scholarly journals Topical Application of Lidocaine and Bupivacaine to Disbudding Wounds in Dairy Calves: Safety, Toxicology and Wound Healing

Animals ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 869
Author(s):  
Meredith Sheil ◽  
Michael Chambers ◽  
Adam Polkinghorne ◽  
Brendan Sharpe
Keyword(s):  
Wound Healing ◽  
Average Daily Gain ◽  
Field Conditions ◽  
Dairy Calves ◽  
Histopathological Analysis ◽  
Antiseptic Solution ◽  
Clinically Significant ◽  
Negative Impacts ◽  
The Impact ◽  
Daily Gain

Tri-Solfen® is a combination topical anaesthetic and antiseptic solution containing lidocaine, bupivacaine, adrenaline and cetrimide. Applied to wounds, it is reported to reduce the pain experienced by calves following thermocautery disbudding. While lidocaine and bupivacaine are widely used in medicine, conflicting data exist on the impact of these compounds when applied directly to the surgical wound. To investigate the safety of Tri-Solfen® applied to thermocautery disbudding wounds of calves, experiments were performed to measure (i) the safety of Tri-Solfen® (including in overdose situations); and (ii) the impact of Tri-Solfen® application at recommended doses on disbudding wound healing under field conditions. Haematological, biochemical and urinalysis parameters did not show clinically significant differences between placebo and Tri-Solfen® groups (1×, 3× and 5× dose). No adverse health impacts were reported. Histopathological analysis of wounds noted a reduction in bacterial colonies in Tri-Solfen®-treated wounds. Under field conditions, no negative impacts on wound healing were noted. Conversely, there was reduced incidence of abnormal wounds, with an associated trend toward improved average daily gain at days 11–12 in Tri-Solfen®-treated animals. These data are considered to support the safety of topical anaesthesia, as formulated in Tri-Solfen®, to the thermocautery disbudding wound in calves.

scholarly journals Grid search approach to discriminate between old and recent inbreeding using phenotypic, pedigree and genomic information

BMC Genomics ◽  
2021 ◽  
Vol 22 (1) ◽  
Author(s):  
Pattarapol Sumreddee ◽  
El Hamidi Hay ◽  
Sajjad Toghiani ◽  
Andrew Roberts ◽  
Samuel E. Aggrey ◽  
...  
Keyword(s):  
Common Ancestor ◽  
Growth Traits ◽  
Average Daily Gain ◽  
Recent Common Ancestor ◽  
Pedigree Information ◽  
Grid Search ◽  
Genomic Information ◽  
The Impact ◽  
Daily Gain ◽  
Harmful Effects

Abstract Background Although inbreeding caused by the mating of animals related through a recent common ancestor is expected to have more harmful effects on phenotypes than ancient inbreeding (old inbreeding), estimating these effects requires a clear definition of recent (new) and ancient (old) inbreeding. Several methods have been proposed to classify inbreeding using pedigree and genomic data. Unfortunately, these methods are largely based on heuristic criteria such as the number of generations from a common ancestor or length of runs of homozygosity (ROH) segments. To mitigate these deficiencies, this study aimed to develop a method to classify pedigree and genomic inbreeding into recent and ancient classes based on a grid search algorithm driven by the assumption that new inbreeding tends to have a more pronounced detrimental effect on traits. The proposed method was tested using a cattle population characterized by a deep pedigree. Results Effects of recent and ancient inbreeding were assessed on four growth traits (birth, weaning and yearling weights and average daily gain). Thresholds to classify inbreeding into recent and ancient classes were trait-specific and varied across traits and sources of information. Using pedigree information, inbreeding generated in the last 10 to 11 generations was considered as recent. When genomic information (ROH) was used, thresholds ranged between four to seven generations, indicating, in part, the ability of ROH segments to characterize the harmful effects of inbreeding in shorter periods of time. Nevertheless, using the proposed classification method, the discrimination between new and old inbreeding was less robust when ROH segments were used compared to pedigree. Using several model comparison criteria, the proposed approach was generally better than existing methods. Recent inbreeding appeared to be more harmful across the growth traits analyzed. However, both new and old inbreeding were found to be associated with decreased yearling weight and average daily gain. Conclusions The proposed method provided a more objective quantitative approach for the classification of inbreeding. The proposed method detected a clear divergence in the effects of old and recent inbreeding using pedigree data and it was superior to existing methods for all analyzed traits. Using ROH data, the discrimination between old and recent inbreeding was less clear and the proposed method was superior to existing approaches for two out of the four analyzed traits. Deleterious effects of recent inbreeding were detected sooner (fewer generations) using genomic information than pedigree. Difference in the results using genomic and pedigree information could be due to the dissimilarity in the number of generations to a common ancestor. Additionally, the uncertainty associated with the identification of ROH segments and associated inbreeding could have an effect on the results. Potential biases in the estimation of inbreeding effects may occur when new and old inbreeding are discriminated based on arbitrary thresholds. To minimize the impact of inbreeding, mating designs should take the different inbreeding origins into consideration.

