scholarly journals Trefoil Factor Family Member 2 (TFF2) as an Inflammatory-Induced and Anti-Inflammatory Tissue Repair Factor

Animals ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 1646
Author(s):  
Abdelaziz Ghanemi ◽  
Mayumi Yoshioka ◽  
Jonny St-Amand
Keyword(s):  
Family Member ◽  
Tissue Repair ◽  
Trefoil Factor ◽  
Mucosal Repair ◽  
Inflammatory Processes ◽  
Trefoil Factor Family ◽  
Repair Factor ◽  
Anti Inflammatory ◽  
Inflammatory Effect ◽  
Inflammatory Tissue

Trefoil factor family member 2 (TFF2) is known for its involvement in mucosal repair. Whereas it is overexpressed during inflammatory processes, adding TFF2 leads to an anti-inflammatory effect that would contribute to create the microenvironment required for tissue repair. These properties present TFF2 with a homeostatic pattern during inflammatory processes as illustrated by selected examples.

scholarly journals High-Fat Diet-Induced Trefoil Factor Family Member 2 (TFF2) to Counteract the Immune-Mediated Damage in Mice

Animals ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 258
Author(s):  
Abdelaziz Ghanemi ◽  
Mayumi Yoshioka ◽  
Jonny St-Amand
Keyword(s):  
Food Intake ◽  
Family Member ◽  
Tissue Repair ◽  
Trefoil Factor ◽  
High Fat ◽  
Immune Mediated ◽  
Physiological Homeostasis ◽  
Immunological Reactions ◽  
Trefoil Factor Family ◽  
The Brain

Physiological homeostasis requires a balance between the immunological functions and the resulting damage/side effects of the immunological reactions including those related to high-fat (HF) diet. Within this context, whereas HF diet, through diverse mechanisms (such as inflammation), leads to immune-mediated damage, trefoil factor family member 2 (Tff2) represents a HF diet-induced gene. On the other hand, TFF2 both promotes tissue repair and reduces inflammation. These properties are towards counteracting the immune-mediated damage resulting from the HF diet. These observations suggest that the HF diet-induction of Tff2 could be a regulatory pathway aiming to counteract the immune-mediated damage resulting from the HF diet. Interestingly, since Tff2 expression increases with HF diet and with Tff2 also expressed in the brain, we also hypothesize that TFF2 could be a HF diet-induced food intake-control signal that reduces appetite. This hypothesis fits with counteracting the immune damage since reducing the food intake will reduce the HF intake and therefore, reduces the HF diet-induced tissue damage. Such food intake signaling would be an indirect mechanism by which TFF2 promotes tissue repair as well as a pathway worth exploring for potential obesity management pharmacotherapies.

scholarly journals Serum Metabolic Profiling Reveals Potential Anti-Inflammatory Effects of the Intake of Black Ginseng Extracts in Beagle Dogs

Molecules ◽  
2020 ◽  
Vol 25 (16) ◽  
pp. 3759 ◽  
Author(s):  
Ye Jin Kim ◽  
Dae Young Lee ◽  
Ho-Eun Park ◽  
Dahye Yoon ◽  
Bumkyu Lee ◽  
...  
Keyword(s):  
Metabolic Profiling ◽  
Serum Biomarkers ◽  
Beagle Dogs ◽  
High Concentration ◽  
Experimental Diet ◽  
Inflammatory Processes ◽  
Black Ginseng ◽  
White Ginseng ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Black ginseng (BG) has better health benefits than white ginseng. The intake of BG changes the levels of metabolites, such as amino acids, fatty acids, and other metabolites. However, there is no research on the effect of BG extract intake on the metabolic profile of dog serum. In this study, serum metabolic profiling was conducted to investigate metabolic differences following the intake of BG extracts in beagle dogs. The beagle dogs were separated into three groups and fed either a regular diet (RD, control), RD with a medium concentration of BG extract (BG-M), or RD with a high concentration of BG extract (BG-H). Differences were observed among the three groups after the dogs ingested the experimental diet for eight weeks. The concentrations of alanine, leucine, isoleucine, and valine changed with the intake of BG extracts. Furthermore, levels of glycine and β-alanine increased in the BG-H group compared to the control and BG-M groups, indicating that BG extracts are associated with anti-inflammatory processes. Our study is the first to demonstrate the potential anti-inflammatory effect of BG extract in beagle dogs. Glycine and β-alanine are proposed as candidate serum biomarkers in dogs that can discriminate between the effects of ingesting BG-H.

