scholarly journals Metabolic and Biomolecular Changes Induced by Incremental Long-Term Training in Young Thoroughbred Racehorses during First Workout Season

Animals ◽  
2020 ◽  
Vol 10 (2) ◽  
pp. 317 ◽  
Author(s):  
Arianna Miglio ◽  
Katia Cappelli ◽  
Stefano Capomaccio ◽  
Samanta Mecocci ◽  
Maurizio Silvestrelli ◽  
...  
Keyword(s):  
Lactate Concentration ◽  
B Cell Lymphoma ◽  
Interleukin 10 ◽  
Fine Tuning ◽  
Interleukin 4 ◽  
Training Period ◽  
Blood Collection ◽  
Amyloid A ◽  
Thoroughbred Racehorses

Training has a huge effect on physiological homeostasis. The Thoroughbred racehorse is a valid animal model to investigate such changes for training schedule fine-tuning. As happens in human athletes, it is hypothesized that biochemical and immune response changes and related biomolecular variations could be induced by training programs. The aim of this study was to investigate, for the first time, the long-term metabolic and biomolecular modifications in young untrained Thoroughbred racehorses in the first 4-month timeframe training period. Twenty-nine clinically healthy, untrained, two-year-old Thoroughbred racehorses were followed during their incremental 4-month sprint exercise schedule. Blood collection was performed once a month, five times (T-30, T0, T30, T60, and T90). For each sample, lactate concentration, plasma cell volume (PCV), and hematobiochemical parameters (glucose, urea, creatinine, aspartate aminotransferase (AST), γ-glutamyltransferase (GGT), alkaline phosphatase (ALP), total bilirubin (Tbil), lactate dehydrogenase (LDH), creatine kinase (CK), cholesterol, triglycerides, albumin (Alb), total proteins (TPs), phosphorus (P), calcium (Ca2+), magnesium (Mg), sodium (Na+), potassium (K−), and chloride (Cl)) were determined. At T-30 and T90, serum protein electrophoresis (SPE), serum amyloid A (SAA), and real-time qPCR were performed on all samples to evaluate the expression of key genes and cytokines related to inflammatory and Th2 immunity responses: Interleukin-4 (IL-4), Interleukin-6 (IL-6), Interleukin-10 (IL-10), Interleukin-1β (IL-1β), Octamer-Binding Transcription Factor 1 (OCT1), B-cell lymphoma/leukemia 11A (BCL11A). Statistical analysis was performed (ANOVA and t test, p < 0.05). Significant modifications were identified compared with T-30 for PCV, glucose, triglycerides, cholesterol, lactate, urea, creatinine, Tbil, ALP, LDH, Na+, K−, Ca2+, SAA, TPs, SPE, IL-6, IL-4, Oct-1, and BCL11A. In conclusion, the first long-term training period was found to induce fundamental systemic changes in untrained Thoroughbreds.

scholarly journals Effect of First Long-Term Training on Whole Blood Count and Blood Clotting Parameters in Thoroughbreds

Animals ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 447
Author(s):  
Arianna Miglio ◽  
Emanuela Falcinelli ◽  
Anna Maria Mezzasoma ◽  
Katia Cappelli ◽  
Samanta Mecocci ◽  
...  
Keyword(s):  
Prothrombin Time ◽  
Blood Clotting ◽  
Blood Count ◽  
Complete Blood Count ◽  
Hematological Parameters ◽  
Training Period ◽  
Blood Collection ◽  
Negative Effects ◽  
Thoroughbred Racehorses

Training has a strong effect on the physiology of hematological parameters and blood coagulation, both in humans and in horses. Several blood changes have been reported after exercise in horses but available data differ. We aimed to investigate modifications in complete blood count and some hemostatic parameters induced by the first training period in young untrained Thoroughbred racehorses to detect a possible labile blood coagulability in racehorses. Twenty-nine untrained 2-year-old Thoroughbreds were followed during their incremental 4-month sprint exercise schedule. Blood collection was performed once a month, five times (T-30, T0, T30, T60 and T90), before and during the training period for measurement of complete blood count (CBC) and blood clotting parameters (prothrombin time—PT, activated partial prothrombin time—APTT, thrombin clotting time—TCT, fibrinogen—Fb, thrombin–antithrombin complex—TAT). Differences among the time points for each parameter were analyzed (ANOVA, Kruskal–Wallis one-way analysis of variance, p < 0.05). In Thoroughbreds, the first long-term exercise workout period was found to induce a statistical increase in red blood cell indexes and lymphocytes, eosinophils and platelet counts, as well as a hypercoagulability state evident at 30 days of training, which returned to basal levels after 90 days. Regular physical exercise seems to blunt the negative effects of acute efforts on hematological and clotting parameters, an effect that may be attributed to the training condition.