280 Descriptive Characteristics of Preweaned Heifer Raising Practices on China Dairy Farms: Colostrum Quality, Passive Transfer Status and Growth Performance

2021 ◽  
Vol 99 (Supplement_3) ◽  
pp. 148-149
Author(s):  
Shuai Liu ◽  
Tianyu Chen ◽  
Jiaqi Li ◽  
Wenli Guo ◽  
Rong Peng ◽  
...  
Keyword(s):  
Growth Performance ◽  
Average Daily Gain ◽  
Passive Transfer ◽  
Dairy Calves ◽  
Serum Total Protein ◽  
Average Birth Weight ◽  
Whole Milk ◽  
Report System ◽  
Few Data ◽  
Daily Gain

Abstract Few data are available on the descriptive characteristics of colostrum quality, passive transfer status and growth performance within a national population in China. This study included 110 dairy operations in 23 provinces, and data were obtained from management software, report system and questionnaires from 2015 to 2019. Data were analyzed using SAS (version 9.0, SAS Institute Inc., Cary, NC, USA). The results showed that colostrum quality was measured in 96.4% of farms and colostrum was pasteurized in 91.8% of farms. 83.6% of colostrum was excellent (Brix > 22%). Colostrum could be fed to calves within 1 hour after birth in 86.4% of farms. Besides, calves that experienced failure of passive transfer (serum total protein < 5.2 g/dl) decreased from 2015 to 2019 and accounted for 0.75% of calves in 2019. Most farms (48.8%) feed 400 kg - 600 kg milk during the preweaning period and whole milk was the main type of liquid diet accounting for 70.6% of farms. Meanwhile, 22.0% of farms chose to feed forage before weaning, and 90.1% of these farms fed oat hay. The average birth weight of calves was 37.8 kg and the average daily gain of preweaning calves was 848.3 g/d. For preweaning calves, the proportion of single housing was more than 60%, whereas postweaning calves were mainly raised in groups. The morbidity of preweaning calves in China decreased annually, from 43.3% in 2015 to 25.4% in 2019. Digestive diseases and respiratory diseases were two main diseases, and accounted for 46.0% and 38.4%, respectively. This study provides an overview on dairy calves raising practices in China.

scholarly journals The Impact of Selection using Residual Average Daily Gain and Marbling EPDs on Growth Performance and Carcass Traits in Angus Steers

2019 ◽  
Vol 3 (2) ◽  
Author(s):  
T. R. Krause ◽  
E. R. Moore ◽  
J. Duggin ◽  
J. R. Segers ◽  
T. D. Pringle
Keyword(s):  
Growth Performance ◽  
Feed Efficiency ◽  
Average Daily Gain ◽  
Backfat Thickness ◽  
Feeding Trial ◽  
Body Weights ◽  
Selection For ◽  
Carcass Merit ◽  
The Impact ◽  
Daily Gain

