scholarly journals Resting-State Functional Connectivity in Late-Life Depression: Higher Global Connectivity and More Long Distance Connections

2013 ◽  
Vol 3 ◽  
Author(s):  
Iwo Jerzy Bohr ◽  
Eva Kenny ◽  
Andrew Blamire ◽  
John T. O’Brien ◽  
Alan J. Thomas ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Late Life ◽  
Late Life Depression ◽  
Resting State Functional Connectivity ◽  
Long Distance ◽  
Global Connectivity

scholarly journals Resting state functional connectivity and treatment response in late-life depression

2013 ◽  
Vol 214 (3) ◽  
pp. 313-321 ◽  
Author(s):  
Carmen Andreescu ◽  
Dana L. Tudorascu ◽  
Meryl A. Butters ◽  
Erica Tamburo ◽  
Meenal Patel ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Treatment Response ◽  
Resting State ◽  
Late Life ◽  
Late Life Depression ◽  
Resting State Functional Connectivity

scholarly journals Resting State Functional Connectivity and Outcomes of Psychotherapies for Late-Life Depression

2020 ◽  
Vol 28 (8) ◽  
pp. 859-868 ◽  
Author(s):  
Nili Solomonov ◽  
Lindsay W. Victoria ◽  
Katharine Dunlop ◽  
Matteo Respino ◽  
Matthew J. Hoptman ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Late Life ◽  
Late Life Depression ◽  
Resting State Functional Connectivity

Resting State Functional Connectivity of the Reward System and Outcomes in Psychotherapies for Late-Life Depression

2020 ◽  
Vol 87 (9) ◽  
pp. S439
Author(s):  
Nili Solomonov ◽  
Lindsay Victoria ◽  
Katharine Dunlop ◽  
Matteo Respino ◽  
Matthew J. Hoptman ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Late Life ◽  
Reward System ◽  
Late Life Depression ◽  
Resting State Functional Connectivity

scholarly journals Resting State Functional Connectivity and Outcomes of Psychotherapies for Late-life Depression

2020 ◽  
Author(s):  
Nili Solomonov ◽  
Lindsay W. Victoria ◽  
Katharine Dunlop ◽  
Matteo Respino ◽  
Matthew Hoptman ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Rating Scale ◽  
Depression Scale ◽  
Late Life ◽  
Anterior Cingulate ◽  
Middle Temporal Gyrus ◽  
Late Life Depression ◽  
Resting State Functional Connectivity ◽  
Depressive Episodes

Background: Problem solving therapy (PST) and “Engage”, a reward-exposure” based therapy, are important treatment options for late-life depression, given modest efficacy of antidepressants in this disorder. Abnormal function of the reward and default mode networks has been observed during depressive episodes. This study examined whether resting state functional connectivity (rsFC) of reward and DMN circuitries is associated with treatment outcomes. Methods: Thirty-two older adults with major depression (mean age = 72.7) were randomized to 9-weeks of either PST or “Engage”. We assessed rsFC at baseline and Week 6. We placed seeds in three a priori regions of interest: subgenual cingulate (sgACC), dorsal anterior cingulate cortex (dACC), and nucleus accumbens (NAcc). Outcome measures included the Hamilton Depression Rating Scale (HAMD) and the Behavioral Activation for Depression Scale (BADS).Results: In both PST and “Engage”, higher rsFC between the sgACC and middle temporal gyrus at baseline was associated with greater improvement in depression severity (HAMD). Preliminary findings suggested that in “Engage” treated participants, lower rsFC between the dACC and DMPFC at baseline was associated with HAM-D improvement. Finally, in Engage only, increased rsFC from baseline to Week 6 between NAcc and Superior Parietal Cortex was associated with increased BADS scores.Conclusion: The results suggest that patients who present with higher rsFC between the sgACC and a structure within the DMN may benefit from behavioral psychotherapies for late life depression. ‘Engage’ may lead to increased rsFC within the reward system reflecting a reconditioning of the reward systems by reward exposure.

