scholarly journals Effects of Diet Supplemented with Excess Pyrroloquinoline Quinone Disodium on Growth Performance, Blood Parameters and Redox Status in Weaned Pigs

Animals ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 359
Author(s):  
Dongxu Ming ◽  
Caiyun Huang ◽  
Wenhui Wang ◽  
Zijie Wang ◽  
Chenyu Shi ◽  
...  
Keyword(s):  
Serum Concentration ◽  
Growth Performance ◽  
Average Daily Gain ◽  
Pyrroloquinoline Quinone ◽  
Control Group ◽  
Growth Promoter ◽  
Feed Conversion ◽  
Weaned Pigs ◽  
Large White ◽  
Diarrhea Incidence

The research was implemented to assess the safety of feeding excess of pyrroloquinoline quinone disodium (PQQ·Na2) to 108 Duroc × Landrace × Large White weaned pigs (BW = 8.38 ± 0.47 kg). Pigs were weaned at 28 d and randomly distributed to one of three diets with six replicates and six pigs per replicate (three males and three females). Pigs in the control group were fed a corn-soybean meal-based diet (without growth promoter) while the two experimental diets were supplied with 7.5 and 75.0 mg/kg PQQ·Na2, respectively. Average daily gain (ADG), average daily feed intake (ADFI), feed conversion (F:G), diarrhea incidence, hematology, serum biochemistry, organ index and general health were determined. Diets supplementation with 7.5 mg/kg PQQ·Na2 in weaned pigs could increase ADG during the entire experimental period (p < 0.05). And there was a tendency to decrease F:G (p = 0.063). The F:G of weaned pigs fed 7.5 and 75.0 mg/kg PQQ·Na2 supplemented diets was decreased by 9.83% and 8.67%, respectively, compared to the control group. Moreover, pigs had reduced diarrhea incidence (p < 0.01) when supplemented with PQQ·Na2. No differences were observed between pigs supplemented with 0.0, 7.5 and 75.0 mg/kg PQQ·Na2 diets on hematological and serum biochemical parameters as well as histological assessment of heart, liver, spleen, lung and kidney. At day 14, pigs had increased activity of glutathione peroxidase (GSH-Px) (p < 0.05), catalase (CAT) (p < 0.05) and total antioxidant capacity (T-AOC) (p < 0.05), and the serum concentration of malondialdehyde (MDA) was decreased (p < 0.01) with PQQ·Na2 supplementation. At day 28, pigs had increased activities of total superoxide dismutase (T-SOD) (p < 0.01), GSH-Px (p < 0.01), CAT (p < 0.05) and T-AOC (p < 0.01), and serum concentration of MDA was lower (p < 0.01) with PQQ·Na2 supplementation. In conclusion, PQQ·Na2 can improve weaned pigs growth performance and serum antioxidant status. Meanwhile high PQQ·Na2 inclusion of 75.0 mg/kg does not appear to result in harmful effects on growth performance of pigs.

Combined administration of bacteriocin- -producing, probiotic strain Enterococcus faecium CCM7420 with Eleutherococcus senticosus and their effect in rabbits

2013 ◽  
Vol 16 (4) ◽  
pp. 619-627 ◽  
Author(s):  
M. Pogány Simonová ◽  
A. Lauková ◽  
L. Chrastinová ◽  
I. Plachá ◽  
V. Strompfová ◽  
...  
Keyword(s):  
Growth Performance ◽  
Enterococcus Faecium ◽  
Average Daily Gain ◽  
Probiotic Strain ◽  
Cholesterol Concentration ◽  
Control Group ◽  
Feed Conversion ◽  
Eleutherococcus Senticosus ◽  
Commercial Diet ◽  
And Control