ObjectivesProfitability in the beef industry has narrow margins regulated by revenue from output traits like growth and carcass merit, but profitability is also largely impacted by input expenses like feed costs. Selecting for improvements in feed efficiency during the finishing phase, one of the most feed intensive segments of the industry, can help to mitigate those input costs. This study compared growth performance, feed efficiency, body composition, and carcass characteristics in Angus steers (n = 321) from bulls divergently selected for feed efficiency and marbling.Materials and MethodsAngus sires were selected based on high (10th percentile or better) and low (85th percentile or worse) residual average daily gain (RADG) EPD as well as high (fifth percentile or better) and average (near 50th percentile) marbling (MARB) EPD. These criteria resulted in a 2 × 2 factorial design with four breeding lines: high RADG/high MARB, high RADG/average MARB, low RADG/high MARB, low RADG/average MARB. Data were analyzed using MIXED procedures of SAS with RADG and MARB as main effects. Significance was set at α = 0.05. Generation was also analyzed, where generation one (GEN1) steers were from a selected sire while generation two (GEN2) steers were from a selected sire and a selected dam.ResultsUltrasound and carcass data revealed no differences (P ≥ 0.12) in 12th rib backfat thickness from weaning through slaughter for the RADG EPD groups. Yield grade and dressing percent did not differ (P ≥ 0.56) across RADG or MARB groups. At the beginning and end of the feeding trial, the high RADG (P ≤ 0.02) group had larger ultrasound ribeye area (REA) than the low RADG group. Carcass REA tended (P = 0.08) to be larger in the high versus low RADG steers. During the feedlot trial and through slaughter, body weight was heavier (P ≤ 0.006) for the high versus low RADG steers but did not differ (P ≥ 0.44) across MARB EPD. Feed efficiency measures did not differ (P ≥ 0.32) across RADG or MARB groups apart from the tendency (P = 0.08) for residual feed intake to be lower in the high versus low RADG steers. Marbling scores differed (P ≤ 0.04) across RADG and MARB groups with the low RADG steers and the high MARB steers having improved marbling. The quality grade distribution across MARB EPD revealed that the average MARB steers graded 73% Choice and 25% Prime while the high MARB steers graded 56% and 42%, respectively. Slice shear force did not differ (P ≥ 0.32) across RADG or MARB EPD. Body weights tended (P = 0.06) to be heavier at the start of the feeding trial for GEN1 versus GEN2 steers. Total gain, average daily gain, and feed to gain (F:G) differed by generation (P ≤ 0.007) with increased rates of gain and reduced F:G in the GEN2 versus GEN1 steers. Body weights did not differ (P = 0.72) across GEN at the end of the feeding trial. Backfat thickness at the start and end of the feedlot phase was less (P ≤ 0.03) and marbling score was improved (P = 0.02) in the GEN2 versus GEN1 steers, respectively.ConclusionThese results suggest that selection using RADG EPD has negligible impacts on meat quality; and that progress in selection for efficiency can be achieved while advancing carcass quality and value. Furthermore, continued divergent selection for feed efficiency and marbling has the potential to improve feed efficiency through advancements in the rate of gain, while enhancing carcass merit through marbling.

scholarly journals Supplementation of Holstein dairy calves fed two levels of crude protein with methionine and lysine

2020 ◽  
Vol 50 (3) ◽  
pp. 442-451
Author(s):  
M. Niroumand ◽  
K. Rezayazdi ◽  
M. Ganjkhanlou
Keyword(s):  
Amino Acid ◽  
Crude Protein ◽  
Average Daily Gain ◽  
Dairy Calves ◽  
Clear Trend ◽  
Reduced Body ◽  
Holstein Calves ◽  
Amino Acid Balance ◽  
Immunoglobin G ◽  
Daily Gain

This study aimed to investigate various levels of crude protein (CP) in starter diets and their supplementation with amino acids (AAs) on efficiency, health, and serum metabolites of dairy calves. Ninety-six newborn Holstein calves were allocated to eight treatments, namely T1) 18% CP unsupplemented starter, T2) T1 supplemented with additional 20% methionine, T3) T1 with additional 20% lysine and 20% methionine, T4) T1 with additional 20% lysine, T5) 22% CP unsupplemented starter, T6) T5 supplemented with additional 20% methionine, T7) T5 supplemented with additional 20% lysine and 20% methionine, and T8) T5 supplemented with additional 20% lysine. Consumption of the starter was not influenced by the level of CP. Calves that received the unsupplemented 22% CP starter had higher average daily gain (ADG) and final weight. But no significant differences among diets were found in feed efficiency. Skeletal growth did not exhibit a clear trend. Calves that received T3 had fewer bouts of diarrhea and reduced body temperature. However, there were no significant dietary effects on immunoglobin G (IgG) or total protein concentration in blood. T1–T3 decreased serum urea concentration. Thus, use of T3 resulted in an improved amino acid balance, and was less expensive than the 22% CP starter.Keywords: amino acid, feed intake, immunity, pre-ruminant calf

