scholarly journals Large Farm Animals Used for Research Purposes: A Survey on Purchase, Housing and Hygiene Management

Animals ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 2158
Author(s):  
Tanja Schmidt ◽  
Fabienne Ferrara ◽  
Anne-Marie Pobloth ◽  
Sarah Jeuthe
Keyword(s):  
Small Ruminants ◽  
Farm Animals ◽  
Laboratory Animals ◽  
Scientific Validity ◽  
Animal Protection ◽  
Current State ◽  
Hygiene Management ◽  
The Status ◽  
Animal Use ◽  
3Rs Principle

Background: Farm animals (FAs) are frequently used in biomedical research. Recommendations for the purchase, housing and health monitoring of these animals (sheep, goats, cattle and pigs) are still missing, and many institutes have developed their own strategies and protocols to face the challenges associated with the use of farm animals. This may influence the comparability of research results and increase data variances, thus increasing animal use that contradicts the obligation to apply the 3Rs principle of reduction, refinement and replacement required in Directive 2010/63 EU and the German animal protection law. Methods: A survey was conducted to define the current state of the art in research institutes working with pigs, and large and small ruminants. Results: The results of the survey clearly show that there are no uniform procedures regarding the purchase, housing and hygiene management of farm animals contrary to small laboratory animals. The facilities make purpose-bound decisions according to their own needs and individual work instructions and implement their own useful protocols to improve and maintain the health of the animals. Conclusion: This survey was the first step to filling the gaps and identifying the status quo and practical applied measures regarding the purchase and hygiene monitoring of FAs in order to improve animal welfare and scientific validity.

Veterinary vaccines against toxoplasmosis

Parasitology ◽  
2014 ◽  
Vol 141 (11) ◽  
pp. 1365-1378 ◽  
Author(s):  
ELŻBIETA HISZCZYŃSKA-SAWICKA ◽  
JUSTYNA M. GATKOWSKA ◽  
MARCIN M. GRZYBOWSKI ◽  
HENRYKA DŁUGOŃSKA
Keyword(s):  
Bird Species ◽  
Congenital Toxoplasmosis ◽  
Protozoan Parasite ◽  
Farm Animals ◽  
Laboratory Animals ◽  
Effective Vaccine ◽  
Current State ◽  
Starting Point ◽  
Wide Range ◽  
Good Starting Point

SUMMARYToxoplasma gondii is a cosmopolitan protozoan parasite that infects a wide range of mammal and bird species. Common infection leads to high economic (e.g. abortions in sheep) and human (e.g. congenital toxoplasmosis or neurotoxoplasmosis in humans) losses. With one exception (Toxovax™ for sheep), there are no vaccines to prevent human or animal toxoplasmosis. The paper presents the current state and challenges in the development of a vaccine against toxoplasmosis, designed for farm animals either bred for consumption or commonly kept on farms and involved in parasite transmission. So far, the trials have mostly revolved around conventional vaccines and, compared with the research using laboratory animals (mainly mice), they have not been very numerous. However, the results obtained are promising and could be a good starting point for developing an effective vaccine to prevent toxoplasmosis.

scholarly journals Studying of S- and L- form Brucella’s Thermo-Extracts Immunogenic Characteristics at Cavies Guinea Pigs

2016 ◽  
Vol 15 (4) ◽  
pp. 82-86 ◽  
Author(s):  
L. M. Mikhailov ◽  
N. L. Barannikova ◽  
L. E. Tokareva ◽  
S. A. Vityazeva ◽  
T. P. Starovoytova ◽  
...  
Keyword(s):  
Guinea Pigs ◽  
Small Ruminants ◽  
Farm Animals ◽  
Laboratory Animals ◽  
Important Species ◽  
Post Vaccination ◽  
Epizootic Process ◽  
Series Of Experiments ◽  
The Russian Federation ◽  
High Doses