Abstract The effect of Enterococcus faecium CCM7420 (EF) - enterocin-producing and probiotic strain of rabbit origin, Eleutherococcus senticosus extract (ES) and their combination (ES+EF) was determined on selected bacteria in faeces and caecum content, leukocytes phagocytosis, blood biochemistry and growth performance. Ninety-six weaned rabbits were divided into 3 experimental (ES, EF, ES+EF) and control group (CG). The rabbits in the groups ES and EF+ES were fed commercial diet enriched with E. senticosus extract (30 g/100 kg feed), rabbits in groups EF and CG were fed untreated diet. The rabbits in the EF and ES+EF groups were administered with an overnight culture of E. faecium CCM7420 strain (500 μl/animal/day into water, 109 CFU/ml). The treatment period lasted 21 days. The microbiological examinations in faecal samples confirmed the presence of E. faecium CCM7420 strain. In groups EF and ES+EF, the reduction of faecal coliforms, Pseudomonas-like sp., Clostridium-like sp. and S. aureus was recorded. Leucocyte phagocytosis significantly increased in all experimental groups (P<0.0001) compared to CG. The lowest GPx values were measured in the ES+EF group. Higher total protein, triglycerides and calcium concentrations were detected in experimental groups compared to CG. The cholesterol concentration decreased in the ES group. The highest average daily gain was recorded in EF group; in ES+EF the better feed conversion ratio and no mortality was recorded. These results indicated that the dietary supplementation with the E. faecium CCM7420 and E. senticosus extract stimulate the leukocytes phagocytosis and reduces the potential pathogens in rabbits digestive tract without oxidative stress and improve the growth performance.

scholarly journals Effect of colistin and tylosin used as feed additives on the performance, diarrhea incidence, and immune response of nursery pigs

2016 ◽  
Vol 37 (4) ◽  
pp. 1947 ◽  
Author(s):  
Kelly Mazutti ◽  
Leandro Batista Costa ◽  
Lígia Valéria Nascimento ◽  
Tobias Fernandes Filho ◽  
Breno Castello Branco Beirão ◽  
...  
Keyword(s):  
Immune Response ◽  
Feed Intake ◽  
Immune Cell ◽  
Average Daily Gain ◽  
Experimental Period ◽  
Feed Additives ◽  
Control Group ◽  
Feed Conversion ◽  
Nursery Pigs ◽  
Diarrhea Incidence

For the last several decades, antimicrobial compounds have been used as feed additives to promote piglet growth at weaning, through the prevention of subclinical and clinical disease. However, few studies have assessed the influence of these antibiotics on the immune response of nursery pigs, as well as the relation between performance, health, and immunity of animals that receive feed additives. Therefore, the present study aimed to evaluate the effects of colistin and tylosin when used as feed additives on the performance, incidence of diarrhea, and immune response of nursery pigs. In this study, 72 weaned pigs (average age, 28 days) were allotted into one of three treatment groups: a control group (feed with no antibiotics), tylosin group (feed containing 22 ppm tylosin), and colistin group (feed containing 20 ppm colistin). Weekly, during a five week period, the average daily feed intake, average daily gain, and feed conversion ratio of the pigs were evaluated. Stools were scored daily, in accordance with a fecal texture scale. Blood samples were collected on the day of housing (d0) and on d7, d21, d28, and d35 for immune cell phenotyping. The results of this study showed that piglets in both the colistin and tylosin groups exhibited a significantly higher average daily feed intake, resulting in a higher body weight at the end of the experimental period (d35) when compared with piglets from the control group. Colistin and tylosin also significantly reduced the incidence of diarrhea. Colistin and tylosin modulated the piglets’ immune responses, particularly on d28, by changing the percentage of circulating B lymphocytes, CD4+CD8+ T cells, and the CD4:CD8 ratio.

scholarly journals The use of phytobiotics in growth stimulation of weaned pigs

2015 ◽  
Vol 69 (1-2) ◽  
pp. 63-74
Author(s):  
Stamen Radulovic ◽  
Radmila Markovic ◽  
Dobrila Jakic-Dimic ◽  
Dragan Sefer
Keyword(s):  
Body Weight ◽  
Average Daily Gain ◽  
Growth Stimulation ◽  
Animal Nutrition ◽  
Control Group ◽  
Feed Conversion ◽  
Growth Promoters ◽  
Weaned Pigs ◽  
Daily Gain ◽  
Stimulation Of

