scholarly journals Evaluation of Tear Production as Measured by Schirmer Test I in Dogs after Acepromazine and Acepromazine–Methadone Premedication

Animals ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 3015
Author(s):  
Claudia Giannetto ◽  
Francesco Macrì ◽  
Annastella Falcone ◽  
Elisabetta Giudice ◽  
Rosalia Crupi ◽  
...  
Keyword(s):  
Repeated Measures ◽  
Experimental Protocol ◽  
Schirmer Test ◽  
Corneal Hydration ◽  
Tear Production ◽  
Schirmer Tear Test ◽  
Data Points ◽  
Experimental Protocols ◽  
Post Hoc ◽  
Major Reduction

The purpose of the current study was to investigate the effects of two commonly used sedation protocols in dogs, acepromazine (ACP) and acepromazine–methadone (ACP–MET) combination, on tear production measured by the Schirmer Tear Test (STT) 1. We hypothesized that both sedation protocols cause a reduction in canine tear production for a variable time. Fifteen client-owned dogs were recruited for the study. Each dog was subjected to sedation twice, 2–3 weeks apart, and they were randomly allocated to one of two groups receiving ACP (0.015 mg kg−1) or ACP–MET (0.010 mg kg−1 and 0.2 mg kg−1) intramuscularly. In both eyes, tear production was measured 15 min before sedation (T0) and 20 min (T20 m), 40 min (T40 m), 1 h (T1), 2 h (T2), 4 h (T4) and 8 h (T8), after drug administration. Two-way repeated measures ANOVA, followed by the Bonferroni post hoc test (p < 0.05), showed a significant effect of time (p < 0.0001) and treatment (p < 0.0001). A significant decrease in tear production at T20 m, T40 m, T1 and T2 compared to T0 was observed in the ACP experimental protocol, while in the ACP + MET protocol, this reduction persisted until T8. Comparing the two experimental protocols, no statistically significant differences were observed at T0 or T20 m, and STT 1 values were statistically lower in the ACP + MET than the ACP protocol at the other data points. In the ACP + MET group, at T40 m, 100% of dogs showed STT 1 readings lower than 15 mm/min. This finding is clinically relevant as it can predispose dogs to corneal injuries. The major reduction in tear production due to the ACP + MET protocol proves the need for adequate corneal hydration, particularly to discourage its use in animals with altered tear production. The data obtained provide important information helping clinicians to better manage the drug’s effects on tear production.

scholarly journals Effects of tramadol on tear production, intraocular pressure, and pupil size in dogs: clinical study

2015 ◽  
Vol 45 (4) ◽  
pp. 724-729 ◽  
Author(s):  
Thaís Ruiz ◽  
Thalita Priscila da Silva Peres ◽  
Wilma Neres da Silva Campos ◽  
Eveline da Cruz Boa Sorte ◽  
Alexandre Pinto Ribeiro
Keyword(s):  
Intraocular Pressure ◽  
Repeated Measures ◽  
Pupil Diameter ◽  
Keratoconjunctivitis Sicca ◽  
Applanation Tonometry ◽  
Tramadol Hydrochloride ◽  
Tear Production ◽  
Schirmer Tear Test ◽  
Healthy Dogs ◽  
To Receive

This study aimed to evaluate the effects of tramadol on tear production, intraocular pressure (IOP) and pupil diameter (PD) in healthy dogs. Dogs were randomly assigned to receive 4mg kg-1 (n=11) and 6mg kg-1 (n=11) of tramadol hydrochloride intramuscularly. Tear production (Schirmer tear test, STT-1), IOP (applanation tonometry) and the PD (electronic pachymetry) were assessed before, 30 and 60 minutes after administration of tramadol. Data were compared by analysis of variance for repeated measures (P<0.05). Parameters evaluated before, at 30 and 60min, in dogs treated with 4 and 6mg kg-1, were respectively: (STT-1) 22.50±3.38, 21.14±3.94 and 21.09±2.99mm min-1; and 23.05±3.73,22.64±3.76 and 22.82±3.25mm min-1. (IOP) 18.14±2.68, 17.68±2.59 and 18.23±3.84mmHg; and 19.05±2.27, 18.91±2.74 and 17.64±2.34mmHg. (PD) 6.71±0.65, 7.22±1.42 and 6.90±1.39mm; and 6.25±1.08, 6.80±1.27 and 6.49±0.90mm. All parameters evaluated did not change significantly among time points and dose regimen. Based on the conditions under which the experiments were conducted, tramadol did not affect tear production, IOP and PD in dogs, and could be used as a preoperative analgesic for intraocular surgery and pain control for any cause in patients affected by uveitis, glaucoma and keratoconjunctivitis sicca

scholarly journals Efficacy of galcanezumab in patients with migraine who did not benefit from commonly prescribed preventive treatments