Relevance. In the Russian Federation is noted the negative dynamics of epizootic process of brucellosis among epidemiologically important species of farm animals (cattle and small ruminants), which represents a threat to the population. Used in Russia live vaccine based on a strain of Brucella abortus 19 the BA has reduced virulence, but capable at high doses (108 -2 109 m.c.) cause a generalized infection in guinea pigs and humans, and in violation of the rules cause post-vaccination complications. Goal. Assess possibility of the thermo-extract derived from the S- and L-forms of Brucella, get an immune response in guinea pigs, and reduce the risk of infection with virulent brucella. Materials and methods. Two series of experiments were carried out on guinea pigs. Immunized guinea pigs thermo-extracts (TE) from a strain of B. abortus I-206 in the S- and L-forms, and live brucellosis vaccine (Scientific and Production Association for Immunological Preparations «Microgen», Russia). To infect guinea pigs using virulent B. abortus 544 (Reference) and B. melitensis I-203 from the museum of living cultures of the Irkutsk Scientific Research Anti-Plague Institute. Results. In the first and second experiment after immunization L TE in dose 5 mg and 10 mg after infection with B. abortus and B. melitensis 5441-203 were approximately similar results. Immunization of Brucella in TE S-form or complex of L + S TE either of two doses (5 mg or 10 mg) cultures after infection B. abortus and B. melitensis 5441-203 gave the same result as a vaccine B. abortus 19VA. Conclusions. The results indicate the prospects of further study of experimental steps for using immunizing agents TE S, L TE and TE S + L on the laboratory animals.

On the Development of Islamic Jurisprudence

1999 ◽  
Vol 16 (1) ◽  
Author(s):  
Murad Wilfried Hofmann
Keyword(s):  
The State ◽  
Current State ◽  
Islamic Jurisprudence ◽  
The Status ◽  
Sensitive Issues ◽  
Status Of Women ◽  
Islam And Democracy

This article examines the state of Islamic jurisprudence with regard to many sensitive issues, such as the status of women and minorities in Islam, Islam and Democracy, hudud punishments. The author explores the current state of Islamic discourse on jurisprudence and identifies three approaches-traditional, secular and reformist. The paper explores the positions of the traditional ulama and the reformist muj­tahids on the mentioned topics and finds the reformist position more sensible and closer to the position of ihe Qur'an and Sunnah. This paper while advocating neo-ijtihad, makes an impressive case for the merit???? and Islamic credibility of the reformist jurisprudence.

Wildlife management and the debate on the ethics of animal use. II. A challenge for the animal protection movement.

2012 ◽  
Vol 18 (2) ◽  
pp. 81 ◽  
Author(s):  
Daniel Lunney
Keyword(s):  
Wildlife Management ◽  
Critical Role ◽  
Animal Liberation ◽  
Ethical Imperative ◽  
Animal Protection ◽  
Wide Range ◽  
Animal Use

How people coexist and interact with animals has become an intensely debated issue in recent times, particularly with the rise of the animal protection movement following the publication of Peter Singer’s book Animal Liberation in 1975. This paper discusses some shortcomings of the philosophical positions taken in this complex debate. Singer has helped put animals on a new footing as a group that cannot morally be ignored, but his focus is mainly on individual, familiar animals that are used or abused by humans. The argument of this paper is that the ethics of managing wildlife hinges on a broader view of animals, and their contexts, than is apparent from Singer’s text. Wildlife managers aim to conserve populations of a wide range of species, and their habitats, but some mechanisms for achieving these aims, such as research and the control of invasive animals, are frequently opposed by elements of the animal protection movement. We need to adapt our attitude to animals, particularly wildlife, away from the traditional legacy of a few familiar species to embrace an ethic that is more ecological and relevant to Australian contexts. The case argued here has been to see the critical role of context — geographical, ecological, historical, relational — as a basis for a degree of reconciliation between conservation-oriented wildlife managers and the rising interest in the ethics of animal use. There is much to be gained for zoologists, wildlife managers and conservation biologists by framing key elements of their case in ethical arguments. Conversely, the challenge for those in the animal protection movement is to expand their philosophical ideas to include the ethical imperative of the conservation of populations of wildlife.

