scholarly journals Longitudinal Alterations in Prefrontal Resting Brain Connectivity in Non-Treatment-Seeking Young Adults With Cannabis Use Disorder

2019 ◽  
Vol 10 ◽  
Author(s):  
Jazmin Camchong ◽  
Paul F. Collins ◽  
Mary P. Becker ◽  
Kelvin O. Lim ◽  
Monica Luciana
Keyword(s):  
Young Adults ◽  
Brain Connectivity ◽  
Cannabis Use ◽  
Treatment Seeking ◽  
Cannabis Use Disorder

scholarly journals A pilot trial of text-delivered peer network counseling to treat young adults with cannabis use disorder

2018 ◽  
Vol 89 ◽  
pp. 1-10 ◽  
Author(s):  
Michael J. Mason ◽  
Nikola M. Zaharakis ◽  
Michael Russell ◽  
Victoria Childress
Keyword(s):  
Young Adults ◽  
Pilot Trial ◽  
Cannabis Use ◽  
Cannabis Use Disorder ◽  
Peer Network ◽  
Peer Network Counseling

scholarly journals Deep Cerebellar Transcranial Electrical Stimulation: Hypothesis and Theory for Cannabis Use Disorder

2020 ◽  
Author(s):  
Anirban Dutta ◽  
Abhishek Ghosh ◽  
Shubhmohan Singh
Keyword(s):  
Young Adults ◽  
Electrical Stimulation ◽  
Information Processing ◽  
Molecular Layer ◽  
Cannabis Use ◽  
Transcranial Electrical Stimulation ◽  
Cannabis Use Disorder ◽  
Cannabis Dependence ◽  
Cerebellar Function ◽  
Home Based

Cannabis is the most widely cultivated, trafficked and abused illicit drug (“WHO | Cannabis,” n.d.; “World Drug Report 2020,” n.d.). In 2018, an estimated 192 million people aged 15-64 years used cannabis for nonmedical purposes globally (Degenhardt et al., 2013). The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 estimated that, across the globe, there were more than 22·1 million people with cannabis dependence (Degenhardt et al., 2018). Moreover, the same study calculated that cannabis dependence could be accounted for 646 thousand Disability Adjusted Life Years, globally. Importantly, cannabis dependence mostly affects young adults (20-24 years), and thus has significant negative impact on the growth and productivity of not only these individuals but also to the societies and nations (Degenhardt et al., 2013). In addition to the dependence syndrome, cannabis use is associated with increased risk of psychosis, cognitive dysfunction, academic problems, and road side accidents (Volkow et al., 2014). A review showed a fairly consistent associations between cannabis use and both lower educational attainment and increased reported use of other illicit drugs (Macleod et al., 2004). In the United States, Cannabis Use Disorder (CUD) is an escalating problem in young adults by legalization (Cerdá et al., 2020) where National Survey on Drug Use and Health reported increased prevalence from 5.1% in 2015 to 5.9% in 2018 in 18-25 year olds (“2019 NSDUH Detailed Tables | CBHSQ Data,” n.d.). The psychoactive effects are due to type 1 cannabinoid receptor (CB1), the cannabinoid binding protein, that are highly expressed in the cerebellar cortex (Marcaggi, 2015). CB1 is primarily found in the molecular layer at the most abundant synapse type in the cerebellum (Marcaggi, 2015) that can shape the spike activity of cerebellar Purkinje cell (Brown et al., 2019). Moreover, granule cell to Purkinje cell synaptic transmission can trigger endocannabinoid release (Alger and Kim, 2011), which may be important for information processing by cerebellar molecular layer interneurons (Dorgans et al., 2019). This suggests that endocannabinoids could be essential to neurocognitive aspects of cerebellar function (Di Marzo et al., 2015),(Marcaggi, 2015),(Alger and Kim, 2011). Accumulating evidence also suggests cerebellar modulation of the reward circuitry and social behaviour, via direct cerebellar innervation of the ventral tegmental area (VTA) including dopamine cell bodies (A1) in the VTA (Carta et al., 2019). The VTA-dopamine (DA) signalling in the nucleus accumbens (NAc) and the medial prefrontal cortex (mPFC) (Lohani et al., 2019) play a key role in motivatedbehaviours and cognition. Cerebellar neuropathological changes can result in aberrant dopaminergic activity in the NAc and mPFC (ROGERS et al., 2011),(Lohani et al., 2019). Therefore, there is a critical need to determine how cerebellum modulate limbic VTA-DA signalling. Cerebellar Non-Invasive Brain Stimulation (NIBS) is postulated to be most relevant in CUD since endocannabinoids are essential to cerebellar function that includes reward-related behaviours, information processing, and cognitive control. (Di Marzo et al., 2015),(Marcaggi, 2015),(Alger and Kim, 2011). Furthermore, cerebellar NIBS can facilitate training of cognitive control in CUD during a during visual cue reactivity paradigm using a mobile virtual reality (VR) interface that can also allow remote delivery of cerebellar NIBS in conjunction with VR-based cognitive training for home-based intervention. Specifically, transcranial electrical stimulation (tES) can be translatable to low-cost (<$150) mobile devices that can be used in a low resource home-based setting (Carvalho et al., 2018).

Who responds best to text-delivered cannabis use disorder treatment? A randomized clinical trial with young adults.

2018 ◽  
Vol 32 (7) ◽  
pp. 699-709 ◽  
Author(s):  
Michael J. Mason ◽  
Nikola M. Zaharakis ◽  
Matthew Moore ◽  
Aaron Brown ◽  
Claudia Garcia ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Young Adults ◽  
Randomized Clinical Trial ◽  
Cannabis Use ◽  
Cannabis Use Disorder ◽  
Disorder Treatment

2.5 STUDY OF CANNABIS USE DISORDER AMONG ADOLESCENTS AND YOUNG ADULTS IN AN AMBULATORY HIV CLINIC SETTING

2019 ◽  
Vol 58 (10) ◽  
pp. S172
Author(s):  
Maria Veronica C. Gonzales Vigilar ◽  
Anil Aranha ◽  
Nikki Cockern ◽  
Elizabeth Secord ◽  
David R. Rosenberg
Keyword(s):  
Young Adults ◽  
Cannabis Use ◽  
Adolescents And Young Adults ◽  
Cannabis Use Disorder ◽  
Clinic Setting

scholarly journals Modulating the cognitive and subjective effects of THC in young adults with cannabis use disorder

2021 ◽  
Vol 14 (6) ◽  
pp. 1662
Author(s):  
Michael Wesley ◽  
Miranda Ramirez ◽  
Skylar Mays ◽  
Colleen Hanlon ◽  
Mark George ◽  
...  
Keyword(s):  
Young Adults ◽  
Subjective Effects ◽  
Cannabis Use ◽  
Cannabis Use Disorder

scholarly journals Cannabis Use Disorder in Young Adults with Acute Myocardial Infarction: Trend Inpatient Study from 2010 to 2014 in the United States

Cureus ◽  
2018 ◽  
Author(s):  
Rikinkumar S Patel ◽  
Shailaja Reddy Katta ◽  
Riddhi Patel ◽  
Virendrasinh Ravat ◽  
Ravikumar Gudipalli ◽  
...  
Keyword(s):  
United States ◽  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Young Adults ◽  
The United States ◽  
Cannabis Use ◽  
Cannabis Use Disorder
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