scholarly journals Characterization of Birdwatching Demand Using a Logit Approach: Comparative Analysis of Source Markets (National vs. Foreign)

Animals ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 965 ◽  
Author(s):  
Marcelino Sánchez-Rivero ◽  
José-Manuel Sánchez-Martín ◽  
Mª Cristina Rodríguez Rangel
Keyword(s):  
Environmental Aspects ◽  
High Resource ◽  
The United Kingdom ◽  
Tourism Activity ◽  
Tourist Demand ◽  
Travel Type ◽  
Structural Change Test ◽  
Tourism Services ◽  
Distinguishing Features

Birdwatching is a tourism activity that relates closely to protected natural spaces and that helps contribute to the balance between economic, social and environmental aspects of sustainability. In some European countries (the United Kingdom, Germany, Holland), this recreational activity has a large number of followers, making it a new segment of tourist demand with great possibilities for growth. The objective of this study is to identify the main characteristics of the demand for birdwatching in one of the European territories having a high resource supply, as is the case with Extremadura (Spain). To do this, a logit modelization has been proposed in order to estimate the probability of going birdwatching in the region, based on a random sample of over 3000 tourists that visited the region in 2017. This characterization of birdwatching demand was carried out using variables such as gender, age, type of travel, type of lodging, and assessment of tourism services. Given that the national and the foreign demand of this tourism modality may present distinct behaviors, and therefore, specific characterizations, a structural change test (Chow test) was also conducted in order to determine to what extent these two segments of demand, based on the source markets, have (or do not have) distinguishing features.

scholarly journals Isolation and characterization of the new SARS-CoV-2 variant in travellers from the United Kingdom to India: VUI-202012/01 of the B.1.1.7 lineage

2021 ◽  
Vol 28 (2) ◽  
Author(s):  
Pragya D Yadav ◽  
Dimpal A Nyayanit ◽  
Rima R Sahay ◽  
Prasad Sarkale ◽  
Jayshri Pethani ◽  
...  
Keyword(s):  
United Kingdom ◽  
Severe Acute Respiratory Syndrome ◽  
Surveillance System ◽  
The United Kingdom ◽  
Isolation And Characterization ◽  
New Variant ◽  
The Uk ◽  
Local Transmission

We have isolated the new severe acute respiratory syndrome coronavirus-2 variant of concern 202 012/01 from the positive coronavirus disease 2019 cases that travelled from the UK to India in the month of December 2020. This emphasizes the need for the strengthened surveillance system to limit the local transmission of this new variant.

Histologic and Histochemical Characterization of Seminal Vesicle Intraluminal Secretions

2001 ◽  
Vol 125 (1) ◽  
pp. 141-145
Author(s):  
Rajal B. Shah ◽  
Min W. Lee ◽  
Alvaro A. Giraldo ◽  
Mahul B. Amin
Keyword(s):  
Seminal Vesicle ◽  
Alcian Blue ◽  
Prostate Carcinoma ◽  
Periodic Acid ◽  
Prostate Gland ◽  
Seminal Vesicles ◽  
Periodic Acid Schiff ◽  
Associated Malignancy ◽  
Distinguishing Features

Abstract Context.—We have observed intraluminal crystalloid morphology in seminal vesicles that is superficially similar to that seen in prostate neoplasia, but found little information on such morphology in the literature. Design.—Two hundred fifty-three prostate specimens (163 needle biopsies, 75 radical prostatectomies with prostate carcinoma, 11 prostates from autopsy, and 4 cystoprostatectomies without prostate carcinoma) were examined for seminal vesicle secretions, which were categorized as (a) dense platelike inspissated, (b) fluidlike, (c) crystalloid morphology, and (d) absent. Histochemical stains (periodic acid–Schiff with and without diastase, Alcian blue at pH 2.5, and mucicarmine) were performed to characterize the nature of secretions. Results.—Proteinaceous secretions were identified in 82% of seminal vesicles examined. Of these, 61% had predominantly dense, platelike, inspissated secretions, 15% had predominantly fluidlike secretions, and 24% had predominantly crystalloid morphology. Although in some cases the crystalloid morphology resembled that of prostatic intraluminal crystalloids, the seminal vesicle crystalloids differed in that they were invariably multiple, had curved edges, and had varied forms (elliptical, cylindrical, rodlike, and rectangular). Seventy-one percent of seminal vesicle crystalloids were associated with dense, platelike, inspissated secretions and appeared to be created by fracturing within platelike secretions. There was no relationship between seminal vesicle crystalloid morphology and associated malignancy in the prostate gland, as it was seen in 24% of cases with prostate carcinoma and 25% of cases without prostate carcinoma (P = 1.0000). Fluidlike secretions were positive for Alcian blue (pH 2.5) and mucicarmine, whereas dense platelike secretions and crystalloid morphology were negative for Alcian blue (pH 2.5) and mucicarmine. Conclusions.—Seminal vesicle secretions are fairly common and, when fluidlike, are composed of acid mucopolysaccharides. Inspissation of secretions appears to be associated with loss of acidity, presumably resulting in dense platelike secretions and crystallization. Awareness of both the crystalloid morphology in seminal vesicle tissue and the distinguishing features from prostatic crystalloids may be important while interpreting prostate needle biopsies in which seminal vesicle epithelium may be confused for prostate carcinoma because of a small acinar morphology with accompanying cytologic atypia and crystalloid morphology.

