scholarly journals Borderline Personality Disorder With Cocaine Dependence: Impulsivity, Emotional Dysregulation and Amygdala Functional Connectivity

2018 ◽  
Vol 9 ◽  
Author(s):  
Thania Balducci ◽  
Jorge J. González-Olvera ◽  
Diego Angeles-Valdez ◽  
Isabel Espinoza-Luna ◽  
Eduardo A. Garza-Villarreal
Keyword(s):  
Borderline Personality Disorder ◽  
Functional Connectivity ◽  
Personality Disorder ◽  
Borderline Personality ◽  
Emotional Dysregulation ◽  
Cocaine Dependence

scholarly journals Borderline personality disorder with cocaine dependence: impulsivity, emotional dysregulation and amygdala functional connectivity

2018 ◽  
Author(s):  
Thania Balducci ◽  
Jorge J Gonzalez-Olvera ◽  
Diego Angeles-Valdez ◽  
Isabel Espinoza-Luna ◽  
Eduardo A Garza-Villarreal
Keyword(s):  
Prefrontal Cortex ◽  
Borderline Personality Disorder ◽  
Functional Connectivity ◽  
Personality Disorder ◽  
Medial Prefrontal Cortex ◽  
Resting State Fmri ◽  
Borderline Personality ◽  
Emotional Dysregulation ◽  
Cocaine Dependence ◽  
Opposing Effects

AbstractObjective: Borderline personality disorder (BPD) is present in 19% of cocaine dependence (CD) cases; however, this dual pathology (DP) is poorly understood. We assessed impulsivity, emotional dysregulation (ED) and amygdala functional connectivity in this DP.Methods. We recruited 69 participants divided into 4 groups: DP (n = 20), CD without BPD (n = 19), BPD without CD (n = 10) and healthy controls (HC, n = 20). We used self-reported instruments to measure impulsivity and ED. We acquired resting state fMRI and performed seed-based analyses of functional connectivity (FC) of bilateral amygdalas.Results. BPD and CD factors had opposing effects in impulsivity and ED, as well as on FC between left amygdala and medial prefrontal cortex. For the FC between right amygdala and left insula, the effect of having both disorders was additive, reducing FC strength. Significant FC clusters were correlated with impulsivity and ED.Conclusions. In this preliminary study, we found that clinical scores of DP patients were closer to those of BPD without CD than to those of CD without BPD, while amygdala to medial prefrontal cortex FC patterns in DP patients were closer to HC than expected.

scholarly journals Mental capacity and borderline personality disorder

2017 ◽  
Vol 41 (1) ◽  
pp. 33-36 ◽  
Author(s):  
Karyn Ayre ◽  
Gareth S. Owen ◽  
Paul Moran
Keyword(s):  
Borderline Personality Disorder ◽  
Personality Disorder ◽  
Borderline Personality ◽  
Emotional Dysregulation ◽  
Mental Capacity ◽  
High Stakes ◽  
Decision Making Capacity ◽  
Clinical Scenarios ◽  
Mental Capacity Act 2005 ◽  
Mental Capacity Act

SummaryThe use of the Mental Capacity Act 2005 in assessing decision-making capacity in patients with borderline personality disorder (BPD) is inconsistent. We believe this may stem from persisting confusion regarding the nosological status of personality disorder and also a failure to recognise the fact that emotional dysregulation and characteristic psychodynamic abnormalities may cause substantial difficulties in using and weighing information. Clearer consensus on these issues is required in order to provide consistent patient care and reduce uncertainty for clinicians in what are often emergency and high-stakes clinical scenarios.

scholarly journals Altered functional connectivity during evaluation of self-relevance in women with borderline personality disorder

2020 ◽  
Vol 27 ◽  
pp. 102324
Author(s):  
Linda Orth ◽  
Jana Zweerings ◽  
Camellia N. Ibrahim ◽  
Irene Neuner ◽  
Pegah Sarkheil
Keyword(s):  
Borderline Personality Disorder ◽  
Functional Connectivity ◽  
Personality Disorder ◽  
Borderline Personality
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