Phytogene feed additives (phytobiotics) are plant origin compounds used in animal nutrition in order to improve their productivity by improving the production performance of animals, feed properties and the quality of food of animal origin. These additives stimulate animal growth by using their natural and physiological potentials and mechanisms providing conditions for the realization of the genetically projected production volumes. Data on the use of phytobiotics as growth stimulators are incomplete and often very contradictory, especially those related to their impact on the health and performance of weaned pigs. Given the relevance and importance of these issues the feeding trial was organized by the group-control system. The experiment lasted for 40 days and it was divided into two phases of 20 days each. Trial was conducted on 24 piglets, F1 generation of Swedish Landrace and Pietrain, weaned from sows at the age of 35 days. Tests were carried out on piglets, with an average body weight of 8.61?1.59 kg, which were subjected to one of the two feeding treatments immediately after weaning. The control group was fed with a mixture without growth promoters, while the experimental group received a diet containing preparation of phytobiotic (Enviva EO 101, Danisco Animal Nutrition) in the amount recommended by the manufacturer (0.1 kg/t). The mixtures for piglets nutrition were formulated in accordance with the recommendations of the NRC (1998), and AEC (1993) and they met the nutritional requirements completely. During the experiment, there was no disturbance of health and/or the manifestation of clinical signs of disease. The control group, fed with the diet without added growth stimulators, achieved body weight (25.32?6.31 kg), average daily gain (0.42?0.12 kg), consumption (0.89 kg) and feed conversion (2.119 ) normal for a given race, age and housing conditions. The use of preparation of phytobiotics as growth promoters, led to better production results in regard to the control group, which was based on higher body weight (27.19?4.77 kg), higher average daily gain (0.46?0.09 kg) and better feed conversion (2.043). The use of phytobiotic, as an alternative option in growth stimulation of weaned pigs, has its nutritive, medical and economic justification.

scholarly journals 19 Effects of glutathione on growth performance and intestinal health of piglets

2019 ◽  
Vol 97 (Supplement_3) ◽  
pp. 19-19
Author(s):  
Xianyong Ma ◽  
Zhimei Tian ◽  
Yiyan Cui ◽  
Zhichang Liu ◽  
Huijie Lu
Keyword(s):  
Growth Performance ◽  
Average Daily Gain ◽  
Control Group ◽  
Standard Diet ◽  
Intestinal Health ◽  
Large White ◽  
Crypt Depth ◽  
Mda Content ◽  
Villous Height ◽  
Mucosal Morphology

Abstract Object: The aim of this experiment was to study the effects of different levels of glutathione (GSH) on growth performance and intestinal health of piglets. Methods: A total of 180 piglets of 21-day-old (Duroc × Landrace × Large White) were randomly divided into 5 groups. The control group was fed a standard diet based on NRC 2012. The treatment group 1 - 4 was supplemented with 50, 100, 200 and 400mg/kg GSH. The experiment lasted 28 days. Results: Compared with the control group, 50mg/kg GSH significantly increased the piglet’s skin and gross color, average daily gain (ADG) and decreased feed gain ratio (F/G) (P &lt; 0.05), while the effect of 100, 200, 400 mg/kg GSH was contrary. The supplementation of 50mg/kg GSH significantly increased the mucosal villi height, the ratio of villous height to crypt depth (VH/CD) and decreased the crypt depth (P &lt; 0.05) in duodenum, jejunum and ileum (P &lt; 0.05), while the effect of 100, 200, 400 mg/kg GSH was contrary; The supplementation of 50mg/kg GSH decreased the concentration of triglyceride in plasma (P &lt; 0.05); The supplementation of 50, 100, 200, 400mg/kg GSH had no effect on the antioxidative indexes of blood, but 400mg/kg GSH increased the activities of T-AOC, GSH, SOD and decreased MDA content in jejunum and ileum; 400mg/kg GSH increased the content of T-SOD in liver (P &lt; 0.05), while 50mg/kg GSH had no effect on SOD, GSH-PX, GSH-SOD in intestine and liver (P &gt; 0.05). 50mg/kg GSH significantly increased T-AOC activity and decreased MDA content in muscle (P &lt; 0.05). Conclusion: Supplementation of 50mg/kg GSH in piglets` diet was the most appropriate and it could significantly improve skin and gross color, growth performance and intestinal mucosal morphology, it also increased the antioxidation ability in muscle of piglets.

