scholarly journals Neuropsychiatric Symptoms in Patients with the Main Etiological Types of Mild Neurocognitive Disorders: A Hospital-Based Case–Control Study

2017 ◽  
Vol 8 ◽  
Author(s):  
Oleg A. Levada ◽  
Nataliya V. Cherednichenko ◽  
Alexandra S. Troyan
2020 ◽  
Vol 112 ◽  
pp. 107437
Author(s):  
Alfred K. Njamnshi ◽  
Eric-Samuel Chokote ◽  
Leonard Ngarka ◽  
Leonard N. Nfor ◽  
Earnest N. Tabah ◽  
...  

HIV Medicine ◽  
2006 ◽  
Vol 7 (8) ◽  
pp. 544-548 ◽  
Author(s):  
TA Rihs ◽  
K Begley ◽  
DE Smith ◽  
J Sarangapany ◽  
A Callaghan ◽  
...  

2018 ◽  
Vol 31 (5) ◽  
pp. 256-264 ◽  
Author(s):  
Oleg A. Levada ◽  
Alexandra S. Troyan ◽  
Nataliya V. Cherednichenko

Background: Diagnosis of subcortical vascular neurocognitive disorders’ (ScVNCDs) is currently based on neuropsychological and neuroimaging approaches; nevertheless, clinical features, apart from cognitive impairments (CI), may provide additional information about ScVNCD phenotypes. We aimed to determine whether CI and neuropsychiatric symptoms (NPS) form such clinical phenotypes in the mild and early stage of major ScVNCD. Methods: Our sample included 88 cognitively normal elderly individuals, 100 patients with mild ScVNCD, and 60 patients with early major ScVNCD. All participants had neuropsychological, neuropsychiatric, neurological, and functional evaluations. The prevalence of NPS was based on the neuropsychiatric inventory. The statistical analyses included parametric and nonparametric tests and multivariate regression. Results: The severity of executive dysfunction increased through stages of ScVNCD progression ( P < .0001). The NPS with significant predictive value for mild ScVNCD membership was depression (odds ratio [OR] = 7.4), whereas for early major ScVNCD were depression (OR = 5.5) and apathy (OR = 7.6). Those distinguishing NPS and impairments of executive tests’ performance significantly correlated ( P < .05) in patients with mild/major ScVNCD. Conclusion: Significant correlation between pathognomonic cognitive and NPS in compared groups suggest that dysexecutive-depressive syndrome can be the main phenotype in mild ScVNCD, while dysexecutive-depressive-apathetic syndrome in the early stage of major ScVNCD. Obtained cognitive–psychopathological phenotypes may allow a better comprehension of the ScVNCD pathophysiology and improve the diagnostic and therapeutic approach.


2021 ◽  
Vol 12 ◽  
Author(s):  
Susanne Bejerot ◽  
Ulrika Hylén ◽  
Martin Glans ◽  
Eva Hesselmark ◽  
Mats B. Humble

Background: Individuals with generalised joint hypermobility (GJH, present in 10–20% of the general population) are at increased risk of being diagnosed with a range of psychiatric and rheumatological conditions. It is unknown whether Paediatric acute-onset neuropsychiatric syndrome (PANS), characterised by childhood onset obsessive-compulsive disorder or restricted eating and typically associated with several comorbid neuropsychiatric symptoms, is associated with GJH. It is also unknown whether extensive psychiatric comorbidity is associated with GJH.Method: This is a case-control study including 105 participants. We compared three groups: Individuals with PANS, individuals with other mental disorders and healthy controls. Joint mobility was assessed with the Beighton scoring system, psychiatric comorbidity with the M.I.N.I. or MINI-KID interview and symptoms of PANS with the PsychoNeuroInflammatory related Signs and Symptoms Inventory (PNISSI).Results: Hypermobility was similar across groups, and high rates of psychiatric comorbidity was not associated with higher Beighton scores.Conclusion: Although GJH is associated with several psychiatric conditions, such as ADHD and anxiety, this does not seem to be the case for PANS according to this preliminary study.


2001 ◽  
Vol 120 (5) ◽  
pp. A657-A658
Author(s):  
A CATS ◽  
E BLOEMENA ◽  
E SCHENK ◽  
I CLINICS ◽  
S MEUWISSEN ◽  
...  

2001 ◽  
Vol 120 (5) ◽  
pp. A442-A442
Author(s):  
B AVIDAN ◽  
A SONNENBERG ◽  
T SCHNELL ◽  
G CHEJFEC ◽  
A METZ ◽  
...  

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