scholarly journals Autism Spectrum Disorders and Perinatal Complications—Is Oxidative Stress the Connection?

2019 ◽  
Vol 10 ◽  
Author(s):  
Vanja Mandic-Maravic ◽  
Marija Mitkovic-Voncina ◽  
Marija Pljesa-Ercegovac ◽  
Ana Savic-Radojevic ◽  
Miroslav Djordjevic ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Autism Spectrum Disorders ◽  
Autism Spectrum ◽  
Perinatal Complications ◽  
Spectrum Disorders

scholarly journals Study of the Effect of Bisphenol A on Oxidative Stress in Children with Autism Spectrum Disorders

2017 ◽  
Vol 33 (2) ◽  
pp. 196-201 ◽  
Author(s):  
Fateheya M. Metwally ◽  
Hend Rashad ◽  
Hala M. Zeidan ◽  
Ayman Kilany ◽  
Ehab R. Abdol Raouf
Keyword(s):  
Oxidative Stress ◽  
Autism Spectrum Disorders ◽  
Bisphenol A ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Spectrum Disorders

scholarly journals Sympathetic, Metabolic Adaptations, and Oxidative Stress in Autism Spectrum Disorders: How Far From Physiology?

2018 ◽  
Vol 9 ◽  
Author(s):  
Antonietta Messina ◽  
Vincenzo Monda ◽  
Francesco Sessa ◽  
Anna Valenzano ◽  
Monica Salerno ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Autism Spectrum Disorders ◽  
Autism Spectrum ◽  
Metabolic Adaptations ◽  
Spectrum Disorders ◽  
And Oxidative Stress

scholarly journals How Robust is the Evidence for a Role of Oxidative Stress in Autism Spectrum Disorders and Intellectual Disabilities?

2020 ◽  
Author(s):  
Shanna L. Burke ◽  
Jessica Cobb ◽  
Rumi Agarwal ◽  
Marlaina Maddux ◽  
Marcus S. Cooke
Keyword(s):  
Oxidative Stress ◽  
Autism Spectrum Disorders ◽  
Autism Spectrum ◽  
Careful Consideration ◽  
Sample Collection ◽  
Spectrum Disorders ◽  
Processing And Storage ◽  
And Storage ◽  
Biomarkers Of Oxidative Stress

Abstract Growing interest in the pathogenesis of autism spectrum disorders (ASDs) and other intellectual and developmental disabilities (IDD) has led to emerging evidence implicating a role for oxidative stress. However, understanding the strength of this association is made challenging by the use of a variety of purported biomarkers of oxidative stress, many of which have either uncertain specificity or flawed methods of analysis. This review aims to address this issue, which is widespread in the ASD and IDD literature, by providing readers with information concerning the strengths and limitations of the choice and analysis of biomarkers of oxidative stress. We highlight that biomarkers and assays should be specific, sensitive, reproducible, precise, robust, and chosen with careful consideration. Future studies should be sufficiently powered and address sample collection, processing, and storage which are, additionally, poorly considered, sources of bad practice, and potential errors. Only with these issues considered, will the data lead to conclusions as to the precise role of oxidative stress in ASDs and IDD.

scholarly journals The Gut Microbiota and Oxidative Stress in Autism Spectrum Disorders (ASD)

2020 ◽  
Vol 2020 ◽  
pp. 1-13
Author(s):  
Tingting Hu ◽  
Yinmiao Dong ◽  
Caixia He ◽  
Mingyi Zhao ◽  
Qingnan He
Keyword(s):  
Oxidative Stress ◽  
Autism Spectrum Disorders ◽  
Neurodevelopmental Disorder ◽  
Autism Spectrum ◽  
Mucosal Barrier ◽  
Autistic Children ◽  
Early Assessment ◽  
Assessment And Treatment ◽  
Spectrum Disorders ◽  
And Oxidative Stress

