine the influence of dietary energy level (11.17 and 11.88 MJ ME kg−1 DM) and crude protein (CP) level (11, 13 and 15% DM basis) on growth and carcass composition and plasma insulin-like growth factor-I (IGF-I) levels of medium frame (MF) and large frame (LF) cattle. Dietary energy level or CP level did not influence the growth of MF steers. Averaged across energy levels, the growth of LF steers increased linearly (P < 0.01; R2 = 0.60) with dietary CP level. No influence of protein level was observed on carcass tissue gain. Apparent CP and DM digestibilities increased (P < 0.05) with increasing CP level on low- but not high-energy rations. Serum IGF-I levels were higher (P < 0.05) in MF steers and in animals fed high-energy rations. Little or no association was observed between serum IGF-I levels and indices of growth or carcass composition. It was concluded that the growth of LF steers was improved on diets formulated to CP levels in excess of those currently recommended. However, the biological mechanism responsible for the improved growth is not clear. Key words: Steers, frame size, protein, energy, IGF-I

scholarly journals High-energy diet does not overcome the negative impact of conjugated linoleic acid on young broiler performance

2020 ◽  
Vol 43 ◽  
pp. e51128
Author(s):  
Katia Maria Cardinal ◽  
Júlia Guazzelli Pezzali ◽  
Lucas de Marques Vilella ◽  
Priscila de Oliveira Moraes ◽  
Andréa Machado Leal Ribeiro
Keyword(s):  
Linoleic Acid ◽  
Energy Level ◽  
Growth Performance ◽  
Conjugated Linoleic Acid ◽  
Negative Impact ◽  
Energy Levels ◽  
High Energy ◽  
Dietary Energy ◽  
Broiler Performance ◽  
Negative Effect

The aim of this study was to evaluate the effect of conjugated linoleic acid (CLA) supplementation in diets with different energy levels in broiler performance. Birds were offered a starter (1-21 d), grower (22-35 d) and finisher (36-42 d) diets; wherein soybean oil was replaced by CLA. The study consisted of a 3 × 2 factorial arrangement with two CLA levels (0 and 1%) and three energy levels (3050, 3100 and 3150 ME kg-1 diet). During the grower and finisher periods, birds were fed diets with same energy level and CLA supplementation was maintained the same. Growth performance was assessed weekly, and carcass and cuts yield were assessed at 42d. Interaction effect of CLA by energy level was observed in broiler performance and carcass yield throughout the study (p > 0.05). During the overall period (1-42 d) broiler performance was not affected by CLA (p > 0.05).However, CLA supplementation (1%) decreased weight gain (p < 0.05) at 21d, regardless of energy level, with no effects on feed intake and feed conversation rate (p > 0.05). The increase in dietary energy was not able to compensate the negative effect on growth performance of broilers supplemented with 1% CLA at the starter period.

scholarly journals Dose-response effects of a new growth hormone receptor antagonist (B2036-PEG) on circulating, hepatic and renal expression of the growth hormone/insulin-like growth factor system in adult mice

2000 ◽  
Vol 167 (2) ◽  
pp. 295-303 ◽  
Author(s):  
JW van Neck ◽  
NF Dits ◽  
V Cingel ◽  
IA Hoppenbrouwers ◽  
SL Drop ◽  
...  
Keyword(s):  
Growth Hormone ◽  
Growth Factor ◽  
Receptor Antagonist ◽  
Growth Hormone Receptor ◽  
Binding Protein ◽  
Mrna Levels ◽  
Insulin Like Growth Factor ◽  
Gh Receptor ◽  
Igf I ◽  
Igfbp 3

The effects of growth hormone (GH) in regulating the expression of the hepatic and renal GH and insulin-like growth factor (IGF) system were studied by administering a novel GH receptor antagonist (GHRA) (B2036-PEG) at different doses (0, 1.25, 2.5, 5 and 10 mg/kg/day) to mice for 7 days. No differences were observed in the groups with respect to body weight, food consumption or blood glucose. However, a dose-dependent decrease was observed in circulating IGF-I levels and in hepatic and renal IGF-I levels at the highest doses. In contrast, in the 5 and 10 mg/kg/day GHRA groups, circulating and hepatic transcriptional IGF binding protein-3 (IGFBP-3) levels were not modified, likely resulting in a significantly decreased IGF-I/IGFBP-3 ratio. Hepatic GH receptor (GHR) and GH binding protein (GHBP) mRNA levels increased significantly in all GHRA dosage groups. Endogenous circulatory GH levels increased significantly in the 2.5 and 5 mg/kg/day GHRA groups. Remarkably, increased circulating IGFBP-4 and hepatic IGFBP-4 mRNA levels were observed in all GHRA administration groups. Renal GHR and GHBP mRNA levels were not modified by GHRA administration at the highest doses. Also, renal IGFBP-3 mRNA levels remained unchanged in most GHRA administration groups, whereas IGFBP-1, -4 and -5 mRNA levels were significantly increased in the 5 and 10 mg/kg/day GHRA administration groups. In conclusion, the effects of a specific GHR blockade on circulating, hepatic and renal GH/IGF axis reported here, may prove useful in the future clinical use of GHRAs.

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