BMC Neurology ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Dulanji K. Kuruppu ◽  
Joshua Tobin ◽  
Yan Dong ◽  
Sheena K. Aurora ◽  
Laura Yunes-Medina ◽  
...  
Keyword(s):  
Repeated Measures ◽  
Migraine Headache ◽  
Mixed Model ◽  
Preventive Treatment ◽  
Response Rates ◽  
Toxin A ◽  
Double Blind ◽  
Preventive Medication ◽  
Onabotulinum Toxin A ◽  
Post Hoc

Abstract Background Galcanezumab is a calcitonin gene-related peptide (CGRP) monoclonal antibody (mAb) indicated for the preventive treatment of migraine. While galcanezumab has demonstrated efficacy in patients who did not respond to prior preventive medications in general, its efficacy in patients who did not benefit from individual, commonly prescribed preventive treatments due to inadequate efficacy or safety/tolerability remains unknown. Methods CONQUER was a 3-month, randomized, double-blind, placebo-controlled, phase 3b study that enrolled patients with episodic or chronic migraine who had 2 to 4 migraine preventive medication category failures in the past 10 years. Patients were randomly assigned 1:1 to receive placebo (N = 230) or galcanezumab 120 mg/month (240 mg loading dose; N = 232). Post hoc analyses were conducted to determine the efficacy of galcanezumab in patients who had not benefited from six of the most commonly prescribed migraine preventive medications. The mean change from baseline in monthly migraine headache days and ≥ 50 % response rates were assessed over months 1–3. Improvement in Migraine-Specific Questionnaire Role Function-Restrictive (MSQ-RFR) scores were assessed at month 3. The endpoints were estimated via mixed model with repeated measures. Results The most common treatment failures due to inadequate efficacy or safety/tolerability, which at least 20 % of patients reported trying without benefit, included topiramate, amitriptyline, propranolol, valproate or divalproex, onabotulinum toxin A, and metoprolol. Patients who had not previously benefited from these treatments had a greater mean reduction in monthly migraine headache days across months 1–3 in the galcanezumab group compared to placebo (all p < 0.01). More patients treated with galcanezumab experienced a ≥ 50 % reduction from baseline in monthly migraine headache days across months 1–3 compared to placebo (all p < 0.05). Galcanezumab-treated patients had a greater improvement in mean MSQ-RFR scores at month 3 compared to placebo (all p < 0.01). Conclusions In this population, galcanezumab was effective in reducing monthly migraine headache days, improving response rates, and enhancing quality of life in patients who had not previously benefited from topiramate, amitriptyline, propranolol, valproate or divalproex, onabotulinum toxin A, and/or metoprolol due to inadequate efficacy or safety/tolerability. Trial registration ClinicalTrials.gov NCT03559257 (CONQUER).

Effect of acepromazine or xylazine on tear production as measured by Schirmer tear test in normal cats

2010 ◽  
Vol 13 (1) ◽  
pp. 1-3 ◽  
Author(s):  
Masoud Selk Ghaffari ◽  
Abdolali Malmasi ◽  
Saied Bokaie
Keyword(s):  
Tear Production ◽  
Schirmer Tear Test

Interfacial Nanoleakage and Bonding of Self-Adhesive Systems Cured with a Modified-Layering Technique to Dentin of Weakened Roots

2013 ◽  
Vol 38 (5) ◽  
pp. E154-E165 ◽  
Author(s):  
E Mobarak ◽  
R Seyam
Keyword(s):  
Bond Strength ◽  
Repeated Measures ◽  
Adhesive Systems ◽  
Root Canals ◽  
Root Region ◽  
Modes Of Failure ◽  
Group A ◽  
Post Hoc ◽  
Vertise Flow ◽  
Self Etch

