scholarly journals B-Mode and Contrast Enhanced Ultrasonography Features of Gastric Inflammatory and Neoplastic Diseases in Dogs

Animals ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 670
Author(s):  
Francesco Simeoni ◽  
Francesca Del Signore ◽  
Giovanni Aste ◽  
Paolo Bargellini ◽  
Giuseppe Rubini ◽  
...  
Keyword(s):  
Imaging Modality ◽  
Gastric Wall ◽  
Rapid Identification ◽  
Gastric Neoplasms ◽  
Control Group ◽  
Undifferentiated Sarcoma ◽  
Contrast Enhanced ◽  
Anesthetized Dogs ◽  
Contrast Enhanced Ultrasonography ◽  
Identification And Characterization

Canine gastric disorders are common in veterinary clinical practice and among these neoplasms require rapid identification and characterization. Standard ultrasound (US) is the imaging modality of choice for gastric wall assessment. The aim of this prospective study is to describe the specific B-mode and contrast enhanced US (CEUS) features of normal, inflammatory, and neoplastic gastric wall in dogs. B-mode US and CEUS of the stomach were performed in anesthetized dogs with or without gastric disorders. Gastric wall qualitative and quantitative parameters were evaluated on B-mode US and CEUS examination. A total of 41 dogs were included: 6 healthy (HEA) as the control group; 9 gastritis (INF); 8 adenocarcinoma (AC); 8 alimentary lymphoma (AL); 4 leiomyosarcoma (LEIS); 2 gastrointestinal stromal tumor (GIST); 2 leiomyoma; 1 undifferentiated sarcoma; 1 metastatic gastric hemangiosarcoma. Gastric tumors appear as a marked wall thickness with absent layers definition and possible regional lymphadenopathy (AC and AL) and steatitis (AC) while gastritis generally shows no/mild thickening and no other alterations on B-mode US. On CEUS, neoplasm shows a higher and faster wash in if compared to that of gastritis. B-mode and CEUS assessment may be useful in the evaluation of canine gastric disorders in the distinction between gastritis and gastric neoplasms, even if there are no specific features able to discriminate between the different tumor histotypes.

scholarly journals B-Mode and Contrast Enhanced Ultrasonography Features of Gastric Inflammatory and Neoplastic Diseases in Cats

Animals ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 1444
Author(s):  
Francesco Simeoni ◽  
Rossella Terragni ◽  
Giuseppe Rubini ◽  
Roberto Tamburro ◽  
Francesca Del Signore ◽  
...  
Keyword(s):  
Gastric Wall ◽  
Control Group ◽  
Wall Thickening ◽  
Low Grade ◽  
Gastric Diseases ◽  
Qualitative And Quantitative ◽  
Quantitative Parameters ◽  
Peak Enhancement ◽  
Contrast Enhanced ◽  
Contrast Enhanced Ultrasonography

Alimentary lymphoma (AL) is the most common malignancy of the feline gastrointestinal tract and may cause variable mild to severe alteration of the gastric wall on ultrasonography (US) that can be very similar to those caused by inflammation (INF). The aim of this prospective study is to establish the value of B-mode and contrast-enhanced US (CEUS) in describing specific features of normal, inflammatory, and neoplastic gastric diseases in feline species. B-mode US and CEUS of the stomach were performed in anesthetized cats with or without gastric disorders. Gastric wall qualitative and quantitative parameters were evaluated on B-mode US and CEUS examination. A total of 29 cats were included: six healthy (HEA) cats as the control group; nine INF; three low-grade lymphoma (LGAL); 10 high-grade lymphoma (HGAL). On B-mode US, there were significant differences in thickness, the wall’s layer definition and echogenicity between HGAL and all the other groups (<0.001). For CEUS, statistical differences between groups were found in the following: HGAL vs. HEA, HGAL vs. INF; HGAL vs. LGAL; INF vs. HEA. Diagnostic accuracy (AUC) and cut-off value were calculated and found to be significant for thickness (3.8 mm) for INF vs. LGAL (AUC > 0.70) and “benign” vs. “malignant” (AUC > 0.90) as well as peak enhancement (34.87 dB) for “benign” vs. “malignant” (AUC > 0.70). INF and LGAL showed an overlap of qualitative and quantitative parameters both on B-mode and CEUS, while HGAL usually appears as a severe wall thickening with absent layer definition, high-contrast uptake, a specific enhancement pattern, regional lymphadenopathy and local steatitis. Thickness and peak enhancement can be useful parameters in the characterization of gastric infiltrates in cats.

scholarly journals Contrast enhanced ultrasonography in assessing the treatment response to transarterial chemoembolization in patients with hepatocellular carcinoma.