Energy and metabolic pathways in trefoil factor family member 2 (Tff2) KO mice beyond the protection from high-fat diet-induced obesity

Life Sciences ◽  
2018 ◽  
Vol 215 ◽  
pp. 190-197 ◽  
Author(s):  
Abdelaziz Ghanemi ◽  
Aicha Melouane ◽  
Octave Mucunguzi ◽  
Mayumi Yoshioka ◽  
Jonny St-Amand
Keyword(s):  
Family Member ◽  
Metabolic Pathways ◽  
High Fat Diet ◽  
Trefoil Factor ◽  
High Fat ◽  
Diet Induced Obesity ◽  
Trefoil Factor Family

Anti-Inflammatory/Tissue Repair Macrophages Enhance the Cartilage-Forming Capacity of Human Bone Marrow-Derived Mesenchymal Stromal Cells

2015 ◽  
Vol 230 (6) ◽  
pp. 1258-1269 ◽  
Author(s):  
Sergio B. Sesia ◽  
Ralph Duhr ◽  
Carolina Medeiros da Cunha ◽  
Atanas Todorov ◽  
Stefan Schaeren ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Tissue Repair ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Anti Inflammatory ◽  
Inflammatory Tissue

A waterborne polyurethane 3D scaffold containing PLGA with a controllable degradation rate and an anti-inflammatory effect for potential applications in neural tissue repair

2020 ◽  
Vol 8 (20) ◽  
pp. 4434-4446 ◽  
Author(s):  
Bohong Du ◽  
Hang Yin ◽  
Yue Chen ◽  
Weiwei Lin ◽  
Yanchao Wang ◽  
...  
Keyword(s):  
Tissue Repair ◽  
Degradation Rate ◽  
Neural Tissue ◽  
Waterborne Polyurethane ◽  
3D Scaffold ◽  
Potential Applications ◽  
Anti Inflammatory ◽  
Controllable Degradation ◽  
Inflammatory Effect

3D connected porous LGPU scaffolds with adjustable degradation and a strong anti-inflammatory effect were prepared for neural tissue repair.

scholarly journals Inhibition of Neutrophil Secretion Upon Adhesion as a Basis for the Anti-Inflammatory Effect of the Tricyclic Antidepressant Imipramine

2021 ◽  
Vol 12 ◽  
Author(s):  
Svetlana I. Galkina ◽  
Ekaterina A. Golenkina ◽  
Natalia V. Fedorova ◽  
Alexander L. Ksenofontov ◽  
Marina V. Serebryakova ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Neutrophil Infiltration ◽  
Tricyclic Antidepressant ◽  
Basement Membranes ◽  
Neutrophil Gelatinase Associated Lipocalin ◽  
Lysine Residues ◽  
Antidepressant Imipramine ◽  
Inflammatory Processes ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Recent studies demonstrate the involvement of inflammatory processes in the development of depression and the anti-inflammatory effects of antidepressants. Infiltration and adhesion of neutrophils to nerve tissues and their aggressive secretion are considered as possible causes of inflammatory processes in depression. We studied the effect of the antidepressant imipramine on the adhesion and accompanied secretion of neutrophils under control conditions and in the presence of lipopolysaccharides (LPS). As a model of integrin-dependent neutrophil infiltration into tissues, we used integrin-dependent adhesion of neutrophils to the fibronectin-coated substrate. Imipramine inhibited neutrophil adhesion and concomitant secretion of proteins, including matrix metalloproteinase 9 (MMP-9) and neutrophil gelatinase-associated lipocalin (NGAL), which modify the extracellular matrix and basement membranes required for cell migration. Imipramine also significantly and selectively blocked the release of the free amino acid hydroxylysine, a product of lysyl hydroxylase, an enzyme that affects the organization of the extracellular matrix by modifying collagen lysine residues. In contrast, imipramine enhanced the release of ROS by neutrophils during adhesion to fibronectin and stimulated apoptosis. The anti-inflammatory effect of imipramine may be associated with the suppression of neutrophil infiltration and their adhesion to nerve tissues by inhibiting the secretion of neutrophils, which provides these processes.