scholarly journals Altered resting-state functional connectivity in late-life depression: A cross-sectional study

2016 ◽  
Vol 189 ◽  
pp. 126-133 ◽  
Author(s):  
Harris A. Eyre ◽  
Hongyu Yang ◽  
Amber M. Leaver ◽  
Kathleen Van Dyk ◽  
Prabha Siddarth ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Late Life ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Late Life Depression ◽  
Resting State Functional Connectivity ◽  
Cross Sectional

scholarly journals Neuroprotective effects of motherhood on brain function in late-life: a resting state fMRI study

2020 ◽  
Author(s):  
Edwina R Orchard ◽  
Phillip GD Ward ◽  
Sidhant Chopra ◽  
Elsdon Storey ◽  
Gary F Egan ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Brain Function ◽  
Late Life ◽  
Older Woman ◽  
Functional Plasticity ◽  
Resting State Functional Connectivity ◽  
Neuroprotective Effects ◽  
Number Of Children ◽  
Age Related

AbstractThe maternal brain undergoes structural and functional plasticity during pregnancy and the postpartum period. Little is known about functional plasticity outside caregiving-specific contexts, and whether changes persist across the lifespan. Structural neuroimaging studies suggest that parenthood may confer a protective effect against the ageing process, however it is unknown whether parenthood is associated with functional brain differences in late-life. We examined the relationship between resting state functional connectivity and number of children parented in 220 healthy older females (73.82±3.53years) and 252 healthy older males (73.95±3.50years). We compared patterns of resting state functional connectivity with three different models of age-related functional change to assess whether these effects may be functionally neuroprotective for the ageing human parental brain. No relationship between functional connectivity and number of children was obtained for males. For females, we found widespread decreasing functional connectivity with increasing number of children parented, with increased segregation between networks, decreased connectivity between hemispheres, and decreased connectivity between anterior and posterior regions. The patterns of functional connectivity related to the number of children an older woman has parented were in the opposite direction to those usually associated with age-related cognitive decline, suggesting that motherhood may be beneficial for brain function in late-life.

Late-Life Depression: Modifications of Brain Resting State Activity

2017 ◽  
Vol 30 (3) ◽  
pp. 140-150 ◽  
Author(s):  
Filippo Cieri ◽  
Roberto Esposito ◽  
Nicoletta Cera ◽  
Valentina Pieramico ◽  
Armando Tartaro ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Resting State ◽  
Elderly Population ◽  
Rating Scale ◽  
Late Life ◽  
Group Differences ◽  
Depression Symptoms ◽  
Late Life Depression ◽  
Potential Biomarker ◽  
Intrinsic Connectivity

Late-life depression (LLD) is a common emotional and mental disability in the elderly population characterized by the presence of depressed mood, the loss of interest or pleasure in daily activities, and other depression symptoms. It has a serious effect on the quality of life of elderly individuals and increases their risk of developing physical and mental diseases. It is an important area of research, given the growing elderly population. Brain functional connectivity modifications represent one of the neurobiological biomarker for LLD even if to date remains poorly understood. In our study, we enrolled 10 elderly patients with depressive symptoms compared to 11 age-matched healthy controls. All participants were evaluated by means of neuropsychological tests and underwent the same functional magnetic resonance imaging (fMRI) protocol to evaluate modifications of brain resting state functional connectivity. Between-group differences were observed for the Geriatric Depression Scale and Hamilton Depression Rating Scale, with higher scores for patients with LLD. Voxel-wise, 1-way analysis of variance revealed between-group differences in left frontoparietal network (lFPN) and sensory motor network (SMN): Increased intrinsic connectivity in the LLD group was observed in the left dorsolateral prefrontal cortex and in the left superior parietal lobule of the lFPN and increased intrinsic connectivity in the LLD group was observed in the bilateral primary somatosensory cortex of the SMN. Our findings support the use of resting state fMRI as a potential biomarker for LLD; even if to confirm the relationship between brain changes and the pathophysiology of LLD, longitudinal neuroimaging studies are required.

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