Functional and Structural Characterization of Acquired Pan-Aminoglycoside Resistance 16S rRNA Methyltransferase NpmB1

2021 ◽  
Author(s):  
Akito Kawai ◽  
Masahiro Suzuki ◽  
Kentaro Tsukamoto ◽  
Yusuke Minato ◽  
Yohei Doi
Keyword(s):  
Amino Acid ◽  
16S Rrna ◽  
Amino Acid Identity ◽  
Single Amino Acid ◽  
Aminoglycoside Resistance ◽  
E Coli ◽  
The United Kingdom ◽  
Amino Acid Variant ◽  
A Site

Post-translational methylation of the A site of 16S rRNA at position A1408 leads to pan-aminoglycoside resistance encompassing both 4,5- and 4,6-disubstituted 2-deoxystreptamine (DOS) aminoglycosides. To date, NpmA is the only acquired enzyme with such function. Here, we present function and structure of NpmB1 whose sequence was identified in Escherichia coli genomes registered from the United Kingdom. NpmB1 possesses 40% amino acid identity with NpmA1 and confers resistance to all clinically relevant aminoglycosides including 4,5-DOS agents. Phylogenetic analysis of NpmB1 and NpmB2, its single amino acid variant, revealed that the encoding gene was likely acquired by E. coli from a soil bacterium. The structure of NpmB1 suggests that it requires a structural change of the β6/7 linker in order to bind to 16S rRNA. These findings establish NpmB1 and NpmB2 as the second group of acquired pan-aminoglycoside resistance 16S rRNA methyltransferases.

scholarly journals La Potencialidad Turística En Los Proyectos De Turismo Rural Comunitario

2017 ◽  
Vol 13 (20) ◽  
pp. 219
Author(s):  
Gabriela Estefanía Román Santamaría ◽  
Mónica Cecilia Zurita Vintimilla ◽  
Gabriela Natalí Fonseca Romero ◽  
Danny Daniel Castillo Vizuete ◽  
Luis Alberto Quevedo Báez
Keyword(s):  
Local Development ◽  
Conservation Of Resources ◽  
Productive Activity ◽  
Planning Tool ◽  
Human Settlement ◽  
Tourist Destination ◽  
Potential Market ◽  
Tourist Demand ◽  
Developmental Support

Tourism is one of the main productive sectors that allow the improvement of the economy in diverse territories. The community of Guasuntos is regarded as a territory with natural and cultural scenic importance. The same, however, can be used in the development of tourism projects with the challenge of turning it into a competitive tourist destination. This was an alternative for local development in generating wealth in favor of the population, fostering the systemic competitiveness of the territory, and generating a guiding process that coordinates public, private, and community efforts. In order to involve the community in the development of this productive activity, an analysis of the situational diagnosis was carried out. Here, information was collected on the biophysical, sociocultural, economic productive components, political human settlement, mobility, energy, and institutional connectivity. In the territory, the inventory of natural and cultural attractions was carried out. This was done using the methodology proposed by the Ministry of Tourism (MINTUR). Finally, the characterization of the tourist demand was carried out. The tourist demand helps to identify the potential market with the consumption capacity of the product. The evaluation of the tourist potential in the territories allows for the identification of the vocation. However, this became a starting tool for the formulation of projects and a planning tool that contributes to the conservation of resources and the implementation of any activity. In addition, it ensures a potential and orderly use of them and serves as a developmental support for the population.

scholarly journals The alpha/B.1.1.7 SARS-CoV-2 variant exhibits significantly higher affinity for ACE-2 and requires lower inoculation doses to cause disease in K18-hACE2 mice

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Rafael Bayarri-Olmos ◽  
Laust Bruun Johnsen ◽  
Manja Idorn ◽  
Line S Reinert ◽  
Anne Rosbjerg ◽  
...  
Keyword(s):  
Monoclonal Antibodies ◽  
United Kingdom ◽  
Disease Progression ◽  
Low Dose ◽  
Transmission Rate ◽  
Functional Characterization ◽  
Fitness Advantage ◽  
The United Kingdom ◽  
A Minor