2016 ◽  
Vol 18 (1) ◽  
pp. 96 ◽  
Author(s):  
Zeno Spârchez ◽  
Tudor Mocan ◽  
Pompilia Radu ◽  
Ofelia Anton ◽  
Nicolae Bolog
Keyword(s):  
Hepatocellular Carcinoma ◽  
Transarterial Chemoembolization ◽  
Imaging Modality ◽  
Imaging Techniques ◽  
Three Dimensional ◽  
Disease Free Survival ◽  
Early Assessment ◽  
Contrast Enhanced ◽  
Contrast Enhanced Ultrasonography ◽  
Current Guidelines

Abstract. The last decades have known continuous development of therapeutic strategies in hepatocellular carcinoma (HCC). Unfortunately the disease it still not diagnosed until it is already at an intermediate or even an advanced disease. In these circumstances transarterial chemoembolization (TACE) is considered an effective treatment for HCC. The most important independent prognostic factor of both disease free survival and overall survival is the presence of complete necrosis. Therefore, treatment outcomes are dictated by the proper use of radiological imaging. Current guidelines recommend contrast enhanced computer tomography (CECT) as the standard imaging technique for evaluating the therapeutic response in patients with HCC after TACE. One of the most important disadvantage of CECT is the overestimation of tumor response. As an attempt to overcome this limitation contrast enhanced ultrasound (CEUS) has gained particular attention as an imaging modality in HCC patients after TACE. Of all available imaging modalities, CEUS performs better in the early and very early assessment of TACE especially after lipiodol TACE. As any other imaging techniques CEUS has disadvantages especially in hypovascular tumors or in cases of tumor multiplicity. Not far from now the current limitations of CEUS will be overcome by the new CEUS techniques that are already tested in clinical practice such as dynamic CEUS with quantification, three-dimensional CEUS or fusion techniques.

scholarly journals Risk Factors of Large Artery Atherosclerotic Ischemic Stroke Based on Carotid Contrast-Enhanced Ultrasonography

2020 ◽  
Author(s):  
Shaoqi Chen ◽  
Xiya Du ◽  
Zhongkeng Yao ◽  
Qingzi Chen ◽  
Xuerui Tan
Keyword(s):  
Risk Factors ◽  
Ischemic Stroke ◽  
Sensitivity And Specificity ◽  
Roc Curve ◽  
Control Group ◽  
Large Artery ◽  
Operating Characteristics ◽  
Carotid Artery Plaque ◽  
Contrast Enhanced ◽  
Contrast Enhanced Ultrasonography

Abstract Background Ischemic stroke is a serious public health issue with a continuously increasing incidence worldwide. This study explores the risk factors of large artery atherosclerotic (LAA) ischemic stroke based on carotid contrast-enhanced ultrasonography (CEUS). Methods A total of 110 patients with LAA ischemic stroke and 34 patients without stroke were included. All participants underwent standard ultrasonography and CEUS, from which carotid artery plaque characteristics were obtained. The predicted performance of artery plaques was evaluated using the area under the receiver operating characteristics (ROC) curve and sensitivity and specificity at the optimal cut-off point. Results Subjects with LAA ischemic stroke were more likely to have a history of hypertension than the control group (P = 0.009). The area under the ROC curve (AUROC) for plaque echogenicity was 0.609 (95% CI, 0.524–0.689). With a cut-off value of ≤ class II (echolucent or predominantly hypoechogenic plaque), the sensitivity and specificity were 84.55% and 32.35%, respectively. The AUROC for plaque thickness was 0.676 (95% CI, 0.593–0.751). With a cut-off value of > 2.4 mm, the sensitivity and specificity were 41.82% and 88.24%, respectively. The AUROC for intraplaque neovascularization was 0.807 (95% CI, 0.733–0.868). With a cut-off value of > grade 2 (extensive appearance of bubbles within plaque), the sensitivity and specificity were 70.91% and 82.35%, respectively. Conclusions Hypertension, echolucent (or predominantly hypoechogenic) plaque, plaque thickness, and degree of intraplaque neovascularization are significantly relevant to LAA ischemic stroke in adults. These results may be helpful for clinical prediction of ischemic stroke risk.

scholarly journals Evaluation of the Safety and Effectiveness of Tubal Inflammatory Drugs Used in Patients with Incomplete Tubal Obstruction After Four-Dimensional Hysterosalpingo-Contrast-Sonography Examination

