scholarly journals Chronic Psychosocial Stress in Mice Is Associated With Increased Acid Sphingomyelinase Activity in Liver and Serum and With Hepatic C16:0-Ceramide Accumulation

2018 ◽  
Vol 9 ◽  
Author(s):  
Martin Reichel ◽  
Cosima Rhein ◽  
Lena M. Hofmann ◽  
Juliana Monti ◽  
Lukasz Japtok ◽  
...  
Keyword(s):  
Psychosocial Stress ◽  
Acid Sphingomyelinase ◽  
Chronic Psychosocial Stress ◽  
Ceramide Accumulation

scholarly journals A 16-week aerobic exercise and mindfulness-based intervention on chronic psychosocial stress: a pilot and feasibility study

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Guy A. Prochilo ◽  
Ricardo J.S. Costa ◽  
Craig Hassed ◽  
Richard Chambers ◽  
Pascal Molenberghs
Keyword(s):  
Emotion Regulation ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Psychosocial Stress ◽  
Retention Rate ◽  
Recruitment Rate ◽  
Trial Registration ◽  
Aerobic Exercise Training ◽  
Definitive Trial ◽  
Chronic Psychosocial Stress

Abstract Objectives Researchers have begun delivering mindfulness and aerobic exercise training concurrently on the premise that a combination intervention will yield salutary outcomes over and above each intervention alone. An estimate of the effect of combination training on chronic psychosocial stress in a nonclinical population has not been established. The objective of this study was to establish protocol feasibility in preparation of a definitive RCT targeting healthy individuals, and to explore the preliminary effect of combination training on reducing chronic psychosocial stress in this population. Methods Twenty-four participants were allocated to a single-arm pre-post study and subjected to 16 weeks of concurrent mindfulness psychoeducation and aerobic exercise training. Feasibility criteria were collected and evaluated. Within-group changes in chronic psychosocial stress, mindfulness, emotion regulation, and cardiorespiratory fitness were also assessed. Primary analyses were based on 17 participants. Results Retention rate, response rate, recruitment rate, and sample size analyses indicate a definitive trial is feasible for detecting most effects with precision. There was also a decline in our primary dependent measure of chronic psychosocial stress (dpretest = −0.56, 95% CI [ −1.14,−0.06]). With regard to secondary measures, there was an increase in the use of cognitive reappraisal, and a reduction in use of maladaptive emotion regulation strategies. We are insufficiently confident to comment on changes in mindfulness and aerobic capacity $\left (\dot {V}O_{2max}\right)$ V ̇ O 2 max . However, there were subgroup improvements in aerobic economy at submaximal exercise intensities. Conclusions We recommend a definitive trial is feasible and should proceed. Trial registration ANZCTR (ID: ACTRN12619001726145). Retrospectively registered December 9, 2019.

scholarly journals Glucocorticoid levels after exposure to predator odor and chronic psychosocial stress with dexamethasone application in rats

2016 ◽  
Vol 32 (5) ◽  
pp. 235-240
Author(s):  
Ana Starcevic ◽  
Sasa Petricevic ◽  
Zoran Radojicic ◽  
Vuk Djulejic ◽  
Andrej Ilankovic ◽  
...  
Keyword(s):  
Psychosocial Stress ◽  
Predator Odor ◽  
Chronic Psychosocial Stress

scholarly journals Chronic psychosocial stress in mice leads to changes in brain functional connectivity and metabolite levels comparable to human depression

NeuroImage ◽  
2016 ◽  
Vol 142 ◽  
pp. 544-552 ◽  
Author(s):  
Joanes Grandjean ◽  
Damiano Azzinnari ◽  
Aline Seuwen ◽  
Hannes Sigrist ◽  
Erich Seifritz ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Psychosocial Stress ◽  
Chronic Psychosocial Stress ◽  
Brain Functional Connectivity

Chronic psychosocial stress results in sensitization of the HPA axis to acute heterotypic stressors despite a reduction of adrenal in vitro ACTH responsiveness

