scholarly journals High Performance Liquid Chromatographic Method for Determination of Sildenafil Citrate (Viagra) in Pharmaceutical Formulation and Industrial Effluent Sample

2013 ◽  
Vol 24 (9) ◽  
pp. 24-31
Author(s):  
Nief R. Ahmed ◽  
Suhaib N. Lottfi
Keyword(s):  
High Performance ◽  
Chromatographic Method ◽  
Industrial Effluent ◽  
High Performance Liquid Chromatographic ◽  
Pharmaceutical Formulation ◽  
Sildenafil Citrate ◽  
Effluent Sample ◽  
Liquid Chromatographic Method ◽  
Liquid Chromatographic

scholarly journals High performance liquid chromatographic method for the determination of guaifenesin in pharmaceutical syrups and in environmental samples

2013 ◽  
Vol 10 (3) ◽  
pp. 1014-1022
Author(s):  
Baghdad Science Journal
Keyword(s):  
High Performance ◽  
Chromatographic Method ◽  
Limit Of Detection ◽  
Industrial Effluent ◽  
High Performance Liquid Chromatographic ◽  
Reversed Phase ◽  
Limit Of Quantification ◽  
Liquid Chromatographic Method ◽  
Liquid Chromatographic

A simple, precise, rapid, and accurate reversed – phase high performance liquid chromatographic method has been developed for the determination of guaifenesin in pure from pharmaceutical formulations.andindustrial effluent. Chromatography was carried out on supelco L7 reversed- phase column (25cm × 4.6mm), 5 microns, using a mixture of methanol –acetonitrile-water: (80: 10 :10 v/v/v) as a mobile phase at a flow rate of 1.0 ml.min-1. Detection was performed at 254nm at ambient temperature. The retention time for guaifenesin was found 2.4 minutes. The calibration curve was linear (r= 0.9998) over a concentration range from 0.08 to 0.8mg/ml. Limit of detection (LOD) and limit of quantification ( LOQ) were found 6µg/ml and 18µg/ml respectively. The method was validated for its linearity, precision and accuracy .The proposed method was successfully applied for the determination of guaifenesin in syrups and industrial effluent samples.

Sign in / Sign up

Export Citation Format

Share Document