SUMMARY Objective The purpose of the study was to evaluate the nanoleakage and bond strength of different self adhesive systems cured with a modified-layering technique (MLT) to dentin of weakened roots. Methods Twenty-one maxillary incisors were decoronated and then root canals were instrumented and obturated with the cold lateral compaction technique. Weakened roots were simulated by flaring root canals until only 1 mm dentin thickness remained. Teeth were distributed into three groups. The canals were backfilled with Vertise Flow (VF group), a self-adhering system, following a modified-layering technique using two light-transmitting posts, sizes 6 and 3. DT Light Post size 2 was cemented using the same material. Remaining roots were prepared and cured in the same way as the VF group. However, in the TS/MF group, Clearfil Tri-S Bond (TS) adhesive and Clearfil Majesty Flow (MF) composite were used, while in the ED/PF group, ED primer II (ED)/Panavia F2.0 (PF) were used. After one week of storage, each root was sectioned to obtain six slices (two slices from each root third: coronal, middle and apical) of 0.9 ± 0.1 mm thickness. Interfacial nanoleakage expression was analyzed using a field emission scanning electron microscope (FEG-SEM), and the micro push-out bond strength (μPOBS) was measured at different root regions. Modes of failure were also determined using SEM. Data were statistically analyzed using two-way analysis of variance with repeated measures and Tukey post hoc test (p≤0.05). Results With MLT, all adhesive systems showed nanoleakage. For μPOBS, there was a statistically significant effect for adhesive systems (p&lt;0.001) but not for root region (p&lt;0.64) or for their interaction (p=0.99). Tukey post hoc test revealed that the bond strength of the VF group was significantly higher than the TS/MF and ED/PF groups for all root regions. Conclusion All of the tested self-adhesive systems cured using MLT had slight nanoleakage and were not sensitive to root regional differences. Self-adhering systems had higher bond strength than self-etch adhesives.

scholarly journals Evaluation of tear production with modified Schirmer tear test-1 during the neonatal period in cats

2011 ◽  
Vol 31 (4) ◽  
pp. 350-354 ◽  
Author(s):  
L.F. Conceição ◽  
A.P. Ribeiro ◽  
M.L.M. Torres ◽  
M.L.G. Lourenço ◽  
J.L. Laus
Keyword(s):  
Reference Values ◽  
Neonatal Period ◽  
Positive Correlation ◽  
Tear Secretion ◽  
Tear Production ◽  
Schirmer Tear Test ◽  
Maturity Parameters ◽  
Time Point

The study aimed to evaluate tear production by means of modified Schirmer tear tes-1 (mSTT-1) in neonate cats. Likewise, correlation between mSTT-1 and STT-1 was assessed in vitro. Standard SST strips were cut in half and after eye lid opening, tear production of neonates (n=15) was daily measured in both eyes (mSTT-1), until the 7th day, and at day 14, 21, and 28. Animals were daily weighted until 28 days of age. Results were compared statistically (P<0.05). During the first 7 days, the overall mSTT-1 mean was 0.76 wetting/minute. Significant differences between right and left eyes were not observed at any time point (P=1.00). Tear secretion increased significantly, from the 14th to 28th day, in comparison with 7 first days (P<0.05). Positive correlation between maturity parameters and tear secretion was observed (P<0.0001). Distance between slopes of each strip changed significantly (P<0.0001). It was concluded that tear secretion in the neonatal period of cats is very below the reference values described for young and adults of the same species. It is not possible to extrapolate results obtained with mSTT-1 to standard STT-1.

Tear production in canine neonates - evaluation using a modified Schirmer tear test

2012 ◽  
Vol 16 (3) ◽  
pp. 175-179 ◽  
Author(s):  
Enry Garcia da Silva ◽  
Lynne S. Sandmeyer ◽  
Juliet R. Gionfriddo ◽  
Fabiano Montiani-Ferreira ◽  
Paula D. Galera
Keyword(s):  
Tear Production ◽  
Schirmer Tear Test

scholarly journals Depth-Related Curing Potential of Ormocer- and Dimethacrylate-Based Bulk-Fill Composites

Materials ◽  
2021 ◽  
Vol 14 (22) ◽  
pp. 6753
Author(s):  
Ramona S. Oltramare ◽  
Reto Odermatt ◽  
Phoebe Burrer ◽  
Thomas Attin ◽  
Tobias T. Tauböck
Keyword(s):  
Double Bond ◽  
Repeated Measures ◽  
In Vitro Study ◽  
High Viscosity ◽  
Degree Of Conversion ◽  
Double Bond Conversion ◽  
Nanohybrid Composite ◽  
Post Hoc ◽  
One Way Anova

The aim of this in vitro study was to investigate the degree of C=C double bond conversion of high-viscosity dimethacrylate- or ormocer-based bulk-fill composites as a function of measurement depth. Four bulk-fill composites (Tetric EvoCeram Bulk Fill, x-tra fil, SonicFill, and Bulk Ormocer) and the conventional nanohybrid composite Tetric EvoCeram were applied in standardized Class II cavities (n = 6 per group) and photoactivated for 20 s at 1350 mW/cm2. The degree of conversion of the composites was assessed using Fourier-transform infrared spectroscopy at seven measurement depths (0.15, 1, 2, 3, 4, 5, 6 mm). Data were analyzed using repeated measures ANOVA and one-way ANOVA with Bonferroni post-hoc tests (α = 0.05). The investigated bulk-fill composites showed at least 80% of their maximum degree of conversion (80% DCmax) up to a measuring depth of at least 4 mm. Tetric EvoCeram Bulk Fill and Bulk Ormocer achieved more than 80% DCmax up to a measuring depth of 5 mm, x-tra fil up to 6 mm. The conventional nanohybrid composite Tetric EvoCeram achieved more than 80% DCmax up to 3 mm. In contrast to the conventional composite, the investigated ormocer- and dimethacrylate-based bulk-fill composites can be photo-polymerized in thick layers of up to at least 4 mm with regard to their degree of C=C double bond conversion.