Influence of polymer-organic solvent ratio on the physical and technological characteristics of gimantan nanoparticles

2020 ◽  
pp. 25-28
Author(s):  
V. Markeev ◽  
E. Blynskaya ◽  
A. Marakhova ◽  
K. Alekseev
Keyword(s):  
Organic Solvent ◽  
Targeted Delivery ◽  
Polymer Nanoparticles ◽  
Solvent Ratio ◽  
Pharmaceutical Substance ◽  
Technological Characteristics ◽  
Inflammatory Processes ◽  
The Creation ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Ensuring targeted delivery of drugs is the most promising and studied direction in pharmacy. This task can be solved by creating nanostructures that can accumulate in the focus of inflammation in case of treatment of inflammatory processes. The results of studies on the creation of polymer nanoparticles with an encapsulated pharmaceutical substance of gimantan, which has a local anti-inflammatory effect, are described.

scholarly journals Trefoil Factor Family Member 2: From a High-Fat-Induced Gene to a Potential Obesity Therapy Target

Metabolites ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 536
Author(s):  
Abdelaziz Ghanemi ◽  
Mayumi Yoshioka ◽  
Jonny St-Amand
Keyword(s):  
Family Member ◽  
Therapeutic Potential ◽  
Trefoil Factor ◽  
High Fat ◽  
Caloric Density ◽  
Low Fat Diet ◽  
Obesity Therapy ◽  
Trefoil Factor Family ◽  
Therapy Target ◽  
Induced Signal

Obesity has its epidemiological patterns continuously increasing. With controlling both diet and exercise being the main approaches to manage the energy metabolism balance, a high-fat (HF) diet is of particular importance. Indeed, lipids have a low satiety potential but a high caloric density. Thus, focusing on pharmacologically targetable pathways remains an approach with promising therapeutic potential. Within this context, trefoil factor family member 2 (Tff2) has been characterized as specifically induced by HF diet rather than low-fat diet. TFF2 has also been linked to diverse neurological mechanisms and metabolic patterns suggesting its role in energy balance. The hypothesis is that TFF2 would be a HF diet-induced signal that regulates metabolism with a focus on lipids. Within this review, we put the spotlight on key findings highlighting this line of thought. Importantly, the hypothetical mechanisms pointed highlight TFF2 as an important contributor to obesity development via increasing lipids intestinal absorption and anabolism. Therefore, an outlook for future experimental activities and evaluation of the therapeutic potential of TFF2 inhibition is given. Indeed, its knockdown or downregulation would contribute to an antiobesity phenotype. We believe this work represents an addition to our understanding of the lipidic molecular implications in obesity, which will contribute to develop therapies aiming to manage the lipidic metabolic pathways including the absorption, storage and metabolism via targeting TFF2-related pathways. We briefly discuss important relevant concepts for both basic and clinical researchers.

Trefoil factor family member 2 (Tff2 ) KO mice are protected from high-fat diet-induced obesity

Obesity ◽  
2013 ◽  
Vol 21 (7) ◽  
pp. 1389-1395 ◽  
Author(s):  
Maria Rita De Giorgio ◽  
Mayumi Yoshioka ◽  
Isabelle Riedl ◽  
Olivier Moreault ◽  
Rose-Guerline Cherizol ◽  
...  
Keyword(s):  
Family Member ◽  
High Fat Diet ◽  
Trefoil Factor ◽  
High Fat ◽  
Diet Induced Obesity ◽  
Trefoil Factor Family
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