scholarly journals Preparation of α,β-Unsaturated Ketones Bearing a Trifluoromethyl Group and Their Application in Organic Synthesis

Molecules ◽  
1997 ◽  
Vol 2 (12) ◽  
pp. 186-232 ◽  
Author(s):  
Valentine Nenajdenko ◽  
Andrei Sanin ◽  
Elizabeth Balenkova
Keyword(s):  
Organic Synthesis ◽  
Trifluoromethyl Group ◽  
Unsaturated Ketones

scholarly journals Palladium-Catalyzed Coupling Reactions on Functionalized 2-Trifluoromethyl-4-chromenone Scaffolds: Synthesis of Highly Functionalized Trifluoromethyl Heterocycles

Synthesis ◽  
2018 ◽  
Vol 51 (06) ◽  
pp. 1342-1352 ◽  
Author(s):  
Javier Izquierdo ◽  
Atul Jain ◽  
Sarki Abdulkadir ◽  
Gary Schiltz
Keyword(s):  
Natural Products ◽  
Organic Synthesis ◽  
Biological Activities ◽  
Structural Complexity ◽  
Biologically Active ◽  
Coupling Reactions ◽  
Trifluoromethyl Group ◽  
Palladium Catalyzed ◽  
Active Natural

The chromenone core is an ubiquitous group in biologically active natural products and has been extensively used in organic synthesis. Fluorine-derived compounds, including those with a trifluoromethyl group (CF3), have shown enhanced biological activities in numerous pharmaceuticals compared with their non-fluorinated analogues. 2-Trifluoromethylchromenones can be readily functionalized at the 8- and 7-positions, providing chromenones cores of high structural complexity, which are excellent precursors for numerous trifluoromethyl heterocycles.

Enantioselective reduction of α,β-unsaturated ketones bearing the trifluoromethyl group

2001 ◽  
Vol 12 (9) ◽  
pp. 1259-1266 ◽  
Author(s):  
Valentine G. Nenajdenko ◽  
Konstantin I. Smolko ◽  
Elizabeth S. Balenkova
Keyword(s):  
Trifluoromethyl Group ◽  
Unsaturated Ketones ◽  
Enantioselective Reduction

THE TRIFLUOROMETHYL GROUP IN ORGANIC SYNTHESIS. A REVIEW

1996 ◽  
Vol 28 (3) ◽  
pp. 289-318 ◽  
Author(s):  
Alexander S. Kiselyov ◽  
Lucjan Strekowski
Keyword(s):  
Organic Synthesis ◽  
Trifluoromethyl Group

ChemInform Abstract: The Trifluoromethyl Group in Organic Synthesis

ChemInform ◽  
2010 ◽  
Vol 27 (42) ◽  
pp. no-no
Author(s):  
A. S. KISELYOV ◽  
L. STREKOWSKI
Keyword(s):  
Organic Synthesis ◽  
Trifluoromethyl Group
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