Autism spectrum disorders (ASDs) are a kind of neurodevelopmental disorder with rapidly increasing morbidity. In recent years, many studies have proposed a possible link between ASD and multiple environmental as well as genetic risk factors; nevertheless, recent studies have still failed to identify the specific pathogenesis. An analysis of the literature showed that oxidative stress and redox imbalance caused by high levels of reactive oxygen species (ROS) are thought to be integral parts of ASD pathophysiology. On the one hand, this review aims to elucidate the communications between oxidative stress, as a risk factor, and ASD. As such, there is also evidence to suggest that early assessment and treatment of antioxidant status are likely to result in improved long-term prognosis by disturbing oxidative stress in the brain to avoid additional irreversible brain damage. Accordingly, we will also discuss the possibility of novel therapies regarding oxidative stress as a target according to recent literature. On the other hand, this review suggests a definite relationship between ASD and an unbalanced gastrointestinal tract (GIT) microbiota (i.e., GIT dysbiosis). A variety of studies have concluded that the intestinal microbiota influences many aspects of human health, including metabolism, the immune and nervous systems, and the mucosal barrier. Additionally, the oxidative stress and GIT dysfunction in autistic children have both been reported to be related to mitochondrial dysfunction. What is the connection between them? Moreover, specific changes in the GIT microbiota are clearly observed in most autistic children, and the related mechanisms and the connection among ASD, the GIT microbiota, and oxidative stress are also discussed, providing a theory and molecular strategies for clinical practice as well as further studies.

Oxidative Stress Markers in Children with Autism Spectrum Disorders

2012 ◽  
Vol 53 ◽  
pp. S21 ◽  
Author(s):  
Maria Elena Gonzalez-Fraguela ◽  
Mei-Li Diaz Hung ◽  
Hector Vera ◽  
Maria Robinson ◽  
Carmem Gottfried
Keyword(s):  
Oxidative Stress ◽  
Autism Spectrum Disorders ◽  
Children With Autism ◽  
Autism Spectrum ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Spectrum Disorders

Prenatal and Perinatal Factors in Autism Spectrum Disorders–a Case Control Study of a Serbian Sample

2017 ◽  
Vol 41 (S1) ◽  
pp. S216-S216
Author(s):  
V. Mandic-Maravic ◽  
M. Pejovic-Milovancevic ◽  
M. Mitkovic-Voncina ◽  
D. Lecic-Tosevski
Keyword(s):  
Risk Factors ◽  
Autism Spectrum Disorders ◽  
Interaction Mechanism ◽  
Autism Spectrum ◽  
Paternal Age ◽  
Environment Interaction ◽  
Perinatal Complications ◽  
Perinatal Factors ◽  
Prenatal Factors ◽  
Spectrum Disorders

IntroductionAutism spectrum disorders (ASD) are complex psychiatric disorders, with both genetic and environmental factors implicated in their etiology. Recent studies suggest the prenatal and early postnatal genesis of ASD, therefore, understanding the effect of environmental risk factors could be important for prevention and treatment of ASD.AimsThe aim of this study was to determine the association of prenatal factors and perinatal complications with ASD.MethodsOur study included 102 subjects with ASD (80% boys) aged 9.35 ± 5.85, and 107 age and sex matched healthy controls (77% boys). For the diagnosis of ASD, we used the ICD-10 criteria and Autism Diagnostic Interview-Revised (ADI-R). A questionnaire regarding prenatal and perinatal factors/complications was administered to all subjects.ResultsLogistic regression model of having autism vs. being a control subject included gender, age, maternal and paternal age at birth, pregnancy order, smoking in pregnancy, number of medication during pregnancy (mostly tocolytics, antihypertensives, antiarrhythmics), and early postnatal complications (mostly prematurity, low birth weight, hyperbilirubinaemia). The model was significant, explaining about the third of variance, with number of medication during pregnancy and having an early postnatal complication as significant predictors.ConclusionsOur study has shown a significant association of specific prenatal and perinatal factors and ASD, even after controlling for other potential confounding variables. Identifying specific risk factors is important for prevention of ASD. It is also the first step in defining basis of the gene–environment interaction mechanism, which might enable development of an individualised therapeutic approach for this group of disorders.Disclosure of interestThe authors have not supplied their declaration of competing interest.

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