Romiplostim as a Viable and Long-term Remedy for Refractory Immune Thrombocytopenia and Concomitant Small B-Cell Lymphoma

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Germame Ajebo ◽  
Paul Dainer ◽  
Jeremy Pantin ◽  
Nathan Ryan ◽  
Charles Bruker
Keyword(s):  
B Cell ◽  
Immune Thrombocytopenia ◽  
Cell Lymphoma ◽  
B Cell Lymphoma

scholarly journals Monitoring Training and Recovery during a Period of Increased Intensity or Volume in Recreational Endurance Athletes

2021 ◽  
Vol 18 (5) ◽  
pp. 2401
Author(s):  
Olli-Pekka Nuuttila ◽  
Ari Nummela ◽  
Keijo Häkkinen ◽  
Santtu Seipäjärvi ◽  
Heikki Kyröläinen
Keyword(s):  
Heart Rate ◽  
Control Period ◽  
Endurance Performance ◽  
Training Period ◽  
Training Intensity ◽  
Countermovement Jump ◽  
Maximal Speed ◽  
Individualized Approach ◽  
Monitoring Training

The purpose of the study was to examine the effects of progressively increased training intensity or volume on the nocturnal heart rate (HR) and heart rate variability (HRV), countermovement jump, perceived recovery, and heart rate-running speed index (HR-RS index). Another aim was to analyze how observed patterns during the training period in these monitoring variables were associated with the changes in endurance performance. Thirty recreationally trained participants performed a 10-week control period of regular training and a 10-week training period of either increased training intensity (INT, n = 13) or volume (VOL, n = 17). Changes in endurance performance were assessed by an incremental treadmill test. Both groups improved their maximal speed on the treadmill (INT 3.4 ± 3.2%, p < 0.001; VOL 2.1 ± 1.8%, p = 0.006). In the monitoring variables, only between-group difference (p = 0.013) was found in nocturnal HR, which decreased in INT (p = 0.016). In addition, perceived recovery decreased in VOL (p = 0.021) and tended to decrease in INT (p = 0.056). When all participants were divided into low-responders and responders in maximal running performance, the increase in the HR-RS index at the end of the training period was greater in responders (p = 0.005). In conclusion, current training periods of increased intensity or volume improved endurance performance to a similar extent. Countermovement jump and HRV remained unaffected, despite a slight decrease in perceived recovery. Long-term monitoring of the HR-RS index may help to predict positive adaptations, while interpretation of other recovery-related markers may need a more individualized approach.

scholarly journals Long-Term Survival and Gradual Recovery of B Cells in Patients (Pts) with Refractory Large B Cell Lymphoma (LBCL) Treated with Axicabtagene Ciloleucel (Axi-Cel)

2021 ◽  
Vol 27 (3) ◽  
pp. S404-S405
Author(s):  
Caron A. Jacobson ◽  
Frederick L. Locke ◽  
Armin Ghobadi ◽  
David B. Miklos ◽  
Lazaros J. Lekakis ◽  
...  
Keyword(s):  
B Cells ◽  
B Cell ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Term Survival ◽  
Long Term Survival ◽  
Large B Cell Lymphoma ◽  
Large B Cell

scholarly journals Regulation of the Anti-Inflammatory Cytokines Interleukin-4 and Interleukin-10 during Pregnancy

2014 ◽  
Vol 5 ◽  
Author(s):  
Piyali Chatterjee ◽  
Valorie L. Chiasson ◽  
Kelsey R. Bounds ◽  
Brett M. Mitchell
Keyword(s):  
Inflammatory Cytokines ◽  
Interleukin 10 ◽  
Interleukin 4 ◽  
Anti Inflammatory
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