2012 ◽  
Vol 37 (10) ◽  
pp. 1676-1687 ◽  
Author(s):  
Nicole Uschold-Schmidt ◽  
Kewir D. Nyuyki ◽  
Andrea M. Füchsl ◽  
Inga D. Neumann ◽  
Stefan O. Reber
Keyword(s):  
Hpa Axis ◽  
Psychosocial Stress ◽  
Chronic Psychosocial Stress

scholarly journals Structural & functional consequences of chronic psychosocial stress on the microbiome & host

2016 ◽  
Vol 63 ◽  
pp. 217-227 ◽  
Author(s):  
Aadil Bharwani ◽  
M. Firoz Mian ◽  
Jane A. Foster ◽  
Michael G. Surette ◽  
John Bienenstock ◽  
...  
Keyword(s):  
Psychosocial Stress ◽  
Functional Consequences ◽  
Chronic Psychosocial Stress

scholarly journals Evaluation of the Effect of Hypericum triquetrifolium Turra on Memory Impairment Induced by Chronic Psychosocial Stress in Rats: Role of BDNF

2020 ◽  
Vol Volume 14 ◽  
pp. 5299-5314
Author(s):  
Karem H Alzoubi ◽  
Laila Abdel-Hafiz ◽  
Omar F Khabour ◽  
Tamam El-Elimat ◽  
Mohammad A Alzubi ◽  
...  
Keyword(s):  
Psychosocial Stress ◽  
Memory Impairment ◽  
Chronic Psychosocial Stress

scholarly journals Acid Sphingomyelinase Deficiency Ameliorates Farber Disease

2019 ◽  
Vol 20 (24) ◽  
pp. 6253 ◽  
Author(s):  
Nadine Beckmann ◽  
Katrin Anne Becker ◽  
Stephanie Kadow ◽  
Fabian Schumacher ◽  
Melanie Kramer ◽  
...  
Keyword(s):  
Therapeutic Target ◽  
Treatment Options ◽  
Acid Sphingomyelinase ◽  
Proof Of Concept ◽  
Lysosomal Storage ◽  
Acid Ceramidase ◽  
Farber Disease ◽  
Ceramidase Deficiency ◽  
Ceramide Accumulation ◽  
Deficient Mice

Farber disease is a rare lysosomal storage disorder resulting from acid ceramidase deficiency and subsequent ceramide accumulation. No treatments for Farber disease are clinically available, and affected patients have a severely shortened lifespan. We have recently reported a novel acid ceramidase deficiency model that mirrors the human disease closely. Acid sphingomyelinase is the enzyme that generates ceramide upstream of acid ceramidase in the lysosomes. Using our acid ceramidase deficiency model, we tested if acid sphingomyelinase could be a potential novel therapeutic target for the treatment of Farber disease. A number of functional acid sphingomyelinase inhibitors are clinically available and have been used for decades to treat major depression. Using these as a therapeutic for Farber disease, thus, has the potential to improve central nervous symptoms of the disease as well, something all other treatment options for Farber disease can’t achieve so far. As a proof-of-concept study, we first cross-bred acid ceramidase deficient mice with acid sphingomyelinase deficient mice in order to prevent ceramide accumulation. Double-deficient mice had reduced ceramide accumulation, fewer disease manifestations, and prolonged survival. We next targeted acid sphingomyelinase pharmacologically, to test if these findings would translate to a setting with clinical applicability. Surprisingly, the treatment of acid ceramidase deficient mice with the acid sphingomyelinase inhibitor amitriptyline was toxic to acid ceramidase deficient mice and killed them within a few days of treatment. In conclusion, our study provides the first proof-of-concept that acid sphingomyelinase could be a potential new therapeutic target for Farber disease to reduce disease manifestations and prolong survival. However, we also identified previously unknown toxicity of the functional acid sphingomyelinase inhibitor amitriptyline in the context of Farber disease, strongly cautioning against the use of this substance class for Farber disease patients.

Inflammation as a psychophysiological biomarker in chronic psychosocial stress

2010 ◽  
Vol 35 (1) ◽  
pp. 115-121 ◽  
Author(s):  
Alexander Hänsel ◽  
Suzi Hong ◽  
Rafael J.A. Cámara ◽  
Roland von Känel
Keyword(s):  
Psychosocial Stress ◽  
Chronic Psychosocial Stress
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