scholarly journals Growth Performance, Nutrient Digestibility and Carcass Characteristics of Pigs Fed Diets Containing Amarula (Sclerocarya Birrea A. Rich) Nut Cake as Replacement To Soybean Meal

2021 ◽  
Author(s):  
Maggy Palesa Mabena ◽  
Moses Ratsaka ◽  
Thobela Nkukwana ◽  
Ingrid Malebana ◽  
Douglas Nkosi
Keyword(s):  
Growth Performance ◽  
Feed Intake ◽  
Average Daily Gain ◽  
Carcass Characteristics ◽  
Live Weight ◽  
Nutrient Digestibility ◽  
Growing Pigs ◽  
Feed Conversion ◽  
Large White ◽  
Sclerocarya Birrea

Abstract This experiment evaluated varying levels of Amarula (Sclerocarya birrea A. Rich) nut cake (ANC) on growth performance, nutrient digestibility and carcass characteristics in pigs. Thirty Large White × Landrace (LW × LR) pigs were stratified by weight (average live weight of 20 ± 5 kg) and randomly allocated to the five experimental diets that contained 0 (control), 50, 100, 150 and 200 g ANC/kg DM. Each pig served as a replicate unit, housed individually. Bodyweight, feed intake, average daily gain (ADG) and feed conversion ratio (FCR) were recorded weekly throughout the trial period. On completion of the growth trial, following a 3-day adaptation, a nutrient digestibility study was conducted over 5 days. Thereafter, pigs were fasted for twelve hours, weighed, slaughtered, and carcass samples were collected for analysis. Feed intake was not affected by dietary treatment, but ADGs were reduced at ANC levels > 15%, resulting in poor FCR. Protein digestibility was reduced at ANC levels > 15%, while ether extract and fibre levels increased. Warm and cold carcass weights were lower at ANC levels > 15, with improved meat redness and lightness. It was concluded that ANC could replace SBM in the diet of growing pigs at less than 15% inclusion level.

scholarly journals Effects of Supplementation with a Quebracho Tannin Product as an Alternative to Antibiotics on Growth Performance, Diarrhea, and Overall Health in Early-Weaned Piglets

Animals ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 3316
Author(s):  
Min Ma ◽  
James K. Chambers ◽  
Kazuyuki Uchida ◽  
Masanori Ikeda ◽  
Makiko Watanabe ◽  
...  
Keyword(s):  
Growth Performance ◽  
Hematological Parameters ◽  
Average Daily Gain ◽  
Feed Conversion ◽  
Weaned Piglets ◽  
Negative Effects ◽  
Vegetable Extract ◽  
Diarrhea Incidence ◽  
Quebracho Tannin ◽  
Mucosal Thickness

This study assessed the feasibility of using a vegetable extract, MGM-P (quebracho tannin product), as an alternative to antibiotics for weaned piglets; it investigated MGM-P effects on growth performance, diarrhea, and overall health in early-weaned piglets. In total, 24 piglets were allocated to three treatment groups fed basal diets supplemented with 0, 0.2%, or 0.3% MGM-P for 20 days. The addition of 0.3% MGM-P to the diet of early-weaned piglets improved diarrhea incidence, hematological parameters, and intestinal mucosa structure. Furthermore, the addition of 0.2% or 0.3% MGM-P to the diet of early-weaned piglets did not affect their overall health. Importantly, MGM-P had no effects on average daily gain (ADG), average daily feed intake (ADFI), or feed conversion ratio (FCR). Gut morphology analysis showed that treatment with 0.3% MGM-P enhanced the jejunal villus height (p < 0.05) while reducing the ileal crypt depth (p < 0.05) and colon mucosal thickness (p < 0.05). Collectively, the findings suggested that the use of MGM-P as an alternative to dietary antibiotics could improve diarrhea incidence in early-weaned piglets without negative effects on growth performance or overall health.