Effects of linseed oil and rumen undegradable protein:rumen degradable protein ratio on performance of Holstein dairy calves

2020 ◽  
Vol 123 (11) ◽  
pp. 1247-1257 ◽  
Author(s):  
M. Kazemi-Bonchenari ◽  
M. Dehghan-Banadaky ◽  
F. Fattahnia ◽  
A. Saleh-Bahmanpour ◽  
M. Jahani-Moghadam ◽  
...  
Keyword(s):  
Feed Efficiency ◽  
Crude Protein ◽  
Protein Production ◽  
Linseed Oil ◽  
Average Daily Gain ◽  
High Ratio ◽  
Dairy Calves ◽  
Protein Ratio ◽  
Daily Gain ◽  
Degradable Protein

AbstractThe present study evaluated the interaction effects of n-3 fatty acids (from linseed oil (LSO), 0 v. 2·5, % DM basis) with rumen undegradable:degradable protein (RUP:RDP) ratios (low ratio (LR) 27:73; high ratio (HR) 38:62 based on crude protein %) in dairy calves’ starter diet. Forty-eight 3-d-old female Holstein dairy calves (41·5 kg of body weight (BW)) were allocated in a 2 × 2 factorial arrangements in the following treatments (n 12 calves/each): (1) no supplementation of LSO with LR (NLSO-LR); (2) no supplementation of LSO with HR (NLSO-HR); (3) supplementation of LSO with LR (LSO-LR) and (4) supplementation of LSO with HR (LSO-HR). The calves were weaned on day 53 of the experiment and remained in the study until day 73. Intake was not affected by LSO and RUP:RDP ratio. However, average daily gain (ADG) was improved with LSO supplementation. Feeding the HR diet increased ADG compared with the LR diet during the entire period. Final BW was greater in calves fed on the LSO than those fed the NLSO diet. Microbial protein production did not differ among treatments. Calves fed on LSO diets had greater feed efficiency than those which were not fed on LSO diets. The calves supplemented with LSO had greater wither and hip heights compared with the unsupplemented calves. The glucose, cholesterol, HDL and insulin concentrations increased in calves supplemented with LSO. In conclusion, the HR diet improved calves’ performance post-weaning; however, LSO could enhance growth performance of dairy calves during the pre-weaning period.

scholarly journals Effect of the Source of Zinc on the Tissue Accumulation of Zinc and Jejunal Mucosal Zinc Transporter Expression in Holstein Dairy Calves

Animals ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 1246 ◽  
Author(s):  
Fengtao Ma ◽  
Yeqianli Wo ◽  
Hongyang Li ◽  
Meinan Chang ◽  
Jingya Wei ◽  
...  
Keyword(s):  
Serum Alkaline Phosphatase ◽  
Effective Means ◽  
Average Daily Gain ◽  
Dairy Calves ◽  
Jejunal Mucosa ◽  
Serum Alkaline Phosphatase Activity ◽  
Zinc Accumulation ◽  
Zinc Concentrations ◽  
Daily Gain ◽  
Transporter Expression

