scholarly journals Comparative Growth and Economic Performances between Indigenous Swamp and Murrah Crossbred Buffaloes in Malaysia

Animals ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 957
Author(s):  
Amirul Faiz Mohd Azmi ◽  
Hasliza Abu Hassim ◽  
Norhariani Mohd Nor ◽  
Hafandi Ahmad ◽  
Goh Yong Meng ◽  
...  
Keyword(s):  
Weight Gain ◽  
Birth Weight ◽  
Cost Savings ◽  
Daily Weight Gain ◽  
Intervention Period ◽  
Net Benefit ◽  
Post Intervention ◽  
Average Birth Weight ◽  
Swamp Buffaloes ◽  
Average Annual Cost

This study was conducted to compare the growth and economic performances between Swamp and Murrah crossbred buffaloes. The records of 108 Swamp and 276 Murrah crossbred buffaloes born between January 2010 and December 2015 were used in this study. The farm was practicing an extensive grazing system without supplementation from January 2010 to December 2011 (pre-intervention) and a new implementation of supplement in the feeding regime from January 2012 to December 2015 (post-intervention). The birth, weaning, and body weight at three monthly intervals, number of calves born, and mortality rate of calves at different years and during pre- and post-intervention were analyzed using a general linear model procedure. The interventions in 2012 had a positive effect on increasing the number of calves born for both breeds, average birth weight, economic performance, and reduce mortality calf rate. As a result, the birth weight of Murrah crossbred buffaloes was higher (36.63 ± 0.50 kg) than Swamp buffaloes (34.69 ± 0.40 kg) (p < 0.05). The average pre-weaning daily weight gain for Swamp and Murrah crossbred buffaloes was 0.73 and 0.98 kg/day (p < 0.05), while the average post-weaning daily weight gain was 0.39 and 0.44 kg/day, respectively (p < 0.05). The Swamp and Murrah crossbred buffaloes achieved the targeted market weight of 250 kg at 18 and 15 months old, respectively, while the targeted breeding weight of 385 kg was achieved at 30 and 26 months old, respectively. In this farm, on average a total of 64 calves were born yearly, with the ratio number of born calves per number of mated dams recorded higher in Murrah crossbred buffaloes as compared to Swamp buffalo (0.64 vs. 0.37) (p < 0.05). Furthermore, the average number of calves born in the post-intervention period (January 2012–December 2015) was significantly higher than in the pre-intervention period (January 2010–December 2011), respectively (Swamp: 23 vs. 8 and Murrah crossbred: 53 vs. 31, respectively) (p < 0.05). Partial budget method was used to estimate the net gain or loss between the two breeds. The average annual revenue was 2304.14 MYR (566.13 USD) for Swamp buffaloes and 4531.50 MYR (1113.39 USD) for Murrah crossbred buffaloes. The average annual cost saving was 340.02 MYR (83.54 USD) for Swamp and 215.75 MYR (53.01 USD) for Murrah crossbred buffaloes. On the other hand, annual added cost was 84.95 MYR (20.87 USD) for Swamp and 96.76 MYR (23.77 USD) for Murrah crossbred buffaloes. Therefore, the annual net benefit was 2559.21 MYR (628.80 USD) for Swamp and 4650.49 MYR (1142.63 USD) for Murrah crossbred buffaloes. As a conclusion, this study had shown that the higher average daily weight gain contributes to better cost savings, as shown by the crossbred buffaloes.

scholarly journals FATTENING AND SLAUGHTER RESULTS ANALYSIS OF HEREFORD BREED BULLS BORN IN DIFFERENT SEASONS

2018 ◽  
Author(s):  
Inga MUIZNIECE ◽  
Daina KAIRISA
Keyword(s):  
Weight Gain ◽  
Birth Weight ◽  
Live Weight ◽  
Daily Weight Gain ◽  
Spring Season ◽  
Research Groups ◽  
Average Daily Weight Gain ◽  
Average Birth Weight ◽  
Different Seasons ◽  
Autumn And Winter