scholarly journals By-products of apricot processing in quail feed: Effects on growth performance, carcass characteristics, and meat physicochemical quality

2021 ◽  
Vol 14 (4) ◽  
pp. 878-883
Author(s):  
Fatma Boubekeur ◽  
Rafik Arbouche ◽  
Yasmine Arbouche ◽  
Fodil Arbouche
Keyword(s):  
Growth Performance ◽  
Soybean Meal ◽  
Average Daily Gain ◽  
Carcass Characteristics ◽  
Live Weight ◽  
Partial Substitution ◽  
Control Group ◽  
Feed Conversion ◽  
Carcass Yield ◽  
By Products

Background and Aim: The rearing of quails can have a stronger attraction for the breeders if we lower the cost prices by introducing by-products in their feed formulas. The aim of this study was to evaluate the effects of the partial substitution of soybean meal by apricot kernel cake (AKC) in the diet of quails, applied either sequentially or during all phases of rearing, on their growth performances, carcass characteristics, and meat physicochemical composition. Materials and Methods: A total of 600 one-day-old quails (Coturnix coturnix japonica), with equal sex ratio and weighing on average 7±0.2 g, were randomly distributed in one control group and three experimental groups, the latter being designed according to the rate of application of AKC in either sequential or non-sequential mode in different rearing phases. Each group was divided into five replicates of 30 quails, randomly distributed according to either substitution rate of soybean meal by the AKC (0%, 10%, 20%, or 30%) or farming phase. Results: The average daily gain from the 1st to 45th days (average daily gain1–45d) was found to be the highest (4.24 g/d/subject, p=0.021) for the 30% AKC-supplemented feed lot in either starter or finish incorporation (DFTAA), having an optimum final live weight of 193.4 g (p=0.028), a lowest feed conversion ratio of 3.08 (p=0.001), and a daily feed intake of 860 g (p=0.01). Carcass yield was recorded the highest (74.4%, p=0.02) with an optimum meat protein level (30.6%, p=0.024) and the lowest fat content (2.26%, p=0.001) for the same group as well. Conclusion: The partial substitution of soybean meal by AKC in the quails' fattening feeding, during the finishing phase and for all rearing phases, led to a better growth performance, a better carcass yield, and an improved chemical composition of meat.

scholarly journals Chito-oligosaccharide as growth promoter replacement for weaned piglets: performance, morphometry, and immune system

2017 ◽  
Vol 38 (5) ◽  
pp. 3253 ◽  
Author(s):  
Eduardo Raele Oliveira ◽  
Caio Abércio da Silva ◽  
Raúl Jorge Hernan Castro-Gómez ◽  
Arturo Pardo Lozano ◽  
David Fernandes Gavioli ◽  
...  
Keyword(s):  
Immune System ◽  
Growth Performance ◽  
Average Daily Gain ◽  
Spleen Weight ◽  
Growth Promoter ◽  
Feed Conversion ◽  
Villus Height ◽  
Intestinal Length ◽  
Diet Formulation ◽  
Duodenal Ph

The objective of this study was to evaluate the chito-oligosaccharide (COS) against two growth promoter antibiotics, colistin and lincomycin, with respect to growth performance, incidence of diarrhea, visceral characteristics, morphometry, and serum immunoglobulin levels (IgA, IgG, and IgM). A total of 96 Pen Ar Lan® piglets (48 barrows and 48 females), weaned at 17 days and with body weight (BW) 5.33 ± 0.37 kg, were subjected to the evaluation of growth performance and serum. Twenty-four animals, females, 35-day-old and with BW 6.86 ± 0.64 kg, were used for the assessment of histology and visceral organ weight. The three treatments were a basic diet formulation supplemented with COS (100 mg kg-1), colistin (40 mg kg-1), or lincomycin (4.4 mg kg-1). The antibiotic treatments showed higher average daily gain (ADG) than COS treatment during the period of 49 to 63 days; whereas the feed conversion ratio (FCR) was higher and incidence of diarrhea was lower for the colistin treatment than for other treatments. The spleen weight and the small intestinal length were higher and duodenal pH was lower for COS than for antibiotics. Morphometry indicated greater villus height and higher ratio of villus height to crypt depth with colistin than with COS and a lower lesion score compared with other treatments. The serum IgA concentration was higher for COS in 35-day-old piglets. According to the results, COS was not efficient to replace colistin as a growth promoter for piglets weaned at 17 days; however, the results related to the immune system suggested that COS is a potentially promising product during weaning.