2022 ◽  
Author(s):  
Yue Zhang ◽  
Qin Wang ◽  
Chun-yan Gao ◽  
Hong-ju Tian ◽  
jiao He ◽  
...  
Keyword(s):  
Postoperative Complications ◽  
Pregnancy Rate ◽  
Control Group ◽  
Basic Information ◽  
Contrast Enhanced ◽  
Significant Difference ◽  
Contrast Enhanced Ultrasonography ◽  
Inflammatory Drugs ◽  
And Control ◽  
Experimental Group

Abstract Background To investigate the safety and effectiveness of tubal inflammatory drugs in patients with incomplete tubal obstruction of at least 1 side after four-dimensional hysterosalpingo-contrast-sonography (4D-HyCoSy) examination. Methods 215 cases of tubal insufficiency were diagnosed by ultrasonography from February 2019 to November 2020.According to retrospective analysis,the patients in this study were divided into experimental and control groups; the experimental group was treated with a push of salpingitis drugs, and the control group received blank control. Basic information, degree of pain, postoperative complications, and pregnancy rate were then compared between the 2 groups. Result(s) : Compared with the control group, there was no significant difference in the basic information; preoperative, intraoperative, or postoperative pain; or in postoperative complications (P > 0.05). The cumulative pregnancy rate of the experimental group (28.0%) was statistically different from that of the control group (15.3%) (P < 0.05). Conclusion(s): We observed that for infertile patients with incomplete obstruction of at least one fallopian tube as diagnosed by contrast-enhanced ultrasonography, salpingitis-treatment drugs effectively improved the pregnancy rate postoperatively, with high effectiveness and safety. This regimen is thus worthy of further investigation and promotion in the future.

scholarly journals Double contrast-enhanced ultrasonography of a small intestinal neuroendocrine tumor: a case report of a recommendable imaging modality

2020 ◽  
Vol 3 (2) ◽  
pp. 147-152
Author(s):  
Jie-ying Zhao ◽  
Hua Zhuang ◽  
Yuan Luo ◽  
Ming-gang Su ◽  
Mo-li Xiong ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Neuroendocrine Tumor ◽  
Neuroendocrine Tumors ◽  
Imaging Modality ◽  
Intestinal Tumors ◽  
Double Contrast ◽  
Diagnostic Challenge ◽  
Contrast Enhanced ◽  
Contrast Enhanced Ultrasonography ◽  
Small Intestinal

Abstract A 57-year-old male presenting with spontaneously relieved abdominal cramp and distension was admitted to the West China Hospital. The diagnosis remained unclear after colonoscopy and computed tomography. Double contrast-enhanced ultrasonography was then performed and a neoplasm in the small intestine was suspected, supported by a thin-section computed tomography and positron emission tomography/computed tomography. This was confirmed pathologically after surgery to be a small intestinal G1 neuroendocrine tumor. Surgery was performed to remove approximately 25 cm of small bowel and a 3-cm solid mass located in the mesentery. The patient had a complete recovery and was tumor-free at the final follow-up. Small intestinal tumors including neuroendocrine tumors have always posed a diagnostic challenge. This case indicated that double contrast-enhanced ultrasonography is feasible in detection of small intestinal neuroendocrine tumors, and it may be an advisable approach assisting diagnosis of small intestinal tumors.

scholarly journals Quantitative Assessment of Renal Function In Children with UPJO By Contrast-enhanced Ultrasound: A Pilot Study

2020 ◽  
Author(s):  
Shuofan Chen ◽  
Defu Lin ◽  
Pei Liu ◽  
Ning Sun ◽  
Wenwen Han ◽  
...  
Keyword(s):  
Renal Function ◽  
Sensitivity And Specificity ◽  
Roc Curve ◽  
Imaging Modality ◽  
Area Under The Curve ◽  
Diagnostic Value ◽  
Control Group ◽  
Time Intensity Curve ◽  
Contrast Enhanced ◽  
Experimental Group