The aim of this study was to explain the birth season effect on Hereford bulls fattening results. The research was made within the project ‘Baltic Grassland Beef’ framework in years 2015 and 2016. Data about 41 Herford purebred bull was used in the research, grown in different farms of Latvia. Bulls were slaughtered in certified slaughterhouse ‘Agaras’ (Lithuania). The average birth weight of the Hereford breed bulls was in border from 42.9 – 45.0 kg. The lowest birth weight was on spring season born bulls – 42.9 kg, but the highest on winter season born bulls - 45.0. Average realization age of bull’s, in the research groups, was on range from 567 days to 661 days. Bulls born on autumn and winter before slaughtering were significantly older, respectively 661 and 655 days with live weight of 519.9 kg un 542.1 kg. On spring born bulls with age 600 days reached the biggest live weight – 542.0 kg, respectively these group bulls average daily weight gain from birth to slaughter per day was the biggest among all the groups – 831.9 g. The highest slaughter weight showed on autumn and winter seasons born bulls, respectively 275.5 kg and 274.8 kg. In the research groups on different seasons born bulls conformation score was from points 2.4 to 2.6. All the bull’s carcass in the research groups were evaluated as 2nd and 3rd fat class. between the age before slaughter and average daily weight gain from birth to slaughter there is an important negative correlation (from r = -0.858 to = -0.977, p&amp;amp;lt;0.05), except on spring season born bulls.

Initial Nutritional Assessment of Infants with Cleft Lip and/or Palate: Interventions and Return to Birth Weight

2017 ◽  
Vol 54 (2) ◽  
pp. 127-136 ◽  
Author(s):  
Alison Kaye ◽  
Kristi Thaete ◽  
Audrey Snell ◽  
Connie Chesser ◽  
Claudia Goldak ◽  
...  
Keyword(s):  
Weight Gain ◽  
Birth Weight ◽  
Breast Milk ◽  
Cleft Palate ◽  
Cleft Lip ◽  
Cleft Lip And Palate ◽  
Nutritional Assessment ◽  
Initial Assessment ◽  
Average Birth Weight ◽  
Nutritional Interventions

Objective To assess and quantify cleft team practices with regard to nutritional support in the neonatal period Design Retrospective review. Setting Tertiary pediatric hospital. Patients One hundred consecutive newborn patients with a diagnosis of cleft lip and/or cleft palate between 2009 and 2012. Main Outcome Measures Birth weight, cleft type, initial cleft team weight measurements, initial feeding practices, recommended nutritional interventions, and follow-up nutritional assessments. Results All patients in the study were evaluated by a registered dietitian and an occupational feeding therapist. Average birth weight and average age at the first cleft team visit were similar for each cleft type: cleft lip (CL), cleft lip and palate (CLP), and cleft palate (CP). The calculated age (in days) for return to birth weight was significantly different between cleft types: CL = 13.58 days, CLP = 15.88 days, and CP = 21.93 days. Exclusive use of breast milk was 50% for patients with CL, 30.3% for patients with CLP, and 21.4% for patients with CP. Detailed nutritional interventions were made for 31 patients at the first visit: two with CL, 14 with CLP, and 15 with CP. Conclusions Distinct differences were seen in neonatal weight gain between cleft types. There was significantly greater total weight gain for patients with CL at their first visit and significantly slower return to birth weight for patients with isolated CP. Patients with CL required far fewer interventions at the initial assessment and were more likely to be provided breast milk exclusively or in combination with formula. Infants with CP were far less likely to receive any breast milk. Patients with CLP and CP required frequent nutritional interventions.

scholarly journals Growth, carcass and meat quality parameters of purebred and crossbred goat kids in extensive pasture

2007 ◽  
Vol 50 (2) ◽  
pp. 186-196 ◽  
Author(s):  
P. Herold ◽  
H. Snell ◽  
E. S. Tawfik
Keyword(s):  
Weight Gain ◽  
Birth Weight ◽  
Landscape Management ◽  
Quality Parameters ◽  
Daily Weight Gain ◽  
Meat Production ◽  
Landscape Conservation ◽  
Grazing Period ◽  
Carcass Performance ◽  
Harsh Conditions