Zinc is considered to be an anti-diarrheal agent, and it may therefore reduce the incidence of diarrhea in young calves. In the present study, we aimed to compare the effect of zinc source on growth performance, the incidence of diarrhea, tissue zinc accumulation, the expression of zinc transporters, and the serum concentrations of zinc-dependent proteins in neonatal Holstein dairy calves. Eighteen male newborn Holstein dairy calves were fed milk and starter diet supplemented with or without 80 mg zinc/d in the form of Zn-Met or ZnO for 14 days, and were then euthanized. Zn-Met supplementation improved average daily gain and feed efficiency, and reduced the incidence of diarrhea, compared with control calves (p < 0.05). It also increased the serum and hepatic zinc concentrations and the mRNA expression of the ZIP4 transporter in the jejunal mucosa of the calves (p < 0.05). In addition, the serum alkaline phosphatase activity and metallothionein concentration were higher in Zn-Met-treated calves than in control calves (p < 0.05). ZnO supplementation had similar effects, but these did not reach significance. Thus, Zn-Met supplementation is an effective means of increasing tissue zinc accumulation and jejunal zinc absorption, and can be used as an anti-diarrheal strategy in neonatal calves.

scholarly journals PSIV-20 Impact of OutPace® Feed Additive on nursery pig growth performance: A meta-analysis

2020 ◽  
Vol 98 (Supplement_3) ◽  
pp. 175-176
Author(s):  
Benjamin Bass ◽  
Stacie Crowder ◽  
Terry Weeden ◽  
Murali Raghavendra Rao ◽  
Brenda de Rodas ◽  
...  
Keyword(s):  
Feed Intake ◽  
Feed Efficiency ◽  
Meta Analysis ◽  
Block Design ◽  
Phase 1 ◽  
Average Daily Gain ◽  
Feed Additive ◽  
Significant Difference ◽  
The Impact ◽  
Daily Gain

Abstract OutPace® Feed Additive (OP), contains a carefully researched blend of activated medium chain fatty acids (MCFAs; PMI, Arden Hills, MN), formulated to help mitigate the effects of stress in nursery pigs. Several studies using OP in both late and full nursery periods resulted in improved pig performance. A meta-analysis using 9 studies (4 studies during late nursery [15 to 26.8 kg BW] and 5 studies during the full nursery [5.9 to 25.4 kg]) was done to determine the impact of OP (included at 0.25% Phase 1 and 2; 0.125% Phase 3) on average daily gain, average daily feed intake, and feed conversion. The combined data was considered a randomized complete block design. Analysis of variance was completed with mixed models using the GLIMMIX procedure of SAS (SAS 9.4, SAS Institute Inc., Cary, NC) and least squares means were compared using Fisher’s least significant difference (P &lt; 0.05). In the analysis of 5 studies conducted in late nursery (45 pens/treatment of 6 to 20 pigs/pen), pigs provided OP had higher average daily gain (0.67 vs 0.63 kg/d; P &lt; 0.05), increased average daily feed intake (0.99 vs 0.97 kg/d; P &lt; 0.05), and improved feed efficiency (0.67 vs 0.65 kg gain/kg feed intake; P &lt; 0.05) compared to pigs fed control diets. Additionally, when pigs were provided OP throughout the nursery period (20 pens/treatment of 7 to 20 pigs/pen), average daily gain was increased 6.1% (0.48 vs 0.45 kg/d; P &lt; 0.05), average daily feed intake tended to be increased 2.2% (0.62 vs 0.61 kg/d; P &lt; 0.1), and feed efficiency was improved 2.7% (0.76 vs 0.74 kg gain/kg feed intake; P &lt; 0.05) compared to pigs provided control diets. In conclusion, providing OP to pigs during the nursery period improved ADG and feed efficiency.

scholarly journals Short communication: Concentrate supplementation strategies in ryegrass pasture for productive performance in lambs

2018 ◽  
Vol 16 (1) ◽  
pp. e06SC02 ◽  
Author(s):  
Sthefany K. Santos ◽  
Margarete K. Falbo ◽  
Itacir E. Sandini ◽  
Fabiano Pacentchuk ◽  
Mikael Neumann ◽  
...  
Keyword(s):  
Lolium Multiflorum ◽  
Average Daily Gain ◽  
Live Weight ◽  
Economic Losses ◽  
Control Group ◽  
Economic Return ◽  
Nutrient Quality ◽  
Concentrate Supplementation ◽  
The Impact ◽  
Daily Gain