Abstract Background: Contrast-enhanced ultrasonography (CEUS) is a new potential modality for the quantitative evaluation of the microvascular perfusion of a parenchymal organ.Objective: To prospectively evaluate the diagnostic value of CEUS in assessing renal function in patients with ureteropelvic junction obstruction (UPJO).Methods: The study protocol was approved by the local ethics committee, and written informed consent was obtained from the patients’ parents or guardians.Ultrasonography (US), CEUS, and radioisotope renography were performed in 51 children (42 boys, 9 girls; mean age, 6.75 ± 4.14 years) with unilateral UPJO. The slope of the ascending curve (A), time to peak (TTP), peak intensity (PI), and area under the curve (AUC) were recorded during CEUS; the quantitative data were calculated by the QLAB system (semiautomated border tracking, Philips Healthcare) software. Sensitivity and specificity values were determined for CEUS and compared with radioisotope renography.Results: CEUS depicted 102 kidneys in 51 patients, in whom the perfusion time-intensity curve（TIC）was determined. The TIC of renal cortical perfusion in all groups showed an asymmetrical single-peak curve, which could be clearly distinguished between the experimental group and the control group. Compared to the control group, the TTP was markedly prolonged but A was significantly decreased in the experimental group (P < 0.05). The ROC curve drawn to differentiate the differential renal function (DRF) using the TTP value provided an area under the ROC curve (AUROC) of 0.86. The diagnostic performance of contrast-enhanced US was better than that of US, as the sensitivity and specificity values were 92.86% and 76.14%, respectively.Conclusions: This preliminary experience represents the first report of evaluating the diagnostic value of CEUS in assessing renal function in children with UPJO. CEUS is a highly sensitive, rapid, and cost-effective diagnostic imaging modality for detecting and monitoring renal function noninvasively.

SAT0338 CONTRAST-ENHANCED ULTRASONOGRAPHY IN THE EVALUATION OF MYOSITIS

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1114.1-1115
Author(s):  
N. Pipitone ◽  
P. Macchioni ◽  
G. Bajocchi ◽  
C. Salvarani
Keyword(s):  
Confidence Interval ◽  
Vastus Lateralis ◽  
Intraclass Correlation ◽  
Guest Speaker ◽  
Control Group ◽  
Muscle Testing ◽  
Thigh Muscles ◽  
Contrast Enhanced ◽  
Linear Probe ◽  
Contrast Enhanced Ultrasonography

Background:contrast-enhanced ultrasonography (CEUS) has been proposed as a tool to assess myositis, but data in the literature are still scarce (Radiologe 2018;58:579).Objectives:to evaluate CEUS as a tool to assess myositis patients and its accuracy in differentiating myositis from common mimickers.Methods:16 patients with myositis (4 polymyositis, 6 dermatomyositis, 2 immune-mediated necrotizing myopathy, 1 inclusion body myositis, 2 overlaps Sjøgren’s syndrome - myositis and 1 Enterovirus-reactive myositis) and 4 controls (2 peripheral neuropathy, 1 limb girdle muscle dystrophy, and 1 metabolic myopathy) underwent after rest CEUS (Esaote MyLab, linear probe 13-5 MHz, Sonovue®) at a room temperature of 20° of the vastus lateralis and medialis muscles. CEUS was performed by 2 ultrasonographists with an expertise in muscle US blinded to the clinical data of the patients. CEUS muscle signal was expressed on a 0-4 scale as described in J Rheumatol 2001; 28:1271 per each muscle group and the global score was divided by four. Creatine kinase (CK), manual muscle test (MTT) and MRI of the thigh muscles were performed within maximum one month from the CEUS. MMT was expressed using the 0-5 Medical Research Council scale; intermediate points were converted into decimals as detailed in Kendall FP et al, Muscle Testing & Function: Testing and Function with Posture and Pain. 5th ed., Lippincott Williams & Wilkins, 2005. MRI of the thigh muscles was considered positive if it showed muscle edema. Myositis was defined active if CK was raised above the reference range and/or MMT showed progressive worsening. Results were expressed as median (range). Between-group comparison was performed with Mann-Whitney test. Statistical analysis was performed with SPSS version 20. The study was approved by the Ethics Committee and all patients provided their written consent.Results:Median (range) age was 38 (69) years in the myositis and 41 (45) years in the control group (p=0.89). Disease duration in the myositis group was 60 (334) months. CEUS muscle score was 0.5 (3) in the myositis group and 2 (3) in the control group (p=0.99). In the myositis group, CEUS score did not differ between treated and untreated patients (p=0.84). CK values were 361 (6442) in the myositis group and 363 (799) in the control group (p=0.68). MMT was significantly lower in the myositis group [4.33 (2)] than in the control group [4.94 (0)] (p=0.038). CEUS was 77% (47-05 95% confidence interval) sensitive and 67% (9-99% 95% confidence interval) specific for a diagnosis of myositis. CEUS was positive in 10/13 patients and negative in 3/13 with active myositis, while was negative in 2/3 patients and positive in 1/3 with inactive myositis. Statistically, CEUS did not discriminate between active and inactive myositis (Fisher’s exact test p= 0.21). All controls had a positive CEUS. No association was found between MRI edema and a positive CEUS (intraclass correlation coefficient p=0.5). No correlation was found between CEUS score, on the one hand, and CK levels or MMT, on the other (Spearman’s rho p>0.05).Conclusion:CEUS has moderate sensitivity for a diagnosis of myositis, but does not discriminate between myositis and some of its common mimickers. Larger studies are required to better evaluate the role of CEUS in patients with myositis.Disclosure of Interests:Nicolo Pipitone Consultant of: Received royalties from Uptodate.comInvestigator for the gevokizumab in myositis Servier study (2014), the sirukumab in GCA GSK study (2016), PI for the ToReMy AIFA funded (2017) study and for the FOREUM funded (2018) GCA study, Speakers bureau: Guest speaker at UCB-sponsored meetings: (Immunology Summits, Prague, 2012, 2013 & 2014, MACRO Meet the expert at the ACademy of RheumatOlogy, Bologna 13 - 14 April 2012, GRAPPA Workshop, Milan 29 January 2016 and Rome 30 November 2017), Fininvest (Catania 2016), Aim Group (Reggio Emilia 2018), I&C (Cologna, 2018), Alfa-Wassermann sponsored meeting (Rhewind, Bologna, February 2016 and 2019), Pierluigi Macchioni: None declared, Gianluigi Bajocchi: None declared, Carlo Salvarani Grant/research support from: consulting and investigator fees from Abbvie, Pfizer, MSD, Roche, Celgene, Novartis, Consultant of: consulting and investigator fees from Abbvie, Pfizer, MSD, Roche, Celgene, Novartis