Abstract. Goats are more and more used as shrub-fighters in landscape conservation. Important traits for the extensive production system are vitality and robustness but also acceptable meat production of kids during the grazing period. To investigate possible selection traits for "landscape conservation suitability", 35 kids were investigated for vitality parameters directly after birth whereas all-in 65 kids were investigated for performance traits under extensive grazing conditions. Birth weight as a parameter for vitality and survivability of kids was significantly influenced by sex, genotype and age of doe. Besides rectal temperature 3 hours p.p., other factors regarded as possible vitality parameters were not influenced by birth weight. Birth weight had a significant influence on daily weight gain during the extensive period; kids with higher birth weight showed slightly better weight gain. Birth weight had also a significant effect on some carcass parts, indicating that higher birth weight implies a high probability of a better carcass performance especially in some valuable parts. Still, the effect of the genotype on carcass performance was considerably higher than any other investigated effect. As a result of the present study, there are indications that birth weight can be taken as a parameter for kids' vitality. Also, it is indicated that goats of Cashmere type as fibre animals are not appropriate for landscape management whereas crossbred animals with a meat, dairy and fibre component in their genotype showed to be a vital animal with acceptable efficiency also in harsh conditions and with an average meat and carcass performance.

Growth-promoting effect of sulphur 201c in pigs

1996 ◽  
Vol 85 (01) ◽  
pp. 15-16 ◽  
Author(s):  
Roberto Searcy-Bernal ◽  
José Soto-Avila ◽  
Germán Guajardo-Bernal
Keyword(s):  
Weight Gain ◽  
Birth Weight ◽  
Controlled Trial ◽  
Daily Weight Gain ◽  
Promoting Effect ◽  
Significant Difference ◽  
Final Weight ◽  
Growth Promoting ◽  
And Control

AbstractIn a blind, placebo-controlled trial, a homoeopathic dynamized dilution of Sulphur 201c was given orally to pregnant sows every 10 days. No significant difference was detected between the birth weight of litters (39 piglets) of treated sows and control litters (40 piglets). On day 30 statistically significant differences were observed both in the final weight of litters, mean total and daily weight gain.

scholarly journals Kangaroo Mother Care –Differences and Quantitative Benefits in Different Subgroups of Low Birth Weight Babies

2020 ◽  
Vol 5 (1) ◽  
Keyword(s):  
Weight Gain ◽  
Birth Weight ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Head Circumference ◽  
Cost Effective ◽  
Kangaroo Mother Care ◽  
Daily Weight Gain ◽  
At Home

Objectives: To determine the effectiveness of Kangaroo Mother Care in subgroups of LBW babies-Preterm AGA, Preterm SGA and Term SGA, To assess any differences in benefits of KMC in relation to duration in the subgroups, To assess weight gain difference in NICU and at home at first follow up visit and up to 40 weeks of follow up to Preterm AGA, Preterm SGA and till gain of 2500g in Term SGA babies. Study design: Prospective observational study. Setting: NICU in a large teaching institute, department of pediatrics, Mahatma Gandhi Memorial Hospital, North Telangana. Subjects and Methods: 240 neonates with birth weight <2500g, hemodynamically stable. Intervention: The subjects are classified into three subgroups-based on gestational age (by new Ballard’s score) and by weight (Lubchenco’ s charts) into Preterm Appropriate for gestational age (PT AGA) (102), Preterm Small for Gestational Age (PT SGA) (88) and Term Small for Gestational age (T SGA) (50). Further categorized into <=32 wks,33-34wks,35- 36wks,>=37wks.KMC was given to all subgroups at hospital and home with mean duration of 9+2hrs at hospital and 5+2hrs at home. Outcome Measures: Growth measured by average daily weight gain, mean weight gain, (weight was measured by electronic weighing scale (seca), head circumference (measured by non-stretchable and non-metallic tape) and total length (measured by infant meter) in follow up to 40 weeks of corrected gestational age in Preterm and up to gain of 2500g in Term SGA were assessed with KMC. Results: Better weight gain was noticed in all the 3 subgroups of LBW neonates with KMC at hospital and home. In spite of lower duration of KMC at home PT AGA (33-34 weeks) subgroup has the highest weight gain (24.5+5.5g/day, p=0.003), highest head circumference gain (0.70+0.5cm/week, p=0.002), highest length gain (0.90+0.6cm/week, p <0.008). The time taken to reach full feeds and the time to reach initiation of direct breastfeeds were comparable in all subgroups but attained much earlier in PT AGA (33-34wks) and PT AGA (35-36wks). Duration of hospital stay is least in PT AGA with mean of 12.68 ± 6.37 days.KMC significantly reduced the incidence of apnea in all subgroups of LBW babies. All babies were on exclusive breastfeeds at the end of the study (98%). Conclusion: We conclude by this present study that KMC improves growth in all sub groups of LBW infants. KMC has significantly reduced the incidence of co mortifies like apnea, hypothermia, hypoglycemia in all the subgroups of LBW babies. KMC is cost effective, easily accessible and acceptable not only to mothers but also by majority of the family members

scholarly journals Faktor- faktor yang berhubungan dengan kejadian stunting pada 1000 hari pertama kehidupan

