scholarly journals Low Birth Weight Disturbs the Intestinal Redox Status and Mitochondrial Morphology and Functions in Newborn Piglets

Animals ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 2561
Author(s):  
Jiaojiao Chen ◽  
Yi Song ◽  
Daiwen Chen ◽  
Bing Yu ◽  
Jun He ◽  
...  
Keyword(s):  
Small Intestine ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Redox Status ◽  
Abnormal Development ◽  
Heme Oxygenase 1 ◽  
Mitochondrial Morphology ◽  
Lower Growth ◽  
Newborn Piglets ◽  
Junction Protein

Low birth-weight (LBW) neonates exhibit a lower growth rate and impaired intestinal development. However, the reasons for abnormal development of small intestine in LBW piglets have not been widely studied. The present study focused on the redox status and mitochondrial morphology and functions of the small intestine in LBW newborn piglets. Ten newborn normal birth-weight (NBW) piglets and LBW piglets from 10 primiparous sows with the same parturition day were selected and sampled immediately without sucking colostrum. The small intestine tissues were collected and measured. Compared with NBW newborn piglets, LBW newborn piglets had a significantly decreased length and weight of the small intestine (p < 0.05) as well as the villus height/crypt depth (V/C) index in the jejunum (p < 0.05). Furthermore, LBW piglets had a lower gene expression of tight junction protein zonula occluden-1 (ZO1), claudin 1, antioxidant enzyme catalase (CAT), glutathione peroxidase (GPX) and heme oxygenase-1 (HO-1) in jejunum (p < 0.05). Meanwhile, LBW induced mitochondrial vacuolation and significantly decreased the mRNA expression of PPARγ coactivator-1α (PGC-1α) (p < 0.05) and tended to decrease the expression of cytochrome coxidase IV (Ccox IV) (p = 0.07) and cytochrome C (Cytc) (p = 0.08). In conclusion, LBW newborn piglets showed an abnormal development of the small intestine and disturbed redox status, and this may be caused by impaired morphology and the functions of mitochondria in the jejunum.

Intrauterine Growth Restriction Alters the Genome-Wide DNA Methylation Profiles in Small Intestine, Liver and Longissimus Dorsi Muscle of Newborn Piglets

2019 ◽  
Vol 20 (7) ◽  
pp. 713-726 ◽  
Author(s):  
Shiyu Tao ◽  
Tianjiao Zhou ◽  
Perot Saelao ◽  
Ying Wang ◽  
Yuhua Zhu ◽  
...  
Keyword(s):  
Small Intestine ◽  
Birth Weight ◽  
Intrauterine Growth Restriction ◽  
Longissimus Dorsi ◽  
Intrauterine Growth ◽  
Longissimus Dorsi Muscle ◽  
Newborn Piglets ◽  
Dorsi Muscle ◽  
Genome Wide ◽  
Differentially Methylated Genes

Intrauterine growth restriction (IUGR) remains a major problem in swine production since the associated low birth weight leads to high rates of pre-weaning morbidity and mortality, and permanent retardation of growth and development. The underlying regulatory mechanisms from the aspects of epigenetic modification has received widespread attention. Studies explore the changes in genome wide methylation in small intestine (SI), liver and longissimus dorsi muscle (LDM) between IUGR and normal birth weight (NBW) newborn piglets using a methylated DNA immunoprecipitation-sequencing (MeDIP-Seq) approach. The data demonstrated that methylated peaks were prominently distributed in distal intergenic regions and the quantities of peaks in IUGR piglets were more than that of NBW piglets. IUGR piglets had relatively high methylated level in promoters, introns and coding exons in all the three tissues. Through KEGG pathway analysis of differentially methylated genes found that 33, 54 and 5 differentially methylated genes in small intestine, liver and longissimus dorsi muscle between NBW and IUGR piglets, respectively, which are related to development and differentiation, carbohydrate and energy metabolism, lipid metabolism, protein turnover, immune response, detoxification, oxidative stress and apoptosis pathway. The objective of this review is to assess the impact of differentially methylation status on developmental delay, metabolic disorders and immune deficiency of IUGR piglets.

scholarly journals Colostrum intake by newborn piglets

1992 ◽  
Vol 72 (1) ◽  
pp. 1-13 ◽  
Author(s):  
David Fraser ◽  
Jeffrey Rushen
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Key Words ◽  
Normal Serum ◽  
Serum Immunoglobulin ◽  
Milk Ejection ◽  
Newborn Piglets ◽  
Significant Tendency

Colostrum intake by newborn piglets was studied by weighing piglets every 10 min for their first 1–4 h with the sow, and their cumulative weight increases were used as estimates of colostrum intake. In seven litters, four piglets were monitored for 4 h beginning about 2 h after the birth of the first piglet in order to determine if colostrum is available continuously or released in discrete ejections. There was little synchrony between litter-mates in their intake in the first hour, but by the second hour of monitoring (starting about 3 h after farrowing began), much of the colostrum was released in discrete ejections and piglets achieved most of their intake during the few 10-min intervals when an ejection occurred. To examine the effect of birth sequence, four piglets were added to the udder each hour for 3 consecutive hours. Piglets added in the last hour showed a small but significant tendency (P < 0.05) to obtain less colostrum than those added in the middle of the sequence. In nine litters, three piglets were confined to posterior and three to anterior teats for 1.5 h to examine the effect of teat position. Those on posterior teats had slightly but significantly (P = 0.02) lower estimated intake than piglets on anterior teats. Although low-birth-weight piglets, late-born piglets, and piglets sucking only posterior teats tended to obtain less colostrum, the differences were small, and most piglets obtained an amount of colostrum consistent with normal serum immunoglobulin concentration. Key words: Piglet, colostrum, suckling behavior, milk ejection, parturition

Redox Status in Very-Low Birth-Weight Newborns

Neonatology ◽  
2004 ◽  
Vol 85 (3) ◽  
pp. 210-216 ◽  
Author(s):  
L. Filippi ◽  
A. Messeri ◽  
C. Dani ◽  
M. Pezzati ◽  
M. Tronchin ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Very Low Birth Weight ◽  
Redox Status
Sign in / Sign up

Export Citation Format

Share Document