scholarly journals Telomere Length and Regulatory Genes as Novel Stress Biomarkers and Their Diversities in Broiler Chickens (Gallus gallus domesticus) Subjected to Corticosterone Feeding

Animals ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. 2759
Author(s):  
Kazeem Ajasa Badmus ◽  
Zulkifli Idrus ◽  
Goh Yong Meng ◽  
Awis Qurni Sazili ◽  
Kamalludin Mamat-Hamidi
Keyword(s):  
Telomere Length ◽  
Broiler Chickens ◽  
Well Being ◽  
Regulatory Genes ◽  
Gallus Domesticus ◽  
Gallus Gallus Domesticus ◽  
Organ Weights ◽  
Stress Biomarkers ◽  
Body Weights ◽  
Novel Biomarkers

This study was designed to characterize telomere length and its regulatory genes and to evaluate their potential as well-being biomarkers. Chickens were fed a diet containing corticosterone (CORT) for 4 weeks and performances, organ weight, plasma CORT levels, telomere lengths and regulatory genes were measured and recorded. Body weights of CORT-fed chickens were significantly suppressed (p < 0.05), and organ weights and circulating CORT plasma levels (p < 0.05) were altered. Interaction effect of CORT and duration was significant (p < 0.05) on heart and liver telomere length. CORT significantly (p < 0.05) shortened the telomere length of the whole blood, muscle, liver and heart. The TRF1, chTERT, TELO2 and HSF1 were significantly (p < 0.05) upregulated in the liver and heart at week 4 although these genes and TERRA were downregulated in the muscles at weeks 2 and 4. Therefore, telomere lengths and their regulators are associated and diverse, so they can be used as novel biomarkers of stress in broiler chickens fed with CORT.

scholarly journals Molecular mechanisms of growth depression in broiler chickens (Gallus Gallus domesticus) mediated by immune stress: a hepatic proteome study

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Aijuan Zheng ◽  
Anrong Zhang ◽  
Zhimin Chen ◽  
Shoaib Ahmed Pirzado ◽  
Wenhuan Chang ◽  
...  
Keyword(s):  
Broiler Chickens ◽  
Molecular Mechanisms ◽  
Gallus Gallus ◽  
Gallus Domesticus ◽  
Economic Losses ◽  
Poultry Production ◽  
Gallus Gallus Domesticus ◽  
Growth Depression ◽  
Stress Group ◽  
Immune Stress

Abstract Background Immunological stress decreases feed intake, suppresses growth and induces economic losses. However, the underlying molecular mechanism remains unclear. Label-free liquid chromatography and mass spectrometry (LC-MS) proteomics techniques were employed to investigate effects of immune stress on the hepatic proteome changes of Arbor Acres broilers (Gallus Gallus domesticus) challenged with Escherichia coli lipopolysaccharide (LPS). Results Proteomic analysis indicated that 111 proteins were differentially expressed in the liver of broiler chickens from the immune stress group. Of these, 28 proteins were down-regulated, and 83 proteins were up-regulated in the immune stress group. Enrichment analysis showed that immune stress upregulated the expression of hepatic proteins involved in defense function, amino acid catabolism, ion transport, wound healing, and hormone secretion. Furthermore, immune stress increased valine, leucine and isoleucine degradation pathways. Conclusion The data suggests that growth depression of broiler chickens induced by immune stress is triggered by hepatic proteome alterations, and provides a new insight into the mechanism by which immune challenge impairs poultry production.

scholarly journals A Review of Current Knowledge on Staphylococcus agnetis in Poultry

Animals ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 1421
Author(s):  
Gustaw M. Szafraniec ◽  
Piotr Szeleszczuk ◽  
Beata Dolka
Keyword(s):  
Virulence Factors ◽  
Broiler Chickens ◽  
Current Knowledge ◽  
Gallus Domesticus ◽  
Gallus Gallus Domesticus ◽  
Poultry Industry ◽  
Emerging Pathogen ◽  
Welfare Losses ◽  
Host Jump ◽  
Global Problems

This review aims to summarize recent discoveries and advancements regarding the characteristics of Staphylococcus agnetis (S. agnetis) and its role in poultry pathology. S. agnetis is an emerging pathogen that was primarily associated with mastitis in dairy cattle. After a presumed host jump from cattle to poultry, it was identified as a pathological agent in broiler chickens (Gallus gallus domesticus), causing lameness induced by bacterial chondronecrosis with osteomyelitis (BCO), septicemia, and valvular endocarditis. Economic and welfare losses caused by lameness are global problems in the poultry industry, and S. agnetis has been shown to have a potential to induce high incidences of lameness in broiler chickens. S. agnetis exhibits a distinct repertoire of virulence factors found in many different staphylococci. It is closely related to S. hyicus and S. chromogenes, hence infections caused by S. agnetis may be misdiagnosed or even undiagnosed. As there are very few reports on S. agnetis in poultry, many facts about its pathogenesis, epidemiology, routes of transmission, and the potential impacts on the poultry industry remain unknown.

Effects of heat stress on the gene expression of nutrient transporters in the jejunum of broiler chickens (Gallus gallus domesticus)

2014 ◽  
Vol 59 (2) ◽  
pp. 127-135 ◽  
Author(s):  
Xiaolei Sun ◽  
Haichao Zhang ◽  
Ardashir Sheikhahmadi ◽  
Yufeng Wang ◽  
Hongchao Jiao ◽  
...  
Keyword(s):  
Gene Expression ◽  
Heat Stress ◽  
Broiler Chickens ◽  
Gallus Gallus ◽  
Gallus Domesticus ◽  
Nutrient Transporters ◽  
Gallus Gallus Domesticus
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