2021 ◽  
Vol 15 (2) ◽  
pp. 256-266
Author(s):  
Yunani Yunani ◽  
Yuniastini Yuniastini
Keyword(s):  
Weight Gain ◽  
Birth Weight ◽  
Health Education ◽  
Pregnant Women ◽  
Family Income ◽  
Average Weight ◽  
Average Birth Weight ◽  
Children Under Five ◽  
Under Five ◽  
Number Of Children

Factors related to  the occurrence of stunting in the first 1000 days of lifeBackground: Stunting is a problem that occurs in children under five and is a condition of failure to thrive in children under five which is a form of chronic malnutrition, repeated infections, and inadequate psychosocial stimulation, especially in the First 1000 Days of Life, from fetus to child. two years old. The percentage of stunting under five in Indonesia is 30.8% in 2018. In Lampung Province, Pesawaran Regency is the second-highest in Lampung, which is 33.5% in the very short category and 17.3% in the short category.Purpose: To find out the factors related to  the occurrence of stunting in the first 1000 days of lifeMethod: The research method uses a descriptive method. The research sample is children in the first 1000 days of life in the Working Area of UPT Puskesmas Kota Dalam Pesawaran Regency in 2020. The number of samples is 266 consisting of 133 stunted children and 133 non-stunted children. Data collection uses a questionnaire.Results: Logistics Regression test found several variables related to stunting, namely the father's height (p=0.008) and the mother's knowledge (p=0.004). Meanwhile, the variables of maternal height, increased weight of pregnant women, birth weight, number of children, breastfeeding, maternal illness during pregnancy, income, distance to health facilities, were not associated with stunting.Conclusion: Descriptively, the data obtained are: The average father's height is 162.72 cm, the average height of the mother is 153.08 cm, the average weight gain during pregnancy is 8.49 kg, the average birth weight is 3114 g, the average knowledge value is 8.77 good category), the number of children is mostly 2 people, breastfeeding is mostly over 12 months, (59.4%), most of the mothers during pregnancy do not suffer from infectious diseases (worms, pulmonary TB, diarrhea), most of the family income is low (93.7%), most of the knowledge is sufficient.Suggestion: The management of the Public health center should improve health education for pre-pregnant women and provide to prevent stunting in their working area. As well as increasing community independence in nutritional adequacy.Keywords: Stunting; First 1000 days of life; Fetus; Weight of pregnancy; Number of children, Family income.Pendahuluan : Stunting merupakan masalah yang terjadi pada anak balita dan merupakan kondisi gagal  tumbuh  pada  anak  balita  yang  merupakan  salah  satu  bentuk  dari  malnutrisi kronis, infeksi berulang, dan stimulasi psikososial yang tidak memadai terutama dalam 1000 Hari Pertama Kehidupan (HPK) yaitu sejak janin hingga anak berusia dua tahun. Persentase balita stunting di Indonesia 30.8 % pada tahun 2018. Di Propinsi Lampung, Kabupaten Pesawaran adalah nomor dua tertinggi di Lampung yakni sebesar 33,5% dalam kategori sangat pendek dan 17,3% dalam kategori pendek.Tujuan: Mengetahui factor yang berhubungan dengan kejadian Stunting pada balita di Wilayah kerja UPT Puskesmas Kota Dalam Tahun 2020.Metode: Penelitian menggunakan metode deskriptif, Sampel penelitian adalah anak  1000 hari  pertama kehidupan di Wilayah Kerja UPT Puskesmas Kota Dalam Kab.Pesawaran Tahun 2020. Jumlah  sampel 266 terdiri dari anak stunting 133 dan  anak tidak stunting 133.  Pengumpulan data menggunakan kuesioner.Hasil: Regresi Logistik menemukan beberapa variabel yang berhubungan dengan stunting yaitu tinggi badan ayah (p=0,000), usia ayah (p=0,000) usia ibu (p=0,009), pertambahan berat badan ibu hamil (p=0,029, jumlah anak (p =0,009) p=0,000), pendapatan keluarga (p=0,000).), weight gain of pregnant women (p=0.029, number of children (p=0.009) p=0.000), family income (p=0.000).Simpulan: Secara deskritif beberapa factor berkaitan erat dengan kejadian stunting dan beberapa factor dapat dicegah terjadinya stunting dengan peningkatan gizi dan nutrisi selama kehamilan.Saran: Manajemen Puskesmas supaya lebih peningkatan health education kepada ibu prahamil dan pendampingan untuk mencegah terjadinya stunting diwilayah kerjanya. Serta peningkatan kemandirian masyarakat dalam kecukupan nutrisi melalui  pemanfaatan halaman rumah.