The alpha/B.1.1.7 SARS-CoV-2 lineage emerged in autumn 2020 in the United Kingdom and transmitted rapidly until winter 2021 when it was responsible for most new COVID-19 cases in many European countries. The incidence domination was likely due to a fitness advantage that could be driven by the RBD residue change (N501Y), which also emerged independently in other Variants of Concern such as the beta/B.1.351 and gamma/P.1 strains. Here we present a functional characterization of the alpha/B.1.1.7 variant and show an eight-fold affinity increase towards human ACE-2. In accordance with this, transgenic hACE-2 mice showed a faster disease progression and severity after infection with a low dose of B.1.1.7, compared to an early 2020 SARS-CoV-2 isolate. When challenged with sera from convalescent individuals or anti-RBD monoclonal antibodies, the N501Y variant showed a minor, but significant elevated evasion potential of ACE-2/RBD antibody neutralization. The data suggest that the single asparagine to tyrosine substitution remarkable rise in affinity may be responsible for the higher transmission rate and severity of the B.1.1.7 variant.

Advancements in the Detection and Sizing of “Pinhole” Metal Loss

2014 ◽  
Author(s):  
Wilson Santamaria ◽  
Martin Bluck
Keyword(s):  
Finite Element ◽  
United Kingdom ◽  
Metal Loss ◽  
Finite Element Models ◽  
Test Program ◽  
Joint Paper ◽  
The United Kingdom ◽  
Software Models ◽  
The World

At IPC 2010 PII Pipeline Solutions (PII) presented the paper “VALIDATION OF LATEST GENERATION MFL IN-LINE INSPECTION TECHNOLOGY LEADS TO IMPROVED DETECTION AND SIZING SPECIFICATION FOR PINHOLES, PITTING, AXIAL GROOVING AND AXIAL SLOTTING”1, IPC 2010-31124. The suggestion was that this improvement would allow operators to make more informed pipeline integrity decisions in future. In the 4 years since this paper was presented many hundreds of runs have been completed with this latest generation MFL ILI technology, capturing information on tens of thousands of kilometers of pipe, and generating a significant volume of dig verification data. In collaboration with Oil & Gas pipeline operators around the world this growing dig verification database has been utilized to improve software models, algorithms, & analysis processes to validate and further enhance system detection, sizing, & reporting capabilities. This paper focuses on the recent collaboration between ExxonMobil and PII, to investigate system capabilities with respect to “Pinholes”, to address a known threat to a specific pipeline in the United Kingdom. This paper will describe the: • Evolution of the “Pinhole” specification that captured the interest of ExxonMobil. • Use of Finite Element models to predict entitlement for characterization of “Pinhole” type defects • Detail of and results from the ExxonMobil sponsored test program that was conducted in early 2013 • The in-line inspection, analysis report, and dig verification that followed for the pipeline in question. This joint paper, prepared and presented in collaboration by ExxonMobil & PII, will reflect the perspective and synergy of the Pipeline Owner/Operator and the ILI Vendor.

scholarly journals Characterization of the Tourist Demand of the Villuercas–Ibores–Jara Geopark: A Destination with the Capacity to Attract Tourists and Visitors

Geosciences ◽  
2019 ◽  
Vol 9 (8) ◽  
pp. 335 ◽  
Author(s):  
José-Manuel Sánchez-Martín ◽  
Juan-Ignacio Rengifo-Gallego ◽  
Luz-María Martín-Delgado
Keyword(s):  
Information System ◽  
Geographical Information System ◽  
Geological Heritage ◽  
Rural Tourism ◽  
Geographical Information ◽  
Tourist Destination ◽  
Generic Framework ◽  
Tourist Resource ◽  
Tourist Demand

Geological heritage has become a tourist resource with huge potential in certain areas, which has given rise to a tourism category known as geotourism which has entered the generic framework of rural tourism. The main elements around which geotourism revolves are geoparks and geosites. However, despite the recognized role which is played by the latter as a tourist resource, there is a widespread lack of knowledge of the characteristics of the demand. This study aims to characterize the demand of the Villuercas–Jara–Ibores geopark in Spain based on information provided by surveys which has subsequently been processed by means of a Geographical Information System. The results obtained allow the differentiation of various types of profile of those providing the demand according to whether we consider visitors to the geopark as a whole or whether we separate tourists (visitors who spend the night in the geopark) from visitors (visitors who do not stay there). Among our main conclusions it should be emphasized that it is only possible to establish a difference between tourists and visitors if the main motivations are taken into account. It should also be stressed that the geopark operates as an internal tourist destination for those spending the night in other regions of Extremadura.

16. Public companies

Business Law ◽  
2021 ◽  
pp. 166-174
Author(s):  
J. Scott Slorach ◽  
Jason Ellis
Keyword(s):  
United Kingdom ◽  
Public Companies ◽  
Advantages And Disadvantages ◽  
The United Kingdom ◽  
Public Company ◽  
Distinguishing Features

This chapter first discusses the distinguishing features of a public company. It then considers the advantages and disadvantages of obtaining a listing with the United Kingdom Listing Authority (UKLA) and the requirements for seeking and maintaining that listing.

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