This study evaluated the effect of two concentrate supplementation strategies on performance, metabolic profile and economic evaluation of suckling lambs and ewes in ryegrass (Lolium multiflorum) pasture. Twenty-seven ewes and 45 lambs were divided into three groups: (1) ryegrass pasture without supplementation - control (CON); (2) CON plus supplemented ewes and lambs at 1% of live weight (SEL), and (3) CON plus creep feeding supplemented lambs at 1% of live weight (CSL). Concentrate use increased (p<0.05) average daily gain (ADG) by 19.95% over CON (21.6 and 18.3% for SEL and CSL, respectively). Concentrate use contributed to minimizing forage quality fluctuation and provided greater ADG stability, mainly when ryegrass nutritional content and digestibility decreased. Blood metabolites profiles did not differ between groups, with exception of phosphorus which was higher for CON than SEL, and calcium which was higher for CSL than CON (p<0.05). Compared to CON, stoking rate values were greater to SEL (p<0.05). Compared to CSL, ewe and total stocking rate were greater (p<0.05) to SEL. Considering the control group as break even feed investment, SEL strategy had a positive economic return, while CSL showed economic losses. Concentrate use increased ADG of lambs and decrease the impact of nutrient quality changes of forage on daily gains, but must be considered that supplemental strategy used could affect negatively economic return.

scholarly journals PSV-36 The impact of selection using residual average daily gain and marbling EPDs on growth performance and carcass traits in angus steers

2019 ◽  
Vol 97 (Supplement_3) ◽  
pp. 340-341
Author(s):  
Taylor Krause ◽  
Edward Moore ◽  
Jason Duggin ◽  
Jacob Segers ◽  
T Dean Pringle
Keyword(s):  
Growth Performance ◽  
Feed Efficiency ◽  
Average Daily Gain ◽  
Breeding Lines ◽  
Efficiency Measures ◽  
Quality Grade ◽  
Selection For ◽  
Main Effects ◽  
The Impact ◽  
Daily Gain

Abstract This study compared growth performance, feed efficiency, body composition, and carcass characteristics in Angus steers (n = 321) from bulls divergently selected for feed efficiency and marbling. Angus sires were selected based on high (10th percentile or better) and low (85th percentile or worse) residual ADG (RADG) EPD as well as high (5th percentile or better) and average (near 50th percentile) marbling (MARB) EPD. These criteria resulted in a 2x2 factorial design with four breeding lines: high RADG/high MARB, high RADG/average MARB, low RADG/high MARB, low RADG/average MARB. Data were analyzed using MIXED procedures of SAS with RADG and MARB as main effects. Ultrasound and carcass data revealed no differences (P ≥ 0.12) in 12th rib backfat thickness from weaning through slaughter for the RADG EPD groups. At the beginning and the end of the feeding trial, the high RADG (P ≤ 0.02) group had larger ultrasound ribeye area than the low RADG group. During the feedlot trial and through slaughter, BW was heavier (P ≤ 0.006) for the high versus low RADG steers but did not differ (P ≥ 0.44) across MARB EPD. Feed efficiency measures did not differ (P ≥ 0.32) across RADG or MARB groups apart from the tendency (P = 0.08) for residual feed intake to be lower in the high versus low RADG steers. Marbling scores differed (P ≤ 0.04) across RADG and MARB groups with the low RADG steers and the high MARB steers having improved marbling. The quality grade distribution across MARB EPD revealed that the average MARB steers graded 73% Choice and 25% Prime while the high MARB steers graded 56% and 42%, respectively. Slice shear force did not differ (P ≥ 0.32) across RADG or MARB EPD. These results suggest that selection using RADG EPD has negligible impacts on meat quality; moreover, they show that progress in selection for efficiency can be accomplished while advancing carcass quality and value.

scholarly journals The impact of selection using residual average daily gain and marbling EPDs on growth, performance, and carcass traits in Angus steers1

2019 ◽  
Vol 97 (6) ◽  
pp. 2450-2459
Author(s):  
Rachael A Detweiler ◽  
T Dean Pringle ◽  
Romdhane Rekaya ◽  
Jonathan B Wells ◽  
Jacob R Segers
Keyword(s):  
Growth Performance ◽  
Average Daily Gain ◽  
Carcass Traits ◽  
The Impact ◽  
Daily Gain
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