Philosophers and Physicians on the Scientific Validity of Latin Physiognomy, 1200-1500

2007 ◽  
Vol 12 (3) ◽  
pp. 285-312 ◽  
Author(s):  
Joseph Ziegler
Keyword(s):  
Early Modern ◽  
Middle Ages ◽  
Theoretical Basis ◽  
Scientific Validity ◽  
Body Of Knowledge ◽  
Rational Explanation ◽  
The Status ◽  
Jean Buridan ◽  
Natural Philosophers ◽  
Sound Theoretical Basis

AbstractThe article surveys and contextualizes the main arguments among philosophers and academic physicians surrounding the status of physiognomy as a valid science from the thirteenth to the early sixteenth centuries. It suggests that despite constant doubts, learned Latin physiognomy in the later Middle Ages was recognized by natural philosophers (William of Spain, Jean Buridan, William of Mirica) and academic physicians (Rolandus Scriptor, Michele Savonarola, Bartolomeo della Rocca [Cocles]) as a body of knowledge rooted in a sound theoretical basis. Physiognomy was characterized by stability and certainty. As a demonstrative science it was expected to provide rational explanation for every bodily sign. In this respect, learned physiognomy in the Middle Ages was dramatically different from its classical sources, from Islamic and possibly from early-modern physiognomy as well.

Current state-of-the-art antiplatelet and anticoagulation therapy in diabetic patients with coronary artery disease

2021 ◽  
Author(s):  
Johny Nicolas ◽  
Victor Razuk ◽  
Gennaro Giustino ◽  
Roxana Mehran
Keyword(s):  
Diabetes Mellitus ◽  
Complex Disease ◽  
Anticoagulation Therapy ◽  
Treatment Strategies ◽  
Diabetic Patients ◽  
Current State ◽  
Organ Systems ◽  
Patients With Diabetes ◽  
The Status ◽  
Artery Disease

Diabetes mellitus is a complex disease that leads to long-term damage to various organ systems. Among the numerous cardiovascular disease-related complications, thrombotic events frequently occur in patients with diabetes. Although guidelines exist for treating and preventing most diabetes-related co-morbidities, the evidence on antithrombotic therapy in primary and secondary prevention is limited due to the scarcity of randomized trials dedicated to patients with diabetes mellitus. Most of the available data are derived from studies that only included a small proportion of patients with diabetes. The present review provides an overview of the status of knowledge on antiplatelet and anticoagulation therapy in patients with diabetes, focusing on the risk–benefit balance of these therapies and future treatment strategies.

What Library 2.0 has taught libraries in Taiwan about e-learning

2015 ◽  
Vol 33 (6) ◽  
pp. 1121-1132 ◽  
Author(s):  
Tien-Chi Huang
Keyword(s):  
Educational Value ◽  
Content Type ◽  
Feedback Model ◽  
Learning Platform ◽  
Current State ◽  
Library Resources ◽  
The Status ◽  
Library Development ◽  
E Learning ◽  
Definition Of

Purpose – This paper aims to review the four elements of Library 2.0, which represents a major innovation, and adopts several pedagogical concepts to investigate other innovations libraries in Taiwan could implement to become ideal libraries. Design/methodology/approach – This paper presents an overview of the essential principles of Library 2.0 and examines the current state of libraries in Taiwan. The authors then present a reciprocal feedback model of Library 2.0+. Findings – A Library 2.0+ model and a concept map of the mutualism between e-learning education and Library 2.0+ were proposed to diminish the gap between the status quo and Library 2.0. Two recommendations are provided: to develop a library learning platform to maximize the education value of the library, and to regard library development as part of the overall community’s development. Users can access library resources anytime/anywhere by visiting the library learning platform without visiting the library. Allowing an individual approach is necessary to realize the social educational value of the library. Moreover, a Library 2.0 library engages more in community development and invites participation with participation in community first. Universities in the community would be good technology partners when developing a Library 2.0 library. Originality/value – Although there has been extensive research of library development in view of Library 2.0, such a topic has never been explored with an educational perspective, especially an e-learning perspective. Given that the definition of Library 2.0 is abstract and fairly broad, the authors take the view of an e-learning platform to make Library 2.0 more figurative. Moreover, through interdisciplinary exploration, concrete suggestions regarding library development are provided to librarians, especially those with similar conditions as those in Taiwan.

scholarly journals Characteristics of the world and Russian production of fruits products (apples and pears)