Correlations between birth weights, weaning weights, 11-week weights, weight gains and feed conversion ratios of early weaned calves

1973 ◽  
Vol 13 (64) ◽  
pp. 483
Author(s):  
J Leibholz
Keyword(s):  
Weight Gain ◽  
Birth Weight ◽  
Significant Positive Correlation ◽  
Conversion Ratio ◽  
Feed Conversion Ratio ◽  
Feed Conversion ◽  
Growth Data ◽  
Average Birth Weight ◽  
Poor Indicator ◽  
Weight Gains

Growth data and feed intakes were recorded from 333 male, Friesian calves from birth to 11 weeks of age. The calves came from seven experiments. All calves were weaned from milk replacer at five weeks and fed a starter from two to eleven weeks of age. The average birth weight of the calves was 42.6 kg, they gained 13.6 kg to weaning at five weeks and 32.2 kg from weaning to 11 weeks of age. There was a significant positive correlation between birth weight and weight at weaning and 11 weeks, but the correlation between birth weight and weight gain to 11 weeks was not significant. The correlation coefficient for the weight gain pre-and post-weaning was 0.20 over all calves. There was a significant negative (r = -0.26) correlation between the weight gain post-weaning and the feed conversion ratio. Hence, it is concluded that birth weight is a poor indicator of subsequent weight gains.

85 PREGNANCIES AND VIABILITY OF THE OFFSPRING AFTER TRANSFER OF HANDMADE CLONED PORCINE EMBRYOS

2007 ◽  
Vol 19 (1) ◽  
pp. 160
Author(s):  
M. Schmidt ◽  
I. B. Bøgh ◽  
Y. Du ◽  
Y. Zhang ◽  
J. Li ◽  
...  
Keyword(s):  
Weight Gain ◽  
Blood Glucose ◽  
Birth Weight ◽  
Body Temperature ◽  
Pregnancy Rate ◽  
Uterine Horn ◽  
The Body ◽  
Daily Weight Gain ◽  
High Birth Weight ◽  
The Mean

