scholarly journals Systemic Administration of Orexin a Loaded Liposomes Potentiates Nucleus Accumbens Shell Dopamine Release by Sucrose Feeding

2018 ◽  
Vol 9 ◽  
Author(s):  
Francesco Lai ◽  
Flavia Cucca ◽  
Roberto Frau ◽  
Francesco Corrias ◽  
Michele Schlich ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Dopamine Release ◽  
Systemic Administration ◽  
Nucleus Accumbens Shell ◽  
Orexin A ◽  
Sucrose Feeding

scholarly journals Different adaptations of dopamine release in Nucleus Accumbens shell and core of individual alcohol drinking groups of mice

2020 ◽  
Vol 175 ◽  
pp. 108176
Author(s):  
Yutong Liu ◽  
Sarah E. Montgomery ◽  
Barbara Juarez ◽  
Carole Morel ◽  
Song Zhang ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Alcohol Drinking ◽  
Dopamine Release ◽  
Nucleus Accumbens Shell

Caffeine Induces a Stimulant Effect and Increases Dopamine Release in the Nucleus Accumbens Shell Through the Pulmonary Inhalation Route of Administration in Rats

2016 ◽  
Vol 31 (1) ◽  
pp. 90-98 ◽  
Author(s):  
Martín Galvalisi ◽  
José Pedro Prieto ◽  
Marcela Martínez ◽  
Juan Andrés Abin-Carriquiry ◽  
Cecilia Scorza
Keyword(s):  
Nucleus Accumbens ◽  
Dopamine Release ◽  
Route Of Administration ◽  
Nucleus Accumbens Shell ◽  
Stimulant Effect

Induction of brain CYP2E1 changes the effects of ethanol on dopamine release in nucleus accumbens shell

2009 ◽  
Vol 100 (1-2) ◽  
pp. 83-90 ◽  
Author(s):  
Lucía Hipólito ◽  
María J. Sánchez-Catalán ◽  
Ana Polache ◽  
Luis Granero
Keyword(s):  
Nucleus Accumbens ◽  
Dopamine Release ◽  
Nucleus Accumbens Shell

scholarly journals Combined effects of systemic alcohol and nicotine on dopamine release in the nucleus accumbens shell

2007 ◽  
Vol 42 (5) ◽  
pp. 413-416 ◽  
Author(s):  
Y. Tizabi ◽  
L. Bai ◽  
R. L. Copeland ◽  
R. E. Taylor
Keyword(s):  
Nucleus Accumbens ◽  
Dopamine Release ◽  
Combined Effects ◽  
Nucleus Accumbens Shell

scholarly journals Orexin signaling in rostral lateral hypothalamus and nucleus accumbens shell in the control of spontaneous physical activity in high- and low-activity rats

2017 ◽  
Vol 312 (3) ◽  
pp. R338-R346 ◽  
Author(s):  
Claudio Perez-Leighton ◽  
Morgan R. Little ◽  
Martha Grace ◽  
Charles Billington ◽  
Catherine M. Kotz
Keyword(s):  
Physical Activity ◽  
Nucleus Accumbens ◽  
Lateral Hypothalamus ◽  
Receptor Expression ◽  
Nucleus Accumbens Shell ◽  
Orexin A ◽  
Orexin Neuron ◽  
Spontaneous Physical Activity ◽  
Low Activity ◽  
Higher Sensitivity

Spontaneous physical activity (SPA) describes activity outside of formal exercise and shows large interindividual variability. The hypothalamic orexin/hypocretin peptides are key regulators of SPA. Orexins drive SPA within multiple brain sites, including rostral lateral hypothalamus (LH) and nucleus accumbens shell (NAcSh). Rats with high basal SPA (high activity, HA) show higher orexin mRNA expression and SPA after injection of orexin-A in rostral LH compared with low-activity (LA) rats. Here, we explored the contribution of orexin signaling in rostral LH and NAcSh to the HA/LA phenotype. We found that HA rats have higher sensitivity to SPA after injection of orexin-A in rostral LH, but not in NAcSh. HA and LA rats showed similar levels of orexin receptor expression in rostral LH, and activation of orexin-producing neurons after orexin-A injection in rostral LH. Also, in HA and LA rats, the coinjection of orexin-A in rostral LH and NAcSh failed to further increase SPA beyond the effects of orexin-A in rostral LH. Pretreatment with muscimol, a GABAA receptor agonist, in NAcSh potentiated SPA produced by orexin-A injection in rostral LH in HA but not in LA rats. Our results suggest that a feedback loop from orexin-responsive neurons in rostral LH to orexin neurons and a the NAcSh–orexin neuron–rostral LH circuit regulate SPA. Overall, our data suggest that differences in orexin sensitivity in rostral LH and its modulation by GABA afferents from NAcSh contribute to individual SPA differences.

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