2018 ◽  
Vol 7 (2) ◽  
pp. 20-26
Author(s):  
Lyubov Georgievna Demenina ◽  
Anna Borisovna Petrova ◽  
Kristina Andreevna Savitskaya ◽  
Lyudmila Mikhailovna Kavelenova
Keyword(s):  
Statistical Data ◽  
Fruit Production ◽  
Biologically Active ◽  
Human Diet ◽  
Current State ◽  
The World ◽  
The Status ◽  
Fruit Growing ◽  
Rosaceae Family ◽  
Active Substances

The paper deals with the peculiarities of the biological characteristics of the most important fruit crops of temperate climates - apple and pear (Rosaceae family, subfamily Maloideae), taking into account the world, national and regional cultivation. Both cultures are characterized by significant food and commodity value, have some differences in the chemical composition of the fruit, including the leading components of the mass and biologically active substances, which determine the peculiarities of their use in the human diet. In both global and national fruit-growing, pears play a secondary role compared to apple, giving way to the number of varieties, the volume of production and the areas occupied. Based on the analysis of available statistical data of the FAO database, the dynamics of changes from 1990 to 2016 of the world production of apple and pear fruits with visualization on the continents, identifying world leaders and major trends are considered. For the USSR (from 1962 to 1990) and in Russian Federation (from 1992 to 2016) the paper presents a picture of changes in the volume of fruit production, discusses the status of fruit production in the country. The features of the historical development and current state of fruit growing in the Samara Region and prospects are discussed.

scholarly journals Development of polyvalent toxoid Clostridium perfringens against anaerobic enterotoxaemia in young cattle and small ruminants

2021 ◽  
Vol 282 ◽  
pp. 04009
Author(s):  
F.Kh. Pulotov ◽  
O.D. Nazarova ◽  
N.A. Akhmadov ◽  
A.I. Karimzoda
Keyword(s):  
Nutrient Medium ◽  
Small Ruminants ◽  
Farm Animals ◽  
Drug Preparation ◽  
Type D ◽  
Industrial Strains ◽  
Type C ◽  
Young Cattle ◽  
C 30 ◽  
Selection Of

The authors of the article presents the results of the development of a polyvalent toxoid from C.perfringens strains against anaerobic enterotoxaemia of young cattle and small ruminants and an assessment of its effectiveness. It is presented the data on the selection of the recipe composition of the nutrient medium, the cultivation of industrial strains, the process of drug preparation, the selection of the optimal ratio of components and the method of controlling the effectiveness. Sequential cultivation of industrial strains of C.perfringens was carried out by cultivating them in flasks, bottles and bioreactors in the nutrient medium developed by the authors, consisting of: 12.0 g/l - liver extract; 25.0 g/l - casein-peptone; 3.2g/l –K2HPO4; 1.8 g/l – KH2PO4; 0.5 g/l – MgSO4. The development of the drug included the selection of optimal and balanced ratios of C. perfringens type A toxoids - 15 IU/ml, C.perfringens type B - 20 IU/ml, C.perfringens type C - 30 IU/ml, C. perfringens type D - 30 IU/ml, which ensured 100% protection of the immunized animals. Studies on laboratory and farm animals revealed the harmlessness, areactogenicity of the drug, which stimulated the development of immunity and resistance to the toxic effects of all strains of C.perfringens.

scholarly journals DIALOGICAL LINGUISTICS IN RUSSIA: THE HISTORY OF FORMATION AND THE CURRENT STATUS

2021 ◽  
pp. 159-173
Author(s):  
N. N. Shpilnaya ◽  
Keyword(s):  
General Theory ◽  
Research Program ◽  
Linguistic Theory ◽  
Final Part ◽  
Current Status ◽  
Interactional Theory ◽  
Current State ◽  
The Status ◽  
History Of ◽  
History Of Formation

The article is an outline of the development of Dialogical Linguistics in Russia. It represents its milestones of formation and the current state. Dialogical Linguistics is considered to be an integral linguistic branch, claiming the status of a distinct «research program» and comprises such sections as follows: Linguistics of Dialogical Text, Linguistic Theory of Replication, Interactional Theory of Dialogue, General Theory of Dialogue. In the final part of the article, the principles of dialogical modeling of linguistic objects are being formulated.

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