scholarly journals Enhancement of Countermovement Jump Performance Using a Heavy Load with Velocity-Loss Repetition Control in Female Volleyball Players

2021 ◽  
Vol 18 (21) ◽  
pp. 11530
Author(s):  
Michal Krzysztofik ◽  
Rafal Kalinowski ◽  
Robert Trybulski ◽  
Aleksandra Filip-Stachnik ◽  
Petr Stastny
Keyword(s):  
Body Mass ◽  
Repeated Measures ◽  
Performance Enhancement ◽  
Countermovement Jump ◽  
Mean Power ◽  
Mean Velocity ◽  
Heavy Load ◽  
Jump Performance ◽  
Volleyball Players ◽  
Post Hoc

Although velocity control in resistance training is widely studied, its utilization in eliciting post-activation performance enhancement (PAPE) responses receives little attention. Therefore, this study aimed to evaluate the effectiveness of heavy-loaded barbell squats (BS) with velocity loss control conditioning activity (CA) on PAPE in subsequent countermovement jump (CMJ) performance. Sixteen resistance-trained female volleyball players participated in this study (age: 24 ± 5 yrs.; body mass: 63.5 ± 5.2 kg; height: 170 ± 6 cm; relative BS one-repetition maximum (1RM): 1.45 ± 0.19 kg/body mass). Each participant performed two different conditions: a set of the BS at 80% 1 RM with repetitions performed until a mean velocity loss of 10% as the CA or a control condition without CA (CNTRL). To assess changes in jump height (JH) and relative mean power output (MP), the CMJ was performed 5 min before and throughout the 10 min after the CA. The two-way analysis of variance with repeated measures showed a significant main effect of condition (p = 0.008; η2 = 0.387) and time (p < 0.0001; η2 = 0.257) for JH. The post hoc test showed a significant decrease in the 10th min in comparison to the value from baseline (p < 0.006) for the CNTRL condition. For the MP, a significant interaction (p = 0.045; η2 = 0.138) was found. The post hoc test showed a significant decrease in the 10th min in comparison to the values from baseline (p < 0.006) for the CNTRL condition. No significant differences were found between all of the time points and the baseline value for the CA condition. The CA used in the current study fails to enhance subsequent countermovement jump performance in female volleyball players. However, the individual analysis showed that 9 out of the 16 participants (56%) responded positively to the applied CA, suggesting that the PAPE effect may be individually dependent and should be carefully verified before implementation in a training program.

scholarly journals Effect of Educational Workshops on Disaster Risk Perception in Nurses

2020 ◽  
pp. 270-278
Keyword(s):  
Risk Perception ◽  
Repeated Measures ◽  
Intervention Group ◽  
Round Table ◽  
Disaster Risk ◽  
National Standards ◽  
Control Group ◽  
Repeated Measures Analysis ◽  
Post Hoc ◽  
And Control

INTRODUCTION: The enhancement of nurses’ risk perception plays a significant role in their preparedness during disasters and emergencies. Therefore, this study aimed to investigate the effect of educational workshops on disaster risk perception in nurses METHODS: This randomized controlled field trial study included 62 nurses working at Razi Hospital, Birjand, Iran. The participants were divided into intervention and control groups. The intervention group was then requested to participate in a one-day intensive educational workshop based on the current national standards. The workshop content included a combination of lecturing methods, round-table exercises, and film display. The data were collected using the demographic characteristic form and researcher-made questionnaires measuring the nurses’ risk perception during disasters and emergencies. Subsequently, the data were analyzed using independent t-test, repeated measures analysis, and Bonferroni post hoc tests. FINDINGS: The mean total score of risk perception were significantly higher in the intervention group before, immediately, and two months after the workshop session, compared to those in the control group (P˂0.001). CONCLUSION: The implementation of nurses’ national preparation program during disasters and emergencies can result in an increase in the nurses’ risk perception during these events. Therefore, regarding the importance of nurses’ preparedness in confrontation with disasters and emergencies, it seems necessary to integrate the National Preparedness Program into the educational programs immediately after recruitment and in the form of in-service courses.

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