Effects of lipopolysaccharide on the growth performance, nitrogenmetabolism and immunity in preruminant calves

2016 ◽  
Author(s):  
N. Zhan ◽  
H. Li ◽  
C. Jiang ◽  
Y. Tu ◽  
D. Diao
Keyword(s):  
Growth Performance ◽  
Average Daily Gain ◽  
Nitrogen Retention ◽  
Utilization Efficiency ◽  
Control Group ◽  
Urinary Concentration ◽  
Feed Conversion ◽  
Sterile Saline ◽  
E Coli ◽  
Lps Challenge

To investigate the effect of lipopolysaccharides (LPS) on the growth performance, nitrogen metabolism and immunity in preruminant calves, forty Chinese Holstein male calves were randomly divided into two groups and injected intraperitoneally with 2.5 mg/kg BW of sterile saline or E. coli LPS (Escherichia coli O55:b55) on day 24, 26, and 28. The LPS challenge decreased average daily gain and feed conversion efficiency compared with control group (p less than0.05). The urinary concentration of nitrogen (pless than0.05) increased, whereas the nitrogen retention decreased (pless than0.05) after LPS-challenge. Injection of LPS increased body temperature, serum concentration of IL-1, TNF-a, IL-2 and IgG of calves. In conclusion, LPS-challenge activated immune responses, decreased utilization efficiency of nitrogen, and negatively impacted growth performance of preruminant calves.

Nutritional effects pre-weaning on growth performance, carcass traits and meat quality of pigs

2020 ◽  
Vol 60 (7) ◽  
pp. 978
Author(s):  
Hong Chen ◽  
Yan Liu ◽  
Hui Li ◽  
Zhengfeng Fang ◽  
Yan Lin ◽  
...  
Keyword(s):  
Serum Concentration ◽  
Growth Performance ◽  
Meat Quality ◽  
Average Daily Gain ◽  
Carcass Traits ◽  
Suckling Period ◽  
Feed Conversion ◽  
Cross Sectional ◽  
Nutritional Restriction

The objective of the present study was to investigate the effect of nutritional restriction during the suckling period on growth performance, carcass traits and meat quality of fattening pigs. A one-way experimental design was used. In total, 24 male pigs of normal birthweight (1.54 ± 0.05 kg) were randomly allocated at 7 days of age to three groups: control, fed ad libitum; 30% nutritional restriction (Re30%); and 60% nutritional restriction (Re60%). The Re30% and Re60% groups showed decreased average daily gain, average daily feed intake and feed conversion ratio from Day 7 to Day 28. After Day 28, differences in these parameters were observed only in the Re60% group relative to the control. With regard to hormone levels, the Re60% group showed decreased serum concentration of insulin-like growth factor-1 at Day 28 and increased serum concentration of growth hormone at Day 147. Furthermore, the Re60% group had decreased carcass weight, ham weight and dressing percentage, and increased carcass lean percentage relative to the control, as well as lower cross-sectional area and myofibre diameter of muscle. The Re60% group had lower levels of myosin heavy chain (MyHC) IIx and MyHC IIb mRNA and a higher percentage of MyHC I and MyHC IIa mRNA in longissimus dorsi muscle than the Re30% group. In conclusion, nutritional restriction during the suckling period decreased weaning weight, with post-weaning growth performance, carcass traits and myofibre type affected in the Re60% group rather than Re30% group.

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