scholarly journals Contrast-enhanced Ultrasound in Obstetrics and Gynecology

2007 ◽  
Vol 1 (2) ◽  
pp. 16-19 ◽  
Author(s):  
Jun Murotsuki
Keyword(s):  
Contrast Media ◽  
Pregnant Women ◽  
Imaging Modality ◽  
First Trimester ◽  
Obstetrics And Gynecology ◽  
Limited Information ◽  
Ultrasound Contrast ◽  
Contrast Enhanced ◽  
Ultrasound Contrast Media ◽  
Contrast Enhanced Ultrasonography

Abstract Ultrasonography is a well-established imaging modality for evaluation of gynecologic tumors. In recent years, more sophisticated technologies like the use of intravascular contrast agents led to an improvement in the ability of the practitioner to differentiate benign from malignant masses. When we consider the safety of contrast-enhanced ultrasonography in obstetrics and gynecology, we must discuss about the effect of ultrasound contrast media on embryo and fetus. The use of ultrasound contrast media in pregnant women always concerns in the obstetricians because of the principle of not exposing a fetus to any drug. Therefore, the literature was reviewed for information about those safety and efficacy because of the uncertainty about the use of contrast media during pregnancy. Based on the limited information available, mutagenic and teratogenic effects have not been described after administration of ultrasound contrast media. No effect on the fetus has been seen after contrast media. The small potential risk associated with the nonthermal bioeffects via acoustic cavitation may be considered to prohibit the use in first trimester pregnant women. In previous studies including human trials, no evidence of adverse effect was reported. Contrast-enhanced ultrasonography could prove a useful adjunct in multiple gestations and in evaluation of uteroplacental circulation. It appears to be very promising potential in obstetrics.

Detection of Complications After Aortic Stent Grafting

2010 ◽  
Vol 6 (2) ◽  
pp. 83 ◽  
Author(s):  
Georgia Tsoumakidou ◽  
Elias Brountzos ◽  
◽  
Keyword(s):  
Imaging Modality ◽  
High Rate ◽  
Stent Grafting ◽  
Contrast Enhanced ◽  
Contrast Nephrotoxicity ◽  
Contrast Enhanced Ultrasonography ◽  
Aneurysm Repair ◽  
Aortic Aneurysm Repair

Today, endovascular aortic aneurysm repair (EVAR) is used as an alternative to open surgery. Although the peri-procedural mortality rate is lower with EVAR, there is a high rate of re-intervention that makes long-term surveillance necessary; therefore, we reviewed the possible complications that can occur after EVAR and focused on the different imaging strategies used for follow-up. So far, multidetector computed tomography angiography (MDCTA) is the most widely accepted surveillance method, but carries the risk of radiation and contrast nephrotoxicity. Radiography, MRA, duplex and contrast-enhanced ultrasonography can also provide high-quality imaging, each with its own advantages and limitations. The ideal follow-up protocol (time intervals and type of imaging modality) needs to be further defined in order to ensure proper endograft function and prevent complications.

Sign in / Sign up

Export Citation Format

Share Document