In several species, nuclear transfer causes a high frequency of fetal loss, high birth weight, malformations, and neonatal death. This study investigates the fetal development of porcine embryos produced by handmade cloning (HMC) and compares the piglets with littermates produced by traditional cloning (TC). HMC embryos were produced from one fetal cell line, LYxD (Landrace/Yorkshire x Duroc) and TC from another (LYDxLYD). For transfer, 11 sows were weaned, and at cycle stage Day 4 after heat, they were anesthetized in lateral recumbence. Through an abdominal incision 40–60 Days 5–7 embryos (69% HMC + 31% TC) were transferred to the upper uterine horn. The tip of the uterine horn was punctured with a blunt 18G needle and a temporary catheter introduced to absorb the blood before inserting an insemination catheter (J-IUIC-351341 Insemi-Cath; Cook Ireland Ltd., Limerick, Ireland) 5–6 cm into the horn and releasing the embryos. Pregnancy was examined by ultrasonography every second week to Day 100. Caesarian sections were performed at Day 115, 24 h after injection of PGF2 (175 �g Estrumate�; Pitman-Moore Ltd., Harefield, UK). The piglets were fed with 15 mL kg-1/3 h colostrum through a stomach tube for the first 12–24 h, until they were left with their dam. Body weight, blood values (oxygen tension, and glucose and hemoglobin concentrations), and body temperature were recorded at birth, 24 h, and 3 weeks of age. The data were analyzed by Fisher's Exact test and are given as LS means � SEM values with a significance level of P &lt; 0.05. The pregnancy rate was 6/11 (55%), with 2 pregnancies developing to term, 2 ongoing (Day 100 and Day 60), and 2 lost (about Day 35). So far, the litter sizes were 3 (1 TC, 2 HMC) and 10 (2 TC, 8 HMC) live piglets, respectively. The mean birth weight of the TC offspring (1045 � 135 g) was lower than that of the HMC piglets (1614 � 177 g) and that of normal piglets on the farm (1520 � 240 g; P &lt; 0.05). One of the HMC piglets of the first litter was rather oversized (2690 g) and another showed rigid flexure of a carpal joint. All other piglets appeared normal on gross morphology and behavior. Blood values were similar for HMC and TC piglets, but the body temperature at Day 0 (36.3 � 0.2 vs. 35.1 � 1.1�C; P &lt; 0.05) and the daily weight gain during the first week (129 � 21 vs. 74 � 13 g; P = 0.06) tended to be higher for the HMC piglets. After 24 hrs, the mean blood glucose concentration was higher in the HMC than in the TC piglets (6.09 � 0.74 vs. 3.67 � 0.19 mmol L-1) and similar to farm piglets of the same age (6.93 � 0.44 mmol L-1), but the difference was not significant after 3 weeks. These preliminary results demonstrate for the first time that HMC in pigs can result in an acceptable pregnancy rate, birth rate, and litter size. The minor differences in birth weight, weight gain, and blood glucose observed between HMC and TC offspring may be explained by the different cell lines used for the 2 methods, and are under current investigation.

Abstract TP73: Evaluation of Intervention Aimed at Reducing Alteplase Returns without Compromising Clinical Care in Acute Ischemic Stroke

Stroke ◽  
2017 ◽  
Vol 48 (suppl_1) ◽  
Author(s):  
Natalie Swearingen ◽  
Jillian T Myers ◽  
Alexandra Lesko
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Best Practice ◽  
Clinical Care ◽  
Cost Savings ◽  
Drug Manufacturer ◽  
Intervention Period ◽  
Post Intervention ◽  
Primary Stroke Center ◽  
The Impact

Introduction: In 2010, the AHA/ASA’s Target Stroke best practice recommendations to reduce door to needle times (DTN) included early pre-mix of intravenous alteplase, which ultimately leads to unused vials. However, hospitals have largely recouped the cost of unused, premixed vials through returns to the drug manufacturer, although this practice is unlikely to continue. As a result, we evaluated an intervention to reduce the number of returned vials and the impact on clinical care at our certified primary stroke center (PSC). Methods: A 6-month pre-intervention period (January 2015-June 2015) was compared to two 6-month post-intervention periods, July 2015-December 2015 and January 2016-May 2016. Acute ischemic stroke patients presenting at our PSC and considered for alteplase treatment were included. Inpatient strokes or those with diagnoses unrelated to stroke or uncertain treatment eligibility were excluded. Primary outcomes were as follows: 1. Percent of alteplase vials returned out of the total number mixed and the associated costs 2. Average DTN time 3. Pharmacy alteplase mix time to needle time. Average minutes (min) with associated p-values and 95% confidence intervals (95%CI) were reported. Price for replacement vials ranged from $6,400 to $8,400 per 100 mg vial. Results: Data from 95 AIS patients were included. The percentage of alteplase returns for the evaluation period were as follows: 40.6% (13/32) for the pre-intervention, 11.4% (4/35) for the first post-intervention and 6.1% (2/33) for the second post-intervention period. Total cost savings was between $128,000 and $168,000 comparing pre and post-intervention periods. Among those treated, DTN times were not significantly different between pre-intervention (55.5 min, n=19), post-1 (59.7 min, n=27) and post-2 (49.9 min, n=30) (p=.13, 95%CI: 50.6,59.1). Similarly, the pharmacy alteplase mix times to needle times were also not significantly different (16.6 min vs 14.8 min vs 11.8 min) across the three time periods (p=.14, 95%CI:12.2,15.9). Conclusion: The percentage of vials returned reduced by over 6-fold after the intervention resulting in considerable cost savings. PSCs can reduce overall waste of alteplase and decrease costs without negatively effecting clinical care.

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